Evidence dossier · candidate cand-dtap-guillain-barr-syndrome · VICP program · · DRAFT — not a determination
This is a draft research-tracking dossier, not a determination that DTaP vaccine causes Guillain-Barré Syndrome (GBS), and not an incidence or legal finding. All evidence is flagged needs_human_review and must be reviewed before any page is published or cited. Every value is grounded in retrieved citations (PMID + retrieval date); unsourced items read "no evidence found / not assessable". Symmetric search: every supporting query has a mirror/null query, and zeros are shown (negative dossiers report the absence of signal).
Claim matrix (C1–C6, computed)
Claim
Label
Status
Missing nodes
C1
Coherent clinical object exists
insufficient_data
missing: A2
C2
Consistent temporal window
insufficient_data
missing: A5
C3
Epidemiologic excess risk
contested
C4
Consistency / replication
contested
C5
Specificity (product / dose)
insufficient_data
missing: C2n
C6
Biological mechanism
insufficient_data
missing: E1
Two evidentiary bars apply to the epi nodes/claims (C3, C4): · VICP — preponderance of the evidence. · CICP (off-Table) — compelling, reliable, valid medical and scientific evidence (higher bar).
Bradford Hill assessment (computed)
Each viewpoint is derived from the node statuses below (see the framework crosswalk in compensation-tables-schema.md §8). Hill's viewpoints are aids to judgement, not a scoring checklist that proves causation; temporality is the only strictly necessary criterion.
Viewpoint
What it asks
Status (from evidence)
Temporality(necessary)
cause precedes effect in a plausible window (necessary)
NASEM (formerly IOM), "Adverse Effects of Vaccines: Evidence and Causality" (2011, updated 2024). Independent grading of epidemiologic and mechanistic evidence, synthesized into one of four causal-conclusion categories. This is a computed approximation of that framework, not a NASEM determination. See compensation-tables-schema.md §8bis.
Case-definition standard: Brighton Collaboration (named in spec §1: Guillain-Barre syndrome) — governs the case-certainty scale on A1/A2/A6/A8 below. See compensation-tables-schema.md §8ter.
Evidence matrix (68 nodes by workstream)
68 of 68 nodes evaluated · 136 PubMed queries logged (supporting + mirror, incl. zeros). Statuses are computed from retrieved citations; not hand-set.
Definition & attribution 24/24 evaluated
A1 · Case reportssupports
Measure: New definite object in risk window T Comparator: Pre-vaccination baseline Hit rule: Definite object present, onset in window, competing causes considered
Finding: A case report describes a 20-month-old girl diagnosed with Guillain-Barré syndrome after DTaP vaccination, with a temporal correlation noted but causal relationship considered debatable; a systematic review of 45 additional published DTP vaccine-related GBS cases is cited.
Case-certainty distribution (Brighton Collaboration): 1 Level 2 (probable). Transparency layer — does not change this node's status or feed C1–C6.
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) case report OR case series Case reports pubmed · 66167 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
12 retrieved record(s)
supports_node 37753771 · Human vaccines & immunotherapeutics (2023) — Guillain Barré syndrome after combined diphtheria, tetanus, and acellular pertussis (DTaP) vaccine: A rare pediatric case report and review of literature.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
ambiguous 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
Measure: Definite object plus objective test Comparator: Reference range / diagnostic criteria Hit rule: Objective confirmation in >=1 case per the working definition
Finding: no evidence found
Case-certainty distribution (Brighton Collaboration): 1 Level 3 (possible). Transparency layer — does not change this node's status or feed C1–C6.
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) case report OR case series Series with objective confirmation pubmed · 5643 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
11 retrieved record(s)
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
ambiguous 32809680 · (2026) — Rubella Vaccine.
ambiguous 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A3 · Onset histogramno_data
Measure: Distribution of onset times after dose Comparator: Pre-specified risk window Hit rule: Onset clusters inside the pre-specified window (not uniform/flat)
Finding: One case report describes a 20-month-old girl with GBS onset temporally correlated with DTaP vaccination, and a systematic review of 45 additional DTP/GBS cases is referenced but onset times are not detailed in the retrieved abstract.
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) case report OR case series Onset histogram pubmed · 4 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
12 retrieved record(s)
ambiguous 37753771 · Human vaccines & immunotherapeutics (2023) — Guillain Barré syndrome after combined diphtheria, tetanus, and acellular pertussis (DTaP) vaccine: A rare pediatric case report and review of literature.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
ambiguous 32809680 · (2026) — Rubella Vaccine.
A4 · Temporal plausibilitymixed
Measure: Onset latency vs object pathophysiology Comparator: Object's known natural latency Hit rule: Onset latency consistent with the object's pathophysiology
Finding: A case report describes a 20-month-old girl who developed GBS with onset after DTaP vaccination, and a systematic review of 45 published DTP-associated GBS cases provides onset latency data; however, the evidence consists solely of case reports and does not establish a consistent latency window or pathophysiology-based plausibility.
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) case report OR case series Temporal plausibility pubmed · 33 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
13 retrieved record(s)
ambiguous 37753771 · Human vaccines & immunotherapeutics (2023) — Guillain Barré syndrome after combined diphtheria, tetanus, and acellular pertussis (DTaP) vaccine: A rare pediatric case report and review of literature.
ambiguous 15638050 · Clinical and experimental rheumatology (2004) — A case-series of adverse events, positive re-challenge of symptoms, and events in identical twins following hepatitis B vaccination: analysis of the Vaccine Adv
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
A5 · Onset-interval documentationmixed
Measure: Onset interval documented in source Comparator: Dose date Hit rule: Onset interval is recorded (not imputed) in a primary source
Finding: The retrieved evidence includes a case report and systematic review (PMID 37753771) describing a 20-month-old girl with GBS onset after DTaP vaccination, with onset interval documented in the source as part of the clinical timeline, but the evidence is limited to a single case report and does not constitute robust onset-interval documentation across multiple primary sources.
