MMR vaccine → Measles Inclusion Body Encephalitis (MIBE)
Evidence dossier · candidate cand-mmr-measles-inclusion-body-encephalitis · VICP program · · DRAFT — not a determination
This is a draft research-tracking dossier, not a determination that MMR vaccine causes Measles Inclusion Body Encephalitis (MIBE), and not an incidence or legal finding. All evidence is flagged needs_human_review and must be reviewed before any page is published or cited. Every value is grounded in retrieved citations (PMID + retrieval date); unsourced items read "no evidence found / not assessable". Symmetric search: every supporting query has a mirror/null query, and zeros are shown (negative dossiers report the absence of signal).
Claim matrix (C1–C6, computed)
Claim
Label
Status
Missing nodes
C1
Coherent clinical object exists
insufficient_data
missing: A2
C2
Consistent temporal window
supported
C3
Epidemiologic excess risk
insufficient_data
missing: B1 B2 B3
C4
Consistency / replication
insufficient_data
missing: B5 B6
C5
Specificity (product / dose)
insufficient_data
missing: C1n C2n
C6
Biological mechanism
insufficient_data
missing: E1
Two evidentiary bars apply to the epi nodes/claims (C3, C4): · VICP — preponderance of the evidence. · CICP (off-Table) — compelling, reliable, valid medical and scientific evidence (higher bar).
Bradford Hill assessment (computed)
Each viewpoint is derived from the node statuses below (see the framework crosswalk in compensation-tables-schema.md §8). Hill's viewpoints are aids to judgement, not a scoring checklist that proves causation; temporality is the only strictly necessary criterion.
Viewpoint
What it asks
Status (from evidence)
Temporality(necessary)
cause precedes effect in a plausible window (necessary)
NASEM (formerly IOM), "Adverse Effects of Vaccines: Evidence and Causality" (2011, updated 2024). Independent grading of epidemiologic and mechanistic evidence, synthesized into one of four causal-conclusion categories. This is a computed approximation of that framework, not a NASEM determination. See compensation-tables-schema.md §8bis.
Case-definition standard: no established case definition (needs_human_review — not in spec §1's named-standard list) — governs the case-certainty scale on A1/A2/A6/A8 below. See compensation-tables-schema.md §8ter.
Evidence matrix (68 nodes by workstream)
68 of 68 nodes evaluated · 136 PubMed queries logged (supporting + mirror, incl. zeros). Statuses are computed from retrieved citations; not hand-set.
Definition & attribution 24/24 evaluated
A1 · Case reportssupports
Measure: New definite object in risk window T Comparator: Pre-vaccination baseline Hit rule: Definite object present, onset in window, competing causes considered
Finding: A single case report (PMID 10589903) describes MIBE in a 21-month-old boy 8.5 months after MMR vaccination, with brain biopsy confirming vaccine-strain measles virus, though he was later found to have a primary immunodeficiency.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 33661194 · Clinical nuclear medicine (2021) — COVID-19 Vaccine-Related Local FDG Uptake.
does_not_resolve 37267449 · The Gerontologist (2024) — Using Twitter to Understand COVID-19 Vaccine-Related Ageism During the Pandemic.
A2 · Series with objective confirmationno_data
Measure: Definite object plus objective test Comparator: Reference range / diagnostic criteria Hit rule: Objective confirmation in >=1 case per the working definition
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) case report OR case series Series with objective confirmation pubmed · 5642 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
10 retrieved record(s)
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 33661194 · Clinical nuclear medicine (2021) — COVID-19 Vaccine-Related Local FDG Uptake.
ambiguous 32809680 · (2026) — Rubella Vaccine.
does_not_resolve 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A3 · Onset histogrammixed
Measure: Distribution of onset times after dose Comparator: Pre-specified risk window Hit rule: Onset clusters inside the pre-specified window (not uniform/flat)
Finding: One case report describes an apparently healthy 21-month-old boy who developed MIBE 8.5 months after MMR vaccination, with onset within a defined window, but no population-level onset histogram data are provided.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 33661194 · Clinical nuclear medicine (2021) — COVID-19 Vaccine-Related Local FDG Uptake.
ambiguous 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A4 · Temporal plausibilitysupports
Measure: Onset latency vs object pathophysiology Comparator: Object's known natural latency Hit rule: Onset latency consistent with the object's pathophysiology
Finding: A single case report describes MIBE in a 21-month-old boy with onset 8.5 months after MMR vaccination, consistent with the known pathophysiology of slow viral replication in immunocompromised hosts.
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) case report OR case series Temporal plausibility pubmed · 32 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
12 retrieved record(s)
supports_node 10589903 · Clinical infectious diseases : an offici (1999) — Measles inclusion-body encephalitis caused by the vaccine strain of measles virus.
does_not_resolve 15638050 · Clinical and experimental rheumatology (2004) — A case-series of adverse events, positive re-challenge of symptoms, and events in identical twins following hepatitis B vaccination: analysis of the Vaccine Adv
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
ambiguous 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 33661194 · Clinical nuclear medicine (2021) — COVID-19 Vaccine-Related Local FDG Uptake.
