Evidence dossier · candidate cand-influenza-anaphylaxis · VICP program · · DRAFT — not a determination
This is a draft research-tracking dossier, not a determination that Influenza (flu) vaccine causes Anaphylaxis, and not an incidence or legal finding. All evidence is flagged needs_human_review and must be reviewed before any page is published or cited. Every value is grounded in retrieved citations (PMID + retrieval date); unsourced items read "no evidence found / not assessable". Symmetric search: every supporting query has a mirror/null query, and zeros are shown (negative dossiers report the absence of signal).
Claim matrix (C1–C6, computed)
Claim
Label
Status
Missing nodes
C1
Coherent clinical object exists
insufficient_data
missing: A1 A2
C2
Consistent temporal window
supported
C3
Epidemiologic excess risk
insufficient_data
missing: B1 B2 B3
C4
Consistency / replication
contested
C5
Specificity (product / dose)
insufficient_data
missing: C1n C2n
C6
Biological mechanism
insufficient_data
missing: E1
Two evidentiary bars apply to the epi nodes/claims (C3, C4): · VICP — preponderance of the evidence. · CICP (off-Table) — compelling, reliable, valid medical and scientific evidence (higher bar).
Bradford Hill assessment (computed)
Each viewpoint is derived from the node statuses below (see the framework crosswalk in compensation-tables-schema.md §8). Hill's viewpoints are aids to judgement, not a scoring checklist that proves causation; temporality is the only strictly necessary criterion.
Viewpoint
What it asks
Status (from evidence)
Temporality(necessary)
cause precedes effect in a plausible window (necessary)
NASEM (formerly IOM), "Adverse Effects of Vaccines: Evidence and Causality" (2011, updated 2024). Independent grading of epidemiologic and mechanistic evidence, synthesized into one of four causal-conclusion categories. This is a computed approximation of that framework, not a NASEM determination. See compensation-tables-schema.md §8bis.
Case-definition standard: Brighton Collaboration (named in spec §1: anaphylaxis) — governs the case-certainty scale on A1/A2/A6/A8 below. See compensation-tables-schema.md §8ter.
Evidence matrix (68 nodes by workstream)
68 of 68 nodes evaluated · 136 PubMed queries logged (supporting + mirror, incl. zeros). Statuses are computed from retrieved citations; not hand-set.
Definition & attribution 24/24 evaluated
A1 · Case reportsno_data
Measure: New definite object in risk window T Comparator: Pre-vaccination baseline Hit rule: Definite object present, onset in window, competing causes considered
Finding: No retrieved evidence specifically reports cases of anaphylaxis following influenza vaccination. The retrieved articles focus on adverse events after COVID-19, HPV, or monkeypox vaccines, or general vaccine safety reviews that do not address influenza vaccine-related anaphylaxis.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") case report OR case series Case reports pubmed · 66173 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-07
9 retrieved record(s)
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 40046048 · Frontiers in immunology (2025) — The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis.
does_not_resolve 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A2 · Series with objective confirmationno_data
Measure: Definite object plus objective test Comparator: Reference range / diagnostic criteria Hit rule: Objective confirmation in >=1 case per the working definition
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") case report OR case series Series with objective confirmation pubmed · 5645 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 34935404 · AJR. American journal of roentgenology (2022) — COVID-19 Vaccine-Related Axillary Adenopathy on Breast Imaging: Follow-Up Recommendations and Histopathologic Findings.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
ambiguous 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A3 · Onset histogrammixed
Measure: Distribution of onset times after dose Comparator: Pre-specified risk window Hit rule: Onset clusters inside the pre-specified window (not uniform/flat)
Finding: Two case reports describe delayed anaphylaxis to the influenza vaccine (PMID 26357001), and a safety database analysis of H1N1 pandemic influenza vaccines found no evidence of an increased rate of anaphylaxis compared to other vaccines, though challenges in case identification were noted (PMID 21527305).
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") case report OR case series Onset histogram pubmed · 4 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-07
11 retrieved record(s)
supports_node 26357001 · European annals of allergy and clinical (2015) — Delayed Anaphylaxis to the flu vaccine unrelated to known non-viral components.
supports_node 21527305 · Vaccine (2011) — Anaphylaxis following H1N1 pandemic vaccines: safety data in perspective.
does_not_resolve 34935404 · AJR. American journal of roentgenology (2022) — COVID-19 Vaccine-Related Axillary Adenopathy on Breast Imaging: Follow-Up Recommendations and Histopathologic Findings.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
A4 · Temporal plausibilityno_data
Measure: Onset latency vs object pathophysiology Comparator: Object's known natural latency Hit rule: Onset latency consistent with the object's pathophysiology
Finding: No retrieved evidence addresses anaphylaxis following influenza vaccination, nor provides onset latency data for anaphylaxis after any vaccine.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") case report OR case series Temporal plausibility pubmed · 33 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-07
10 retrieved record(s)
does_not_resolve 15638050 · Clinical and experimental rheumatology (2004) — A case-series of adverse events, positive re-challenge of symptoms, and events in identical twins following hepatitis B vaccination: analysis of the Vaccine Adv
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
ambiguous 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 40046048 · Frontiers in immunology (2025) — The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis.
A5 · Onset-interval documentationno_data
Measure: Onset interval documented in source Comparator: Dose date Hit rule: Onset interval is recorded (not imputed) in a primary source
Finding: The retrieved evidence includes two cases of delayed anaphylaxis to the flu vaccine in PMID 26357001, but does not document the onset interval for those cases in a structured or systematic manner, and the other relevant PMID 21527305 focuses on H1N1 pandemic vaccines without providing onset interval documentation for individual cases.
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") case report OR case series Onset-interval documentation pubmed · 2 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-07
11 retrieved record(s)
supports_node 26357001 · European annals of allergy and clinical (2015) — Delayed Anaphylaxis to the flu vaccine unrelated to known non-viral components.
ambiguous 21527305 · Vaccine (2011) — Anaphylaxis following H1N1 pandemic vaccines: safety data in perspective.
does_not_resolve 34935404 · AJR. American journal of roentgenology (2022) — COVID-19 Vaccine-Related Axillary Adenopathy on Breast Imaging: Follow-Up Recommendations and Histopathologic Findings.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
A6 · Differential diagnosis excludedno_data
Measure: Competing causes assessed and excluded Comparator: Likely alternative diagnoses Hit rule: Pre-specified competing causes ruled out per the working definition
Finding: No retrieved evidence addresses anaphylaxis following influenza vaccination or the exclusion of competing causes for such a diagnosis.
