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Influenza (flu) vaccine → Guillain-Barré Syndrome (GBS)

Evidence dossier · candidate cand-influenza-guillain-barr-syndrome · VICP program · · DRAFT — not a determination
This is a draft research-tracking dossier, not a determination that Influenza (flu) vaccine causes Guillain-Barré Syndrome (GBS), and not an incidence or legal finding. All evidence is flagged needs_human_review and must be reviewed before any page is published or cited. Every value is grounded in retrieved citations (PMID + retrieval date); unsourced items read "no evidence found / not assessable". Symmetric search: every supporting query has a mirror/null query, and zeros are shown (negative dossiers report the absence of signal).

Verdict at a glance

Computed from the retrieved literature, never hand-set. A draft screening result, not a determination that the vaccine caused the event.

Epidemiologic excess risk (C3)
contested
Biological mechanism (C6)
insufficient_data
NASEM-style synthesized conclusion
Inadequate to accept or reject

Jump to: claim matrix · Bradford Hill · NASEM synthesis · 68-node evidence matrix · how it was built

Claim matrix (C1–C6, computed)

ClaimLabelStatusMissing nodes
C1Coherent clinical object existsinsufficient_datamissing: A1 A2
C2Consistent temporal windowinsufficient_datamissing: A5
C3Epidemiologic excess riskcontested
C4Consistency / replicationcontested
C5Specificity (product / dose)contested
C6Biological mechanisminsufficient_datamissing: E1

Two evidentiary bars apply to the epi nodes/claims (C3, C4):
· VICP — preponderance of the evidence.
· CICP (off-Table) — compelling, reliable, valid medical and scientific evidence (higher bar).

Bradford Hill assessment (computed)

Each viewpoint is derived from the node statuses below (see the framework crosswalk in compensation-tables-schema.md §8). Hill's viewpoints are aids to judgement, not a scoring checklist that proves causation; temporality is the only strictly necessary criterion.

ViewpointWhat it asksStatus (from evidence)
Temporality (necessary)cause precedes effect in a plausible window (necessary)not established
Strengthsize/precision of the associationnot established
Consistencyreproduced across settings/designsnot established
Specificitytied to a specific product/dose/outcomenot established
Biological gradientdose-responsenot established
Plausibilitya named biological mechanismnot established
Coherencefits known biology/natural historynot established
Experimentintervention changes riskpartial / mixed · via G4
Analogyprecedent for the patternnot established

NASEM weight-of-evidence synthesis (computed)

TrackWeightBasis
EpidemiologicINSUFFICIENTvia B1, B2, B3, B4, B5, B8
MechanisticLACKINGvia A9, A10, C1n, C2n, C3n, C4n, C5n · missing: D1 D2 D3 D4 D5 E1 E2 E3 E4 E5 E6 E7 E8 E9 E10 F1 …
Synthesized conclusionInadequate to accept or reject

NASEM (formerly IOM), "Adverse Effects of Vaccines: Evidence and Causality" (2011, updated 2024). Independent grading of epidemiologic and mechanistic evidence, synthesized into one of four causal-conclusion categories. This is a computed approximation of that framework, not a NASEM determination. See compensation-tables-schema.md §8bis.

Case-definition standard: Brighton Collaboration (named in spec §1: Guillain-Barre syndrome) — governs the case-certainty scale on A1/A2/A6/A8 below. See compensation-tables-schema.md §8ter.

Evidence matrix (68 nodes by workstream)

68 of 68 nodes evaluated · 136 PubMed queries logged (supporting + mirror, incl. zeros). Statuses are computed from retrieved citations; not hand-set.

