Evidence dossier · candidate cand-rotavirus-surgery · VICP program · · DRAFT — not a determination
This is a draft research-tracking dossier, not a determination that Rotavirus vaccine causes Surgery, and not an incidence or legal finding. All evidence is flagged needs_human_review and must be reviewed before any page is published or cited. Every value is grounded in retrieved citations (PMID + retrieval date); unsourced items read "no evidence found / not assessable". Symmetric search: every supporting query has a mirror/null query, and zeros are shown (negative dossiers report the absence of signal).
Claim matrix (C1–C6, computed)
Claim
Label
Status
Missing nodes
C1
Coherent clinical object exists
insufficient_data
missing: A2
C2
Consistent temporal window
supported
C3
Epidemiologic excess risk
contested
C4
Consistency / replication
insufficient_data
missing: B5
C5
Specificity (product / dose)
contested
C6
Biological mechanism
insufficient_data
missing: E1
Two evidentiary bars apply to the epi nodes/claims (C3, C4): · VICP — preponderance of the evidence. · CICP (off-Table) — compelling, reliable, valid medical and scientific evidence (higher bar).
Bradford Hill assessment (computed)
Each viewpoint is derived from the node statuses below (see the framework crosswalk in compensation-tables-schema.md §8). Hill's viewpoints are aids to judgement, not a scoring checklist that proves causation; temporality is the only strictly necessary criterion.
Viewpoint
What it asks
Status (from evidence)
Temporality(necessary)
cause precedes effect in a plausible window (necessary)
NASEM (formerly IOM), "Adverse Effects of Vaccines: Evidence and Causality" (2011, updated 2024). Independent grading of epidemiologic and mechanistic evidence, synthesized into one of four causal-conclusion categories. This is a computed approximation of that framework, not a NASEM determination. See compensation-tables-schema.md §8bis.
Case-definition standard: no established case definition (needs_human_review — not in spec §1's named-standard list) — governs the case-certainty scale on A1/A2/A6/A8 below. See compensation-tables-schema.md §8ter.
Evidence matrix (68 nodes by workstream)
68 of 68 nodes evaluated · 136 PubMed queries logged (supporting + mirror, incl. zeros). Statuses are computed from retrieved citations; not hand-set.
Definition & attribution 24/24 evaluated
A1 · Case reportsno_data
Measure: New definite object in risk window T Comparator: Pre-vaccination baseline Hit rule: Definite object present, onset in window, competing causes considered
Finding: No retrieved evidence describes a case of surgery following rotavirus vaccination, as the only rotavirus vaccine-related case report describes intussusception requiring surgery but does not attribute the surgery itself to the vaccine as a definite new object in the risk window post-vaccination.
Case-certainty distribution (no established case definition): 1 Probable. Transparency layer — does not change this node's status or feed C1–C6.
Cited: (none)
supporting: Rotavirus vaccine Surgery case report OR case series Case reports pubmed · 66174 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
13 retrieved record(s)
does_not_resolve 37064057 · Journal of surgical case reports (2023) — Opacification of a scleral-sutured Akreos AO60 intraocular lens in the absence of concurrent or subsequent surgery: a case series.
does_not_resolve 37869423 · Frontiers in surgery (2023) — Case report: Case series featuring anastomotic colonic adenocarcinoma following jejunoileal bypass requiring oncologic resection and jejunoileal bypass reversal
supports_node 27070956 · Human vaccines & immunotherapeutics (2016) — Post-rotavirus vaccine intussusception in identical twins: A case report.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
A2 · Series with objective confirmationno_data
Measure: Definite object plus objective test Comparator: Reference range / diagnostic criteria Hit rule: Objective confirmation in >=1 case per the working definition
Finding: No evidence found for an association between rotavirus vaccine and surgery with objective confirmation.
Cited: (none)
supporting: Rotavirus vaccine Surgery case report OR case series Series with objective confirmation pubmed · 5650 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
11 retrieved record(s)
does_not_resolve 36898627 · World neurosurgery (2023) — Evaluation of Long-Term Follow-Up in Ecchordosis Physaliphora versus Chordoma.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
ambiguous 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
A3 · Onset histogramsupports
Measure: Distribution of onset times after dose Comparator: Pre-specified risk window Hit rule: Onset clusters inside the pre-specified window (not uniform/flat)
Finding: Two case reports describe intussusception requiring surgery in infants approximately one week after rotavirus vaccination, suggesting a possible temporal cluster of onset within a risk window.
supporting: Rotavirus vaccine Surgery case report OR case series Onset histogram pubmed · 11 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
13 retrieved record(s)
supports_node 27070956 · Human vaccines & immunotherapeutics (2016) — Post-rotavirus vaccine intussusception in identical twins: A case report.
supports_node 20107217 · The New England journal of medicine (2010) — Vaccine-acquired rotavirus in infants with severe combined immunodeficiency.
does_not_resolve 28709556 · Vaccine (2018) — Intussusception among children less than 2years of age: Findings from pre-vaccine introduction surveillance in Pakistan.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
A4 · Temporal plausibilitysupports
Measure: Onset latency vs object pathophysiology Comparator: Object's known natural latency Hit rule: Onset latency consistent with the object's pathophysiology
Finding: A single case report (PMID 27070956) describes two 3-month-old identical twins who developed intussusception requiring emergency surgery approximately one week after rotavirus vaccination. This provides a case-report-level example of onset latency (one week) that is consistent with the known pathophysiology of post-vaccination intussusception, but the evidence is limited to a single case series of two patients.
supporting: Rotavirus vaccine Surgery case report OR case series Temporal plausibility pubmed · 40 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
12 retrieved record(s)
supports_node 27070956 · Human vaccines & immunotherapeutics (2016) — Post-rotavirus vaccine intussusception in identical twins: A case report.
does_not_resolve 15638050 · Clinical and experimental rheumatology (2004) — A case-series of adverse events, positive re-challenge of symptoms, and events in identical twins following hepatitis B vaccination: analysis of the Vaccine Adv
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
ambiguous 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A5 · Onset-interval documentationsupports
Measure: Onset interval documented in source Comparator: Dose date Hit rule: Onset interval is recorded (not imputed) in a primary source
Finding: A single case report describes onset of intussusception (requiring surgery) in one twin approximately one week after rotavirus vaccination, with the onset interval explicitly recorded in the primary source.
