Evidence dossier · candidate cand-hpv-seizure · VICP program · · DRAFT — not a determination
This is a draft research-tracking dossier, not a determination that HPV vaccine causes Seizure, and not an incidence or legal finding. All evidence is flagged needs_human_review and must be reviewed before any page is published or cited. Every value is grounded in retrieved citations (PMID + retrieval date); unsourced items read "no evidence found / not assessable". Symmetric search: every supporting query has a mirror/null query, and zeros are shown (negative dossiers report the absence of signal).
Claim matrix (C1–C6, computed)
Claim
Label
Status
Missing nodes
C1
Coherent clinical object exists
insufficient_data
missing: A1 A2
C2
Consistent temporal window
insufficient_data
missing: A5
C3
Epidemiologic excess risk
contested
C4
Consistency / replication
insufficient_data
missing: B5
C5
Specificity (product / dose)
insufficient_data
missing: C1n C2n
C6
Biological mechanism
insufficient_data
missing: E1
Two evidentiary bars apply to the epi nodes/claims (C3, C4): · VICP — preponderance of the evidence. · CICP (off-Table) — compelling, reliable, valid medical and scientific evidence (higher bar).
Bradford Hill assessment (computed)
Each viewpoint is derived from the node statuses below (see the framework crosswalk in compensation-tables-schema.md §8). Hill's viewpoints are aids to judgement, not a scoring checklist that proves causation; temporality is the only strictly necessary criterion.
Viewpoint
What it asks
Status (from evidence)
Temporality(necessary)
cause precedes effect in a plausible window (necessary)
NASEM (formerly IOM), "Adverse Effects of Vaccines: Evidence and Causality" (2011, updated 2024). Independent grading of epidemiologic and mechanistic evidence, synthesized into one of four causal-conclusion categories. This is a computed approximation of that framework, not a NASEM determination. See compensation-tables-schema.md §8bis.
Case-definition standard: Brighton Collaboration (named in spec §1: seizures) — governs the case-certainty scale on A1/A2/A6/A8 below. See compensation-tables-schema.md §8ter.
Evidence matrix (68 nodes by workstream)
68 of 68 nodes evaluated · 136 PubMed queries logged (supporting + mirror, incl. zeros). Statuses are computed from retrieved citations; not hand-set.
Definition & attribution 24/24 evaluated
A1 · Case reportsno_data
Measure: New definite object in risk window T Comparator: Pre-vaccination baseline Hit rule: Definite object present, onset in window, competing causes considered
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure case report OR case series Case reports pubmed · 66201 hits · run 2026-09-09
mirror: HPV vaccine Seizure alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
11 retrieved record(s)
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
ambiguous 32809680 · (2026) — Rubella Vaccine.
does_not_resolve 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A2 · Series with objective confirmationno_data
Measure: Definite object plus objective test Comparator: Reference range / diagnostic criteria Hit rule: Objective confirmation in >=1 case per the working definition
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure case report OR case series Series with objective confirmation pubmed · 5650 hits · run 2026-09-09
mirror: HPV vaccine Seizure alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
11 retrieved record(s)
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
ambiguous 32809680 · (2026) — Rubella Vaccine.
ambiguous 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A3 · Onset histogramno_data
Measure: Distribution of onset times after dose Comparator: Pre-specified risk window Hit rule: Onset clusters inside the pre-specified window (not uniform/flat)
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure case report OR case series Onset histogram pubmed · 6 hits · run 2026-09-09
mirror: HPV vaccine Seizure alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
11 retrieved record(s)
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A4 · Temporal plausibilityno_data
Measure: Onset latency vs object pathophysiology Comparator: Object's known natural latency Hit rule: Onset latency consistent with the object's pathophysiology
Finding: No retrieved evidence addresses temporal plausibility of seizure after HPV vaccination; the only seizure-related mention is for routine childhood immunizations generally, not HPV vaccine specifically.
Cited: (none)
supporting: HPV vaccine Seizure case report OR case series Temporal plausibility pubmed · 35 hits · run 2026-09-09
mirror: HPV vaccine Seizure alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
13 retrieved record(s)
does_not_resolve 15638050 · Clinical and experimental rheumatology (2004) — A case-series of adverse events, positive re-challenge of symptoms, and events in identical twins following hepatitis B vaccination: analysis of the Vaccine Adv
does_not_resolve 31860076 · Brain : a journal of neurology (2020) — Disrupted basal ganglia-thalamocortical loops in focal to bilateral tonic-clonic seizures.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
A5 · Onset-interval documentationno_data
Measure: Onset interval documented in source Comparator: Dose date Hit rule: Onset interval is recorded (not imputed) in a primary source
Finding: No evidence retrieved addresses onset-interval documentation for HPV vaccine-related seizure; all retrieved articles discuss other vaccines or unrelated adverse events.