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) case report OR case series Onset-interval documentation pubmed · 2 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
12 retrieved record(s)
ambiguous 37753771 · Human vaccines & immunotherapeutics (2023) — Guillain Barré syndrome after combined diphtheria, tetanus, and acellular pertussis (DTaP) vaccine: A rare pediatric case report and review of literature.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
does_not_resolve 38500249 · Journal of movement disorders (2024) — COVID-19 Vaccine-Related Movement Disorders: A Systematic Review.
A6 · Differential diagnosis excludedno_data
Measure: Competing causes assessed and excluded Comparator: Likely alternative diagnoses Hit rule: Pre-specified competing causes ruled out per the working definition
Finding: One case report describes a 20-month-old girl diagnosed with Guillain-Barré syndrome after DTaP vaccination, with authors noting the exact causal relationship is debatable; no systematic exclusion of competing causes is explicitly documented in the abstract.
Case-certainty distribution (Brighton Collaboration): 1 Level 2 (probable), 1 Level 3 (possible). Transparency layer — does not change this node's status or feed C1–C6.
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) case report OR case series Differential diagnosis excluded pubmed · 429 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
12 retrieved record(s)
ambiguous 37753771 · Human vaccines & immunotherapeutics (2023) — Guillain Barré syndrome after combined diphtheria, tetanus, and acellular pertussis (DTaP) vaccine: A rare pediatric case report and review of literature.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
does_not_resolve 38500249 · Journal of movement disorders (2024) — COVID-19 Vaccine-Related Movement Disorders: A Systematic Review.
A7 · Rechallenge / re-exposureno_data
Measure: Object recurs on a further dose Comparator: First-dose response Hit rule: Object recurs after a subsequent dose (re-exposure)
Finding: A single case report describes a 20-month-old girl who developed Guillain-Barré syndrome after DTaP vaccination, representing a possible recurrence on re-exposure, but the abstract does not confirm that this was a rechallenge event (i.e., GBS after a subsequent dose following a prior vaccine-related episode). No other retrieved evidence addresses DTaP vaccine and GBS in the context of rechallenge.
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) case report OR case series Rechallenge / re-exposure pubmed · 4 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
12 retrieved record(s)
ambiguous 37753771 · Human vaccines & immunotherapeutics (2023) — Guillain Barré syndrome after combined diphtheria, tetanus, and acellular pertussis (DTaP) vaccine: A rare pediatric case report and review of literature.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
does_not_resolve 38500249 · Journal of movement disorders (2024) — COVID-19 Vaccine-Related Movement Disorders: A Systematic Review.
A8 · Adjudicated by criteria (Brighton Collaboration)mixed
Measure: Object adjudicated by published criteria Comparator: Published clinical / Brighton criteria Hit rule: Cases adjudicated to 'definite' by a published criterion set
Finding: A single case report describes a 20-month-old girl who developed Guillain-Barré syndrome after DTaP vaccination, with temporal correlation but uncertain causal relationship.
Case-certainty distribution (Brighton Collaboration): 1 Level 2 (probable). Transparency layer — does not change this node's status or feed C1–C6.
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) case report OR case series Adjudicated by criteria pubmed · 41 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
12 retrieved record(s)
supports_node 37753771 · Human vaccines & immunotherapeutics (2023) — Guillain Barré syndrome after combined diphtheria, tetanus, and acellular pertussis (DTaP) vaccine: A rare pediatric case report and review of literature.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
ambiguous 32809680 · (2026) — Rubella Vaccine.
A9 · Natural-history consistencymixed
Measure: Course matches the object's natural history Comparator: Known natural history of the object Hit rule: Clinical course (onset, peak, recovery) matches the object's natural history
Finding: A single case report describes a 20-month-old girl who developed Guillain-Barré syndrome after DTaP vaccination, with onset, progressive weakness, areflexia, and albuminocytologic dissociation consistent with the natural history of GBS, but the authors note that the exact causal relationship is still debatable.
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) case report OR case series Natural-history consistency pubmed · 105 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
12 retrieved record(s)
ambiguous 37753771 · Human vaccines & immunotherapeutics (2023) — Guillain Barré syndrome after combined diphtheria, tetanus, and acellular pertussis (DTaP) vaccine: A rare pediatric case report and review of literature.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
does_not_resolve 38500249 · Journal of movement disorders (2024) — COVID-19 Vaccine-Related Movement Disorders: A Systematic Review.
A10 · No confounding objectno_data
Measure: Not attributable to a co-occurring condition Comparator: Co-occurring illness that could produce the object Hit rule: Object not better explained by a co-occurring condition (infection, etc.)
Finding: A single case report describes a 20-month-old girl who developed Guillain-Barré syndrome after DTaP vaccination, with a temporal correlation but uncertain causal relationship; the report summarizes 45 other published GBS cases after DTP-containing vaccines.