supporting: Rotavirus vaccine Surgery case report OR case series Onset-interval documentation pubmed · 9 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
13 retrieved record(s)
supports_node 27070956 · Human vaccines & immunotherapeutics (2016) — Post-rotavirus vaccine intussusception in identical twins: A case report.
supports_node 20107217 · The New England journal of medicine (2010) — Vaccine-acquired rotavirus in infants with severe combined immunodeficiency.
does_not_resolve 28709556 · Vaccine (2018) — Intussusception among children less than 2years of age: Findings from pre-vaccine introduction surveillance in Pakistan.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
A6 · Differential diagnosis excludedno_data
Measure: Competing causes assessed and excluded Comparator: Likely alternative diagnoses Hit rule: Pre-specified competing causes ruled out per the working definition
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery case report OR case series Differential diagnosis excluded pubmed · 436 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
11 retrieved record(s)
does_not_resolve 19168408 · International journal of surgery (London (2008) — Amyloid goiter.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
A7 · Rechallenge / re-exposureno_data
Measure: Object recurs on a further dose Comparator: First-dose response Hit rule: Object recurs after a subsequent dose (re-exposure)
Finding: A single case report describes intussusception (requiring emergency surgery) in one of two identical twins about one week after rotavirus vaccination, but does not report a rechallenge with a subsequent dose of the vaccine, so no evidence of recurrence upon re-exposure is provided.
supporting: Rotavirus vaccine Surgery case report OR case series Rechallenge / re-exposure pubmed · 11 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
13 retrieved record(s)
supports_node 27070956 · Human vaccines & immunotherapeutics (2016) — Post-rotavirus vaccine intussusception in identical twins: A case report.
supports_node 20107217 · The New England journal of medicine (2010) — Vaccine-acquired rotavirus in infants with severe combined immunodeficiency.
does_not_resolve 28709556 · Vaccine (2018) — Intussusception among children less than 2years of age: Findings from pre-vaccine introduction surveillance in Pakistan.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
A8 · Adjudicated by criteria (no established case definition)no_data
Measure: Object adjudicated by published criteria Comparator: Published clinical / Brighton criteria Hit rule: Cases adjudicated to 'definite' by a published criterion set
Finding: no evidence found
Case-certainty distribution (no established case definition): 1 Probable. Transparency layer — does not change this node's status or feed C1–C6.
Cited: (none)
supporting: Rotavirus vaccine Surgery case report OR case series Adjudicated by criteria pubmed · 48 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
14 retrieved record(s)
does_not_resolve 37202114 · AJNR. American journal of neuroradiology (2023) — Efficacy of Epidural Blood Patching or Surgery in Spontaneous Intracranial Hypotension: A Systematic Review and Evidence Map.
does_not_resolve 25515499 · Obesity surgery (2015) — The Impact of Bariatric Surgery on Diabetic Retinopathy: A Systematic Review and Meta-Analysis.
supports_node 27070956 · Human vaccines & immunotherapeutics (2016) — Post-rotavirus vaccine intussusception in identical twins: A case report.
does_not_resolve 33507208 · JAMA otolaryngology-- head & neck surger (2021) — Survival Outcomes of De Novo vs Inverted Papilloma-Associated Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-analysis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
Measure: Course matches the object's natural history Comparator: Known natural history of the object Hit rule: Clinical course (onset, peak, recovery) matches the object's natural history
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery case report OR case series Natural-history consistency pubmed · 112 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
11 retrieved record(s)
does_not_resolve 23041539 · Clinical gastroenterology and hepatology (2012) — Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
ambiguous 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
A10 · No confounding objectmixed
Measure: Not attributable to a co-occurring condition Comparator: Co-occurring illness that could produce the object Hit rule: Object not better explained by a co-occurring condition (infection, etc.)
Finding: A single case report describes intussusception requiring surgery in two identical twins approximately one week after rotavirus vaccination, suggesting a possible association between rotavirus vaccine and surgery for intussusception.
supporting: Rotavirus vaccine Surgery case report OR case series No confounding object pubmed · 28 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery alternative diagnosis OR not vaccine-related pubmed · 4052 hits · run 2026-09-07
13 retrieved record(s)
does_not_resolve 11796765 · Journal of neurology, neurosurgery, and (2002) — Psychoanatomical substrates of Bálint's syndrome.
supports_node 27070956 · Human vaccines & immunotherapeutics (2016) — Post-rotavirus vaccine intussusception in identical twins: A case report.
does_not_resolve 34312836 · Clinical pharmacology and therapeutics (2022) — Angiotensin-Converting Enzyme Inhibitors Used Concomitantly with Insulin Secretagogues and the Risk of Serious Hypoglycemia.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
D1 · Predicted site of injuryno_data
Measure: Object at the site the mechanism predicts Comparator: Predicted anatomic site from the mechanism Hit rule: Object localizes to the anatomic site the mechanism predicts
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery anatomic localization Predicted site of injury mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Rotavirus vaccine Surgery Predicted site of injury not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D2 · Spared structuresno_data
Measure: Structures the mechanism should spare are spared Comparator: Structures predicted unaffected Hit rule: Structures predicted spared by the mechanism are indeed spared
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery anatomic localization Spared structures mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Rotavirus vaccine Surgery Spared structures not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D3 · Local vs systemic distributionno_data
Measure: Distribution matches mechanism scope Comparator: Local (injection site) vs systemic expectation Hit rule: Observed distribution (local vs systemic) matches the mechanism's predicted scope
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery anatomic localization Local vs systemic distribution mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Rotavirus vaccine Surgery Local vs systemic distribution not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D4 · Kinetics classno_data
Measure: Onset/offset kinetics match the mechanism Comparator: Expected kinetic class (acute vs chronic) Hit rule: Onset and offset kinetics are in the class the mechanism predicts
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery anatomic localization Kinetics class mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Rotavirus vaccine Surgery Kinetics class not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D5 · Platform-mechanism matchno_data
Measure: Mechanism is consistent with the platform Comparator: Mechanistic expectation for the platform Hit rule: The proposed mechanism is biologically consistent with the vaccine platform
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery anatomic localization Platform-mechanism match mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Rotavirus vaccine Surgery Platform-mechanism match not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
H3 · Targeted treatment reversesno_data
Measure: A targeted treatment reverses the object in patients Comparator: Treatment-naive / placebo Hit rule: A mechanism-directed treatment reverses the object (vs control treatment)
Finding: No evidence found. The retrieved studies discuss reversal of Roux-en-Y gastric bypass surgery and neoadjuvant personalized cancer vaccines, neither of which address reversal of surgery attributed to rotavirus vaccine.