A5 · Onset-interval documentationsupports
Measure: Onset interval documented in source Comparator: Dose date Hit rule: Onset interval is recorded (not imputed) in a primary source
Finding: A single case report (PMID 10589903) describes MIBE in a 21-month-old boy 8.5 months after MMR vaccination, with onset interval explicitly recorded in the source. No other retrieved evidence pertains to MMR vaccine or MIBE.
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) case report OR case series Onset-interval documentation pubmed · 1 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
11 retrieved record(s)
supports_node 10589903 · Clinical infectious diseases : an offici (1999) — Measles inclusion-body encephalitis caused by the vaccine strain of measles virus.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 33661194 · Clinical nuclear medicine (2021) — COVID-19 Vaccine-Related Local FDG Uptake.
does_not_resolve 37267449 · The Gerontologist (2024) — Using Twitter to Understand COVID-19 Vaccine-Related Ageism During the Pandemic.
A6 · Differential diagnosis excludedno_data
Measure: Competing causes assessed and excluded Comparator: Likely alternative diagnoses Hit rule: Pre-specified competing causes ruled out per the working definition
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) case report OR case series Differential diagnosis excluded pubmed · 428 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
11 retrieved record(s)
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
ambiguous 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 35251812 · Cureus (2022) — COVID-19 Vaccine-Related Myocarditis: A Descriptive Study of 40 Case Reports.
ambiguous 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
A7 · Rechallenge / re-exposureno_data
Measure: Object recurs on a further dose Comparator: First-dose response Hit rule: Object recurs after a subsequent dose (re-exposure)
Finding: A single case report (PMID 10589903) describes MIBE occurring in an apparently healthy child 8.5 months after MMR vaccination, but the child was later found to have a primary immunodeficiency; there is no reported rechallenge or re-exposure to a further dose of MMR vaccine, and thus no evidence of recurrence after a subsequent dose.
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) case report OR case series Rechallenge / re-exposure pubmed · 3 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
12 retrieved record(s)
supports_node 10589903 · Clinical infectious diseases : an offici (1999) — Measles inclusion-body encephalitis caused by the vaccine strain of measles virus.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 35251812 · Cureus (2022) — COVID-19 Vaccine-Related Myocarditis: A Descriptive Study of 40 Case Reports.
does_not_resolve 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A8 · Adjudicated by criteria (no established case definition)supports
Measure: Object adjudicated by published criteria Comparator: Published clinical / Brighton criteria Hit rule: Cases adjudicated to 'definite' by a published criterion set
Finding: A single case report describes MIBE in an apparently healthy 21-month-old boy occurring 8.5 months after MMR vaccination, with brain biopsy confirmation and detection of measles vaccine strain virus, though an underlying primary immunodeficiency was identified.
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) case report OR case series Adjudicated by criteria pubmed · 40 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
11 retrieved record(s)
supports_node 10589903 · Clinical infectious diseases : an offici (1999) — Measles inclusion-body encephalitis caused by the vaccine strain of measles virus.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 40927603 · Journal of healthcare, science and the h (2024) — The Effects of Covid-19 Vaccination on Menstruation: Are women with underlying reproductive health conditions, particularly black women at a higher risk for vac
A9 · Natural-history consistencymixed
Measure: Course matches the object's natural history Comparator: Known natural history of the object Hit rule: Clinical course (onset, peak, recovery) matches the object's natural history
Finding: A single case report describes MIBE occurring in an immunocompromised child 8.5 months after MMR vaccination, with clinical course and histopathology consistent with natural MIBE, but the onset is far outside typical risk windows for vaccine-attributed adverse events and the patient had an underlying immune deficiency.
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) case report OR case series Natural-history consistency pubmed · 104 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
11 retrieved record(s)
supports_node 10589903 · Clinical infectious diseases : an offici (1999) — Measles inclusion-body encephalitis caused by the vaccine strain of measles virus.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
ambiguous 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 33661194 · Clinical nuclear medicine (2021) — COVID-19 Vaccine-Related Local FDG Uptake.
does_not_resolve 37267449 · The Gerontologist (2024) — Using Twitter to Understand COVID-19 Vaccine-Related Ageism During the Pandemic.
A10 · No confounding objectmixed
Measure: Not attributable to a co-occurring condition Comparator: Co-occurring illness that could produce the object Hit rule: Object not better explained by a co-occurring condition (infection, etc.)
Finding: A single case report describes a 21-month-old boy who developed measles inclusion-body encephalitis (MIBE) 8.5 months after MMR vaccination, with measles vaccine strain virus identified in brain tissue; however, the child was found to have an underlying primary immunodeficiency (depressed CD8 count, dysgammaglobulinemia) that likely contributed to the event.