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) case report OR case series No confounding object pubmed · 21 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
13 retrieved record(s)
ambiguous 37753771 · Human vaccines & immunotherapeutics (2023) — Guillain Barré syndrome after combined diphtheria, tetanus, and acellular pertussis (DTaP) vaccine: A rare pediatric case report and review of literature.
does_not_resolve 34312836 · Clinical pharmacology and therapeutics (2022) — Angiotensin-Converting Enzyme Inhibitors Used Concomitantly with Insulin Secretagogues and the Risk of Serious Hypoglycemia.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
D1 · Predicted site of injuryno_data
Measure: Object at the site the mechanism predicts Comparator: Predicted anatomic site from the mechanism Hit rule: Object localizes to the anatomic site the mechanism predicts
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) anatomic localization Predicted site of injury mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Predicted site of injury not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D2 · Spared structuresno_data
Measure: Structures the mechanism should spare are spared Comparator: Structures predicted unaffected Hit rule: Structures predicted spared by the mechanism are indeed spared
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Spared structures not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D3 · Local vs systemic distributionno_data
Measure: Distribution matches mechanism scope Comparator: Local (injection site) vs systemic expectation Hit rule: Observed distribution (local vs systemic) matches the mechanism's predicted scope
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) anatomic localization Local vs systemic distribution mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Local vs systemic distribution not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D4 · Kinetics classno_data
Measure: Onset/offset kinetics match the mechanism Comparator: Expected kinetic class (acute vs chronic) Hit rule: Onset and offset kinetics are in the class the mechanism predicts
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Kinetics class not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D5 · Platform-mechanism matchno_data
Measure: Mechanism is consistent with the platform Comparator: Mechanistic expectation for the platform Hit rule: The proposed mechanism is biologically consistent with the vaccine platform
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Platform-mechanism match not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
H3 · Targeted treatment reversesno_data
Measure: A targeted treatment reverses the object in patients Comparator: Treatment-naive / placebo Hit rule: A mechanism-directed treatment reverses the object (vs control treatment)
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Targeted treatment reverses intervention OR treatment OR reversal pubmed · 15142089 hits · run 2026-09-07
Measure: No node's finding contradicts another Comparator: Internal consistency across nodes Hit rule: No evaluated node directly contradicts another (coherence)
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) No internal contradiction coherence OR latency OR susceptibility pubmed · 870055 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) No internal contradiction inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
I2 · Analogy to a known objectno_data
Measure: Object analogous to a well-established analog Comparator: Established analog's profile Hit rule: The object's profile matches a well-established analog on key features
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Analogy to a known object coherence OR latency OR susceptibility pubmed · 870055 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Analogy to a known object inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
I5 · Latency coherenceno_data
Measure: Observed latency matches the mechanism's latency Comparator: Mechanism-predicted latency Hit rule: Observed onset latency is coherent with the mechanism's predicted latency
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Latency coherence coherence OR latency OR susceptibility pubmed · 870055 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Latency coherence inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
J1 · Pre-specificationno_data
Measure: Window/hit-rule pre-specified before data Comparator: Pre-specified vs post-hoc Hit rule: The risk window, object, and hit rule were pre-specified before data were seen
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Pre-specification pre-specified OR adjudicated pubmed · 13550 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Pre-specification post-hoc OR hypothesis-generating only pubmed · 1699 hits · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 39353737 · BMJ quality & safety (2025) — Adverse diagnostic events in hospitalised patients: a single-centre, retrospective cohort study.
J2 · Contrary-evidence logno_data
Measure: Contrary evidence is logged, not omitted Comparator: Support-only dossier Hit rule: Contrary / null / refuting findings are logged and shown alongside support
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Contrary-evidence log pre-specified OR adjudicated pubmed · 13550 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Contrary-evidence log post-hoc OR hypothesis-generating only pubmed · 1699 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
J3 · No temporality-only claimno_data
Measure: Claim not based on temporality alone Comparator: Sequence-only evidence Hit rule: The claim is not supported by temporal sequence alone (independent evidence exists)
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) No temporality-only claim pre-specified OR adjudicated pubmed · 13550 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) No temporality-only claim post-hoc OR hypothesis-generating only pubmed · 1699 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
J4 · Passive-surveillance roleno_data
Measure: Passive-surveillance findings bounded correctly Comparator: Active-surveillance confirmation Hit rule: Passive-surveillance signals are framed as hypothesis-generating, not confirmatory
Finding: The retrieved evidence describes a method to enhance detection of immune-related adverse events (irAEs) using large language models and ICD codes in patients receiving immune checkpoint inhibitor therapy. It does not address DTaP vaccine or Guillain-Barré Syndrome.
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Passive-surveillance role pre-specified OR adjudicated pubmed · 13550 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Passive-surveillance role post-hoc OR hypothesis-generating only pubmed · 1699 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
J5 · Dose mappingno_data
Measure: Dose/lot exposure mapped to the object Comparator: Unmapped exposure Hit rule: Dose / lot exposure is mapped to the object where the mechanism predicts it
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Dose mapping pre-specified OR adjudicated pubmed · 13550 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Dose mapping post-hoc OR hypothesis-generating only pubmed · 1699 hits · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
Epidemiologic chassis 13/13 evaluated
B1 · Excess vs baselineno_data
Measure: RR/IRR vs unexposed or prior window Comparator: Unvaccinated person-time or pre-vaccination window Hit rule: RR/IRR > 1 with CI excluding 1 after pre-specified confounders
Finding: One self-controlled case series study (PMID 40664645) evaluated GBS after COVID-19 mRNA vaccines, and a multinational SCCS study (PMID 40440921) assessed GBS after COVID-19 vaccination or SARS-CoV-2 infection; neither directly addressed DTaP vaccine and GBS, and no retrieved evidence examined that specific pair.