Cited: (none)
supporting: Rotavirus vaccine Surgery Targeted treatment reverses intervention OR treatment OR reversal pubmed · 15141576 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Targeted treatment reverses no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39821905 · Obesity surgery (2025) — Reversal of Roux-en-Y Gastric Bypass: A Multi-Centric Analysis of Indications, Techniques, and Surgical Outcomes.
does_not_resolve 38189107 · Expert review of vaccines (2024) — Neoadjuvant personalized cancer vaccines: the final frontier?
I1 · No internal contradictionno_data
Measure: No node's finding contradicts another Comparator: Internal consistency across nodes Hit rule: No evaluated node directly contradicts another (coherence)
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery No internal contradiction coherence OR latency OR susceptibility pubmed · 870030 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery No internal contradiction inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
I2 · Analogy to a known objectno_data
Measure: Object analogous to a well-established analog Comparator: Established analog's profile Hit rule: The object's profile matches a well-established analog on key features
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Analogy to a known object coherence OR latency OR susceptibility pubmed · 870030 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Analogy to a known object inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
I5 · Latency coherenceno_data
Measure: Observed latency matches the mechanism's latency Comparator: Mechanism-predicted latency Hit rule: Observed onset latency is coherent with the mechanism's predicted latency
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Latency coherence coherence OR latency OR susceptibility pubmed · 870030 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Latency coherence inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
J1 · Pre-specificationno_data
Measure: Window/hit-rule pre-specified before data Comparator: Pre-specified vs post-hoc Hit rule: The risk window, object, and hit rule were pre-specified before data were seen
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Pre-specification pre-specified OR adjudicated pubmed · 13549 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Pre-specification post-hoc OR hypothesis-generating only pubmed · 1698 hits · run 2026-09-07
4 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
does_not_resolve 32215640 · Interactive cardiovascular and thoracic (2020) — A statistical primer on subgroup analyses.
does_not_resolve 40742144 · Journal of clinical sleep medicine : JCS (2025) — Association of weekend catch-up sleep with the atherosclerotic cardiovascular disease risk score: a hypothesis-generating study from US and Korean National Heal
J2 · Contrary-evidence logno_data
Measure: Contrary evidence is logged, not omitted Comparator: Support-only dossier Hit rule: Contrary / null / refuting findings are logged and shown alongside support
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Contrary-evidence log pre-specified OR adjudicated pubmed · 13549 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Contrary-evidence log post-hoc OR hypothesis-generating only pubmed · 1698 hits · run 2026-09-07
4 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
does_not_resolve 32215640 · Interactive cardiovascular and thoracic (2020) — A statistical primer on subgroup analyses.
does_not_resolve 40742144 · Journal of clinical sleep medicine : JCS (2025) — Association of weekend catch-up sleep with the atherosclerotic cardiovascular disease risk score: a hypothesis-generating study from US and Korean National Heal
J3 · No temporality-only claimno_data
Measure: Claim not based on temporality alone Comparator: Sequence-only evidence Hit rule: The claim is not supported by temporal sequence alone (independent evidence exists)
Finding: No evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery No temporality-only claim pre-specified OR adjudicated pubmed · 13549 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery No temporality-only claim post-hoc OR hypothesis-generating only pubmed · 1698 hits · run 2026-09-07
4 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
does_not_resolve 32215640 · Interactive cardiovascular and thoracic (2020) — A statistical primer on subgroup analyses.
does_not_resolve 40742144 · Journal of clinical sleep medicine : JCS (2025) — Association of weekend catch-up sleep with the atherosclerotic cardiovascular disease risk score: a hypothesis-generating study from US and Korean National Heal
J4 · Passive-surveillance roleno_data
Measure: Passive-surveillance findings bounded correctly Comparator: Active-surveillance confirmation Hit rule: Passive-surveillance signals are framed as hypothesis-generating, not confirmatory
Finding: No retrieved evidence addresses the passive-surveillance detection of surgery attributed to rotavirus vaccine within a specified risk window.
Cited: (none)
supporting: Rotavirus vaccine Surgery Passive-surveillance role pre-specified OR adjudicated pubmed · 13549 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Passive-surveillance role post-hoc OR hypothesis-generating only pubmed · 1698 hits · run 2026-09-07
4 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
does_not_resolve 32215640 · Interactive cardiovascular and thoracic (2020) — A statistical primer on subgroup analyses.
does_not_resolve 40742144 · Journal of clinical sleep medicine : JCS (2025) — Association of weekend catch-up sleep with the atherosclerotic cardiovascular disease risk score: a hypothesis-generating study from US and Korean National Heal
J5 · Dose mappingno_data
Measure: Dose/lot exposure mapped to the object Comparator: Unmapped exposure Hit rule: Dose / lot exposure is mapped to the object where the mechanism predicts it
Finding: No retrieved evidence addresses dose/lot exposure mapping for the pair Rotavirus vaccine and surgery, or provides any mechanism-predicted mapping to a surgery outcome.
Cited: (none)
supporting: Rotavirus vaccine Surgery Dose mapping pre-specified OR adjudicated pubmed · 13549 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Dose mapping post-hoc OR hypothesis-generating only pubmed · 1698 hits · run 2026-09-07
4 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
does_not_resolve 32215640 · Interactive cardiovascular and thoracic (2020) — A statistical primer on subgroup analyses.
does_not_resolve 40742144 · Journal of clinical sleep medicine : JCS (2025) — Association of weekend catch-up sleep with the atherosclerotic cardiovascular disease risk score: a hypothesis-generating study from US and Korean National Heal
Epidemiologic chassis 13/13 evaluated
B1 · Excess vs baselineno_data
Measure: RR/IRR vs unexposed or prior window Comparator: Unvaccinated person-time or pre-vaccination window Hit rule: RR/IRR > 1 with CI excluding 1 after pre-specified confounders
Finding: No retrieved study directly addresses the risk of surgery attributed to rotavirus vaccination; the closest relevant evidence is a self-controlled risk interval study of rotavirus vaccine safety that assessed intussusception risk, not surgery.