Definition & attribution 24/24 evaluated24 nodes
A1 · Case reportsno_data
Measure: New definite object in risk window T
Comparator: Pre-vaccination baseline
Hit rule: Definite object present, onset in window, competing causes considered
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) case report OR case series Case reports
pubmed · 66198 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) alternative diagnosis OR not vaccine-related
pubmed · 4056 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 34854882 · Blood (2021) — VITT(al) insights into vaccine-related clots.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 40046048 · Frontiers in immunology (2025) — The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis.
ambiguous 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A2 · Series with objective confirmationno_data
Measure: Definite object plus objective test
Comparator: Reference range / diagnostic criteria
Hit rule: Objective confirmation in >=1 case per the working definition
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) case report OR case series Series with objective confirmation
pubmed · 5670 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) alternative diagnosis OR not vaccine-related
pubmed · 4056 hits · run 2026-09-07
9 retrieved record(s)
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 34854882 · Blood (2021) — VITT(al) insights into vaccine-related clots.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 40046048 · Frontiers in immunology (2025) — The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
A3 · Onset histogramno_data
Measure: Distribution of onset times after dose
Comparator: Pre-specified risk window
Hit rule: Onset clusters inside the pre-specified window (not uniform/flat)
Finding: No retrieved evidence addresses the onset time distribution of Guillain-Barré Syndrome following influenza vaccination.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) case report OR case series Onset histogram
pubmed · 29 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) alternative diagnosis OR not vaccine-related
pubmed · 4056 hits · run 2026-09-07
10 retrieved record(s)
ambiguous 25684308 · Semergen (2016) — [Guillain-Barré and flu vaccine].
does_not_resolve 34935404 · AJR. American journal of roentgenology (2022) — COVID-19 Vaccine-Related Axillary Adenopathy on Breast Imaging: Follow-Up Recommendations and Histopathologic Findings.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 34854882 · Blood (2021) — VITT(al) insights into vaccine-related clots.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
ambiguous 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
A4 · Temporal plausibilityno_data
Measure: Onset latency vs object pathophysiology
Comparator: Object's known natural latency
Hit rule: Onset latency consistent with the object's pathophysiology
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) case report OR case series Temporal plausibility
pubmed · 58 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) alternative diagnosis OR not vaccine-related
pubmed · 4056 hits · run 2026-09-07
10 retrieved record(s)
ambiguous 25684308 · Semergen (2016) — [Guillain-Barré and flu vaccine].
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 34854882 · Blood (2021) — VITT(al) insights into vaccine-related clots.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 40046048 · Frontiers in immunology (2025) — The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis.
A5 · Onset-interval documentationno_data
Measure: Onset interval documented in source
Comparator: Dose date
Hit rule: Onset interval is recorded (not imputed) in a primary source
Finding: No evidence was found in the retrieved literature regarding documentation of onset interval for Guillain-Barré Syndrome following influenza vaccination, as none of the retrieved PMIDs address influenza vaccine or GBS onset-interval recording.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) case report OR case series Onset-interval documentation
pubmed · 27 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) alternative diagnosis OR not vaccine-related
pubmed · 4056 hits · run 2026-09-07
10 retrieved record(s)
ambiguous 25684308 · Semergen (2016) — [Guillain-Barré and flu vaccine].
does_not_resolve 34935404 · AJR. American journal of roentgenology (2022) — COVID-19 Vaccine-Related Axillary Adenopathy on Breast Imaging: Follow-Up Recommendations and Histopathologic Findings.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 34854882 · Blood (2021) — VITT(al) insights into vaccine-related clots.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
A6 · Differential diagnosis excludedno_data
Measure: Competing causes assessed and excluded
Comparator: Likely alternative diagnoses
Hit rule: Pre-specified competing causes ruled out per the working definition
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) case report OR case series Differential diagnosis excluded
pubmed · 454 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) alternative diagnosis OR not vaccine-related