Cited: (none)
supporting: HPV vaccine Seizure case report OR case series Onset-interval documentation pubmed · 4 hits · run 2026-09-09
mirror: HPV vaccine Seizure alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
11 retrieved record(s)
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
Measure: Competing causes assessed and excluded Comparator: Likely alternative diagnoses Hit rule: Pre-specified competing causes ruled out per the working definition
Finding: The retrieved evidence includes no studies specifically evaluating competing causes of seizures after HPV vaccination; the only mention of seizures refers to general pediatric vaccine-related adverse events in a review that does not address HPV vaccine or differential diagnosis exclusion.
Case-certainty distribution (Brighton Collaboration): 1 Level 3 (possible). Transparency layer — does not change this node's status or feed C1–C6.
Cited: (none)
supporting: HPV vaccine Seizure case report OR case series Differential diagnosis excluded pubmed · 431 hits · run 2026-09-09
mirror: HPV vaccine Seizure alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
11 retrieved record(s)
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
A8 · Adjudicated by criteria (Brighton Collaboration)no_data
Measure: Object adjudicated by published criteria Comparator: Published clinical / Brighton criteria Hit rule: Cases adjudicated to 'definite' by a published criterion set
Finding: No retrieved evidence addresses HPV vaccine-related seizures; the only evidence discussing vaccine-related seizures is a general review of pediatric vaccine adverse events (PMID 16871116) that is not specific to HPV vaccine or the defined risk window and adjudication criteria.
Cited: (none)
supporting: HPV vaccine Seizure case report OR case series Adjudicated by criteria pubmed · 43 hits · run 2026-09-09
mirror: HPV vaccine Seizure alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
11 retrieved record(s)
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
Measure: Course matches the object's natural history Comparator: Known natural history of the object Hit rule: Clinical course (onset, peak, recovery) matches the object's natural history
Finding: The retrieved evidence does not address HPV vaccine-related seizures or any seizure-related adverse events. The only study mentioning seizures after vaccination is a general review of vaccine-related adverse events in children (PMID 16871116), but it does not specifically discuss HPV vaccine or seizure natural history.
Cited: (none)
supporting: HPV vaccine Seizure case report OR case series Natural-history consistency pubmed · 107 hits · run 2026-09-09
mirror: HPV vaccine Seizure alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
11 retrieved record(s)
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
ambiguous 32809680 · (2026) — Rubella Vaccine.
does_not_resolve 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A10 · No confounding objectno_data
Measure: Not attributable to a co-occurring condition Comparator: Co-occurring illness that could produce the object Hit rule: Object not better explained by a co-occurring condition (infection, etc.)
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure case report OR case series No confounding object pubmed · 23 hits · run 2026-09-09
mirror: HPV vaccine Seizure alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
12 retrieved record(s)
does_not_resolve 34312836 · Clinical pharmacology and therapeutics (2022) — Angiotensin-Converting Enzyme Inhibitors Used Concomitantly with Insulin Secretagogues and the Risk of Serious Hypoglycemia.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
ambiguous 32809680 · (2026) — Rubella Vaccine.
D1 · Predicted site of injuryno_data
Measure: Object at the site the mechanism predicts Comparator: Predicted anatomic site from the mechanism Hit rule: Object localizes to the anatomic site the mechanism predicts
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure anatomic localization Predicted site of injury mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
mirror: HPV vaccine Seizure Predicted site of injury not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
D2 · Spared structuresno_data
Measure: Structures the mechanism should spare are spared Comparator: Structures predicted unaffected Hit rule: Structures predicted spared by the mechanism are indeed spared
mirror: HPV vaccine Seizure Spared structures not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
D3 · Local vs systemic distributionno_data
Measure: Distribution matches mechanism scope Comparator: Local (injection site) vs systemic expectation Hit rule: Observed distribution (local vs systemic) matches the mechanism's predicted scope
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure anatomic localization Local vs systemic distribution mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
mirror: HPV vaccine Seizure Local vs systemic distribution not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
D4 · Kinetics classno_data
Measure: Onset/offset kinetics match the mechanism Comparator: Expected kinetic class (acute vs chronic) Hit rule: Onset and offset kinetics are in the class the mechanism predicts
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure anatomic localization Kinetics class mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
mirror: HPV vaccine Seizure Kinetics class not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
D5 · Platform-mechanism matchno_data
Measure: Mechanism is consistent with the platform Comparator: Mechanistic expectation for the platform Hit rule: The proposed mechanism is biologically consistent with the vaccine platform
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure anatomic localization Platform-mechanism match mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
mirror: HPV vaccine Seizure Platform-mechanism match not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
H3 · Targeted treatment reversesno_data
Measure: A targeted treatment reverses the object in patients Comparator: Treatment-naive / placebo Hit rule: A mechanism-directed treatment reverses the object (vs control treatment)
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Targeted treatment reverses intervention OR treatment OR reversal pubmed · 15146614 hits · run 2026-09-09
Measure: No node's finding contradicts another Comparator: Internal consistency across nodes Hit rule: No evaluated node directly contradicts another (coherence)
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure No internal contradiction coherence OR latency OR susceptibility pubmed · 870416 hits · run 2026-09-09
mirror: HPV vaccine Seizure No internal contradiction inconsistent OR contradicts pubmed · 27618 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 8550283 · International journal of epidemiology (1995) — Minimum attack rate for measuring measles vaccine efficacy.
does_not_resolve 15578364 · Clinical infectious diseases : an offici (2004) — Varicella vaccine for susceptible adults: do it today.