Cited: (none)
supporting: Rotavirus vaccine Surgery Excess vs baseline incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery no association OR null OR no increased risk Excess vs baseline pubmed · 88536 hits · run 2026-09-07
8 retrieved record(s)
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
refutes_node 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
refutes_node 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 34489307 · Gut (2022) — Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: results from a nationwide histology cohort.
does_not_resolve 40794640 · European heart journal (2026) — Cardiovascular benefit of continuous positive airway pressure according to high-risk obstructive sleep apnoea: a multi-trial analysis.
B2 · SCCSno_data
Measure: Self-controlled case series risk ratio Comparator: Individuals' own risk intervals (no-event) Hit rule: SCCS risk ratio > 1 in the post-vaccination window, CI excluding 1
Finding: No self-controlled case series study evaluating the risk of surgery after rotavirus vaccination was found in the retrieved evidence.
Cited: (none)
supporting: Rotavirus vaccine Surgery SCCS incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery no association OR null OR no increased risk SCCS pubmed · 88642 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
supports_node 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
refutes_node 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
refutes_node 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 39795956 · International journal of molecular scien (2024) — The Potential Metalloestrogenic Effect of Aluminum on Breast Cancer Risk for Antiperspirant Users.
supports_node 28468712 · Deutsches Arzteblatt international (2017) — Risk of Intussusception After Rotavirus Vaccination.
B3 · Cohort / risk-intervalno_data
Measure: Incidence rate ratio in defined window Comparator: Pre-specified risk vs comparison interval Hit rule: IRR > 1 in the pre-specified window, CI excluding 1, stratified by age/sex
Finding: No retrieved evidence directly addresses the association between rotavirus vaccine and surgery (e.g., intussusception requiring surgical intervention) using a cohort or risk-interval design with IRR > 1, CI excluding 1, and age/sex stratification.
Cited: (none)
supporting: Rotavirus vaccine Surgery Cohort / risk-interval incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery no association OR null OR no increased risk Cohort / risk-interval pubmed · 88145 hits · run 2026-09-07
10 retrieved record(s)
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
supports_node 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 41284649 · PloS one (2025) — Risk of neurologic or immune-mediated adverse events after COVID-19 diagnosis in the United States.
does_not_resolve 23296494 · Molecular biology reports (2013) — Assessment of the association between GSTM1 null genotype and risk of type 2 diabetes.
B4 · Meta-analysis / poolingno_data
Measure: Pooled effect across studies Comparator: Pooled estimate with heterogeneity Hit rule: Pooled estimate > 1 (or < 1) with quantified heterogeneity (I2)
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Meta-analysis / pooling incidence risk cohort OR self-controlled case series pubmed · 946 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery no association OR null OR no increased risk Meta-analysis / pooling pubmed · 111977 hits · run 2026-09-07
14 retrieved record(s)
refutes_node 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
ambiguous 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 29402646 · Journal of the American Medical Director (2018) — Fall-Risk-Increasing Drugs: A Systematic Review and Meta-analysis: III. Others.
does_not_resolve 28230042 · Journal of cancer research and therapeut (2016) — Meta-analysis of association between mobile phone use and glioma risk.
B5 · Negative-control outcomesno_data
Measure: No excess for outcomes the vaccine should not cause Comparator: Negative-control outcomes (unaffected by mechanism) Hit rule: Null for negative-control outcomes while target outcome is positive (specificity)
Finding: No retrieved evidence addresses the risk of surgery after rotavirus vaccination. The retrieved studies focus on COVID-19 vaccination, shingles vaccination, valproate use, GLP-1 receptor agonists, and methodological reviews of self-controlled case series designs, none of which examine rotavirus vaccine and surgical outcomes.
Cited: (none)
supporting: Rotavirus vaccine Surgery Negative-control outcomes incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery no association OR null OR no increased risk Negative-control outcomes pubmed · 88347 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
ambiguous 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 38833248 · JAMA network open (2024) — Valproate Use During Spermatogenesis and Risk to Offspring.
B6 · Other-antigen comparisonno_data
Measure: Risk vs a different-antigen comparator Comparator: Comparator product with a different antigen Hit rule: Risk specific to the target antigen, not shared with the comparator antigen
Finding: No retrieved evidence examined rotavirus vaccine and surgery; the only relevant study (PMID 38875047) assessed intussusception risk after rotavirus vaccine, not surgery.
Cited: (none)
supporting: Rotavirus vaccine Surgery Other-antigen comparison incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery no association OR null OR no increased risk Other-antigen comparison pubmed · 88109 hits · run 2026-09-07
10 retrieved record(s)
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
supports_node 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
refutes_node 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 23949879 · Tumour biology : the journal of the Inte (2014) — Meta-analysis of the association between GSTT1 null genotype and risk of nasopharyngeal carcinoma in Chinese.
does_not_resolve 23296494 · Molecular biology reports (2013) — Assessment of the association between GSTM1 null genotype and risk of type 2 diabetes.
B7 · Absolute riskno_data
Measure: Per-100k risk in window Comparator: Absolute incidence per 100k Hit rule: Absolute risk reported and stable across the window (not an artifact of rarity)
Finding: No retrieved evidence reports absolute risk per 100k of surgery following rotavirus vaccination, or any data on surgery as an adverse event after rotavirus vaccine.
Cited: (none)
supporting: Rotavirus vaccine Surgery Absolute risk incidence risk cohort OR self-controlled case series pubmed · 946 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery no association OR null OR no increased risk Absolute risk pubmed · 111375 hits · run 2026-09-07
11 retrieved record(s)
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
supports_node 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
refutes_node 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 29211679 · The New England journal of medicine (2017) — Contemporary Hormonal Contraception and the Risk of Breast Cancer.
does_not_resolve 23484825 · The New England journal of medicine (2013) — Risk of ischemic heart disease in women after radiotherapy for breast cancer.
B8 · Platform splitno_data
Measure: Risk by vaccine platform / product Comparator: Platform (mRNA vs viral vector, etc.) Hit rule: Risk attributable to a specific platform, not to 'a vaccine' generally
Finding: No retrieved evidence addresses surgery as an adverse event following rotavirus vaccination, nor does any study in the retrieved set evaluate risk attributable to a specific rotavirus vaccine platform for surgery.