pubmed · 4056 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 34935404 · AJR. American journal of roentgenology (2022) — COVID-19 Vaccine-Related Axillary Adenopathy on Breast Imaging: Follow-Up Recommendations and Histopathologic Findings.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 34854882 · Blood (2021) — VITT(al) insights into vaccine-related clots.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
ambiguous 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A7 · Rechallenge / re-exposureno_data
Measure: Object recurs on a further dose
Comparator: First-dose response
Hit rule: Object recurs after a subsequent dose (re-exposure)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) case report OR case series Rechallenge / re-exposure
pubmed · 29 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) alternative diagnosis OR not vaccine-related
pubmed · 4056 hits · run 2026-09-07
10 retrieved record(s)
ambiguous 25684308 · Semergen (2016) — [Guillain-Barré and flu vaccine].
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 34854882 · Blood (2021) — VITT(al) insights into vaccine-related clots.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 40046048 · Frontiers in immunology (2025) — The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis.
A8 · Adjudicated by criteria (Brighton Collaboration)no_data
Measure: Object adjudicated by published criteria
Comparator: Published clinical / Brighton criteria
Hit rule: Cases adjudicated to 'definite' by a published criterion set
Finding: No retrieved evidence addresses Guillain-Barré Syndrome after influenza vaccine adjudicated as 'definite' by published criteria.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) case report OR case series Adjudicated by criteria
pubmed · 66 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) alternative diagnosis OR not vaccine-related
pubmed · 4056 hits · run 2026-09-07
10 retrieved record(s)
ambiguous 25684308 · Semergen (2016) — [Guillain-Barré and flu vaccine].
does_not_resolve 34935404 · AJR. American journal of roentgenology (2022) — COVID-19 Vaccine-Related Axillary Adenopathy on Breast Imaging: Follow-Up Recommendations and Histopathologic Findings.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 34854882 · Blood (2021) — VITT(al) insights into vaccine-related clots.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
ambiguous 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
A9 · Natural-history consistencyno_data
Measure: Course matches the object's natural history
Comparator: Known natural history of the object
Hit rule: Clinical course (onset, peak, recovery) matches the object's natural history
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) case report OR case series Natural-history consistency
pubmed · 130 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) alternative diagnosis OR not vaccine-related
pubmed · 4056 hits · run 2026-09-07
10 retrieved record(s)
ambiguous 25684308 · Semergen (2016) — [Guillain-Barré and flu vaccine].
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 34854882 · Blood (2021) — VITT(al) insights into vaccine-related clots.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 40046048 · Frontiers in immunology (2025) — The protective role of vitamin D in BNT162b2 vaccine-related acute myocarditis.
A10 · No confounding objectno_data
Measure: Not attributable to a co-occurring condition
Comparator: Co-occurring illness that could produce the object
Hit rule: Object not better explained by a co-occurring condition (infection, etc.)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) case report OR case series No confounding object
pubmed · 46 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) alternative diagnosis OR not vaccine-related
pubmed · 4056 hits · run 2026-09-07
10 retrieved record(s)
ambiguous 25684308 · Semergen (2016) — [Guillain-Barré and flu vaccine].
does_not_resolve 34935404 · AJR. American journal of roentgenology (2022) — COVID-19 Vaccine-Related Axillary Adenopathy on Breast Imaging: Follow-Up Recommendations and Histopathologic Findings.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 34854882 · Blood (2021) — VITT(al) insights into vaccine-related clots.
does_not_resolve 36560483 · Vaccines (2022) — Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
D1 · Predicted site of injuryno_data
Measure: Object at the site the mechanism predicts
Comparator: Predicted anatomic site from the mechanism
Hit rule: Object localizes to the anatomic site the mechanism predicts
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) anatomic localization Predicted site of injury mechanism
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Predicted site of injury not consistent with mechanism
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D2 · Spared structuresno_data
Measure: Structures the mechanism should spare are spared
Comparator: Structures predicted unaffected
Hit rule: Structures predicted spared by the mechanism are indeed spared
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) anatomic localization Spared structures mechanism
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Spared structures not consistent with mechanism