I2 · Analogy to a known objectno_data
Measure: Object analogous to a well-established analog Comparator: Established analog's profile Hit rule: The object's profile matches a well-established analog on key features
Finding: No evidence found. The retrieved PMID 2699706 discusses melanoma etiology and risk factors, with no mention of HPV vaccine, seizure, or any vaccine adverse event.
Cited: (none)
supporting: HPV vaccine Seizure Analogy to a known object coherence OR latency OR susceptibility pubmed · 870416 hits · run 2026-09-09
mirror: HPV vaccine Seizure Analogy to a known object inconsistent OR contradicts pubmed · 27618 hits · run 2026-09-09
1 retrieved record(s)
does_not_resolve 2699706 · Annali italiani di chirurgia (1989) — Etiology and risk factors of melanoma.
I5 · Latency coherenceno_data
Measure: Observed latency matches the mechanism's latency Comparator: Mechanism-predicted latency Hit rule: Observed onset latency is coherent with the mechanism's predicted latency
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Latency coherence coherence OR latency OR susceptibility pubmed · 870416 hits · run 2026-09-09
mirror: HPV vaccine Seizure Latency coherence inconsistent OR contradicts pubmed · 27618 hits · run 2026-09-09
1 retrieved record(s)
does_not_resolve 15578364 · Clinical infectious diseases : an offici (2004) — Varicella vaccine for susceptible adults: do it today.
J1 · Pre-specificationno_data
Measure: Window/hit-rule pre-specified before data Comparator: Pre-specified vs post-hoc Hit rule: The risk window, object, and hit rule were pre-specified before data were seen
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Pre-specification pre-specified OR adjudicated pubmed · 13562 hits · run 2026-09-09
mirror: HPV vaccine Seizure Pre-specification post-hoc OR hypothesis-generating only pubmed · 1719 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
Measure: Contrary evidence is logged, not omitted Comparator: Support-only dossier Hit rule: Contrary / null / refuting findings are logged and shown alongside support
Finding: The retrieved evidence does not address HPV vaccine-associated seizure; PMID 39226489 focuses on immune-related adverse events from immune checkpoint inhibitors using large language models, and PMID 36088907 discusses drug-induced acute kidney injury risk prediction models.
Cited: (none)
supporting: HPV vaccine Seizure Contrary-evidence log pre-specified OR adjudicated pubmed · 13562 hits · run 2026-09-09
mirror: HPV vaccine Seizure Contrary-evidence log post-hoc OR hypothesis-generating only pubmed · 1719 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
Measure: Claim not based on temporality alone Comparator: Sequence-only evidence Hit rule: The claim is not supported by temporal sequence alone (independent evidence exists)
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure No temporality-only claim pre-specified OR adjudicated pubmed · 13562 hits · run 2026-09-09
mirror: HPV vaccine Seizure No temporality-only claim post-hoc OR hypothesis-generating only pubmed · 1719 hits · run 2026-09-09
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
J4 · Passive-surveillance roleno_data
Measure: Passive-surveillance findings bounded correctly Comparator: Active-surveillance confirmation Hit rule: Passive-surveillance signals are framed as hypothesis-generating, not confirmatory
Finding: The retrieved evidence discusses LLM and ICD code comparisons for identifying immune-related adverse events from immune checkpoint inhibitors, and clinical adjudication of drug-induced acute kidney injury; neither addresses passive-surveillance signals for seizure following HPV vaccination.
Cited: (none)
supporting: HPV vaccine Seizure Passive-surveillance role pre-specified OR adjudicated pubmed · 13562 hits · run 2026-09-09
mirror: HPV vaccine Seizure Passive-surveillance role post-hoc OR hypothesis-generating only pubmed · 1719 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
Measure: Dose/lot exposure mapped to the object Comparator: Unmapped exposure Hit rule: Dose / lot exposure is mapped to the object where the mechanism predicts it
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Dose mapping pre-specified OR adjudicated pubmed · 13562 hits · run 2026-09-09
mirror: HPV vaccine Seizure Dose mapping post-hoc OR hypothesis-generating only pubmed · 1719 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
Measure: RR/IRR vs unexposed or prior window Comparator: Unvaccinated person-time or pre-vaccination window Hit rule: RR/IRR > 1 with CI excluding 1 after pre-specified confounders
Finding: A self-controlled case series study evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines assessed seizure as an adverse event, but no specific results for the HPV vaccine and seizure association were reported. No retrieved evidence examines the HPV vaccine and seizure endpoint.