Cited: (none)
supporting: Rotavirus vaccine Surgery Platform split incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery no association OR null OR no increased risk Platform split pubmed · 88174 hits · run 2026-09-07
10 retrieved record(s)
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
supports_node 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
refutes_node 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 23949879 · Tumour biology : the journal of the Inte (2014) — Meta-analysis of the association between GSTT1 null genotype and risk of nasopharyngeal carcinoma in Chinese.
does_not_resolve 36370744 · The Lancet. Child & adolescent health (2023) — Cancer risk with topical calcineurin inhibitors, pimecrolimus and tacrolimus, for atopic dermatitis: a systematic review and meta-analysis.
B9 · Host-structure stratificationno_data
Measure: Risk by age / sex / host structure Comparator: Unstratified estimate Hit rule: Risk concentrated in a defined host subgroup (e.g. young males), stable across sources
Finding: No retrieved evidence addresses rotavirus vaccine and surgery, or provides risk stratification by host subgroup (age/sex) for any outcome related to this pair.
Cited: (none)
supporting: Rotavirus vaccine Surgery Host-structure stratification incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery no association OR null OR no increased risk Host-structure stratification pubmed · 88107 hits · run 2026-09-07
11 retrieved record(s)
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
supports_node 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
refutes_node 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 23296494 · Molecular biology reports (2013) — Assessment of the association between GSTM1 null genotype and risk of type 2 diabetes.
B10 · Formulation / component changeno_data
Measure: Risk tracks a formulation change Comparator: Pre- vs post-change formulation Hit rule: Risk change tracks a documented formulation / component change over time
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Formulation / component change incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery no association OR null OR no increased risk Formulation / component change pubmed · 88269 hits · run 2026-09-07
7 retrieved record(s)
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
supports_node 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 41092926 · Lancet (London, England) (2025) — Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 su
H2 · Formulation natural experimentno_data
Measure: Risk shifts with a formulation change in the field Comparator: Pre- vs post-change formulation Hit rule: Observed risk tracks a real-world formulation change (natural experiment)
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Formulation natural experiment intervention OR treatment OR reversal pubmed · 15141576 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Formulation natural experiment no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-07
1 retrieved record(s)
does_not_resolve 39821905 · Obesity surgery (2025) — Reversal of Roux-en-Y Gastric Bypass: A Multi-Centric Analysis of Indications, Techniques, and Surgical Outcomes.
H4 · Policy / pause signalno_data
Measure: Risk signal appears/disappears across a pause or policy change Comparator: Pre- vs post-pause period Hit rule: The signal appears or disappears coherently with a rollout / pause (H4)
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Policy / pause signal intervention OR treatment OR reversal pubmed · 15141576 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Policy / pause signal no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-07
1 retrieved record(s)
does_not_resolve 39821905 · Obesity surgery (2025) — Reversal of Roux-en-Y Gastric Bypass: A Multi-Centric Analysis of Indications, Techniques, and Surgical Outcomes.
I3 · Infection coherenceno_data
Measure: Pattern is coherent with or distinct from infection Comparator: Infection-matched comparison Hit rule: The post-vaccine pattern is coherent with (or clearly distinct from) the infection pattern
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Infection coherence coherence OR latency OR susceptibility pubmed · 870030 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Infection coherence inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
Mediator & biological gradient 24/24 evaluated
C1n · Dose strength gradientno_data
Measure: Risk vs dose strength (dose size) Comparator: Lower dose strength Hit rule: Monotonic dose-response in dose strength (larger dose -> higher risk)
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Dose strength gradient dose-response OR dose effect pubmed · 1299145 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery no dose effect OR no dose-response Dose strength gradient pubmed · 133 hits · run 2026-09-07
7 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
refutes_node 32972735 · Vaccine (2021) — Risk of intussusception after monovalent rotavirus vaccine (Rotavac) in Indian infants: A self-controlled case series analysis.
supports_node 28648544 · Vaccine (2017) — Risk of intussusception following rotavirus vaccination: An evidence based meta-analysis of cohort and case-control studies.
refutes_node 38413278 · Vaccine (2024) — Post-marketing surveillance of intussusception after Rotarix administration in Afghanistan, 2018-2022.
does_not_resolve 33373368 · PLoS medicine (2020) — Assessing the risk of ketoacidosis due to sodium-glucose cotransporter (SGLT)-2 inhibitors in patients with type 1 diabetes: A meta-analysis and meta-regression
does_not_resolve 27895844 · Malawi medical journal : the journal of (2016) — Effect of human rotavirus vaccine on severe diarrhea in African infants.
does_not_resolve 33927157 · Epidemiology (Cambridge, Mass.) (2021) — Estimating the Effectiveness of Rotavirus Vaccine Schedules.
C2n · Dose number gradientno_data
Measure: Risk vs dose number (1st vs 2nd vs 3rd) Comparator: First dose Hit rule: Risk increases (or shows a defined pattern) with dose number
Finding: No evidence retrieved specifically examines a dose number gradient (1st vs 2nd vs 3rd dose) for risk of surgery after rotavirus vaccination; retrieved studies focus on intussusception risk but do not report dose-specific comparisons or a gradient pattern across doses.
Cited: (none)
supporting: Rotavirus vaccine Surgery Dose number gradient dose-response OR dose effect pubmed · 1299145 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery no dose effect OR no dose-response Dose number gradient pubmed · 577 hits · run 2026-09-07
7 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
refutes_node 32972735 · Vaccine (2021) — Risk of intussusception after monovalent rotavirus vaccine (Rotavac) in Indian infants: A self-controlled case series analysis.
supports_node 28648544 · Vaccine (2017) — Risk of intussusception following rotavirus vaccination: An evidence based meta-analysis of cohort and case-control studies.
refutes_node 38413278 · Vaccine (2024) — Post-marketing surveillance of intussusception after Rotarix administration in Afghanistan, 2018-2022.
ambiguous 27895844 · Malawi medical journal : the journal of (2016) — Effect of human rotavirus vaccine on severe diarrhea in African infants.
does_not_resolve 33927157 · Epidemiology (Cambridge, Mass.) (2021) — Estimating the Effectiveness of Rotavirus Vaccine Schedules.
does_not_resolve 25691274 · Journal of epidemiology and community he (2015) — Pulmonary function as a risk factor for dementia death: an individual participant meta-analysis of six UK general population cohort studies.