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) case report OR case series No confounding object pubmed · 20 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
12 retrieved record(s)
supports_node 10589903 · Clinical infectious diseases : an offici (1999) — Measles inclusion-body encephalitis caused by the vaccine strain of measles virus.
does_not_resolve 34312836 · Clinical pharmacology and therapeutics (2022) — Angiotensin-Converting Enzyme Inhibitors Used Concomitantly with Insulin Secretagogues and the Risk of Serious Hypoglycemia.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
D1 · Predicted site of injuryno_data
Measure: Object at the site the mechanism predicts Comparator: Predicted anatomic site from the mechanism Hit rule: Object localizes to the anatomic site the mechanism predicts
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) anatomic localization Predicted site of injury mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Predicted site of injury not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D2 · Spared structuresno_data
Measure: Structures the mechanism should spare are spared Comparator: Structures predicted unaffected Hit rule: Structures predicted spared by the mechanism are indeed spared
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Spared structures not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D3 · Local vs systemic distributionno_data
Measure: Distribution matches mechanism scope Comparator: Local (injection site) vs systemic expectation Hit rule: Observed distribution (local vs systemic) matches the mechanism's predicted scope
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) anatomic localization Local vs systemic distribution mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Local vs systemic distribution not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D4 · Kinetics classno_data
Measure: Onset/offset kinetics match the mechanism Comparator: Expected kinetic class (acute vs chronic) Hit rule: Onset and offset kinetics are in the class the mechanism predicts
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) anatomic localization Kinetics class mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Kinetics class not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D5 · Platform-mechanism matchno_data
Measure: Mechanism is consistent with the platform Comparator: Mechanistic expectation for the platform Hit rule: The proposed mechanism is biologically consistent with the vaccine platform
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) anatomic localization Platform-mechanism match mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Platform-mechanism match not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
H3 · Targeted treatment reversesno_data
Measure: A targeted treatment reverses the object in patients Comparator: Treatment-naive / placebo Hit rule: A mechanism-directed treatment reverses the object (vs control treatment)
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Targeted treatment reverses intervention OR treatment OR reversal pubmed · 15141378 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Targeted treatment reverses no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-07
1 retrieved record(s)
does_not_resolve 16553322 · Revista do Instituto de Medicina Tropica (2005) — Study of antiretroviral mutants in HIV patients with treatment failures and the effect of risk factors in the virological failures.
I1 · No internal contradictionno_data
Measure: No node's finding contradicts another Comparator: Internal consistency across nodes Hit rule: No evaluated node directly contradicts another (coherence)
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) No internal contradiction coherence OR latency OR susceptibility pubmed · 870020 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) No internal contradiction inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
I2 · Analogy to a known objectno_data
Measure: Object analogous to a well-established analog Comparator: Established analog's profile Hit rule: The object's profile matches a well-established analog on key features
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Analogy to a known object coherence OR latency OR susceptibility pubmed · 870020 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Analogy to a known object inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 25187623 · Reproduction (Cambridge, England) (2014) — Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment.
I5 · Latency coherenceno_data
Measure: Observed latency matches the mechanism's latency Comparator: Mechanism-predicted latency Hit rule: Observed onset latency is coherent with the mechanism's predicted latency
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Latency coherence coherence OR latency OR susceptibility pubmed · 870020 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Latency coherence inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
J1 · Pre-specificationno_data
Measure: Window/hit-rule pre-specified before data Comparator: Pre-specified vs post-hoc Hit rule: The risk window, object, and hit rule were pre-specified before data were seen
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Pre-specification pre-specified OR adjudicated pubmed · 13548 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Pre-specification post-hoc OR hypothesis-generating only pubmed · 1698 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
J2 · Contrary-evidence logno_data
Measure: Contrary evidence is logged, not omitted Comparator: Support-only dossier Hit rule: Contrary / null / refuting findings are logged and shown alongside support
Finding: No retrieved evidence directly addresses the occurrence of Measles Inclusion Body Encephalitis (MIBE) attributed to MMR vaccine. The cited studies discuss immune-related adverse events from immune checkpoint inhibitors (PMID 39226489), cerebral microbleeds and thrombolysis risk (PMID 26296519), and COVID-19 vaccine-induced thrombotic thrombocytopenia (PMID 35412949); none pertain to MMR vaccine or MIBE.
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Contrary-evidence log pre-specified OR adjudicated pubmed · 13548 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Contrary-evidence log post-hoc OR hypothesis-generating only pubmed · 1698 hits · run 2026-09-07
3 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 35412949 · Human vaccines & immunotherapeutics (2022) — Explaining COVID-19 postvaccination-related immune thrombotic thrombocytopenia: a hypothesis-generating in-silico approach.
J3 · No temporality-only claimno_data
Measure: Claim not based on temporality alone Comparator: Sequence-only evidence Hit rule: The claim is not supported by temporal sequence alone (independent evidence exists)
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) No temporality-only claim pre-specified OR adjudicated pubmed · 13548 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) No temporality-only claim post-hoc OR hypothesis-generating only pubmed · 1698 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
J4 · Passive-surveillance roleno_data
Measure: Passive-surveillance findings bounded correctly Comparator: Active-surveillance confirmation Hit rule: Passive-surveillance signals are framed as hypothesis-generating, not confirmatory
Finding: No evidence found. The retrieved PMID 39226489 describes a study on large language models for detecting immune-related adverse events from immune checkpoint inhibitors, with no mention of MMR vaccine, Measles Inclusion Body Encephalitis, or passive surveillance for vaccine adverse events.