Cited: (none)
supporting: HPV vaccine Seizure Excess vs baseline incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: HPV vaccine Seizure no association OR null OR no increased risk Excess vs baseline pubmed · 88511 hits · run 2026-09-09
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
refutes_node 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
ambiguous 34049735 · Vaccine (2021) — Safety of vaccines used for routine immunization in the United States: An updated systematic review and meta-analysis.
does_not_resolve 34672967 · Lancet (London, England) (2021) — Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, pha
does_not_resolve 34489307 · Gut (2022) — Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: results from a nationwide histology cohort.
B2 · SCCSno_data
Measure: Self-controlled case series risk ratio Comparator: Individuals' own risk intervals (no-event) Hit rule: SCCS risk ratio > 1 in the post-vaccination window, CI excluding 1
Finding: No retrieved evidence directly reports on the association between HPV vaccine and seizure using a self-controlled case series (SCCS) design.
Cited: (none)
supporting: HPV vaccine Seizure SCCS incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: HPV vaccine Seizure no association OR null OR no increased risk SCCS pubmed · 88621 hits · run 2026-09-09
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
ambiguous 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 24700656 · Clinical infectious diseases : an offici (2014) — Risk of stroke following herpes zoster: a self-controlled case-series study.
refutes_node 34049735 · Vaccine (2021) — Safety of vaccines used for routine immunization in the United States: An updated systematic review and meta-analysis.
does_not_resolve 39795956 · International journal of molecular scien (2024) — The Potential Metalloestrogenic Effect of Aluminum on Breast Cancer Risk for Antiperspirant Users.
B3 · Cohort / risk-intervalno_data
Measure: Incidence rate ratio in defined window Comparator: Pre-specified risk vs comparison interval Hit rule: IRR > 1 in the pre-specified window, CI excluding 1, stratified by age/sex
Finding: No retrieved study directly examines the IRR for seizure after HPV vaccine using a pre-specified risk window stratified by age/sex with a CI excluding 1. One SCCS study (PMID 40664645) evaluated seizure after XBB.1.5 COVID-19 mRNA vaccines but not HPV vaccine.
Cited: (none)
supporting: HPV vaccine Seizure Cohort / risk-interval incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: HPV vaccine Seizure no association OR null OR no increased risk Cohort / risk-interval pubmed · 88120 hits · run 2026-09-09
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
ambiguous 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
ambiguous 34049735 · Vaccine (2021) — Safety of vaccines used for routine immunization in the United States: An updated systematic review and meta-analysis.
refutes_node 28162825 · Vaccine (2017) — Safety of quadrivalent live attenuated influenza vaccine in subjects aged 2-49years.
refutes_node 20643726 · Pediatrics (2010) — Lack of association between acellular pertussis vaccine and seizures in early childhood.
B4 · Meta-analysis / poolingno_data
Measure: Pooled effect across studies Comparator: Pooled estimate with heterogeneity Hit rule: Pooled estimate > 1 (or < 1) with quantified heterogeneity (I2)
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Meta-analysis / pooling incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: HPV vaccine Seizure no association OR null OR no increased risk Meta-analysis / pooling pubmed · 111978 hits · run 2026-09-09
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
refutes_node 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 24700656 · Clinical infectious diseases : an offici (2014) — Risk of stroke following herpes zoster: a self-controlled case-series study.
does_not_resolve 29402646 · Journal of the American Medical Director (2018) — Fall-Risk-Increasing Drugs: A Systematic Review and Meta-analysis: III. Others.
does_not_resolve 28230042 · Journal of cancer research and therapeut (2016) — Meta-analysis of association between mobile phone use and glioma risk.
B5 · Negative-control outcomesno_data
Measure: No excess for outcomes the vaccine should not cause Comparator: Negative-control outcomes (unaffected by mechanism) Hit rule: Null for negative-control outcomes while target outcome is positive (specificity)
Finding: No retrieved evidence addresses HPV vaccine and seizure. The retrieved studies focus on shingles, zoster, rotavirus, COVID-19 mRNA vaccines, and valproate, with only one study mentioning seizure as an adverse event after XBB.1.5-containing COVID-19 mRNA vaccines, not HPV vaccine.
Cited: (none)
supporting: HPV vaccine Seizure Negative-control outcomes incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: HPV vaccine Seizure no association OR null OR no increased risk Negative-control outcomes pubmed · 88322 hits · run 2026-09-09
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
ambiguous 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 24700656 · Clinical infectious diseases : an offici (2014) — Risk of stroke following herpes zoster: a self-controlled case-series study.
does_not_resolve 34049735 · Vaccine (2021) — Safety of vaccines used for routine immunization in the United States: An updated systematic review and meta-analysis.
does_not_resolve 38833248 · JAMA network open (2024) — Valproate Use During Spermatogenesis and Risk to Offspring.