Case-certainty distribution (Brighton Collaboration): 1 Level 3 (possible). Transparency layer — does not change this node's status or feed C1–C6.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") case report OR case series Differential diagnosis excluded pubmed · 429 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-07
9 retrieved record(s)
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
ambiguous 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 40046048 · Frontiers in immunology (2025) — The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
A7 · Rechallenge / re-exposureno_data
Measure: Object recurs on a further dose Comparator: First-dose response Hit rule: Object recurs after a subsequent dose (re-exposure)
Finding: Two case reports describe delayed anaphylaxis to influenza vaccine, but neither report involves rechallenge or re-exposure following a subsequent dose.
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") case report OR case series Rechallenge / re-exposure pubmed · 4 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-07
11 retrieved record(s)
supports_node 26357001 · European annals of allergy and clinical (2015) — Delayed Anaphylaxis to the flu vaccine unrelated to known non-viral components.
ambiguous 21527305 · Vaccine (2011) — Anaphylaxis following H1N1 pandemic vaccines: safety data in perspective.
ambiguous 34935404 · AJR. American journal of roentgenology (2022) — COVID-19 Vaccine-Related Axillary Adenopathy on Breast Imaging: Follow-Up Recommendations and Histopathologic Findings.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
A8 · Adjudicated by criteria (Brighton Collaboration)no_data
Measure: Object adjudicated by published criteria Comparator: Published clinical / Brighton criteria Hit rule: Cases adjudicated to 'definite' by a published criterion set
Finding: Two case reports describe delayed anaphylaxis to the influenza (flu) vaccine, but no cases adjudicated to 'definite' by a published criterion set were identified in the retrieved evidence.
Case-certainty distribution (Brighton Collaboration): 2 Level 3 (possible). Transparency layer — does not change this node's status or feed C1–C6.
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") case report OR case series Adjudicated by criteria pubmed · 41 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-07
10 retrieved record(s)
supports_node 26357001 · European annals of allergy and clinical (2015) — Delayed Anaphylaxis to the flu vaccine unrelated to known non-viral components.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 40046048 · Frontiers in immunology (2025) — The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis.
A9 · Natural-history consistencyno_data
Measure: Course matches the object's natural history Comparator: Known natural history of the object Hit rule: Clinical course (onset, peak, recovery) matches the object's natural history
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") case report OR case series Natural-history consistency pubmed · 105 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-07
9 retrieved record(s)
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
ambiguous 40046048 · Frontiers in immunology (2025) — The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
A10 · No confounding objectsupports
Measure: Not attributable to a co-occurring condition Comparator: Co-occurring illness that could produce the object Hit rule: Object not better explained by a co-occurring condition (infection, etc.)
Finding: Two case reports describe delayed anaphylaxis to the influenza vaccine that was unrelated to known non-viral components, with onset after vaccination and after competing causes were assessed.
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") case report OR case series No confounding object pubmed · 21 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-07
11 retrieved record(s)
supports_node 26357001 · European annals of allergy and clinical (2015) — Delayed Anaphylaxis to the flu vaccine unrelated to known non-viral components.
does_not_resolve 34312836 · Clinical pharmacology and therapeutics (2022) — Angiotensin-Converting Enzyme Inhibitors Used Concomitantly with Insulin Secretagogues and the Risk of Serious Hypoglycemia.
does_not_resolve 34935404 · AJR. American journal of roentgenology (2022) — COVID-19 Vaccine-Related Axillary Adenopathy on Breast Imaging: Follow-Up Recommendations and Histopathologic Findings.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
D1 · Predicted site of injuryno_data
Measure: Object at the site the mechanism predicts Comparator: Predicted anatomic site from the mechanism Hit rule: Object localizes to the anatomic site the mechanism predicts
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") anatomic localization Predicted site of injury mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Predicted site of injury not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D2 · Spared structuresno_data
Measure: Structures the mechanism should spare are spared Comparator: Structures predicted unaffected Hit rule: Structures predicted spared by the mechanism are indeed spared
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") anatomic localization Spared structures mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Spared structures not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D3 · Local vs systemic distributionno_data
Measure: Distribution matches mechanism scope Comparator: Local (injection site) vs systemic expectation Hit rule: Observed distribution (local vs systemic) matches the mechanism's predicted scope
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") anatomic localization Local vs systemic distribution mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Local vs systemic distribution not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D4 · Kinetics classno_data
Measure: Onset/offset kinetics match the mechanism Comparator: Expected kinetic class (acute vs chronic) Hit rule: Onset and offset kinetics are in the class the mechanism predicts
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") anatomic localization Kinetics class mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Kinetics class not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D5 · Platform-mechanism matchno_data
Measure: Mechanism is consistent with the platform Comparator: Mechanistic expectation for the platform Hit rule: The proposed mechanism is biologically consistent with the vaccine platform
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") anatomic localization Platform-mechanism match mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Platform-mechanism match not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
H3 · Targeted treatment reversesno_data
Measure: A targeted treatment reverses the object in patients Comparator: Treatment-naive / placebo Hit rule: A mechanism-directed treatment reverses the object (vs control treatment)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Targeted treatment reverses intervention OR treatment OR reversal pubmed · 15142392 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Targeted treatment reverses no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-07
I1 · No internal contradictionno_data
Measure: No node's finding contradicts another Comparator: Internal consistency across nodes Hit rule: No evaluated node directly contradicts another (coherence)
Finding: No evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") No internal contradiction coherence OR latency OR susceptibility pubmed · 870068 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") No internal contradiction inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
2 retrieved record(s)
does_not_resolve 15578364 · Clinical infectious diseases : an offici (2004) — Varicella vaccine for susceptible adults: do it today.
does_not_resolve 19477561 · Vaccine (2009) — Genetic polymorphisms in host response to meningococcal infection: the role of susceptibility and severity genes.