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Excess vs baseline incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) no association OR null OR no increased risk Excess vs baseline pubmed · 88468 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 41979390 · Statistics in medicine (2026) — Flexible and Interpretable Modeling of Overlapping Exposure Risks in Self-Controlled Case Series Analysis.
supports_node 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
ambiguous 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
refutes_node 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 34672967 · Lancet (London, England) (2021) — Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, pha
does_not_resolve 34489307 · Gut (2022) — Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: results from a nationwide histology cohort.
B2 · SCCSno_data
Measure: Self-controlled case series risk ratio Comparator: Individuals' own risk intervals (no-event) Hit rule: SCCS risk ratio > 1 in the post-vaccination window, CI excluding 1
Finding: The retrieved evidence includes only a case report and systematic review (PMID 37753771) describing a pediatric GBS case after DTaP vaccination, but no SCCS study specifically examining DTaP vaccine and GBS with a risk ratio and CI excluding 1.
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) SCCS incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) no association OR null OR no increased risk SCCS pubmed · 88576 hits · run 2026-09-07
11 retrieved record(s)
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
refutes_node 32098853 · Neurology (2020) — Seasonal influenza vaccine and Guillain-Barré syndrome: A self-controlled case series study.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
refutes_node 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 39795956 · International journal of molecular scien (2024) — The Potential Metalloestrogenic Effect of Aluminum on Breast Cancer Risk for Antiperspirant Users.
B3 · Cohort / risk-intervalno_data
Measure: Incidence rate ratio in defined window Comparator: Pre-specified risk vs comparison interval Hit rule: IRR > 1 in the pre-specified window, CI excluding 1, stratified by age/sex
Finding: The retrieved evidence includes only a single case report (PMID 37753771) describing a temporal association between DTaP vaccination and GBS in a 20-month-old girl, but no cohort or risk-interval study (IRR > 1, CI excluding 1, stratified by age/sex) was found for the DTaP-GBS pair. The other studies address influenza, COVID-19, or rotavirus vaccines, and several are methodological or unrelated to DTaP or GBS.
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Cohort / risk-interval incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) no association OR null OR no increased risk Cohort / risk-interval pubmed · 88077 hits · run 2026-09-07
11 retrieved record(s)
refutes_node 32098853 · Neurology (2020) — Seasonal influenza vaccine and Guillain-Barré syndrome: A self-controlled case series study.
does_not_resolve 41979390 · Statistics in medicine (2026) — Flexible and Interpretable Modeling of Overlapping Exposure Risks in Self-Controlled Case Series Analysis.
supports_node 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
refutes_node 32752037 · Vaccines (2020) — Incidence of Guillain-Barré Syndrome is not Associated with Influenza Vaccination in the Elderly.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
supports_node 37753771 · Human vaccines & immunotherapeutics (2023) — Guillain Barré syndrome after combined diphtheria, tetanus, and acellular pertussis (DTaP) vaccine: A rare pediatric case report and review of literature.
does_not_resolve 41284649 · PloS one (2025) — Risk of neurologic or immune-mediated adverse events after COVID-19 diagnosis in the United States.
B4 · Meta-analysis / poolingno_data
Measure: Pooled effect across studies Comparator: Pooled estimate with heterogeneity Hit rule: Pooled estimate > 1 (or < 1) with quantified heterogeneity (I2)
Finding: No retrieved evidence provides a pooled effect estimate with quantified heterogeneity for the association between DTaP vaccine and Guillain-Barré Syndrome; the only directly relevant study (PMID 37753771) is a case report and literature review without a meta-analysis or pooled estimate.
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Meta-analysis / pooling incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) no association OR null OR no increased risk Meta-analysis / pooling pubmed · 111910 hits · run 2026-09-07
9 retrieved record(s)
ambiguous 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
refutes_node 32752037 · Vaccines (2020) — Incidence of Guillain-Barré Syndrome is not Associated with Influenza Vaccination in the Elderly.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 35489031 · Journal of clinical psychopharmacology (2022) — Prescription Stimulants and the Risk of Psychosis: A Systematic Review of Observational Studies.
does_not_resolve 29402646 · Journal of the American Medical Director (2018) — Fall-Risk-Increasing Drugs: A Systematic Review and Meta-analysis: III. Others.
supports_node 37753771 · Human vaccines & immunotherapeutics (2023) — Guillain Barré syndrome after combined diphtheria, tetanus, and acellular pertussis (DTaP) vaccine: A rare pediatric case report and review of literature.
does_not_resolve 28230042 · Journal of cancer research and therapeut (2016) — Meta-analysis of association between mobile phone use and glioma risk.
B5 · Negative-control outcomesno_data
Measure: No excess for outcomes the vaccine should not cause Comparator: Negative-control outcomes (unaffected by mechanism) Hit rule: Null for negative-control outcomes while target outcome is positive (specificity)
Finding: No retrieved evidence assesses DTaP vaccine and Guillain-Barré syndrome. The studies retrieved focus on seasonal influenza vaccine, COVID-19 vaccination, or SARS-CoV-2 infection, not DTaP vaccine.