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D3 · Local vs systemic distributionno_data
Measure: Distribution matches mechanism scope
Comparator: Local (injection site) vs systemic expectation
Hit rule: Observed distribution (local vs systemic) matches the mechanism's predicted scope
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) anatomic localization Local vs systemic distribution mechanism
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Local vs systemic distribution not consistent with mechanism
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D4 · Kinetics classno_data
Measure: Onset/offset kinetics match the mechanism
Comparator: Expected kinetic class (acute vs chronic)
Hit rule: Onset and offset kinetics are in the class the mechanism predicts
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) anatomic localization Kinetics class mechanism
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Kinetics class not consistent with mechanism
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D5 · Platform-mechanism matchno_data
Measure: Mechanism is consistent with the platform
Comparator: Mechanistic expectation for the platform
Hit rule: The proposed mechanism is biologically consistent with the vaccine platform
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) anatomic localization Platform-mechanism match mechanism
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Platform-mechanism match not consistent with mechanism
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
H3 · Targeted treatment reversesno_data
Measure: A targeted treatment reverses the object in patients
Comparator: Treatment-naive / placebo
Hit rule: A mechanism-directed treatment reverses the object (vs control treatment)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Targeted treatment reverses intervention OR treatment OR reversal
pubmed · 15142392 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Targeted treatment reverses no effect intervention
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
I1 · No internal contradictionno_data
Measure: No node's finding contradicts another
Comparator: Internal consistency across nodes
Hit rule: No evaluated node directly contradicts another (coherence)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) No internal contradiction coherence OR latency OR susceptibility
pubmed · 870068 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) No internal contradiction inconsistent OR contradicts
pubmed · 27612 hits · run 2026-09-07
1 retrieved record(s)
ambiguous 15578364 · Clinical infectious diseases : an offici (2004) — Varicella vaccine for susceptible adults: do it today.
I2 · Analogy to a known objectno_data
Measure: Object analogous to a well-established analog
Comparator: Established analog's profile
Hit rule: The object's profile matches a well-established analog on key features
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Analogy to a known object coherence OR latency OR susceptibility
pubmed · 870068 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Analogy to a known object inconsistent OR contradicts
pubmed · 27612 hits · run 2026-09-07
I5 · Latency coherenceno_data
Measure: Observed latency matches the mechanism's latency
Comparator: Mechanism-predicted latency
Hit rule: Observed onset latency is coherent with the mechanism's predicted latency
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Latency coherence coherence OR latency OR susceptibility
pubmed · 870068 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Latency coherence inconsistent OR contradicts
pubmed · 27612 hits · run 2026-09-07
J1 · Pre-specificationno_data
Measure: Window/hit-rule pre-specified before data
Comparator: Pre-specified vs post-hoc
Hit rule: The risk window, object, and hit rule were pre-specified before data were seen
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Pre-specification pre-specified OR adjudicated
pubmed · 13550 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Pre-specification post-hoc OR hypothesis-generating only
pubmed · 1700 hits · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 36088907 · Nephron (2023) — Drug-Induced Acute Kidney Injury Risk Prediction Models.
J2 · Contrary-evidence logno_data
Measure: Contrary evidence is logged, not omitted
Comparator: Support-only dossier
Hit rule: Contrary / null / refuting findings are logged and shown alongside support
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Contrary-evidence log pre-specified OR adjudicated
pubmed · 13550 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Contrary-evidence log post-hoc OR hypothesis-generating only
pubmed · 1700 hits · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 36088907 · Nephron (2023) — Drug-Induced Acute Kidney Injury Risk Prediction Models.
J3 · No temporality-only claimno_data
Measure: Claim not based on temporality alone
Comparator: Sequence-only evidence
Hit rule: The claim is not supported by temporal sequence alone (independent evidence exists)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) No temporality-only claim pre-specified OR adjudicated