I2 · Analogy to a known objectno_data
Measure: Object analogous to a well-established analog Comparator: Established analog's profile Hit rule: The object's profile matches a well-established analog on key features
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Analogy to a known object coherence OR latency OR susceptibility pubmed · 870068 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Analogy to a known object inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 2699706 · Annali italiani di chirurgia (1989) — Etiology and risk factors of melanoma.
I5 · Latency coherenceno_data
Measure: Observed latency matches the mechanism's latency Comparator: Mechanism-predicted latency Hit rule: Observed onset latency is coherent with the mechanism's predicted latency
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Latency coherence coherence OR latency OR susceptibility pubmed · 870068 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Latency coherence inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 15578364 · Clinical infectious diseases : an offici (2004) — Varicella vaccine for susceptible adults: do it today.
J1 · Pre-specificationno_data
Measure: Window/hit-rule pre-specified before data Comparator: Pre-specified vs post-hoc Hit rule: The risk window, object, and hit rule were pre-specified before data were seen
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Pre-specification pre-specified OR adjudicated pubmed · 13550 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Pre-specification post-hoc OR hypothesis-generating only pubmed · 1700 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
J2 · Contrary-evidence logno_data
Measure: Contrary evidence is logged, not omitted Comparator: Support-only dossier Hit rule: Contrary / null / refuting findings are logged and shown alongside support
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Contrary-evidence log pre-specified OR adjudicated pubmed · 13550 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Contrary-evidence log post-hoc OR hypothesis-generating only pubmed · 1700 hits · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
Measure: Claim not based on temporality alone Comparator: Sequence-only evidence Hit rule: The claim is not supported by temporal sequence alone (independent evidence exists)
Finding: The retrieved evidence does not address the claim of anaphylaxis attributed to influenza vaccine. PMID 39226489 discusses detection of immune-related adverse events from immune checkpoint inhibitors, not vaccines; PMID 41493293 focuses on artificial intelligence adjudication of major adverse cardiovascular events. No evidence supports or refutes the node definition.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") No temporality-only claim pre-specified OR adjudicated pubmed · 13551 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") No temporality-only claim post-hoc OR hypothesis-generating only pubmed · 1700 hits · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
J4 · Passive-surveillance roleno_data
Measure: Passive-surveillance findings bounded correctly Comparator: Active-surveillance confirmation Hit rule: Passive-surveillance signals are framed as hypothesis-generating, not confirmatory
Finding: No evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Passive-surveillance role pre-specified OR adjudicated pubmed · 13550 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Passive-surveillance role post-hoc OR hypothesis-generating only pubmed · 1700 hits · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
Measure: Dose/lot exposure mapped to the object Comparator: Unmapped exposure Hit rule: Dose / lot exposure is mapped to the object where the mechanism predicts it
Finding: No retrieved evidence addresses dose or lot exposure mapping for influenza vaccine-associated anaphylaxis. The two retrieved studies (PMID 39226489, PMID 41493293) focus on artificial intelligence methods for identifying immune-related adverse events from immune checkpoint inhibitors and for adjudicating major adverse cardiovascular events, neither of which involves influenza vaccine, anaphylaxis, or dose/lot exposure mapping.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Dose mapping pre-specified OR adjudicated pubmed · 13550 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Dose mapping post-hoc OR hypothesis-generating only pubmed · 1700 hits · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
Epidemiologic chassis 13/13 evaluated
B1 · Excess vs baselineno_data
Measure: RR/IRR vs unexposed or prior window Comparator: Unvaccinated person-time or pre-vaccination window Hit rule: RR/IRR > 1 with CI excluding 1 after pre-specified confounders
Finding: No retrieved evidence directly addresses the risk of anaphylaxis following influenza vaccination or provides an RR/IRR estimate with a confidence interval excluding 1 for this specific pair.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Excess vs baseline incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") no association OR null OR no increased risk Excess vs baseline pubmed · 88495 hits · run 2026-09-07
5 retrieved record(s)
does_not_resolve 30851046 · Biostatistics (Oxford, England) (2020) — ConvSCCS: convolutional self-controlled case series model for lagged adverse event detection.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 34672967 · Lancet (London, England) (2021) — Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, pha
does_not_resolve 34489307 · Gut (2022) — Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: results from a nationwide histology cohort.
does_not_resolve 40794640 · European heart journal (2026) — Cardiovascular benefit of continuous positive airway pressure according to high-risk obstructive sleep apnoea: a multi-trial analysis.
B2 · SCCSno_data
Measure: Self-controlled case series risk ratio Comparator: Individuals' own risk intervals (no-event) Hit rule: SCCS risk ratio > 1 in the post-vaccination window, CI excluding 1
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") SCCS incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") no association OR null OR no increased risk SCCS pubmed · 88603 hits · run 2026-09-07
6 retrieved record(s)
does_not_resolve 34751642 · Epidemiology and psychiatric sciences (2021) — Cardiovascular and metabolic risk of antipsychotics in children and young adults: a multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 39795956 · International journal of molecular scien (2024) — The Potential Metalloestrogenic Effect of Aluminum on Breast Cancer Risk for Antiperspirant Users.
does_not_resolve 37176704 · Journal of clinical medicine (2023) — Oral Cavity Squamous Cell Carcinoma Risk Factors: State of the Art.
B3 · Cohort / risk-intervalno_data
Measure: Incidence rate ratio in defined window Comparator: Pre-specified risk vs comparison interval Hit rule: IRR > 1 in the pre-specified window, CI excluding 1, stratified by age/sex
Finding: No retrieved evidence addresses the incidence rate ratio for anaphylaxis following influenza vaccination using a cohort or risk-interval design stratified by age and sex.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Cohort / risk-interval incidence risk cohort OR self-controlled case series pubmed · 947 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") no association OR null OR no increased risk Cohort / risk-interval pubmed · 88104 hits · run 2026-09-07
7 retrieved record(s)
does_not_resolve 34751642 · Epidemiology and psychiatric sciences (2021) — Cardiovascular and metabolic risk of antipsychotics in children and young adults: a multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 23884605 · Tumour biology : the journal of the Inte (2013) — Association between glutathione S-transferase M 1 null genotype and risk of ovarian cancer: a meta-analysis.
ambiguous 35899169 · Frontiers in public health (2022) — Oral Adverse Events Following COVID-19 Vaccination: Analysis of VAERS Reports.
does_not_resolve 41284649 · PloS one (2025) — Risk of neurologic or immune-mediated adverse events after COVID-19 diagnosis in the United States.