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Negative-control outcomes incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) no association OR null OR no increased risk Negative-control outcomes pubmed · 88279 hits · run 2026-09-07
9 retrieved record(s)
refutes_node 32098853 · Neurology (2020) — Seasonal influenza vaccine and Guillain-Barré syndrome: A self-controlled case series study.
does_not_resolve 41979390 · Statistics in medicine (2026) — Flexible and Interpretable Modeling of Overlapping Exposure Risks in Self-Controlled Case Series Analysis.
supports_node 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
refutes_node 32752037 · Vaccines (2020) — Incidence of Guillain-Barré Syndrome is not Associated with Influenza Vaccination in the Elderly.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 42371637 · JAMA internal medicine (2026) — Prenatal Acetaminophen (Paracetamol) Use and the Risk of Autism and/or Attention-Deficit/Hyperactivity Disorder Among Sibling-Matched Cohorts.
does_not_resolve 38833248 · JAMA network open (2024) — Valproate Use During Spermatogenesis and Risk to Offspring.
B6 · Other-antigen comparisonno_data
Measure: Risk vs a different-antigen comparator Comparator: Comparator product with a different antigen Hit rule: Risk specific to the target antigen, not shared with the comparator antigen
Finding: No retrieved evidence directly compares the risk of Guillain-Barré syndrome following DTaP vaccine versus a different-antigen comparator. The only DTaP-related evidence is a single case report (PMID 37753771) that does not include a comparator antigen or provide a comparative risk estimate.
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Other-antigen comparison incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) no association OR null OR no increased risk Other-antigen comparison pubmed · 88041 hits · run 2026-09-07
10 retrieved record(s)
refutes_node 32098853 · Neurology (2020) — Seasonal influenza vaccine and Guillain-Barré syndrome: A self-controlled case series study.
ambiguous 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
refutes_node 32752037 · Vaccines (2020) — Incidence of Guillain-Barré Syndrome is not Associated with Influenza Vaccination in the Elderly.
does_not_resolve 40987135 · JACC. Advances (2025) — Risk of Major Adverse Cardiovascular Events During Acute Streptococcus pneumoniae Infection in COPD Patients.
supports_node 37753771 · Human vaccines & immunotherapeutics (2023) — Guillain Barré syndrome after combined diphtheria, tetanus, and acellular pertussis (DTaP) vaccine: A rare pediatric case report and review of literature.
does_not_resolve 23296494 · Molecular biology reports (2013) — Assessment of the association between GSTM1 null genotype and risk of type 2 diabetes.
B7 · Absolute riskno_data
Measure: Per-100k risk in window Comparator: Absolute incidence per 100k Hit rule: Absolute risk reported and stable across the window (not an artifact of rarity)
Finding: The retrieved evidence includes a case report of GBS after DTaP vaccination in a 20-month-old girl (PMID 37753771), but no absolute risk (per-100k) estimate in a defined risk window for DTaP and GBS is reported. Other cited studies address GBS after COVID-19 or influenza vaccines, not DTaP.
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Absolute risk incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) no association OR null OR no increased risk Absolute risk pubmed · 111308 hits · run 2026-09-07
12 retrieved record(s)
does_not_resolve 41979390 · Statistics in medicine (2026) — Flexible and Interpretable Modeling of Overlapping Exposure Risks in Self-Controlled Case Series Analysis.
refutes_node 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
refutes_node 32098853 · Neurology (2020) — Seasonal influenza vaccine and Guillain-Barré syndrome: A self-controlled case series study.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 29211679 · The New England journal of medicine (2017) — Contemporary Hormonal Contraception and the Risk of Breast Cancer.
does_not_resolve 23484825 · The New England journal of medicine (2013) — Risk of ischemic heart disease in women after radiotherapy for breast cancer.
B8 · Platform splitno_data
Measure: Risk by vaccine platform / product Comparator: Platform (mRNA vs viral vector, etc.) Hit rule: Risk attributable to a specific platform, not to 'a vaccine' generally
Finding: Only one case report (PMID 37753771) describes a temporal association between DTaP vaccination and Guillain-Barré syndrome, without platform-specific comparative risk analysis. No retrieved evidence provides attributable-risk estimates for DTaP versus other vaccine platforms.
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Platform split incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) no association OR null OR no increased risk Platform split pubmed · 88106 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 41979390 · Statistics in medicine (2026) — Flexible and Interpretable Modeling of Overlapping Exposure Risks in Self-Controlled Case Series Analysis.
refutes_node 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 30214635 · Theranostics (2018) — CD28(null) pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death.
ambiguous 37753771 · Human vaccines & immunotherapeutics (2023) — Guillain Barré syndrome after combined diphtheria, tetanus, and acellular pertussis (DTaP) vaccine: A rare pediatric case report and review of literature.
does_not_resolve 36370744 · The Lancet. Child & adolescent health (2023) — Cancer risk with topical calcineurin inhibitors, pimecrolimus and tacrolimus, for atopic dermatitis: a systematic review and meta-analysis.
B9 · Host-structure stratificationno_data
Measure: Risk by age / sex / host structure Comparator: Unstratified estimate Hit rule: Risk concentrated in a defined host subgroup (e.g. young males), stable across sources
Finding: The only directly relevant evidence for DTaP vaccine and GBS is a single pediatric case report (PMID 37753771) describing a 20-month-old girl who developed GBS after DTaP vaccination, with the authors noting the causal relationship remains debatable. No retrieved studies provide stratified risk estimates by age, sex, or host structure for DTaP and GBS.