B6 · Other-antigen comparisonno_data
Measure: Risk vs a different-antigen comparator Comparator: Comparator product with a different antigen Hit rule: Risk specific to the target antigen, not shared with the comparator antigen
Finding: The retrieved evidence does not contain any study specifically comparing the risk of seizure after HPV vaccination versus a different-antigen comparator; the studies address other vaccines (e.g., zoster, rotavirus, COVID-19) or unrelated outcomes (e.g., shingles, stroke, cancer genetics).
Cited: (none)
supporting: HPV vaccine Seizure Other-antigen comparison incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: HPV vaccine Seizure no association OR null OR no increased risk Other-antigen comparison pubmed · 88084 hits · run 2026-09-09
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
refutes_node 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 24700656 · Clinical infectious diseases : an offici (2014) — Risk of stroke following herpes zoster: a self-controlled case-series study.
refutes_node 34049735 · Vaccine (2021) — Safety of vaccines used for routine immunization in the United States: An updated systematic review and meta-analysis.
does_not_resolve 23949879 · Tumour biology : the journal of the Inte (2014) — Meta-analysis of the association between GSTT1 null genotype and risk of nasopharyngeal carcinoma in Chinese.
B7 · Absolute riskno_data
Measure: Per-100k risk in window Comparator: Absolute incidence per 100k Hit rule: Absolute risk reported and stable across the window (not an artifact of rarity)
Finding: No retrieved evidence directly reports absolute risk per 100,000 of seizure following HPV vaccination. The only retrieved study that mentions seizure as an outcome evaluates XBB.1.5-containing COVID-19 mRNA vaccines (PMID 40664645 2025), not HPV vaccine.
Cited: (none)
supporting: HPV vaccine Seizure Absolute risk incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: HPV vaccine Seizure no association OR null OR no increased risk Absolute risk pubmed · 111378 hits · run 2026-09-09
ambiguous 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
refutes_node 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 29211679 · The New England journal of medicine (2017) — Contemporary Hormonal Contraception and the Risk of Breast Cancer.
does_not_resolve 26950145 · Nutrients (2016) — An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity.
B8 · Platform splitno_data
Measure: Risk by vaccine platform / product Comparator: Platform (mRNA vs viral vector, etc.) Hit rule: Risk attributable to a specific platform, not to 'a vaccine' generally
Finding: No retrieved evidence specifically addresses the attributable risk of seizures following HPV vaccination by vaccine platform or product. The retrieved studies focus on other vaccines (shingles, rotavirus, COVID-19 mRNA, routine immunization) and do not provide data on HPV vaccine platform-specific seizure risk.
Cited: (none)
supporting: HPV vaccine Seizure Platform split incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: HPV vaccine Seizure no association OR null OR no increased risk Platform split pubmed · 88149 hits · run 2026-09-09
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
ambiguous 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 34049735 · Vaccine (2021) — Safety of vaccines used for routine immunization in the United States: An updated systematic review and meta-analysis.
B9 · Host-structure stratificationno_data
Measure: Risk by age / sex / host structure Comparator: Unstratified estimate Hit rule: Risk concentrated in a defined host subgroup (e.g. young males), stable across sources
Finding: The retrieved evidence does not address HPV vaccine and seizure risk in any host subgroup; all studies cited concern other vaccines (Shingrix, zoster live, rotavirus, COVID-19 mRNA, zoster-stroke) or are general methodological/systematic reviews. No study in the retrieved list examines HPV vaccine or seizure as an adverse event in the context of age, sex, or host structure stratification.
Cited: (none)
supporting: HPV vaccine Seizure Host-structure stratification incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: HPV vaccine Seizure no association OR null OR no increased risk Host-structure stratification pubmed · 88082 hits · run 2026-09-09
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
refutes_node 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 24700656 · Clinical infectious diseases : an offici (2014) — Risk of stroke following herpes zoster: a self-controlled case-series study.
refutes_node 34049735 · Vaccine (2021) — Safety of vaccines used for routine immunization in the United States: An updated systematic review and meta-analysis.
B10 · Formulation / component changeno_data
Measure: Risk tracks a formulation change Comparator: Pre- vs post-change formulation Hit rule: Risk change tracks a documented formulation / component change over time
Finding: No retrieved evidence addresses HPV vaccine, seizure, or formulation/component changes over time; all cited studies focus on shingles, rotavirus, COVID-19 mRNA, or zoster vaccines, with no mention of HPV vaccine formulation changes or seizure risk tracking such changes.