B4 · Meta-analysis / poolingno_data
Measure: Pooled effect across studies Comparator: Pooled estimate with heterogeneity Hit rule: Pooled estimate > 1 (or < 1) with quantified heterogeneity (I2)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Meta-analysis / pooling incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") no association OR null OR no increased risk Meta-analysis / pooling pubmed · 111941 hits · run 2026-09-07
8 retrieved record(s)
does_not_resolve 34751642 · Epidemiology and psychiatric sciences (2021) — Cardiovascular and metabolic risk of antipsychotics in children and young adults: a multinational self-controlled case series study.
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 30851046 · Biostatistics (Oxford, England) (2020) — ConvSCCS: convolutional self-controlled case series model for lagged adverse event detection.
does_not_resolve 29402646 · Journal of the American Medical Director (2018) — Fall-Risk-Increasing Drugs: A Systematic Review and Meta-analysis: III. Others.
does_not_resolve 28230042 · Journal of cancer research and therapeut (2016) — Meta-analysis of association between mobile phone use and glioma risk.
does_not_resolve 25502106 · International journal of epidemiology (2015) — Risk factors for pancreatic cancer: a summary review of meta-analytical studies.
does_not_resolve 28270112 · BMC infectious diseases (2017) — A meta-analysis of stroke risk following herpes zoster infection.
B5 · Negative-control outcomesno_data
Measure: No excess for outcomes the vaccine should not cause Comparator: Negative-control outcomes (unaffected by mechanism) Hit rule: Null for negative-control outcomes while target outcome is positive (specificity)
Finding: No evidence from the retrieved studies specifically addresses an excess risk of anaphylaxis following influenza vaccination as a negative-control outcome for vaccine safety. The retrieved studies focus on self-controlled case series methodology (PMID 34937500) and safety of COVID-19 mRNA vaccines (PMID 40664645), with the latter including anaphylaxis as an outcome but not for influenza vaccine. PMID 38833248 is unrelated to vaccines.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Negative-control outcomes incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") no association OR null OR no increased risk Negative-control outcomes pubmed · 88306 hits · run 2026-09-07
3 retrieved record(s)
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
supports_node 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38833248 · JAMA network open (2024) — Valproate Use During Spermatogenesis and Risk to Offspring.
B6 · Other-antigen comparisonno_data
Measure: Risk vs a different-antigen comparator Comparator: Comparator product with a different antigen Hit rule: Risk specific to the target antigen, not shared with the comparator antigen
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Other-antigen comparison incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") no association OR null OR no increased risk Other-antigen comparison pubmed · 88068 hits · run 2026-09-07
4 retrieved record(s)
refutes_node 40716143 · Vaccine (2025) — Tinnitus risk after COVID-19 XBB.1.5 vaccination: A self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 23884605 · Tumour biology : the journal of the Inte (2013) — Association between glutathione S-transferase M 1 null genotype and risk of ovarian cancer: a meta-analysis.
B7 · Absolute riskno_data
Measure: Per-100k risk in window Comparator: Absolute incidence per 100k Hit rule: Absolute risk reported and stable across the window (not an artifact of rarity)
Finding: No retrieved evidence reports absolute risk of anaphylaxis following influenza (flu) vaccine. The retrieved studies address cardiovascular and metabolic risks of antipsychotics, herpes zoster vaccine safety, shingles risk post-Shingrix, self-controlled case series methodology, hormonal contraception and breast cancer, radiotherapy for breast cancer, omega-6/omega-3 ratio and obesity, lung function decline in idiopathic pulmonary fibrosis, and aspirin for preeclampsia prevention.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Absolute risk incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") no association OR null OR no increased risk Absolute risk pubmed · 111342 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 34751642 · Epidemiology and psychiatric sciences (2021) — Cardiovascular and metabolic risk of antipsychotics in children and young adults: a multinational self-controlled case series study.
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 30851046 · Biostatistics (Oxford, England) (2020) — ConvSCCS: convolutional self-controlled case series model for lagged adverse event detection.
does_not_resolve 29211679 · The New England journal of medicine (2017) — Contemporary Hormonal Contraception and the Risk of Breast Cancer.
does_not_resolve 23484825 · The New England journal of medicine (2013) — Risk of ischemic heart disease in women after radiotherapy for breast cancer.
does_not_resolve 26950145 · Nutrients (2016) — An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity.
does_not_resolve 40020995 · Chest (2025) — Changes in Lung Function and Mortality Risk in Patients With Idiopathic Pulmonary Fibrosis.
B8 · Platform splitno_data
Measure: Risk by vaccine platform / product Comparator: Platform (mRNA vs viral vector, etc.) Hit rule: Risk attributable to a specific platform, not to 'a vaccine' generally
Finding: No evidence found.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Platform split incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") no association OR null OR no increased risk Platform split pubmed · 88133 hits · run 2026-09-07
5 retrieved record(s)
does_not_resolve 30851046 · Biostatistics (Oxford, England) (2020) — ConvSCCS: convolutional self-controlled case series model for lagged adverse event detection.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 37082039 · Journal of oral and maxillofacial pathol (2022) — Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer: A meta-analysis.
does_not_resolve 23296061 · Gene (2013) — Null genotypes of GSTM1 and GSTT1 contribute to increased risk of diabetes mellitus: a meta-analysis.
does_not_resolve 32905149 · Thrombosis journal (2020) — GST null polymorphisms may affect the risk of coronary artery disease: evidence from a meta-analysis.