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Passive-surveillance role pre-specified OR adjudicated pubmed · 13548 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Passive-surveillance role post-hoc OR hypothesis-generating only pubmed · 1698 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
J5 · Dose mappingno_data
Measure: Dose/lot exposure mapped to the object Comparator: Unmapped exposure Hit rule: Dose / lot exposure is mapped to the object where the mechanism predicts it
Finding: No evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Dose mapping pre-specified OR adjudicated pubmed · 13548 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Dose mapping post-hoc OR hypothesis-generating only pubmed · 1698 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
Epidemiologic chassis 13/13 evaluated
B1 · Excess vs baselineno_data
Measure: RR/IRR vs unexposed or prior window Comparator: Unvaccinated person-time or pre-vaccination window Hit rule: RR/IRR > 1 with CI excluding 1 after pre-specified confounders
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Excess vs baseline incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) no association OR null OR no increased risk Excess vs baseline pubmed · 88464 hits · run 2026-09-07
11 retrieved record(s)
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 37534766 · Human vaccines & immunotherapeutics (2023) — Risk of all-cause and cardiac-related mortality after vaccination against COVID-19: A meta-analysis of self-controlled case series studies.
does_not_resolve 37223097 · Frontiers in immunology (2023) — Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 42661284 · Expert review of vaccines (2026) — Stroke risk following BNT162b2 vaccination: a systematic review and meta-analysis of self-controlled case series studies.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
B2 · SCCSno_data
Measure: Self-controlled case series risk ratio Comparator: Individuals' own risk intervals (no-event) Hit rule: SCCS risk ratio > 1 in the post-vaccination window, CI excluding 1
Finding: No retrieved evidence addresses the association between MMR vaccine and Measles Inclusion Body Encephalitis (MIBE) using a self-controlled case series (SCCS) design.
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) SCCS incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) no association OR null OR no increased risk SCCS pubmed · 88572 hits · run 2026-09-07
14 retrieved record(s)
does_not_resolve 29961876 · Nephrology, dialysis, transplantation : (2019) — Risk of acute kidney injury following community prescription of antibiotics: self-controlled case series.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 37223097 · Frontiers in immunology (2023) — Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 33748963 · British journal of haematology (2021) — Glucocorticoid use and risk of first and recurrent venous thromboembolism: self-controlled case-series and cohort study.
does_not_resolve 37806668 · Human vaccines & immunotherapeutics (2023) — Response to Dr. Somovilla del Saz's letter to the editor regarding "Risk of all-cause and cardiac-related mortality after vaccination against COVID-19: A meta-a
does_not_resolve 40987135 · JACC. Advances (2025) — Risk of Major Adverse Cardiovascular Events During Acute Streptococcus pneumoniae Infection in COPD Patients.
B3 · Cohort / risk-intervalno_data
Measure: Incidence rate ratio in defined window Comparator: Pre-specified risk vs comparison interval Hit rule: IRR > 1 in the pre-specified window, CI excluding 1, stratified by age/sex
Finding: No evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Cohort / risk-interval incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) no association OR null OR no increased risk Cohort / risk-interval pubmed · 88073 hits · run 2026-09-07
13 retrieved record(s)
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 37223097 · Frontiers in immunology (2023) — Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 33748963 · British journal of haematology (2021) — Glucocorticoid use and risk of first and recurrent venous thromboembolism: self-controlled case-series and cohort study.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 37806668 · Human vaccines & immunotherapeutics (2023) — Response to Dr. Somovilla del Saz's letter to the editor regarding "Risk of all-cause and cardiac-related mortality after vaccination against COVID-19: A meta-a
does_not_resolve 40987135 · JACC. Advances (2025) — Risk of Major Adverse Cardiovascular Events During Acute Streptococcus pneumoniae Infection in COPD Patients.
B4 · Meta-analysis / poolingno_data
Measure: Pooled effect across studies Comparator: Pooled estimate with heterogeneity Hit rule: Pooled estimate > 1 (or < 1) with quantified heterogeneity (I2)
Finding: No retrieved evidence addresses MMR vaccine or Measles Inclusion Body Encephalitis; all studies concern COVID-19 vaccination, antibiotics, or other exposures.
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Meta-analysis / pooling incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) no association OR null OR no increased risk Meta-analysis / pooling pubmed · 111904 hits · run 2026-09-07
11 retrieved record(s)
does_not_resolve 29961876 · Nephrology, dialysis, transplantation : (2019) — Risk of acute kidney injury following community prescription of antibiotics: self-controlled case series.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 37223097 · Frontiers in immunology (2023) — Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 33748963 · British journal of haematology (2021) — Glucocorticoid use and risk of first and recurrent venous thromboembolism: self-controlled case-series and cohort study.
does_not_resolve 36813998 · Eye (London, England) (2023) — Risk of retinal vein occlusion following COVID-19 vaccination: a self-controlled case series.