Cited: (none)
supporting: HPV vaccine Seizure Formulation / component change incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: HPV vaccine Seizure no association OR null OR no increased risk Formulation / component change pubmed · 88244 hits · run 2026-09-09
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 24700656 · Clinical infectious diseases : an offici (2014) — Risk of stroke following herpes zoster: a self-controlled case-series study.
refutes_node 34049735 · Vaccine (2021) — Safety of vaccines used for routine immunization in the United States: An updated systematic review and meta-analysis.
does_not_resolve 41092926 · Lancet (London, England) (2025) — Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 su
H2 · Formulation natural experimentno_data
Measure: Risk shifts with a formulation change in the field Comparator: Pre- vs post-change formulation Hit rule: Observed risk tracks a real-world formulation change (natural experiment)
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Formulation natural experiment intervention OR treatment OR reversal pubmed · 15146614 hits · run 2026-09-09
Measure: Risk signal appears/disappears across a pause or policy change Comparator: Pre- vs post-pause period Hit rule: The signal appears or disappears coherently with a rollout / pause (H4)
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Policy / pause signal intervention OR treatment OR reversal pubmed · 15146614 hits · run 2026-09-09
mirror: HPV vaccine Seizure Policy / pause signal no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-09
I3 · Infection coherenceno_data
Measure: Pattern is coherent with or distinct from infection Comparator: Infection-matched comparison Hit rule: The post-vaccine pattern is coherent with (or clearly distinct from) the infection pattern
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Infection coherence coherence OR latency OR susceptibility pubmed · 870416 hits · run 2026-09-09
mirror: HPV vaccine Seizure Infection coherence inconsistent OR contradicts pubmed · 27618 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 8550283 · International journal of epidemiology (1995) — Minimum attack rate for measuring measles vaccine efficacy.
ambiguous 15578364 · Clinical infectious diseases : an offici (2004) — Varicella vaccine for susceptible adults: do it today.
Mediator & biological gradient 24/24 evaluated
C1n · Dose strength gradientno_data
Measure: Risk vs dose strength (dose size) Comparator: Lower dose strength Hit rule: Monotonic dose-response in dose strength (larger dose -> higher risk)
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Dose strength gradient dose-response OR dose effect pubmed · 1299586 hits · run 2026-09-09
mirror: HPV vaccine Seizure no dose effect OR no dose-response Dose strength gradient pubmed · 114 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
ambiguous 37344264 · Vaccine (2023) — Safety of simultaneous vaccination with COVID-19 vaccines in the Vaccine Safety Datalink.
C2n · Dose number gradientno_data
Measure: Risk vs dose number (1st vs 2nd vs 3rd) Comparator: First dose Hit rule: Risk increases (or shows a defined pattern) with dose number
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Dose number gradient dose-response OR dose effect pubmed · 1299586 hits · run 2026-09-09
mirror: HPV vaccine Seizure no dose effect OR no dose-response Dose number gradient pubmed · 559 hits · run 2026-09-09
3 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 30316563 · Radiotherapy and oncology : journal of t (2019) — Volume effects of radiotherapy on the risk of second primary cancers: A systematic review of clinical and epidemiological studies.
does_not_resolve 42106826 · The international journal of behavioral (2026) — Physical activity, falls, and dementia risk in adults aged ≥ 60: evidence from three cohorts.
C3n · Measured-exposure tertilesno_data
Measure: Risk vs measured exposure tertile Comparator: Lowest-exposure tertile Hit rule: Risk ordered by measured-exposure tertile (high > mid > low)
Finding: The retrieved evidence does not address the HPV vaccine-seizure pair or the relationship between seizure risk and measured-exposure tertiles. PMID 31740498 mentions near real-time surveillance for 9vHPV vaccine safety but its abstract does not report seizure outcomes or exposure tertile analyses.
Cited: (none)
supporting: HPV vaccine Seizure Measured-exposure tertiles dose-response OR dose effect pubmed · 1299586 hits · run 2026-09-09
mirror: HPV vaccine Seizure no dose effect OR no dose-response Measured-exposure tertiles pubmed · 3 hits · run 2026-09-09
3 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
ambiguous 37344264 · Vaccine (2023) — Safety of simultaneous vaccination with COVID-19 vaccines in the Vaccine Safety Datalink.
refutes_node 31740498 · Pediatrics (2019) — Near Real-Time Surveillance to Assess the Safety of the 9-Valent Human Papillomavirus Vaccine.
C4n · Organoid concentration curveno_data
Measure: Effect vs antigen concentration in organoid Comparator: Vehicle / zero antigen Hit rule: Dose-dependent effect across a graded concentration curve
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Organoid concentration curve dose-response OR dose effect pubmed · 1299586 hits · run 2026-09-09
mirror: HPV vaccine Seizure no dose effect OR no dose-response Organoid concentration curve pubmed · 14 hits · run 2026-09-09
3 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
ambiguous 37344264 · Vaccine (2023) — Safety of simultaneous vaccination with COVID-19 vaccines in the Vaccine Safety Datalink.
refutes_node 31740498 · Pediatrics (2019) — Near Real-Time Surveillance to Assess the Safety of the 9-Valent Human Papillomavirus Vaccine.