C3n · Measured-exposure tertilesno_data
Measure: Risk vs measured exposure tertile Comparator: Lowest-exposure tertile Hit rule: Risk ordered by measured-exposure tertile (high > mid > low)
Finding: The retrieved evidence includes multiple studies on intussusception after rotavirus vaccination (e.g., PMIDs 32972735, 28648544, 38413278, 37884416) but none report on the risk of surgery in relation to measured-exposure tertiles of rotavirus vaccine, nor do any studies address surgery as a separate adverse event. The only surgical procedure mentioned is treatment for intussusception, which is not analyzed by exposure tertile.
Cited: (none)
supporting: Rotavirus vaccine Surgery Measured-exposure tertiles dose-response OR dose effect pubmed · 1299145 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery no dose effect OR no dose-response Measured-exposure tertiles pubmed · 22 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
refutes_node 32972735 · Vaccine (2021) — Risk of intussusception after monovalent rotavirus vaccine (Rotavac) in Indian infants: A self-controlled case series analysis.
supports_node 28648544 · Vaccine (2017) — Risk of intussusception following rotavirus vaccination: An evidence based meta-analysis of cohort and case-control studies.
refutes_node 38413278 · Vaccine (2024) — Post-marketing surveillance of intussusception after Rotarix administration in Afghanistan, 2018-2022.
does_not_resolve 27895844 · Malawi medical journal : the journal of (2016) — Effect of human rotavirus vaccine on severe diarrhea in African infants.
does_not_resolve 33927157 · Epidemiology (Cambridge, Mass.) (2021) — Estimating the Effectiveness of Rotavirus Vaccine Schedules.
refutes_node 30048564 · Paediatric and perinatal epidemiology (2018) — Rotavirus vaccination and short-term risk of adverse events in US infants.
refutes_node 35690869 · Allergy, asthma, and clinical immunology (2022) — Evaluation of rotavirus vaccine administration among a 22q11.2DS patient population.
C4n · Organoid concentration curveno_data
Measure: Effect vs antigen concentration in organoid Comparator: Vehicle / zero antigen Hit rule: Dose-dependent effect across a graded concentration curve
Finding: No retrieved evidence addresses a dose-dependent effect of rotavirus antigen concentration on surgery in organoid models.
Cited: (none)
supporting: Rotavirus vaccine Surgery Organoid concentration curve dose-response OR dose effect pubmed · 1299145 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery no dose effect OR no dose-response Organoid concentration curve pubmed · 33 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 27895844 · Malawi medical journal : the journal of (2016) — Effect of human rotavirus vaccine on severe diarrhea in African infants.
supports_node 28648544 · Vaccine (2017) — Risk of intussusception following rotavirus vaccination: An evidence based meta-analysis of cohort and case-control studies.
does_not_resolve 33927157 · Epidemiology (Cambridge, Mass.) (2021) — Estimating the Effectiveness of Rotavirus Vaccine Schedules.
refutes_node 38413278 · Vaccine (2024) — Post-marketing surveillance of intussusception after Rotarix administration in Afghanistan, 2018-2022.
refutes_node 30048564 · Paediatric and perinatal epidemiology (2018) — Rotavirus vaccination and short-term risk of adverse events in US infants.
refutes_node 32972735 · Vaccine (2021) — Risk of intussusception after monovalent rotavirus vaccine (Rotavac) in Indian infants: A self-controlled case series analysis.
does_not_resolve 35690869 · Allergy, asthma, and clinical immunology (2022) — Evaluation of rotavirus vaccine administration among a 22q11.2DS patient population.
C5n · EC50 vs Cmax coherenceno_data
Measure: Measured exposure reaches effect threshold Comparator: Pharmacokinetic Cmax vs EC50 Hit rule: Achieved exposure (Cmax/tissue) plausibly reaches the in-vitro EC50
Finding: All retrieved studies on rotavirus vaccine address intussusception, infection prevention, or other outcomes; none assess surgery as an adverse event or provide pharmacokinetic exposure (Cmax/tissue) measurements for rotavirus vaccine.
Cited: (none)
supporting: Rotavirus vaccine Surgery EC50 vs Cmax coherence dose-response OR dose effect pubmed · 1299145 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery no dose effect OR no dose-response EC50 vs Cmax coherence pubmed · 22 hits · run 2026-09-07
10 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
does_not_resolve 27895844 · Malawi medical journal : the journal of (2016) — Effect of human rotavirus vaccine on severe diarrhea in African infants.
supports_node 28648544 · Vaccine (2017) — Risk of intussusception following rotavirus vaccination: An evidence based meta-analysis of cohort and case-control studies.
does_not_resolve 33927157 · Epidemiology (Cambridge, Mass.) (2021) — Estimating the Effectiveness of Rotavirus Vaccine Schedules.
refutes_node 38413278 · Vaccine (2024) — Post-marketing surveillance of intussusception after Rotarix administration in Afghanistan, 2018-2022.
refutes_node 32972735 · Vaccine (2021) — Risk of intussusception after monovalent rotavirus vaccine (Rotavac) in Indian infants: A self-controlled case series analysis.
refutes_node 30048564 · Paediatric and perinatal epidemiology (2018) — Rotavirus vaccination and short-term risk of adverse events in US infants.
E1 · Mediator identified in casesno_data
Measure: Mediator present in affected tissue/cells Comparator: Unaffected tissue / control Hit rule: The hypothesized mediator is detected in the affected compartment and not (or less) in control
Finding: No evidence retrieved discusses detection of a mediator in affected tissue/cells linking rotavirus vaccine to surgery.