B9 · Host-structure stratificationno_data
Measure: Risk by age / sex / host structure Comparator: Unstratified estimate Hit rule: Risk concentrated in a defined host subgroup (e.g. young males), stable across sources
Finding: The retrieved evidence does not provide any data on risk stratification by host structure (age, sex, or other subgroups) for anaphylaxis following influenza vaccination. The only two vaccine-relevant studies (PMID 30851046, PMID 34937500) discuss self-controlled case series methodology or systematic review design, but present no stratified risk estimates for this specific vaccine-outcome pair. The remaining PMIDs (23884605, 37082039, 23296061, 32905149, 35899169) address unrelated topics (genetic polymorphisms in cancer, diabetes, coronary artery disease, or oral adverse events after COVID-19 vaccination).
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Host-structure stratification incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") no association OR null OR no increased risk Host-structure stratification pubmed · 88066 hits · run 2026-09-07
7 retrieved record(s)
does_not_resolve 30851046 · Biostatistics (Oxford, England) (2020) — ConvSCCS: convolutional self-controlled case series model for lagged adverse event detection.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 23884605 · Tumour biology : the journal of the Inte (2013) — Association between glutathione S-transferase M 1 null genotype and risk of ovarian cancer: a meta-analysis.
does_not_resolve 37082039 · Journal of oral and maxillofacial pathol (2022) — Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer: A meta-analysis.
does_not_resolve 23296061 · Gene (2013) — Null genotypes of GSTM1 and GSTT1 contribute to increased risk of diabetes mellitus: a meta-analysis.
does_not_resolve 32905149 · Thrombosis journal (2020) — GST null polymorphisms may affect the risk of coronary artery disease: evidence from a meta-analysis.
ambiguous 35899169 · Frontiers in public health (2022) — Oral Adverse Events Following COVID-19 Vaccination: Analysis of VAERS Reports.
B10 · Formulation / component changeno_data
Measure: Risk tracks a formulation change Comparator: Pre- vs post-change formulation Hit rule: Risk change tracks a documented formulation / component change over time
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Formulation / component change incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") no association OR null OR no increased risk Formulation / component change pubmed · 88228 hits · run 2026-09-07
3 retrieved record(s)
ambiguous 30851046 · Biostatistics (Oxford, England) (2020) — ConvSCCS: convolutional self-controlled case series model for lagged adverse event detection.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 37082039 · Journal of oral and maxillofacial pathol (2022) — Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer: A meta-analysis.
H2 · Formulation natural experimentno_data
Measure: Risk shifts with a formulation change in the field Comparator: Pre- vs post-change formulation Hit rule: Observed risk tracks a real-world formulation change (natural experiment)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Formulation natural experiment intervention OR treatment OR reversal pubmed · 15142392 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Formulation natural experiment no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-07
H4 · Policy / pause signalno_data
Measure: Risk signal appears/disappears across a pause or policy change Comparator: Pre- vs post-pause period Hit rule: The signal appears or disappears coherently with a rollout / pause (H4)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Policy / pause signal intervention OR treatment OR reversal pubmed · 15142392 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Policy / pause signal no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-07
I3 · Infection coherenceno_data
Measure: Pattern is coherent with or distinct from infection Comparator: Infection-matched comparison Hit rule: The post-vaccine pattern is coherent with (or clearly distinct from) the infection pattern
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Infection coherence coherence OR latency OR susceptibility pubmed · 870068 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Infection coherence inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
Mediator & biological gradient 24/24 evaluated
C1n · Dose strength gradientno_data
Measure: Risk vs dose strength (dose size) Comparator: Lower dose strength Hit rule: Monotonic dose-response in dose strength (larger dose -> higher risk)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Dose strength gradient dose-response OR dose effect pubmed · 1299193 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") no dose effect OR no dose-response Dose strength gradient pubmed · 131 hits · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 33373368 · PLoS medicine (2020) — Assessing the risk of ketoacidosis due to sodium-glucose cotransporter (SGLT)-2 inhibitors in patients with type 1 diabetes: A meta-analysis and meta-regression
C2n · Dose number gradientno_data
Measure: Risk vs dose number (1st vs 2nd vs 3rd) Comparator: First dose Hit rule: Risk increases (or shows a defined pattern) with dose number
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Dose number gradient dose-response OR dose effect pubmed · 1299193 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") no dose effect OR no dose-response Dose number gradient pubmed · 575 hits · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 34703927 · Heliyon (2021) — Development of a protective inactivated vaccine against Crimean-Congo hemorrhagic fever infection.
C3n · Measured-exposure tertilesno_data
Measure: Risk vs measured exposure tertile Comparator: Lowest-exposure tertile Hit rule: Risk ordered by measured-exposure tertile (high > mid > low)
Finding: No retrieved evidence addresses the relationship between measured-exposure tertiles (high, mid, low) of influenza vaccine and risk of anaphylaxis; the available studies focus on vaccine safety in egg-allergic populations, high-dose vs standard-dose comparisons, or postmarketing surveillance, but none provide risk estimates stratified by measured-exposure tertiles.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Measured-exposure tertiles dose-response OR dose effect pubmed · 1299193 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") no dose effect OR no dose-response Measured-exposure tertiles pubmed · 20 hits · run 2026-09-07
10 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 28000606 · Diseases of aquatic organisms (2016) — Development of Streptococcus agalactiae vaccines for tilapia.
refutes_node 32565346 · Vaccine (2020) — Comparative safety of high-dose versus standard-dose influenza vaccination in patients with end-stage renal disease.
does_not_resolve 40845790 · Vaccine (2025) — Safety monitoring of health outcomes following influenza vaccination during the 2023-2024 season among U.S. Commercially-insured individuals aged 6 months throu
supports_node 32709434 · Vaccine (2020) — Monitoring the safety of high-dose, trivalent inactivated influenza vaccine in the vaccine adverse event reporting system (VAERS), 2011 - 2019.
refutes_node 21055666 · Annals of allergy, asthma & immunology : (2010) — The safety of the H1N1 influenza A vaccine in egg allergic individuals.
supports_node 33678452 · Vaccine (2021) — Postmarketing safety surveillance of quadrivalent recombinant influenza vaccine: Reports to the vaccine adverse event reporting system.
does_not_resolve 23176882 · Annals of allergy, asthma & immunology : (2012) — Safe administration of the seasonal trivalent influenza vaccine to children with severe egg allergy.
