:root {
  color-scheme: light dark;
  --bg: #f6f7f9;
  --bg-elevated: #ffffff;
  --bg-muted: #eef0f3;
  --border: #dde1e6;
  --text: #1a1d23;
  --text-muted: #5b6270;
  --text-faint: #8890a0;
  --accent: #1d5fbf;
  --accent-bg: #e8f0fd;
  --signal: #b3261e;
  --signal-bg: #fdecea;
  --nosignal: #1e7d44;
  --nosignal-bg: #e9f7ee;
  --warn: #9a6700;
  --warn-bg: #fff6dc;
  --row-hover: #f0f4fa;
  --shadow: 0 1px 2px rgba(20, 24, 32, 0.06), 0 1px 12px rgba(20, 24, 32, 0.04);
  --radius: 10px;
  --mono: "SFMono-Regular", Consolas, "Liberation Mono", Menlo, monospace;
  --sans: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, Helvetica, Arial, sans-serif;
}

@media (prefers-color-scheme: dark) {
  :root {
    --bg: #14161b;
    --bg-elevated: #1c1f26;
    --bg-muted: #21242c;
    --border: #2c313c;
    --text: #e7e9ee;
    --text-muted: #a1a8b5;
    --text-faint: #6d7383;
    --accent: #6ea3f5;
    --accent-bg: #1c2c48;
    --signal: #f2867d;
    --signal-bg: #3a1c1c;
    --nosignal: #6fce97;
    --nosignal-bg: #123322;
    --warn: #e2b64f;
    --warn-bg: #3a2f0f;
    --row-hover: #232732;
    --shadow: 0 1px 2px rgba(0, 0, 0, 0.3), 0 1px 16px rgba(0, 0, 0, 0.25);
  }
}

* { box-sizing: border-box; }

html, body {
  margin: 0;
  padding: 0;
  background: var(--bg);
  color: var(--text);
  font-family: var(--sans);
}

body {
  min-height: 100vh;
  display: flex;
  flex-direction: column;
}

a { color: var(--accent); text-decoration: none; }
a:hover { text-decoration: underline; }

.site-header {
  border-bottom: 1px solid var(--border);
  background: var(--bg-elevated);
  position: sticky;
  top: 0;
  z-index: 20;
}

.site-header-inner {
  max-width: 1080px;
  margin: 0 auto;
  padding: 14px 20px;
  display: flex;
  align-items: baseline;
  gap: 10px;
  flex-wrap: wrap;
}

.brand {
  font-size: 17px;
  font-weight: 700;
  letter-spacing: -0.01em;
  color: var(--text);
}
.brand span { color: var(--accent); }

.brand-sub {
  font-size: 12.5px;
  color: var(--text-muted);
}

.header-search {
  margin-left: auto;
  min-width: 220px;
  flex: 1 1 260px;
  max-width: 420px;
  position: relative;
}

main {
  flex: 1;
  width: 100%;
  max-width: 1080px;
  margin: 0 auto;
  padding: 24px 20px 40px;
}

.disclaimer {
  font-size: 12.5px;
  line-height: 1.55;
  color: var(--text-muted);
  background: var(--bg-muted);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  padding: 12px 14px;
  margin-bottom: 22px;
}
.disclaimer strong { color: var(--text); }

.stat-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(150px, 1fr));
  gap: 10px;
  margin-bottom: 26px;
}

.stat-card {
  background: var(--bg-elevated);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  padding: 12px 14px;
  box-shadow: var(--shadow);
}

.stat-value {
  font-size: 21px;
  font-weight: 700;
  font-variant-numeric: tabular-nums;
}
.stat-label {
  font-size: 11.5px;
  text-transform: uppercase;
  letter-spacing: 0.04em;
  color: var(--text-muted);
  margin-top: 2px;
}

input[type="search"], input[type="text"] {
  width: 100%;
  font-size: 14px;
  padding: 8px 12px;
  border-radius: 8px;
  border: 1px solid var(--border);
  background: var(--bg-muted);
  color: var(--text);
  font-family: var(--sans);
}
input[type="search"]:focus, input[type="text"]:focus {
  outline: 2px solid var(--accent);
  outline-offset: -1px;
  background: var(--bg-elevated);
}

.search-results {
  position: absolute;
  top: calc(100% + 6px);
  left: 0;
  right: 0;
  background: var(--bg-elevated);
  border: 1px solid var(--border);
  border-radius: 10px;
  box-shadow: var(--shadow);
  max-height: 400px;
  overflow-y: auto;
  z-index: 30;
}
.search-results:empty { display: none; }