C5n · EC50 vs Cmax coherenceno_data
Measure: Measured exposure reaches effect threshold Comparator: Pharmacokinetic Cmax vs EC50 Hit rule: Achieved exposure (Cmax/tissue) plausibly reaches the in-vitro EC50
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure EC50 vs Cmax coherence dose-response OR dose effect pubmed · 1299586 hits · run 2026-09-09
mirror: HPV vaccine Seizure no dose effect OR no dose-response EC50 vs Cmax coherence pubmed · 3 hits · run 2026-09-09
3 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
refutes_node 31740498 · Pediatrics (2019) — Near Real-Time Surveillance to Assess the Safety of the 9-Valent Human Papillomavirus Vaccine.
ambiguous 37344264 · Vaccine (2023) — Safety of simultaneous vaccination with COVID-19 vaccines in the Vaccine Safety Datalink.
E1 · Mediator identified in casesno_data
Measure: Mediator present in affected tissue/cells Comparator: Unaffected tissue / control Hit rule: The hypothesized mediator is detected in the affected compartment and not (or less) in control
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure mechanism Mediator identified in cases in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: HPV vaccine Seizure Mediator identified in cases not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
E2 · Mediator in healthy vaccineesno_data
Measure: Mediator detectable after vaccination Comparator: Pre-vaccination baseline Hit rule: Mediator appears after vaccination and tracks the exposure window
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure mechanism Mediator in healthy vaccinees in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: HPV vaccine Seizure Mediator in healthy vaccinees not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
E3 · Infection contrastno_data
Measure: Mediator absent/low after natural infection Comparator: Recovered natural infection Hit rule: Mediator signal is specific to vaccination vs a comparable natural-infection control
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure mechanism Infection contrast in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: HPV vaccine Seizure Infection contrast not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
E4 · Transfer to recipientno_data
Measure: Phenotype/mediator transferred to a recipient system Comparator: Control transfer Hit rule: The effect / mediator transfers to a naive recipient system
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure mechanism Transfer to recipient in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: HPV vaccine Seizure Transfer to recipient not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
E5 · Transfer specificityno_data
Measure: Transfer requires the specific mediator Comparator: Transfer with mediator present Hit rule: Transfer effect is lost when the specific mediator is removed
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure mechanism Transfer specificity in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: HPV vaccine Seizure Transfer specificity not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
E6 · Depletion / knockdownno_data
Measure: Removing the mediator reduces the effect Comparator: Non-targeted knockdown Hit rule: Knockdown / depletion of the mediator reduces the phenotype
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure mechanism Depletion / knockdown in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
Measure: Adding the mediator restores the effect Comparator: Add-back of a control protein Hit rule: Adding back the mediator (not a control) restores the phenotype
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure mechanism Add-back rescue in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: HPV vaccine Seizure Add-back rescue not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
E8 · Neutralizationno_data
Measure: Neutralizing the mediator blocks the effect Comparator: Isotype control Hit rule: Neutralization of the mediator (not an isotype control) blocks the phenotype
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure mechanism Neutralization in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: HPV vaccine Seizure Neutralization not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
E9 · Isotype controlno_data
Measure: Isotype control does not reproduce the effect Comparator: Active antibody Hit rule: An isotype control fails to reproduce the block/activation
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure mechanism Isotype control in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: HPV vaccine Seizure Isotype control not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
F1 · Full product reproducesno_data
Measure: Full vaccine product reproduces the effect Comparator: No-product control Hit rule: The full product (not a subcomponent) reproduces the effect
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Full product reproduces component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
mirror: HPV vaccine Seizure Full product reproduces no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-09
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F2 · Empty vector / particleno_data
Measure: Vector/particle without antigen reproduces (or not) Comparator: Full product Hit rule: Effect attributed to (or excluded from) the vector/particle backbone alone
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Empty vector / particle component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
does_not_resolve 15174971 · Expert opinion on biological therapy (2004) — Particle-mediated DNA vaccine delivery to the skin.
does_not_resolve 29550258 · Immunology letters (2018) — Live bacterial vaccine vector and delivery strategies of heterologous antigen: A review.
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 25142448 · Current gene therapy (2014) — Improving DNA vaccine performance through vector design.
does_not_resolve 27384578 · Viruses (2016) — Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines.
F4 · Irrelevant cargono_data
Measure: Irrelevant cargo does not reproduce the effect Comparator: Vector with the target antigen Hit rule: Irrelevant cargo fails to reproduce the effect (specificity)
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Irrelevant cargo component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
does_not_resolve 15174971 · Expert opinion on biological therapy (2004) — Particle-mediated DNA vaccine delivery to the skin.
does_not_resolve 29550258 · Immunology letters (2018) — Live bacterial vaccine vector and delivery strategies of heterologous antigen: A review.