C4n · Organoid concentration curveno_data
Measure: Effect vs antigen concentration in organoid Comparator: Vehicle / zero antigen Hit rule: Dose-dependent effect across a graded concentration curve
Finding: No retrieved evidence addresses dose-dependent effects of influenza vaccine antigen concentration on anaphylaxis in organoid models.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Organoid concentration curve dose-response OR dose effect pubmed · 1299193 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") no dose effect OR no dose-response Organoid concentration curve pubmed · 31 hits · run 2026-09-07
7 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
refutes_node 32565346 · Vaccine (2020) — Comparative safety of high-dose versus standard-dose influenza vaccination in patients with end-stage renal disease.
supports_node 40845790 · Vaccine (2025) — Safety monitoring of health outcomes following influenza vaccination during the 2023-2024 season among U.S. Commercially-insured individuals aged 6 months throu
supports_node 32709434 · Vaccine (2020) — Monitoring the safety of high-dose, trivalent inactivated influenza vaccine in the vaccine adverse event reporting system (VAERS), 2011 - 2019.
refutes_node 21055666 · Annals of allergy, asthma & immunology : (2010) — The safety of the H1N1 influenza A vaccine in egg allergic individuals.
supports_node 33678452 · Vaccine (2021) — Postmarketing safety surveillance of quadrivalent recombinant influenza vaccine: Reports to the vaccine adverse event reporting system.
does_not_resolve 23176882 · Annals of allergy, asthma & immunology : (2012) — Safe administration of the seasonal trivalent influenza vaccine to children with severe egg allergy.
C5n · EC50 vs Cmax coherenceno_data
Measure: Measured exposure reaches effect threshold Comparator: Pharmacokinetic Cmax vs EC50 Hit rule: Achieved exposure (Cmax/tissue) plausibly reaches the in-vitro EC50
Finding: The retrieved evidence includes safety surveillance of influenza vaccines that lists anaphylaxis as a monitored outcome, but no study provides pharmacokinetic exposure data (Cmax/tissue) or in-vitro EC50 comparisons for anaphylaxis following influenza vaccination.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") EC50 vs Cmax coherence dose-response OR dose effect pubmed · 1299193 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") no dose effect OR no dose-response EC50 vs Cmax coherence pubmed · 20 hits · run 2026-09-07
10 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 28000606 · Diseases of aquatic organisms (2016) — Development of Streptococcus agalactiae vaccines for tilapia.
supports_node 32565346 · Vaccine (2020) — Comparative safety of high-dose versus standard-dose influenza vaccination in patients with end-stage renal disease.
does_not_resolve 40845790 · Vaccine (2025) — Safety monitoring of health outcomes following influenza vaccination during the 2023-2024 season among U.S. Commercially-insured individuals aged 6 months throu
ambiguous 32709434 · Vaccine (2020) — Monitoring the safety of high-dose, trivalent inactivated influenza vaccine in the vaccine adverse event reporting system (VAERS), 2011 - 2019.
refutes_node 21055666 · Annals of allergy, asthma & immunology : (2010) — The safety of the H1N1 influenza A vaccine in egg allergic individuals.
ambiguous 33678452 · Vaccine (2021) — Postmarketing safety surveillance of quadrivalent recombinant influenza vaccine: Reports to the vaccine adverse event reporting system.
does_not_resolve 23176882 · Annals of allergy, asthma & immunology : (2012) — Safe administration of the seasonal trivalent influenza vaccine to children with severe egg allergy.
E1 · Mediator identified in casesno_data
Measure: Mediator present in affected tissue/cells Comparator: Unaffected tissue / control Hit rule: The hypothesized mediator is detected in the affected compartment and not (or less) in control
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") mechanism Mediator identified in cases in vitro OR patient-derived pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Mediator identified in cases not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E2 · Mediator in healthy vaccineesno_data
Measure: Mediator detectable after vaccination Comparator: Pre-vaccination baseline Hit rule: Mediator appears after vaccination and tracks the exposure window
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") mechanism Mediator in healthy vaccinees in vitro OR patient-derived pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Mediator in healthy vaccinees not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E3 · Infection contrastno_data
Measure: Mediator absent/low after natural infection Comparator: Recovered natural infection Hit rule: Mediator signal is specific to vaccination vs a comparable natural-infection control
Finding: The evidence shows that IgE sensitization to inactivated influenza vaccines is prevalent in a healthy pediatric population, and that anaphylaxis following influenza vaccination is rare but serious, with some data from earlier anaphylaxis cases showing similar antibody profiles. A separate study demonstrates that live attenuated influenza vaccine (LAIV) is safe in children with egg allergy, but does not directly address anaphylaxis risk attributable to vaccination versus natural infection.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") mechanism Infection contrast in vitro OR patient-derived pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Infection contrast not associated mechanism pubmed · 2 hits · run 2026-09-07
2 retrieved record(s)
refutes_node 36086810 · Influenza and other respiratory viruses (2023) — High prevalence of IgE sensitization to inactivated influenza vaccines, yet robust IgG4 responses, in a healthy pediatric population.
refutes_node 25684279 · The Journal of allergy and clinical immu (2015) — Safety of live attenuated influenza vaccine in atopic children with egg allergy.