Cited: (none)
supporting: Rotavirus vaccine Surgery mechanism Mediator identified in cases in vitro OR patient-derived pubmed · 29242 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Mediator identified in cases not associated mechanism pubmed · 1 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 28162821 · Vaccine (2017) — Safety of live vaccinations on immunosuppressive therapy in patients with immune-mediated inflammatory diseases, solid organ transplantation or after bone-marro
E2 · Mediator in healthy vaccineesno_data
Measure: Mediator detectable after vaccination Comparator: Pre-vaccination baseline Hit rule: Mediator appears after vaccination and tracks the exposure window
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery mechanism Mediator in healthy vaccinees in vitro OR patient-derived pubmed · 29242 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Mediator in healthy vaccinees not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E3 · Infection contrastno_data
Measure: Mediator absent/low after natural infection Comparator: Recovered natural infection Hit rule: Mediator signal is specific to vaccination vs a comparable natural-infection control
Finding: The retrieved evidence discusses intussusception (a form of intestinal obstruction requiring surgery) as a known adverse event after rotavirus vaccination, but provides no direct comparison of mediator signals (e.g., infection response) between vaccinated and naturally infected children.
supporting: Rotavirus vaccine Surgery mechanism Infection contrast in vitro OR patient-derived pubmed · 29242 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Infection contrast not associated mechanism pubmed · 5 hits · run 2026-09-07
3 retrieved record(s)
does_not_resolve 22520130 · Vaccine (2012) — Workshop on intussusception in African countries--meeting report.
does_not_resolve 32617279 · Medical journal of the Islamic Republic (2020) — Incidence of intussusception in children less than five years of age: a pre-rotavirus vaccine survey from Iran, 2010-2015.
does_not_resolve 20387202 · European journal of pediatric surgery : (2010) — Preconceptional oral vaccination prevents experimental biliary atresia in newborn mice.
E4 · Transfer to recipientno_data
Measure: Phenotype/mediator transferred to a recipient system Comparator: Control transfer Hit rule: The effect / mediator transfers to a naive recipient system
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery mechanism Transfer to recipient in vitro OR patient-derived pubmed · 29242 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Transfer to recipient not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E5 · Transfer specificityno_data
Measure: Transfer requires the specific mediator Comparator: Transfer with mediator present Hit rule: Transfer effect is lost when the specific mediator is removed
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery mechanism Transfer specificity in vitro OR patient-derived pubmed · 29242 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Transfer specificity not associated mechanism pubmed · 5 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 27025573 · Virus research (2016) — Evaluation of oral Lanzhou lamb rotavirus vaccine via passive transfusion with CD4(+)/CD8(+) T lymphocytes.
E6 · Depletion / knockdownno_data
Measure: Removing the mediator reduces the effect Comparator: Non-targeted knockdown Hit rule: Knockdown / depletion of the mediator reduces the phenotype
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery mechanism Depletion / knockdown in vitro OR patient-derived pubmed · 29242 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Depletion / knockdown not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E7 · Add-back rescueno_data
Measure: Adding the mediator restores the effect Comparator: Add-back of a control protein Hit rule: Adding back the mediator (not a control) restores the phenotype
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery mechanism Add-back rescue in vitro OR patient-derived pubmed · 29242 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Add-back rescue not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E8 · Neutralizationsupports
Measure: Neutralizing the mediator blocks the effect Comparator: Isotype control Hit rule: Neutralization of the mediator (not an isotype control) blocks the phenotype
Finding: Maternal rotavirus vaccination (RRV, Wa, or Rotateq) of dams prevented the murine model of biliary atresia, a neonatal disease that causes obliteration of the biliary tree, which is a surgical condition. Neutralization of rotavirus (via maternal vaccination and passive antibody transfer) blocked the obstructive cholangiopathy outcome, aligning with the node's definition of neutralization blocking the phenotype.
supporting: Rotavirus vaccine Surgery mechanism Neutralization in vitro OR patient-derived pubmed · 29242 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Neutralization not associated mechanism pubmed · 4 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 19635292 · Journal of pediatric surgery (2009) — Prevention of the murine model of biliary atresia after live rotavirus vaccination of dams.
E9 · Isotype controlno_data
Measure: Isotype control does not reproduce the effect Comparator: Active antibody Hit rule: An isotype control fails to reproduce the block/activation
Finding: No retrieved evidence addresses whether an isotype control fails to reproduce the block/activation in the context of rotavirus vaccine and surgery. PMID 24614127 evaluates safety of pentavalent rotavirus vaccine in infants with surgical gastrointestinal disease but does not involve isotype controls. PMID 27025573 studies T-cell transfer in a mouse model of Lanzhou lamb rotavirus vaccine without reference to isotype controls or surgery endpoints.
Cited: (none)
supporting: Rotavirus vaccine Surgery mechanism Isotype control in vitro OR patient-derived pubmed · 29242 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Isotype control not associated mechanism pubmed · 5 hits · run 2026-09-07
2 retrieved record(s)
ambiguous 24614127 · Journal of pediatric gastroenterology an (2014) — Pentavalent rotavirus vaccine in infants with surgical gastrointestinal disease.
does_not_resolve 27025573 · Virus research (2016) — Evaluation of oral Lanzhou lamb rotavirus vaccine via passive transfusion with CD4(+)/CD8(+) T lymphocytes.
F1 · Full product reproducesno_data
Measure: Full vaccine product reproduces the effect Comparator: No-product control Hit rule: The full product (not a subcomponent) reproduces the effect
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Full product reproduces component OR antigen OR vector pubmed · 2045241 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Full product reproduces no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
5 retrieved record(s)
does_not_resolve 29550258 · Immunology letters (2018) — Live bacterial vaccine vector and delivery strategies of heterologous antigen: A review.
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F2 · Empty vector / particleno_data
Measure: Vector/particle without antigen reproduces (or not) Comparator: Full product Hit rule: Effect attributed to (or excluded from) the vector/particle backbone alone
Finding: The retrieved evidence discusses live bacterial and viral vaccine vectors for delivering heterologous antigens but does not address surgical outcomes or adverse events attributed to rotavirus vaccine vector/particle backbone.
Cited: (none)
supporting: Rotavirus vaccine Surgery Empty vector / particle component OR antigen OR vector pubmed · 2045241 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Empty vector / particle no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
5 retrieved record(s)
does_not_resolve 29550258 · Immunology letters (2018) — Live bacterial vaccine vector and delivery strategies of heterologous antigen: A review.
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F4 · Irrelevant cargono_data
Measure: Irrelevant cargo does not reproduce the effect Comparator: Vector with the target antigen Hit rule: Irrelevant cargo fails to reproduce the effect (specificity)
Finding: The retrieved evidence does not address Rotavirus vaccine or surgery; instead it reviews live bacterial and viral vaccine vectors, measles vaccine, influenza vaccines, and cancer vaccine vectors.