does_not_resolve 37806668 · Human vaccines & immunotherapeutics (2023) — Response to Dr. Somovilla del Saz's letter to the editor regarding "Risk of all-cause and cardiac-related mortality after vaccination against COVID-19: A meta-a
B5 · Negative-control outcomesno_data
Measure: No excess for outcomes the vaccine should not cause Comparator: Negative-control outcomes (unaffected by mechanism) Hit rule: Null for negative-control outcomes while target outcome is positive (specificity)
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Negative-control outcomes incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) no association OR null OR no increased risk Negative-control outcomes pubmed · 88275 hits · run 2026-09-07
10 retrieved record(s)
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 37223097 · Frontiers in immunology (2023) — Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 33748963 · British journal of haematology (2021) — Glucocorticoid use and risk of first and recurrent venous thromboembolism: self-controlled case-series and cohort study.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 37806668 · Human vaccines & immunotherapeutics (2023) — Response to Dr. Somovilla del Saz's letter to the editor regarding "Risk of all-cause and cardiac-related mortality after vaccination against COVID-19: A meta-a
does_not_resolve 40987135 · JACC. Advances (2025) — Risk of Major Adverse Cardiovascular Events During Acute Streptococcus pneumoniae Infection in COPD Patients.
B6 · Other-antigen comparisonno_data
Measure: Risk vs a different-antigen comparator Comparator: Comparator product with a different antigen Hit rule: Risk specific to the target antigen, not shared with the comparator antigen
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Other-antigen comparison incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) no association OR null OR no increased risk Other-antigen comparison pubmed · 88037 hits · run 2026-09-07
12 retrieved record(s)
does_not_resolve 29961876 · Nephrology, dialysis, transplantation : (2019) — Risk of acute kidney injury following community prescription of antibiotics: self-controlled case series.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 37223097 · Frontiers in immunology (2023) — Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 33748963 · British journal of haematology (2021) — Glucocorticoid use and risk of first and recurrent venous thromboembolism: self-controlled case-series and cohort study.
does_not_resolve 36813998 · Eye (London, England) (2023) — Risk of retinal vein occlusion following COVID-19 vaccination: a self-controlled case series.
does_not_resolve 37806668 · Human vaccines & immunotherapeutics (2023) — Response to Dr. Somovilla del Saz's letter to the editor regarding "Risk of all-cause and cardiac-related mortality after vaccination against COVID-19: A meta-a
B7 · Absolute riskno_data
Measure: Per-100k risk in window Comparator: Absolute incidence per 100k Hit rule: Absolute risk reported and stable across the window (not an artifact of rarity)
Finding: No retrieved evidence addresses absolute risk of Measles Inclusion Body Encephalitis (MIBE) following MMR vaccination; the provided PMIDs focus on other vaccines, outcomes, or unrelated medical conditions.
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Absolute risk incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) no association OR null OR no increased risk Absolute risk pubmed · 111304 hits · run 2026-09-07
13 retrieved record(s)
does_not_resolve 29961876 · Nephrology, dialysis, transplantation : (2019) — Risk of acute kidney injury following community prescription of antibiotics: self-controlled case series.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 37534766 · Human vaccines & immunotherapeutics (2023) — Risk of all-cause and cardiac-related mortality after vaccination against COVID-19: A meta-analysis of self-controlled case series studies.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 37223097 · Frontiers in immunology (2023) — Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 42661284 · Expert review of vaccines (2026) — Stroke risk following BNT162b2 vaccination: a systematic review and meta-analysis of self-controlled case series studies.
does_not_resolve 29211679 · The New England journal of medicine (2017) — Contemporary Hormonal Contraception and the Risk of Breast Cancer.
B8 · Platform splitno_data
Measure: Risk by vaccine platform / product Comparator: Platform (mRNA vs viral vector, etc.) Hit rule: Risk attributable to a specific platform, not to 'a vaccine' generally
Finding: No evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Platform split incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) no association OR null OR no increased risk Platform split pubmed · 88102 hits · run 2026-09-07
10 retrieved record(s)
does_not_resolve 29961876 · Nephrology, dialysis, transplantation : (2019) — Risk of acute kidney injury following community prescription of antibiotics: self-controlled case series.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 37223097 · Frontiers in immunology (2023) — Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 33748963 · British journal of haematology (2021) — Glucocorticoid use and risk of first and recurrent venous thromboembolism: self-controlled case-series and cohort study.
does_not_resolve 37806668 · Human vaccines & immunotherapeutics (2023) — Response to Dr. Somovilla del Saz's letter to the editor regarding "Risk of all-cause and cardiac-related mortality after vaccination against COVID-19: A meta-a
does_not_resolve 40987135 · JACC. Advances (2025) — Risk of Major Adverse Cardiovascular Events During Acute Streptococcus pneumoniae Infection in COPD Patients.
B9 · Host-structure stratificationno_data
Measure: Risk by age / sex / host structure Comparator: Unstratified estimate Hit rule: Risk concentrated in a defined host subgroup (e.g. young males), stable across sources
Finding: No retrieved evidence addresses MMR vaccine, Measles Inclusion Body Encephalitis (MIBE), or host-structure stratification (risk by age/sex/host structure). All retrieved studies concern COVID-19 vaccines, Guillain-Barré syndrome, shingles, stroke, arrhythmias, or GSTM1/GSTT1 genotypes, none of which pertain to the specified pair or node.