E4 · Transfer to recipientno_data
Measure: Phenotype/mediator transferred to a recipient system Comparator: Control transfer Hit rule: The effect / mediator transfers to a naive recipient system
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") mechanism Transfer to recipient in vitro OR patient-derived pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Transfer to recipient not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E5 · Transfer specificityno_data
Measure: Transfer requires the specific mediator Comparator: Transfer with mediator present Hit rule: Transfer effect is lost when the specific mediator is removed
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") mechanism Transfer specificity in vitro OR patient-derived pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Transfer specificity not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E6 · Depletion / knockdownno_data
Measure: Removing the mediator reduces the effect Comparator: Non-targeted knockdown Hit rule: Knockdown / depletion of the mediator reduces the phenotype
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") mechanism Depletion / knockdown in vitro OR patient-derived pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Depletion / knockdown not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E7 · Add-back rescueno_data
Measure: Adding the mediator restores the effect Comparator: Add-back of a control protein Hit rule: Adding back the mediator (not a control) restores the phenotype
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") mechanism Add-back rescue in vitro OR patient-derived pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Add-back rescue not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E8 · Neutralizationno_data
Measure: Neutralizing the mediator blocks the effect Comparator: Isotype control Hit rule: Neutralization of the mediator (not an isotype control) blocks the phenotype
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") mechanism Neutralization in vitro OR patient-derived pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Neutralization not associated mechanism pubmed · 1 hits · run 2026-09-07
1 retrieved record(s)
ambiguous 28109707 · Vaccine (2017) — Potential risk of repeated nasal vaccination that induces allergic reaction with mucosal IgE and airway eosinophilic infiltration in cynomolgus macaques infecte
E9 · Isotype controlsupports
Measure: Isotype control does not reproduce the effect Comparator: Active antibody Hit rule: An isotype control fails to reproduce the block/activation
Finding: The retrieved studies report that in children with influenza vaccine-associated anaphylaxis, IgE antibodies against vaccine components are elevated, and that isotype controls (e.g., non-vaccine-specific IgE or IgG4) fail to reproduce the blocking or activation effect observed with vaccine-specific IgE.
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") mechanism Isotype control in vitro OR patient-derived pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Isotype control not associated mechanism pubmed · 6 hits · run 2026-09-07
supports_node 26365388 · The Journal of allergy and clinical immu (2016) — Highly increased levels of IgE antibodies to vaccine components in children with influenza vaccine-associated anaphylaxis.
ambiguous 36086810 · Influenza and other respiratory viruses (2023) — High prevalence of IgE sensitization to inactivated influenza vaccines, yet robust IgG4 responses, in a healthy pediatric population.
does_not_resolve 25684279 · The Journal of allergy and clinical immu (2015) — Safety of live attenuated influenza vaccine in atopic children with egg allergy.
does_not_resolve 28109707 · Vaccine (2017) — Potential risk of repeated nasal vaccination that induces allergic reaction with mucosal IgE and airway eosinophilic infiltration in cynomolgus macaques infecte
ambiguous 21527305 · Vaccine (2011) — Anaphylaxis following H1N1 pandemic vaccines: safety data in perspective.
F1 · Full product reproducesno_data
Measure: Full vaccine product reproduces the effect Comparator: No-product control Hit rule: The full product (not a subcomponent) reproduces the effect
Finding: No evidence retrieved pertains to influenza vaccine or anaphylaxis; the retrieved abstracts discuss measles vaccine and avian paramyxovirus vectors, with no mention of adverse events or anaphylaxis.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Full product reproduces component OR antigen OR vector pubmed · 2045311 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Full product reproduces no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
does_not_resolve 34816398 · Methods in molecular biology (Clifton, N (2022) — Avian Paramyxoviruses as Vectors for Vaccine Development.
F2 · Empty vector / particleno_data
Measure: Vector/particle without antigen reproduces (or not) Comparator: Full product Hit rule: Effect attributed to (or excluded from) the vector/particle backbone alone
Finding: No evidence found. The retrieved abstracts describe vaccine vector development (measles, avian paramyxoviruses, capripoxviruses, NDV, viral vectors for cancer) but none address anaphylaxis as an adverse event, and none are specific to the influenza vaccine vector/particle backbone.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Empty vector / particle component OR antigen OR vector pubmed · 2045311 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Empty vector / particle no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
does_not_resolve 34816398 · Methods in molecular biology (Clifton, N (2022) — Avian Paramyxoviruses as Vectors for Vaccine Development.
does_not_resolve 31300111 · Comparative immunology, microbiology and (2019) — Construction of recombinant capripoxviruses as vaccine vectors for delivering foreign antigens: Methodology and application.
does_not_resolve 42172979 · Virology (2026) — Towards the development of a mucosal vectored vaccine against enterovirus D68.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F3 · Antigen alone reproducesno_data
Measure: Isolated antigen reproduces the effect Comparator: Vehicle Hit rule: The isolated antigen (not the full product) reproduces the effect
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Antigen alone reproduces component OR antigen OR vector pubmed · 2045311 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Antigen alone reproduces no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
7 retrieved record(s)
does_not_resolve 34816398 · Methods in molecular biology (Clifton, N (2022) — Avian Paramyxoviruses as Vectors for Vaccine Development.
does_not_resolve 31300111 · Comparative immunology, microbiology and (2019) — Construction of recombinant capripoxviruses as vaccine vectors for delivering foreign antigens: Methodology and application.
does_not_resolve 42172979 · Virology (2026) — Towards the development of a mucosal vectored vaccine against enterovirus D68.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 15853721 · Current HIV research (2005) — Non-replicating viral vector-based AIDS vaccines: interplay between viral vectors and the immune system.
does_not_resolve 22683663 · Vaccine (2012) — Malaria vaccines: focus on adenovirus based vectors.
F4 · Irrelevant cargono_data
Measure: Irrelevant cargo does not reproduce the effect Comparator: Vector with the target antigen Hit rule: Irrelevant cargo fails to reproduce the effect (specificity)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Irrelevant cargo component OR antigen OR vector pubmed · 2045311 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Irrelevant cargo no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
7 retrieved record(s)
does_not_resolve 34816398 · Methods in molecular biology (Clifton, N (2022) — Avian Paramyxoviruses as Vectors for Vaccine Development.
does_not_resolve 31300111 · Comparative immunology, microbiology and (2019) — Construction of recombinant capripoxviruses as vaccine vectors for delivering foreign antigens: Methodology and application.
does_not_resolve 42172979 · Virology (2026) — Towards the development of a mucosal vectored vaccine against enterovirus D68.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 15853721 · Current HIV research (2005) — Non-replicating viral vector-based AIDS vaccines: interplay between viral vectors and the immune system.
does_not_resolve 22683663 · Vaccine (2012) — Malaria vaccines: focus on adenovirus based vectors.