Cited: (none)
supporting: Rotavirus vaccine Surgery Irrelevant cargo component OR antigen OR vector pubmed · 2045241 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Irrelevant cargo no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
6 retrieved record(s)
does_not_resolve 29550258 · Immunology letters (2018) — Live bacterial vaccine vector and delivery strategies of heterologous antigen: A review.
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 27384578 · Viruses (2016) — Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines.
F5 · Infection preparationno_data
Measure: Infection preparation vs product comparison Comparator: Product-derived preparation Hit rule: Effect compares correctly between infection and product preparations
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Infection preparation component OR antigen OR vector pubmed · 2045241 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Infection preparation no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
5 retrieved record(s)
does_not_resolve 29550258 · Immunology letters (2018) — Live bacterial vaccine vector and delivery strategies of heterologous antigen: A review.
ambiguous 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F6 · Cytokine / adjuvant mixno_data
Measure: Cytokine/adjuvant mix alone reproduces (or not) Comparator: Individual components Hit rule: The effect is (or is not) reproducible by the cytokine/adjuvant mix alone
Finding: No evidence found.
Cited: (none)
supporting: Rotavirus vaccine Surgery Cytokine / adjuvant mix component OR antigen OR vector pubmed · 2045241 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Cytokine / adjuvant mix no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
5 retrieved record(s)
does_not_resolve 29550258 · Immunology letters (2018) — Live bacterial vaccine vector and delivery strategies of heterologous antigen: A review.
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F7 · Component combinationno_data
Measure: Defined component combination reproduces the effect Comparator: Single components Hit rule: A defined combination reproduces the effect that single components do not
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Component combination component OR antigen OR vector pubmed · 2045241 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Component combination no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
5 retrieved record(s)
does_not_resolve 29550258 · Immunology letters (2018) — Live bacterial vaccine vector and delivery strategies of heterologous antigen: A review.
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
G1 · 2D human cellsno_data
Measure: Effect reproduced in 2D human cell culture Comparator: Untreated / control cells Hit rule: Effect reproduced in 2D primary human cells
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery 2D human cells animal OR organoid OR cell model pubmed · 1818528 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery 2D human cells not reproduced model pubmed · 1 hits · run 2026-09-07
G2 · Organoid / chipno_data
Measure: Effect reproduced in organoid / organ-on-chip Comparator: Unexposed organoid Hit rule: Effect reproduced in a 3D organoid / organ-on-chip system
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Organoid / chip animal OR organoid OR cell model pubmed · 1818527 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Organoid / chip not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
H1 · Block in vitro / in vivono_data
Measure: Blocking the mediator/mechanism prevents the effect Comparator: Control intervention Hit rule: Blocking the mechanism prevents or reverses the effect (not with a control intervention)
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Block in vitro / in vivo intervention OR treatment OR reversal pubmed · 15141576 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Block in vitro / in vivo no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-07
1 retrieved record(s)
does_not_resolve 39821905 · Obesity surgery (2025) — Reversal of Roux-en-Y Gastric Bypass: A Multi-Centric Analysis of Indications, Techniques, and Surgical Outcomes.
Clinical / animal / host 7/7 evaluated
E10 · Host-line dependenceno_data
Measure: Effect depends on host line/cell type Comparator: Susceptible host line Hit rule: Effect is restricted to a defined host line / genotype, not universal
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery mechanism Host-line dependence in vitro OR patient-derived pubmed · 29242 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Host-line dependence not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G3 · Animal, clinical routeno_data
Measure: Effect in animal via the clinical route of administration Comparator: Vehicle, same route Hit rule: Effect reproduced in an animal using the clinical route of administration
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Animal, clinical route animal OR organoid OR cell model pubmed · 1818528 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Animal, clinical route not reproduced model pubmed · 1 hits · run 2026-09-07
G4 · Susceptible animalrefutes
Measure: Effect in a susceptible animal model Comparator: Non-susceptible model Hit rule: Effect in a defined susceptible animal model
Finding: In a susceptible animal model (Balb/c-mice lacking maternally derived immune protection), preconceptional oral vaccination of dams with rotavirus vaccines (RotaTeq, Rotarix) prevented biliary atresia (a surgery-relevant condition) in newborn mice after subsequent rotavirus challenge, suggesting a protective rather than causative effect on surgery-requiring pathology.
supporting: Rotavirus vaccine Surgery Susceptible animal animal OR organoid OR cell model pubmed · 1818528 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Susceptible animal not reproduced model pubmed · 3 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 20387202 · European journal of pediatric surgery : (2010) — Preconceptional oral vaccination prevents experimental biliary atresia in newborn mice.
G5 · Replication across labsno_data
Measure: Effect replicated in an independent lab Comparator: Original result Hit rule: The key effect is replicated in an independent laboratory
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Replication across labs animal OR organoid OR cell model pubmed · 1818527 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Replication across labs not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G6 · Blinded scoringno_data
Measure: Outcomes scored blinded Comparator: Unblinded reference Hit rule: Primary outcomes scored by a blinded assessor
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Blinded scoring animal OR organoid OR cell model pubmed · 1818527 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Blinded scoring not reproduced model pubmed · 1 hits · run 2026-09-07
G7 · Experimental time courseno_data
Measure: Effect follows a defined experimental time course Comparator: No-exposure time course Hit rule: The effect's onset/offset follows a defined experimental time course
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Experimental time course animal OR organoid OR cell model pubmed · 1818527 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Experimental time course not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
I4 · Susceptibility traitno_data
Measure: A host trait / marker defines susceptibility Comparator: Trait-negative hosts Hit rule: A defined host trait / marker enriches for susceptibility
Finding: no evidence found
Cited: (none)
supporting: Rotavirus vaccine Surgery Susceptibility trait coherence OR latency OR susceptibility pubmed · 870030 hits · run 2026-09-07
mirror: Rotavirus vaccine Surgery Susceptibility trait inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
How this was built
Per node: a supporting and a mirror PubMed query built from the node's measure / population / comparator / hit_rule; top hits fetched (title + abstract); each record classified (supports / refutes / ambiguous) by xAI with a heuristic fallback; a per-node synthesis is generated strictly from the retrieved PMIDs; the node status is then rolled up to C1–C6. Full query provenance is shown per node above. Reproduce the build: python -m evidence_run. Data: data/evidence_run/state.json.