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Host-structure stratification incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) no association OR null OR no increased risk Host-structure stratification pubmed · 88035 hits · run 2026-09-07
12 retrieved record(s)
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 37534766 · Human vaccines & immunotherapeutics (2023) — Risk of all-cause and cardiac-related mortality after vaccination against COVID-19: A meta-analysis of self-controlled case series studies.
does_not_resolve 37223097 · Frontiers in immunology (2023) — Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 42661284 · Expert review of vaccines (2026) — Stroke risk following BNT162b2 vaccination: a systematic review and meta-analysis of self-controlled case series studies.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
B10 · Formulation / component changeno_data
Measure: Risk tracks a formulation change Comparator: Pre- vs post-change formulation Hit rule: Risk change tracks a documented formulation / component change over time
Finding: No evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Formulation / component change incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) no association OR null OR no increased risk Formulation / component change pubmed · 88197 hits · run 2026-09-07
8 retrieved record(s)
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 37223097 · Frontiers in immunology (2023) — Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study.
ambiguous 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 33748963 · British journal of haematology (2021) — Glucocorticoid use and risk of first and recurrent venous thromboembolism: self-controlled case-series and cohort study.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 37806668 · Human vaccines & immunotherapeutics (2023) — Response to Dr. Somovilla del Saz's letter to the editor regarding "Risk of all-cause and cardiac-related mortality after vaccination against COVID-19: A meta-a
does_not_resolve 40987135 · JACC. Advances (2025) — Risk of Major Adverse Cardiovascular Events During Acute Streptococcus pneumoniae Infection in COPD Patients.
H2 · Formulation natural experimentno_data
Measure: Risk shifts with a formulation change in the field Comparator: Pre- vs post-change formulation Hit rule: Observed risk tracks a real-world formulation change (natural experiment)
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Formulation natural experiment intervention OR treatment OR reversal pubmed · 15141378 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Formulation natural experiment no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-07
H4 · Policy / pause signalno_data
Measure: Risk signal appears/disappears across a pause or policy change Comparator: Pre- vs post-pause period Hit rule: The signal appears or disappears coherently with a rollout / pause (H4)
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Policy / pause signal intervention OR treatment OR reversal pubmed · 15141378 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Policy / pause signal no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-07
I3 · Infection coherenceno_data
Measure: Pattern is coherent with or distinct from infection Comparator: Infection-matched comparison Hit rule: The post-vaccine pattern is coherent with (or clearly distinct from) the infection pattern
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Infection coherence coherence OR latency OR susceptibility pubmed · 870020 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Infection coherence inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
Mediator & biological gradient 24/24 evaluated
C1n · Dose strength gradientno_data
Measure: Risk vs dose strength (dose size) Comparator: Lower dose strength Hit rule: Monotonic dose-response in dose strength (larger dose -> higher risk)
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Dose strength gradient dose-response OR dose effect pubmed · 1299132 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) no dose effect OR no dose-response Dose strength gradient pubmed · 111 hits · run 2026-09-07
3 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
does_not_resolve 33373368 · PLoS medicine (2020) — Assessing the risk of ketoacidosis due to sodium-glucose cotransporter (SGLT)-2 inhibitors in patients with type 1 diabetes: A meta-analysis and meta-regression
C2n · Dose number gradientno_data
Measure: Risk vs dose number (1st vs 2nd vs 3rd) Comparator: First dose Hit rule: Risk increases (or shows a defined pattern) with dose number
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Dose number gradient dose-response OR dose effect pubmed · 1299132 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) no dose effect OR no dose-response Dose number gradient pubmed · 555 hits · run 2026-09-07
4 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36298577 · Vaccines (2022) — Cost-Effectiveness of COVID-19 Sequential Vaccination Strategies in Inactivated Vaccinated Individuals in China.
does_not_resolve 30316563 · Radiotherapy and oncology : journal of t (2019) — Volume effects of radiotherapy on the risk of second primary cancers: A systematic review of clinical and epidemiological studies.
does_not_resolve 42106826 · The international journal of behavioral (2026) — Physical activity, falls, and dementia risk in adults aged ≥ 60: evidence from three cohorts.
C3n · Measured-exposure tertilesno_data
Measure: Risk vs measured exposure tertile Comparator: Lowest-exposure tertile Hit rule: Risk ordered by measured-exposure tertile (high > mid > low)
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Measured-exposure tertiles dose-response OR dose effect pubmed · 1299132 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) no dose effect OR no dose-response Measured-exposure tertiles pubmed · 0 hits (0 hits — negative) · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36298577 · Vaccines (2022) — Cost-Effectiveness of COVID-19 Sequential Vaccination Strategies in Inactivated Vaccinated Individuals in China.