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Host-structure stratification incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) no association OR null OR no increased risk Host-structure stratification pubmed · 88039 hits · run 2026-09-07
11 retrieved record(s)
refutes_node 32098853 · Neurology (2020) — Seasonal influenza vaccine and Guillain-Barré syndrome: A self-controlled case series study.
supports_node 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
refutes_node 32752037 · Vaccines (2020) — Incidence of Guillain-Barré Syndrome is not Associated with Influenza Vaccination in the Elderly.
does_not_resolve 40987135 · JACC. Advances (2025) — Risk of Major Adverse Cardiovascular Events During Acute Streptococcus pneumoniae Infection in COPD Patients.
does_not_resolve 30214635 · Theranostics (2018) — CD28(null) pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death.
ambiguous 37753771 · Human vaccines & immunotherapeutics (2023) — Guillain Barré syndrome after combined diphtheria, tetanus, and acellular pertussis (DTaP) vaccine: A rare pediatric case report and review of literature.
B10 · Formulation / component changeno_data
Measure: Risk tracks a formulation change Comparator: Pre- vs post-change formulation Hit rule: Risk change tracks a documented formulation / component change over time
Finding: One pediatric case report (PMID 37753771) describes a temporal association between DTaP vaccination and Guillain-Barré Syndrome, but no population-level epidemiological study in the retrieved evidence evaluates whether GBS risk tracks a documented formulation/component change of DTaP vaccine over time.
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Formulation / component change incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) no association OR null OR no increased risk Formulation / component change pubmed · 88201 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
ambiguous 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 40987135 · JACC. Advances (2025) — Risk of Major Adverse Cardiovascular Events During Acute Streptococcus pneumoniae Infection in COPD Patients.
does_not_resolve 22709951 · Vaccine (2012) — Vaccine and Immunization Surveillance in Ontario (VISION) - using linked health administrative databases to monitor vaccine safety.
refutes_node 32098853 · Neurology (2020) — Seasonal influenza vaccine and Guillain-Barré syndrome: A self-controlled case series study.
does_not_resolve 41092926 · Lancet (London, England) (2025) — Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 su
does_not_resolve 30214635 · Theranostics (2018) — CD28(null) pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death.
H2 · Formulation natural experimentno_data
Measure: Risk shifts with a formulation change in the field Comparator: Pre- vs post-change formulation Hit rule: Observed risk tracks a real-world formulation change (natural experiment)
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Formulation natural experiment intervention OR treatment OR reversal pubmed · 15142089 hits · run 2026-09-07
Measure: Risk signal appears/disappears across a pause or policy change Comparator: Pre- vs post-pause period Hit rule: The signal appears or disappears coherently with a rollout / pause (H4)
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Policy / pause signal intervention OR treatment OR reversal pubmed · 15142089 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Policy / pause signal no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-07
1 retrieved record(s)
does_not_resolve 38189107 · Expert review of vaccines (2024) — Neoadjuvant personalized cancer vaccines: the final frontier?
I3 · Infection coherenceno_data
Measure: Pattern is coherent with or distinct from infection Comparator: Infection-matched comparison Hit rule: The post-vaccine pattern is coherent with (or clearly distinct from) the infection pattern
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Infection coherence coherence OR latency OR susceptibility pubmed · 870055 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Infection coherence inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
Mediator & biological gradient 24/24 evaluated
C1n · Dose strength gradientno_data
Measure: Risk vs dose strength (dose size) Comparator: Lower dose strength Hit rule: Monotonic dose-response in dose strength (larger dose -> higher risk)
Finding: The only retrieved evidence mentioning Guillain-Barré Syndrome is a safety study of DTaP-IPV/Hib vaccine that lists GBS as a monitored outcome but does not report any dose-strength gradient analysis or results for GBS by dose size. No retrieved study addresses monotonic dose-response in DTaP dose strength and GBS risk.
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Dose strength gradient dose-response OR dose effect pubmed · 1299145 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) no dose effect OR no dose-response Dose strength gradient pubmed · 114 hits · run 2026-09-07
3 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
refutes_node 27373595 · Vaccine (2016) — Safety of DTaP-IPV/Hib vaccine administered routinely to infants and toddlers.
C2n · Dose number gradientno_data
Measure: Risk vs dose number (1st vs 2nd vs 3rd) Comparator: First dose Hit rule: Risk increases (or shows a defined pattern) with dose number
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Dose number gradient dose-response OR dose effect pubmed · 1299145 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) no dose effect OR no dose-response Dose number gradient pubmed · 558 hits · run 2026-09-07
5 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
does_not_resolve 42488947 · Hypertension (Dallas, Tex. : 1979) (2026) — Clinical Modifiers of Salt Sensitivity: A Meta-Regression and Risk Translation Study.
does_not_resolve 30316563 · Radiotherapy and oncology : journal of t (2019) — Volume effects of radiotherapy on the risk of second primary cancers: A systematic review of clinical and epidemiological studies.
does_not_resolve 42106826 · The international journal of behavioral (2026) — Physical activity, falls, and dementia risk in adults aged ≥ 60: evidence from three cohorts.
C3n · Measured-exposure tertilesno_data
Measure: Risk vs measured exposure tertile Comparator: Lowest-exposure tertile Hit rule: Risk ordered by measured-exposure tertile (high > mid > low)
Finding: The retrieved evidence includes a safety study of DTaP-IPV/Hib vaccine that monitored for Guillain-Barré Syndrome (GBS) but does not report GBS risk stratified by measured-exposure tertiles, and other abstracts address unrelated vaccines (MenB-4C, COVID-19, Tdap) or non-tertile incidence rates in Chinese children.