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 25142448 · Current gene therapy (2014) — Improving DNA vaccine performance through vector design.
does_not_resolve 27384578 · Viruses (2016) — Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines.
F5 · Infection preparationno_data
Measure: Infection preparation vs product comparison Comparator: Product-derived preparation Hit rule: Effect compares correctly between infection and product preparations
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Infection preparation component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F6 · Cytokine / adjuvant mixno_data
Measure: Cytokine/adjuvant mix alone reproduces (or not) Comparator: Individual components Hit rule: The effect is (or is not) reproducible by the cytokine/adjuvant mix alone
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Cytokine / adjuvant mix component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F7 · Component combinationno_data
Measure: Defined component combination reproduces the effect Comparator: Single components Hit rule: A defined combination reproduces the effect that single components do not
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Component combination component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
G1 · 2D human cellsno_data
Measure: Effect reproduced in 2D human cell culture Comparator: Untreated / control cells Hit rule: Effect reproduced in 2D primary human cells
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure 2D human cells animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: HPV vaccine Seizure 2D human cells not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G2 · Organoid / chipno_data
Measure: Effect reproduced in organoid / organ-on-chip Comparator: Unexposed organoid Hit rule: Effect reproduced in a 3D organoid / organ-on-chip system
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Organoid / chip animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: HPV vaccine Seizure Organoid / chip not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
H1 · Block in vitro / in vivono_data
Measure: Blocking the mediator/mechanism prevents the effect Comparator: Control intervention Hit rule: Blocking the mechanism prevents or reverses the effect (not with a control intervention)
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Block in vitro / in vivo intervention OR treatment OR reversal pubmed · 15146614 hits · run 2026-09-09
mirror: HPV vaccine Seizure Block in vitro / in vivo no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-09
1 retrieved record(s)
does_not_resolve 26937198 · Vascular health and risk management (2016) — Reversing anticoagulant effects of novel oral anticoagulants: role of ciraparantag, andexanet alfa, and idarucizumab.
Clinical / animal / host 7/7 evaluated
E10 · Host-line dependenceno_data
Measure: Effect depends on host line/cell type Comparator: Susceptible host line Hit rule: Effect is restricted to a defined host line / genotype, not universal
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure mechanism Host-line dependence in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: HPV vaccine Seizure Host-line dependence not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G3 · Animal, clinical routeno_data
Measure: Effect in animal via the clinical route of administration Comparator: Vehicle, same route Hit rule: Effect reproduced in an animal using the clinical route of administration
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Animal, clinical route animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: HPV vaccine Seizure Animal, clinical route not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G4 · Susceptible animalno_data
Measure: Effect in a susceptible animal model Comparator: Non-susceptible model Hit rule: Effect in a defined susceptible animal model
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Susceptible animal animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: HPV vaccine Seizure Susceptible animal not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G5 · Replication across labsno_data
Measure: Effect replicated in an independent lab Comparator: Original result Hit rule: The key effect is replicated in an independent laboratory
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Replication across labs animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: HPV vaccine Seizure Replication across labs not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G6 · Blinded scoringno_data
Measure: Outcomes scored blinded Comparator: Unblinded reference Hit rule: Primary outcomes scored by a blinded assessor
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Blinded scoring animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: HPV vaccine Seizure Blinded scoring not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G7 · Experimental time courseno_data
Measure: Effect follows a defined experimental time course Comparator: No-exposure time course Hit rule: The effect's onset/offset follows a defined experimental time course
Finding: no evidence found
Cited: (none)
supporting: HPV vaccine Seizure Experimental time course animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: HPV vaccine Seizure Experimental time course not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
I4 · Susceptibility traitno_data
Measure: A host trait / marker defines susceptibility Comparator: Trait-negative hosts Hit rule: A defined host trait / marker enriches for susceptibility
Finding: No retrieved evidence addresses a host trait or marker that enriches for susceptibility to seizure after HPV vaccination.
Cited: (none)
supporting: HPV vaccine Seizure Susceptibility trait coherence OR latency OR susceptibility pubmed · 870416 hits · run 2026-09-09
mirror: HPV vaccine Seizure Susceptibility trait inconsistent OR contradicts pubmed · 27618 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 8550283 · International journal of epidemiology (1995) — Minimum attack rate for measuring measles vaccine efficacy.
does_not_resolve 2699706 · Annali italiani di chirurgia (1989) — Etiology and risk factors of melanoma.
How this was built
Per node: a supporting and a mirror PubMed query built from the node's measure / population / comparator / hit_rule; top hits fetched (title + abstract); each record classified (supports / refutes / ambiguous) by xAI with a heuristic fallback; a per-node synthesis is generated strictly from the retrieved PMIDs; the node status is then rolled up to C1–C6. Full query provenance is shown per node above. Reproduce the build: python -m evidence_run. Data: data/evidence_run/state.json.