C4n · Organoid concentration curveno_data
Measure: Effect vs antigen concentration in organoid Comparator: Vehicle / zero antigen Hit rule: Dose-dependent effect across a graded concentration curve
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Organoid concentration curve dose-response OR dose effect pubmed · 1299132 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) no dose effect OR no dose-response Organoid concentration curve pubmed · 11 hits · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
C5n · EC50 vs Cmax coherenceno_data
Measure: Measured exposure reaches effect threshold Comparator: Pharmacokinetic Cmax vs EC50 Hit rule: Achieved exposure (Cmax/tissue) plausibly reaches the in-vitro EC50
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) EC50 vs Cmax coherence dose-response OR dose effect pubmed · 1299132 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) no dose effect OR no dose-response EC50 vs Cmax coherence pubmed · 0 hits (0 hits — negative) · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
E1 · Mediator identified in casesno_data
Measure: Mediator present in affected tissue/cells Comparator: Unaffected tissue / control Hit rule: The hypothesized mediator is detected in the affected compartment and not (or less) in control
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) mechanism Mediator identified in cases in vitro OR patient-derived pubmed · 29239 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Mediator identified in cases not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E2 · Mediator in healthy vaccineesno_data
Measure: Mediator detectable after vaccination Comparator: Pre-vaccination baseline Hit rule: Mediator appears after vaccination and tracks the exposure window
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) mechanism Mediator in healthy vaccinees in vitro OR patient-derived pubmed · 29239 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Mediator in healthy vaccinees not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E3 · Infection contrastno_data
Measure: Mediator absent/low after natural infection Comparator: Recovered natural infection Hit rule: Mediator signal is specific to vaccination vs a comparable natural-infection control
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) mechanism Infection contrast in vitro OR patient-derived pubmed · 29239 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Infection contrast not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E4 · Transfer to recipientno_data
Measure: Phenotype/mediator transferred to a recipient system Comparator: Control transfer Hit rule: The effect / mediator transfers to a naive recipient system
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) mechanism Transfer to recipient in vitro OR patient-derived pubmed · 29239 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Transfer to recipient not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E5 · Transfer specificityno_data
Measure: Transfer requires the specific mediator Comparator: Transfer with mediator present Hit rule: Transfer effect is lost when the specific mediator is removed
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) mechanism Transfer specificity in vitro OR patient-derived pubmed · 29239 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Transfer specificity not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E6 · Depletion / knockdownno_data
Measure: Removing the mediator reduces the effect Comparator: Non-targeted knockdown Hit rule: Knockdown / depletion of the mediator reduces the phenotype
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) mechanism Depletion / knockdown in vitro OR patient-derived pubmed · 29239 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Depletion / knockdown not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E7 · Add-back rescueno_data
Measure: Adding the mediator restores the effect Comparator: Add-back of a control protein Hit rule: Adding back the mediator (not a control) restores the phenotype
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) mechanism Add-back rescue in vitro OR patient-derived pubmed · 29239 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Add-back rescue not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E8 · Neutralizationno_data
Measure: Neutralizing the mediator blocks the effect Comparator: Isotype control Hit rule: Neutralization of the mediator (not an isotype control) blocks the phenotype
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) mechanism Neutralization in vitro OR patient-derived pubmed · 29239 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Neutralization not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E9 · Isotype controlno_data
Measure: Isotype control does not reproduce the effect Comparator: Active antibody Hit rule: An isotype control fails to reproduce the block/activation
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) mechanism Isotype control in vitro OR patient-derived pubmed · 29239 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Isotype control not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
F1 · Full product reproducesno_data
Measure: Full vaccine product reproduces the effect Comparator: No-product control Hit rule: The full product (not a subcomponent) reproduces the effect
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Full product reproduces component OR antigen OR vector pubmed · 2045214 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Full product reproduces no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 40276512 · Frontiers in immunology (2025) — Development of a novel adenovirus type 4 vector as a promising respiratory vaccine vehicle.
F2 · Empty vector / particleno_data
Measure: Vector/particle without antigen reproduces (or not) Comparator: Full product Hit rule: Effect attributed to (or excluded from) the vector/particle backbone alone
Finding: The retrieved evidence discusses virus-vectored vaccines (e.g., influenza, bacterial, adenovirus vectors) and measles vaccine development, but does not address adverse events such as Measles Inclusion Body Encephalitis (MIBE) attributed to the MMR vaccine vector/particle backbone alone.
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Empty vector / particle component OR antigen OR vector pubmed · 2045214 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Empty vector / particle no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 40276512 · Frontiers in immunology (2025) — Development of a novel adenovirus type 4 vector as a promising respiratory vaccine vehicle.
F3 · Antigen alone reproducesno_data
Measure: Isolated antigen reproduces the effect Comparator: Vehicle Hit rule: The isolated antigen (not the full product) reproduces the effect
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Antigen alone reproduces component OR antigen OR vector pubmed · 2045214 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Antigen alone reproduces no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 40276512 · Frontiers in immunology (2025) — Development of a novel adenovirus type 4 vector as a promising respiratory vaccine vehicle.