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Measured-exposure tertiles dose-response OR dose effect pubmed · 1299145 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) no dose effect OR no dose-response Measured-exposure tertiles pubmed · 3 hits · run 2026-09-07
5 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
refutes_node 27373595 · Vaccine (2016) — Safety of DTaP-IPV/Hib vaccine administered routinely to infants and toddlers.
does_not_resolve 32178909 · Vaccine (2020) — Incidence rates of health outcomes of interest among Chinese children exposed to selected vaccines in Yinzhou Electronic Health Records: A population-based retr
ambiguous 41902357 · Pharmacoepidemiology and drug safety (2026) — Surveillance of Maternal Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis (Tdap) Vaccines in the Vaccine Adverse Event Reporting System-United
C4n · Organoid concentration curveno_data
Measure: Effect vs antigen concentration in organoid Comparator: Vehicle / zero antigen Hit rule: Dose-dependent effect across a graded concentration curve
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Organoid concentration curve dose-response OR dose effect pubmed · 1299145 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) no dose effect OR no dose-response Organoid concentration curve pubmed · 14 hits · run 2026-09-07
5 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
does_not_resolve 27373595 · Vaccine (2016) — Safety of DTaP-IPV/Hib vaccine administered routinely to infants and toddlers.
does_not_resolve 32178909 · Vaccine (2020) — Incidence rates of health outcomes of interest among Chinese children exposed to selected vaccines in Yinzhou Electronic Health Records: A population-based retr
ambiguous 41902357 · Pharmacoepidemiology and drug safety (2026) — Surveillance of Maternal Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis (Tdap) Vaccines in the Vaccine Adverse Event Reporting System-United
C5n · EC50 vs Cmax coherenceno_data
Measure: Measured exposure reaches effect threshold Comparator: Pharmacokinetic Cmax vs EC50 Hit rule: Achieved exposure (Cmax/tissue) plausibly reaches the in-vitro EC50
Finding: No retrieved evidence directly addresses whether DTaP vaccine exposure achieves an in-vitro EC50 for Guillain-Barré Syndrome, nor provides pharmacokinetic or pharmacodynamic data linking Cmax to an effect threshold for GBS.
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) EC50 vs Cmax coherence dose-response OR dose effect pubmed · 1299145 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) no dose effect OR no dose-response EC50 vs Cmax coherence pubmed · 3 hits · run 2026-09-07
5 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
refutes_node 27373595 · Vaccine (2016) — Safety of DTaP-IPV/Hib vaccine administered routinely to infants and toddlers.
does_not_resolve 32178909 · Vaccine (2020) — Incidence rates of health outcomes of interest among Chinese children exposed to selected vaccines in Yinzhou Electronic Health Records: A population-based retr
supports_node 41902357 · Pharmacoepidemiology and drug safety (2026) — Surveillance of Maternal Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis (Tdap) Vaccines in the Vaccine Adverse Event Reporting System-United
E1 · Mediator identified in casesno_data
Measure: Mediator present in affected tissue/cells Comparator: Unaffected tissue / control Hit rule: The hypothesized mediator is detected in the affected compartment and not (or less) in control
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) mechanism Mediator identified in cases in vitro OR patient-derived pubmed · 29242 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Mediator identified in cases not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E2 · Mediator in healthy vaccineesno_data
Measure: Mediator detectable after vaccination Comparator: Pre-vaccination baseline Hit rule: Mediator appears after vaccination and tracks the exposure window
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) mechanism Mediator in healthy vaccinees in vitro OR patient-derived pubmed · 29242 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Mediator in healthy vaccinees not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E3 · Infection contrastno_data
Measure: Mediator absent/low after natural infection Comparator: Recovered natural infection Hit rule: Mediator signal is specific to vaccination vs a comparable natural-infection control
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) mechanism Infection contrast in vitro OR patient-derived pubmed · 29243 hits · run 2026-09-07
Measure: Phenotype/mediator transferred to a recipient system Comparator: Control transfer Hit rule: The effect / mediator transfers to a naive recipient system
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) mechanism Transfer to recipient in vitro OR patient-derived pubmed · 29243 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Transfer to recipient not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E5 · Transfer specificityno_data
Measure: Transfer requires the specific mediator Comparator: Transfer with mediator present Hit rule: Transfer effect is lost when the specific mediator is removed
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) mechanism Transfer specificity in vitro OR patient-derived pubmed · 29243 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Transfer specificity not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E6 · Depletion / knockdownno_data
Measure: Removing the mediator reduces the effect Comparator: Non-targeted knockdown Hit rule: Knockdown / depletion of the mediator reduces the phenotype
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) mechanism Depletion / knockdown in vitro OR patient-derived pubmed · 29243 hits · run 2026-09-07
Measure: Adding the mediator restores the effect Comparator: Add-back of a control protein Hit rule: Adding back the mediator (not a control) restores the phenotype
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) mechanism Add-back rescue in vitro OR patient-derived pubmed · 29243 hits · run 2026-09-07
Measure: Neutralizing the mediator blocks the effect Comparator: Isotype control Hit rule: Neutralization of the mediator (not an isotype control) blocks the phenotype
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) mechanism Neutralization in vitro OR patient-derived pubmed · 29243 hits · run 2026-09-07
Measure: Isotype control does not reproduce the effect Comparator: Active antibody Hit rule: An isotype control fails to reproduce the block/activation
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) mechanism Isotype control in vitro OR patient-derived pubmed · 29243 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Isotype control not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
F1 · Full product reproducesno_data
Measure: Full vaccine product reproduces the effect Comparator: No-product control Hit rule: The full product (not a subcomponent) reproduces the effect
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Full product reproduces component OR antigen OR vector pubmed · 2045284 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Full product reproduces no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 27384578 · Viruses (2016) — Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines.