.search-result-row {
  display: flex;
  align-items: center;
  gap: 8px;
  padding: 8px 12px;
  border-bottom: 1px solid var(--border);
  cursor: pointer;
  font-size: 13.5px;
}
.search-result-row:last-child { border-bottom: none; }
.search-result-row:hover, .search-result-row.active { background: var(--row-hover); }

.tag {
  font-size: 10.5px;
  font-weight: 700;
  text-transform: uppercase;
  letter-spacing: 0.03em;
  padding: 2px 6px;
  border-radius: 5px;
  flex-shrink: 0;
}
.tag-drug { background: var(--accent-bg); color: var(--accent); }
.tag-reaction { background: var(--bg-muted); color: var(--text-muted); }

.section-title {
  font-size: 13px;
  font-weight: 700;
  text-transform: uppercase;
  letter-spacing: 0.04em;
  color: var(--text-muted);
  margin: 30px 0 10px;
  display: flex;
  align-items: center;
  justify-content: space-between;
}

.panel {
  background: var(--bg-elevated);
  border: 1px solid var(--border);
  border-radius: var(--radius);
  box-shadow: var(--shadow);
  overflow: hidden;
}

table {
  width: 100%;
  border-collapse: collapse;
  font-size: 13.5px;
}

thead th {
  text-align: left;
  font-size: 11px;
  text-transform: uppercase;
  letter-spacing: 0.03em;
  color: var(--text-muted);
  background: var(--bg-muted);
  padding: 9px 12px;
  border-bottom: 1px solid var(--border);
  white-space: nowrap;
  cursor: pointer;
  user-select: none;
}
thead th:hover { color: var(--text); }
thead th.num, td.num { text-align: right; font-variant-numeric: tabular-nums; }
thead th .arrow { opacity: 0.5; margin-left: 3px; font-size: 10px; }

tbody td {
  padding: 8px 12px;
  border-bottom: 1px solid var(--border);
  vertical-align: middle;
}
tbody tr:last-child td { border-bottom: none; }
tbody tr:hover { background: var(--row-hover); }

.rank {
  color: var(--text-faint);
  font-variant-numeric: tabular-nums;
  width: 28px;
}

.entity-link { font-weight: 600; }

.badge {
  display: inline-flex;
  align-items: center;
  gap: 4px;
  font-size: 11px;
  font-weight: 700;
  padding: 2px 7px;
  border-radius: 999px;
}
.badge-signal { background: var(--signal-bg); color: var(--signal); }
.badge-nosignal { background: var(--nosignal-bg); color: var(--nosignal); }
.badge-warn { background: var(--warn-bg); color: var(--warn); }

.ci { color: var(--text-faint); font-size: 12px; }

.empty-state {
  padding: 30px 16px;
  text-align: center;
  color: var(--text-muted);
  font-size: 13.5px;
}

.page-head {
  margin-bottom: 18px;
}
.page-head .eyebrow {
  font-size: 12px;
  text-transform: uppercase;
  letter-spacing: 0.04em;
  color: var(--text-muted);
  margin-bottom: 4px;
}
.page-head h1 {
  font-size: 26px;
  margin: 0 0 6px;
  letter-spacing: -0.01em;
}
.page-head .meta {
  font-size: 13px;
  color: var(--text-muted);
}
.back-link {
  font-size: 13px;
  display: inline-block;
  margin-bottom: 14px;
}

.controls-row {
  display: flex;
  gap: 10px;
  align-items: center;
  margin-bottom: 12px;
  flex-wrap: wrap;
}
.controls-row .header-search { max-width: 320px; margin-left: 0; }

.count-pill {
  font-size: 12px;
  color: var(--text-muted);
  margin-left: auto;
}

.site-footer {
  border-top: 1px solid var(--border);
  padding: 18px 20px 26px;
  font-size: 12px;
  color: var(--text-faint);
  text-align: center;
}

.skeleton-row td {
  color: transparent;
}
.skeleton {
  display: inline-block;
  height: 12px;
  border-radius: 4px;
  background: var(--bg-muted);
  width: 80%;
}

.error-banner {
  background: var(--signal-bg);
  color: var(--signal);
  border: 1px solid var(--signal);
  border-radius: var(--radius);
  padding: 12px 14px;
  font-size: 13.5px;
  margin-bottom: 16px;
}

.low-n { color: var(--text-faint); }
.low-n::after { content: " ⚠"; font-size: 10px; }

@media (max-width: 640px) {
  table { font-size: 12.5px; }
  thead th, tbody td { padding: 7px 8px; }
}