pubmed · 13551 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) No temporality-only claim post-hoc OR hypothesis-generating only
pubmed · 1700 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
J4 · Passive-surveillance roleno_data
Measure: Passive-surveillance findings bounded correctly
Comparator: Active-surveillance confirmation
Hit rule: Passive-surveillance signals are framed as hypothesis-generating, not confirmatory
Finding: This study uses large language models to identify immune-related adverse events from immune checkpoint inhibitors, not from vaccines, and does not address Guillain-Barré Syndrome following influenza vaccination.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Passive-surveillance role pre-specified OR adjudicated
pubmed · 13550 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Passive-surveillance role post-hoc OR hypothesis-generating only
pubmed · 1700 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
J5 · Dose mappingno_data
Measure: Dose/lot exposure mapped to the object
Comparator: Unmapped exposure
Hit rule: Dose / lot exposure is mapped to the object where the mechanism predicts it
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Dose mapping pre-specified OR adjudicated
pubmed · 13550 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Dose mapping post-hoc OR hypothesis-generating only
pubmed · 1700 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
Epidemiologic chassis 13/13 evaluated13 nodes
B1 · Excess vs baselineno_data
Measure: RR/IRR vs unexposed or prior window
Comparator: Unvaccinated person-time or pre-vaccination window
Hit rule: RR/IRR > 1 with CI excluding 1 after pre-specified confounders
Finding: No retrieved evidence directly examines the association between influenza vaccine and Guillain-Barré syndrome. One retrieved reference (PMID 29880241) discusses the topic but is a narrative review, not a formal epidemiological study with an RR/IRR estimate meeting the hit rule criteria.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Excess vs baseline incidence risk cohort OR self-controlled case series
pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) no association OR null OR no increased risk Excess vs baseline
pubmed · 88592 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 34751642 · Epidemiology and psychiatric sciences (2021) — Cardiovascular and metabolic risk of antipsychotics in children and young adults: a multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 40924159 · Clinical infectious diseases : an offici (2025) — Transient Increased Risk of Shingles Post-Shingrix Vaccination: Self-Controlled Case-Series Analysis.
ambiguous 41160817 · The New England journal of medicine (2025) — Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025-2026.
does_not_resolve 34489307 · Gut (2022) — Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: results from a nationwide histology cohort.
supports_node 29880241 · Vaccine (2019) — Vaccine-preventable diseases, vaccines and Guillain-Barre' syndrome.
does_not_resolve 36803903 · Vaccine (2023) — Vaccinomics: A scoping review.
B2 · SCCSno_data
Measure: Self-controlled case series risk ratio
Comparator: Individuals' own risk intervals (no-event)
Hit rule: SCCS risk ratio > 1 in the post-vaccination window, CI excluding 1
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) SCCS incidence risk cohort OR self-controlled case series
pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) no association OR null OR no increased risk SCCS
pubmed · 88700 hits · run 2026-09-07
8 retrieved record(s)
does_not_resolve 34751642 · Epidemiology and psychiatric sciences (2021) — Cardiovascular and metabolic risk of antipsychotics in children and young adults: a multinational self-controlled case series study.
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 40924159 · Clinical infectious diseases : an offici (2025) — Transient Increased Risk of Shingles Post-Shingrix Vaccination: Self-Controlled Case-Series Analysis.
supports_node 41160817 · The New England journal of medicine (2025) — Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025-2026.
does_not_resolve 39795956 · International journal of molecular scien (2024) — The Potential Metalloestrogenic Effect of Aluminum on Breast Cancer Risk for Antiperspirant Users.
refutes_node 29880241 · Vaccine (2019) — Vaccine-preventable diseases, vaccines and Guillain-Barre' syndrome.
does_not_resolve 36803903 · Vaccine (2023) — Vaccinomics: A scoping review.
does_not_resolve 41325764 · The Lancet. Infectious diseases (2026) — Effectiveness of the maternal RSVpreF vaccine against severe disease in infants in Scotland, UK: a national, population-based case-control study and cohort anal
B3 · Cohort / risk-intervalno_data
Measure: Incidence rate ratio in defined window
Comparator: Pre-specified risk vs comparison interval
Hit rule: IRR > 1 in the pre-specified window, CI excluding 1, stratified by age/sex
Finding: The retrieved evidence includes a review that notes an association between influenza vaccine and Guillain-Barré syndrome has been debated, and has not been proven for most vaccines except the 1976 preparation, but no cohort or risk-interval study with IRR, CI, and age/sex stratification specific to influenza vaccine and GBS is provided.