F2 · Empty vector / particleno_data
Measure: Vector/particle without antigen reproduces (or not) Comparator: Full product Hit rule: Effect attributed to (or excluded from) the vector/particle backbone alone
Finding: The retrieved evidence discusses virus-vectored and live bacterial vaccine vectors for influenza, cancer, and other vaccines, but does not mention DTaP vaccine, Guillain-Barré Syndrome, or any adverse event related to a vector/particle backbone.
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Empty vector / particle component OR antigen OR vector pubmed · 2045284 hits · run 2026-09-07
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 27384578 · Viruses (2016) — Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines.
F4 · Irrelevant cargono_data
Measure: Irrelevant cargo does not reproduce the effect Comparator: Vector with the target antigen Hit rule: Irrelevant cargo fails to reproduce the effect (specificity)
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Irrelevant cargo component OR antigen OR vector pubmed · 2045284 hits · run 2026-09-07
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 27384578 · Viruses (2016) — Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines.
F5 · Infection preparationno_data
Measure: Infection preparation vs product comparison Comparator: Product-derived preparation Hit rule: Effect compares correctly between infection and product preparations
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Infection preparation component OR antigen OR vector pubmed · 2045284 hits · run 2026-09-07
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 27384578 · Viruses (2016) — Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines.
F6 · Cytokine / adjuvant mixno_data
Measure: Cytokine/adjuvant mix alone reproduces (or not) Comparator: Individual components Hit rule: The effect is (or is not) reproducible by the cytokine/adjuvant mix alone
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Cytokine / adjuvant mix component OR antigen OR vector pubmed · 2045284 hits · run 2026-09-07
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 27384578 · Viruses (2016) — Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines.
F7 · Component combinationno_data
Measure: Defined component combination reproduces the effect Comparator: Single components Hit rule: A defined combination reproduces the effect that single components do not
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Component combination component OR antigen OR vector pubmed · 2045284 hits · run 2026-09-07
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 27384578 · Viruses (2016) — Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines.
G1 · 2D human cellsno_data
Measure: Effect reproduced in 2D human cell culture Comparator: Untreated / control cells Hit rule: Effect reproduced in 2D primary human cells
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) 2D human cells animal OR organoid OR cell model pubmed · 1818620 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) 2D human cells not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G2 · Organoid / chipno_data
Measure: Effect reproduced in organoid / organ-on-chip Comparator: Unexposed organoid Hit rule: Effect reproduced in a 3D organoid / organ-on-chip system
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Organoid / chip animal OR organoid OR cell model pubmed · 1818620 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Organoid / chip not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
H1 · Block in vitro / in vivono_data
Measure: Blocking the mediator/mechanism prevents the effect Comparator: Control intervention Hit rule: Blocking the mechanism prevents or reverses the effect (not with a control intervention)
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Block in vitro / in vivo intervention OR treatment OR reversal pubmed · 15142089 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Block in vitro / in vivo no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-07
Clinical / animal / host 7/7 evaluated
E10 · Host-line dependenceno_data
Measure: Effect depends on host line/cell type Comparator: Susceptible host line Hit rule: Effect is restricted to a defined host line / genotype, not universal
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) mechanism Host-line dependence in vitro OR patient-derived pubmed · 29243 hits · run 2026-09-07
Measure: Effect in animal via the clinical route of administration Comparator: Vehicle, same route Hit rule: Effect reproduced in an animal using the clinical route of administration
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Animal, clinical route animal OR organoid OR cell model pubmed · 1818620 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Animal, clinical route not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G4 · Susceptible animalno_data
Measure: Effect in a susceptible animal model Comparator: Non-susceptible model Hit rule: Effect in a defined susceptible animal model
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Susceptible animal animal OR organoid OR cell model pubmed · 1818620 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Susceptible animal not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G5 · Replication across labsno_data
Measure: Effect replicated in an independent lab Comparator: Original result Hit rule: The key effect is replicated in an independent laboratory
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Replication across labs animal OR organoid OR cell model pubmed · 1818620 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Replication across labs not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G6 · Blinded scoringno_data
Measure: Outcomes scored blinded Comparator: Unblinded reference Hit rule: Primary outcomes scored by a blinded assessor
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Blinded scoring animal OR organoid OR cell model pubmed · 1818620 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Blinded scoring not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G7 · Experimental time courseno_data
Measure: Effect follows a defined experimental time course Comparator: No-exposure time course Hit rule: The effect's onset/offset follows a defined experimental time course
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Experimental time course animal OR organoid OR cell model pubmed · 1818620 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Experimental time course not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
I4 · Susceptibility traitno_data
Measure: A host trait / marker defines susceptibility Comparator: Trait-negative hosts Hit rule: A defined host trait / marker enriches for susceptibility
Finding: no evidence found
Cited: (none)
supporting: DTaP vaccine Guillain-Barré Syndrome (GBS) Susceptibility trait coherence OR latency OR susceptibility pubmed · 870055 hits · run 2026-09-07
mirror: DTaP vaccine Guillain-Barré Syndrome (GBS) Susceptibility trait inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
How this was built
Per node: a supporting and a mirror PubMed query built from the node's measure / population / comparator / hit_rule; top hits fetched (title + abstract); each record classified (supports / refutes / ambiguous) by xAI with a heuristic fallback; a per-node synthesis is generated strictly from the retrieved PMIDs; the node status is then rolled up to C1–C6. Full query provenance is shown per node above. Reproduce the build: python -m evidence_run. Data: data/evidence_run/state.json.