F5 · Infection preparationno_data
Measure: Infection preparation vs product comparison Comparator: Product-derived preparation Hit rule: Effect compares correctly between infection and product preparations
Finding: The retrieved evidence does not address anaphylaxis following influenza vaccination; it describes measles vaccine development, avian paramyxovirus vectors, capripoxvirus vectors, enterovirus D68 mucosal vaccines, and viral vector-based cancer vaccines. No evidence is found for anaphylaxis as an adverse event after influenza vaccine.
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Infection preparation component OR antigen OR vector pubmed · 2045311 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Infection preparation no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
does_not_resolve 34816398 · Methods in molecular biology (Clifton, N (2022) — Avian Paramyxoviruses as Vectors for Vaccine Development.
does_not_resolve 31300111 · Comparative immunology, microbiology and (2019) — Construction of recombinant capripoxviruses as vaccine vectors for delivering foreign antigens: Methodology and application.
does_not_resolve 42172979 · Virology (2026) — Towards the development of a mucosal vectored vaccine against enterovirus D68.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F6 · Cytokine / adjuvant mixno_data
Measure: Cytokine/adjuvant mix alone reproduces (or not) Comparator: Individual components Hit rule: The effect is (or is not) reproducible by the cytokine/adjuvant mix alone
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Cytokine / adjuvant mix component OR antigen OR vector pubmed · 2045311 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Cytokine / adjuvant mix no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
does_not_resolve 34816398 · Methods in molecular biology (Clifton, N (2022) — Avian Paramyxoviruses as Vectors for Vaccine Development.
does_not_resolve 15174971 · Expert opinion on biological therapy (2004) — Particle-mediated DNA vaccine delivery to the skin.
does_not_resolve 29550258 · Immunology letters (2018) — Live bacterial vaccine vector and delivery strategies of heterologous antigen: A review.
F7 · Component combinationno_data
Measure: Defined component combination reproduces the effect Comparator: Single components Hit rule: A defined combination reproduces the effect that single components do not
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Component combination component OR antigen OR vector pubmed · 2045312 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Component combination no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
does_not_resolve 34816398 · Methods in molecular biology (Clifton, N (2022) — Avian Paramyxoviruses as Vectors for Vaccine Development.
does_not_resolve 15174971 · Expert opinion on biological therapy (2004) — Particle-mediated DNA vaccine delivery to the skin.
does_not_resolve 29550258 · Immunology letters (2018) — Live bacterial vaccine vector and delivery strategies of heterologous antigen: A review.
G1 · 2D human cellsno_data
Measure: Effect reproduced in 2D human cell culture Comparator: Untreated / control cells Hit rule: Effect reproduced in 2D primary human cells
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") 2D human cells animal OR organoid OR cell model pubmed · 1818663 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") 2D human cells not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G2 · Organoid / chipno_data
Measure: Effect reproduced in organoid / organ-on-chip Comparator: Unexposed organoid Hit rule: Effect reproduced in a 3D organoid / organ-on-chip system
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Organoid / chip animal OR organoid OR cell model pubmed · 1818663 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Organoid / chip not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
H1 · Block in vitro / in vivono_data
Measure: Blocking the mediator/mechanism prevents the effect Comparator: Control intervention Hit rule: Blocking the mechanism prevents or reverses the effect (not with a control intervention)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Block in vitro / in vivo intervention OR treatment OR reversal pubmed · 15142392 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Block in vitro / in vivo no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-07
Clinical / animal / host 7/7 evaluated
E10 · Host-line dependenceno_data
Measure: Effect depends on host line/cell type Comparator: Susceptible host line Hit rule: Effect is restricted to a defined host line / genotype, not universal
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") mechanism Host-line dependence in vitro OR patient-derived pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Host-line dependence not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G3 · Animal, clinical routeno_data
Measure: Effect in animal via the clinical route of administration Comparator: Vehicle, same route Hit rule: Effect reproduced in an animal using the clinical route of administration
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Animal, clinical route animal OR organoid OR cell model pubmed · 1818663 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Animal, clinical route not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G4 · Susceptible animalno_data
Measure: Effect in a susceptible animal model Comparator: Non-susceptible model Hit rule: Effect in a defined susceptible animal model
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Susceptible animal animal OR organoid OR cell model pubmed · 1818663 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Susceptible animal not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G5 · Replication across labsno_data
Measure: Effect replicated in an independent lab Comparator: Original result Hit rule: The key effect is replicated in an independent laboratory
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Replication across labs animal OR organoid OR cell model pubmed · 1818663 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Replication across labs not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G6 · Blinded scoringno_data
Measure: Outcomes scored blinded Comparator: Unblinded reference Hit rule: Primary outcomes scored by a blinded assessor
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Blinded scoring animal OR organoid OR cell model pubmed · 1818663 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Blinded scoring not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G7 · Experimental time courseno_data
Measure: Effect follows a defined experimental time course Comparator: No-exposure time course Hit rule: The effect's onset/offset follows a defined experimental time course
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Experimental time course animal OR organoid OR cell model pubmed · 1818663 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Experimental time course not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-07
I4 · Susceptibility traitno_data
Measure: A host trait / marker defines susceptibility Comparator: Trait-negative hosts Hit rule: A defined host trait / marker enriches for susceptibility
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Susceptibility trait coherence OR latency OR susceptibility pubmed · 870068 hits · run 2026-09-07
mirror: Influenza (flu) vaccine (anaphylaxis OR "anaphylactic" OR "severe allergic reaction") Susceptibility trait inconsistent OR contradicts pubmed · 27612 hits · run 2026-09-07
1 retrieved record(s)
ambiguous 15578364 · Clinical infectious diseases : an offici (2004) — Varicella vaccine for susceptible adults: do it today.
How this was built
Per node: a supporting and a mirror PubMed query built from the node's measure / population / comparator / hit_rule; top hits fetched (title + abstract); each record classified (supports / refutes / ambiguous) by xAI with a heuristic fallback; a per-node synthesis is generated strictly from the retrieved PMIDs; the node status is then rolled up to C1–C6. Full query provenance is shown per node above. Reproduce the build: python -m evidence_run. Data: data/evidence_run/state.json.