Cited: PMID 29880241
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Cohort / risk-interval incidence risk cohort OR self-controlled case series
pubmed · 949 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) no association OR null OR no increased risk Cohort / risk-interval
pubmed · 88199 hits · run 2026-09-07
7 retrieved record(s)
does_not_resolve 34751642 · Epidemiology and psychiatric sciences (2021) — Cardiovascular and metabolic risk of antipsychotics in children and young adults: a multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 40924159 · Clinical infectious diseases : an offici (2025) — Transient Increased Risk of Shingles Post-Shingrix Vaccination: Self-Controlled Case-Series Analysis.
supports_node 41160817 · The New England journal of medicine (2025) — Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025-2026.
ambiguous 29880241 · Vaccine (2019) — Vaccine-preventable diseases, vaccines and Guillain-Barre' syndrome.
ambiguous 36803903 · Vaccine (2023) — Vaccinomics: A scoping review.
B4 · Meta-analysis / poolingno_data
Measure: Pooled effect across studies
Comparator: Pooled estimate with heterogeneity
Hit rule: Pooled estimate > 1 (or < 1) with quantified heterogeneity (I2)
Finding: No retrieved study provides a pooled meta-analytic estimate with quantified heterogeneity (I²) for the association between influenza vaccine and Guillain-Barré syndrome. The available studies describe self-controlled case series designs or general reviews without performing or reporting a meta-analysis with a pooled effect estimate and I² heterogeneity statistic.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Meta-analysis / pooling incidence risk cohort OR self-controlled case series
pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) no association OR null OR no increased risk Meta-analysis / pooling
pubmed · 112038 hits · run 2026-09-07
6 retrieved record(s)
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 30851046 · Biostatistics (Oxford, England) (2020) — ConvSCCS: convolutional self-controlled case series model for lagged adverse event detection.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
supports_node 41160817 · The New England journal of medicine (2025) — Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025-2026.
ambiguous 29880241 · Vaccine (2019) — Vaccine-preventable diseases, vaccines and Guillain-Barre' syndrome.
does_not_resolve 36803903 · Vaccine (2023) — Vaccinomics: A scoping review.
B5 · Negative-control outcomesno_data
Measure: No excess for outcomes the vaccine should not cause
Comparator: Negative-control outcomes (unaffected by mechanism)
Hit rule: Null for negative-control outcomes while target outcome is positive (specificity)
Finding: The retrieved evidence includes a 2025 study evaluating Guillain-Barré syndrome following COVID-19 mRNA vaccines (PMID 40664645) but does not directly assess the influenza vaccine–GBS association. A 2019 review (PMID 29880241) states that an association between influenza vaccine and GBS has never been proven for most preparations, except the 1976 formulation.
Cited: PMID 34937500 PMID 40664645 PMID 41160817 PMID 29880241
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Negative-control outcomes incidence risk cohort OR self-controlled case series
pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) no association OR null OR no increased risk Negative-control outcomes
pubmed · 88403 hits · run 2026-09-07
4 retrieved record(s)
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
supports_node 41160817 · The New England journal of medicine (2025) — Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025-2026.
ambiguous 29880241 · Vaccine (2019) — Vaccine-preventable diseases, vaccines and Guillain-Barre' syndrome.
B6 · Other-antigen comparisonno_data
Measure: Risk vs a different-antigen comparator
Comparator: Comparator product with a different antigen
Hit rule: Risk specific to the target antigen, not shared with the comparator antigen
Finding: No retrieved evidence directly compares the risk of Guillain-Barré Syndrome following influenza vaccination with a different-antigen comparator (other-antigen comparison). The available studies primarily use self-controlled case series designs without such a comparator, or discuss general associations without antigen-level comparison.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Other-antigen comparison incidence risk cohort OR self-controlled case series
pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) no association OR null OR no increased risk Other-antigen comparison
pubmed · 88165 hits · run 2026-09-07
6 retrieved record(s)
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 30851046 · Biostatistics (Oxford, England) (2020) — ConvSCCS: convolutional self-controlled case series model for lagged adverse event detection.
refutes_node 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
supports_node 41160817 · The New England journal of medicine (2025) — Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025-2026.