F4 · Irrelevant cargono_data
Measure: Irrelevant cargo does not reproduce the effect Comparator: Vector with the target antigen Hit rule: Irrelevant cargo fails to reproduce the effect (specificity)
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Irrelevant cargo component OR antigen OR vector pubmed · 2045214 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Irrelevant cargo no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 27384578 · Viruses (2016) — Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines.
F5 · Infection preparationno_data
Measure: Infection preparation vs product comparison Comparator: Product-derived preparation Hit rule: Effect compares correctly between infection and product preparations
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Infection preparation component OR antigen OR vector pubmed · 2045214 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Infection preparation no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 27384578 · Viruses (2016) — Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines.
F6 · Cytokine / adjuvant mixno_data
Measure: Cytokine/adjuvant mix alone reproduces (or not) Comparator: Individual components Hit rule: The effect is (or is not) reproducible by the cytokine/adjuvant mix alone
Finding: No retrieved evidence addresses whether the MMR vaccine effect of Measles Inclusion Body Encephalitis (MIBE) is reproducible by a cytokine/adjuvant mix alone.
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Cytokine / adjuvant mix component OR antigen OR vector pubmed · 2045214 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Cytokine / adjuvant mix no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 27384578 · Viruses (2016) — Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines.
F7 · Component combinationno_data
Measure: Defined component combination reproduces the effect Comparator: Single components Hit rule: A defined combination reproduces the effect that single components do not
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Component combination component OR antigen OR vector pubmed · 2045214 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Component combination no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 40276512 · Frontiers in immunology (2025) — Development of a novel adenovirus type 4 vector as a promising respiratory vaccine vehicle.
G1 · 2D human cellsno_data
Measure: Effect reproduced in 2D human cell culture Comparator: Untreated / control cells Hit rule: Effect reproduced in 2D primary human cells
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) 2D human cells animal OR organoid OR cell model pubmed · 1818474 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) 2D human cells not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G2 · Organoid / chipno_data
Measure: Effect reproduced in organoid / organ-on-chip Comparator: Unexposed organoid Hit rule: Effect reproduced in a 3D organoid / organ-on-chip system
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Organoid / chip animal OR organoid OR cell model pubmed · 1818474 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Organoid / chip not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
H1 · Block in vitro / in vivono_data
Measure: Blocking the mediator/mechanism prevents the effect Comparator: Control intervention Hit rule: Blocking the mechanism prevents or reverses the effect (not with a control intervention)
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Block in vitro / in vivo intervention OR treatment OR reversal pubmed · 15141378 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Block in vitro / in vivo no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-07
Clinical / animal / host 7/7 evaluated
E10 · Host-line dependenceno_data
Measure: Effect depends on host line/cell type Comparator: Susceptible host line Hit rule: Effect is restricted to a defined host line / genotype, not universal
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) mechanism Host-line dependence in vitro OR patient-derived pubmed · 29239 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Host-line dependence not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G3 · Animal, clinical routeno_data
Measure: Effect in animal via the clinical route of administration Comparator: Vehicle, same route Hit rule: Effect reproduced in an animal using the clinical route of administration
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Animal, clinical route animal OR organoid OR cell model pubmed · 1818474 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Animal, clinical route not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G4 · Susceptible animalno_data
Measure: Effect in a susceptible animal model Comparator: Non-susceptible model Hit rule: Effect in a defined susceptible animal model
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Susceptible animal animal OR organoid OR cell model pubmed · 1818474 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Susceptible animal not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G5 · Replication across labsno_data
Measure: Effect replicated in an independent lab Comparator: Original result Hit rule: The key effect is replicated in an independent laboratory
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Replication across labs animal OR organoid OR cell model pubmed · 1818474 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Replication across labs not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G6 · Blinded scoringno_data
Measure: Outcomes scored blinded Comparator: Unblinded reference Hit rule: Primary outcomes scored by a blinded assessor
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Blinded scoring animal OR organoid OR cell model pubmed · 1818474 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Blinded scoring not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G7 · Experimental time courseno_data
Measure: Effect follows a defined experimental time course Comparator: No-exposure time course Hit rule: The effect's onset/offset follows a defined experimental time course
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Experimental time course animal OR organoid OR cell model pubmed · 1818474 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Experimental time course not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
I4 · Susceptibility traitno_data
Measure: A host trait / marker defines susceptibility Comparator: Trait-negative hosts Hit rule: A defined host trait / marker enriches for susceptibility
Finding: no evidence found
Cited: (none)
supporting: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Susceptibility trait coherence OR latency OR susceptibility pubmed · 870020 hits · run 2026-09-07
mirror: MMR vaccine Measles Inclusion Body Encephalitis (MIBE) Susceptibility trait inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
How this was built
Per node: a supporting and a mirror PubMed query built from the node's measure / population / comparator / hit_rule; top hits fetched (title + abstract); each record classified (supports / refutes / ambiguous) by xAI with a heuristic fallback; a per-node synthesis is generated strictly from the retrieved PMIDs; the node status is then rolled up to C1–C6. Full query provenance is shown per node above. Reproduce the build: python -m evidence_run. Data: data/evidence_run/state.json.