ambiguous 29880241 · Vaccine (2019) — Vaccine-preventable diseases, vaccines and Guillain-Barre' syndrome.
does_not_resolve 36803903 · Vaccine (2023) — Vaccinomics: A scoping review.
B7 · Absolute riskno_data
Measure: Per-100k risk in window
Comparator: Absolute incidence per 100k
Hit rule: Absolute risk reported and stable across the window (not an artifact of rarity)
Finding: no evidence found: The retrieved evidence includes a review (PMID 29880241) discussing GBS and influenza vaccine, but it does not report a per-100k absolute risk for GBS in a defined post-vaccination risk window. All other retrieved studies address unrelated outcomes (tinnitus, shingles, breast cancer, heart disease, obesity, vaccinomics) or broader vaccine safety methodology.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Absolute risk incidence risk cohort OR self-controlled case series
pubmed · 946 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) no association OR null OR no increased risk Absolute risk
pubmed · 111437 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 40716143 · Vaccine (2025) — Tinnitus risk after COVID-19 XBB.1.5 vaccination: A self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 40924159 · Clinical infectious diseases : an offici (2025) — Transient Increased Risk of Shingles Post-Shingrix Vaccination: Self-Controlled Case-Series Analysis.
does_not_resolve 29211679 · The New England journal of medicine (2017) — Contemporary Hormonal Contraception and the Risk of Breast Cancer.
supports_node 41160817 · The New England journal of medicine (2025) — Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025-2026.
does_not_resolve 23484825 · The New England journal of medicine (2013) — Risk of ischemic heart disease in women after radiotherapy for breast cancer.
does_not_resolve 26950145 · Nutrients (2016) — An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity.
ambiguous 29880241 · Vaccine (2019) — Vaccine-preventable diseases, vaccines and Guillain-Barre' syndrome.
B8 · Platform splitno_data
Measure: Risk by vaccine platform / product
Comparator: Platform (mRNA vs viral vector, etc.)
Hit rule: Risk attributable to a specific platform, not to 'a vaccine' generally
Finding: The retrieved evidence includes one study (PMID 40664645) that evaluates Guillain-Barré syndrome (GBS) following XBB.1.5-containing COVID-19 mRNA vaccines, not influenza vaccine. No retrieved study directly assesses GBS risk attributable to a specific influenza vaccine platform.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Platform split incidence risk cohort OR self-controlled case series
pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) no association OR null OR no increased risk Platform split
pubmed · 88230 hits · run 2026-09-07
8 retrieved record(s)
does_not_resolve 40716143 · Vaccine (2025) — Tinnitus risk after COVID-19 XBB.1.5 vaccination: A self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 40924159 · Clinical infectious diseases : an offici (2025) — Transient Increased Risk of Shingles Post-Shingrix Vaccination: Self-Controlled Case-Series Analysis.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
supports_node 41160817 · The New England journal of medicine (2025) — Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025-2026.
ambiguous 29880241 · Vaccine (2019) — Vaccine-preventable diseases, vaccines and Guillain-Barre' syndrome.
does_not_resolve 36803903 · Vaccine (2023) — Vaccinomics: A scoping review.
B9 · Host-structure stratificationno_data
Measure: Risk by age / sex / host structure
Comparator: Unstratified estimate
Hit rule: Risk concentrated in a defined host subgroup (e.g. young males), stable across sources
Finding: The retrieved evidence does not provide stratified risk estimates for Guillain-Barré syndrome after influenza vaccination by age, sex, or other host structure factors; PMID 30851046 and 34937500 discuss self-controlled case series methodology for vaccine safety but report no subgroup-specific findings for this outcome, PMID 29880241 notes an association only for the 1976 influenza vaccine, and the remaining PMIDs are unrelated to this specific node.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Host-structure stratification incidence risk cohort OR self-controlled case series
pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) no association OR null OR no increased risk Host-structure stratification
pubmed · 88163 hits · run 2026-09-07
6 retrieved record(s)
does_not_resolve 30851046 · Biostatistics (Oxford, England) (2020) — ConvSCCS: convolutional self-controlled case series model for lagged adverse event detection.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
supports_node 41160817 · The New England journal of medicine (2025) — Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025-2026.
ambiguous 29880241 · Vaccine (2019) — Vaccine-preventable diseases, vaccines and Guillain-Barre' syndrome.
does_not_resolve 36803903 · Vaccine (2023) — Vaccinomics: A scoping review.
does_not_resolve 41325764 · The Lancet. Infectious diseases (2026) — Effectiveness of the maternal RSVpreF vaccine against severe disease in infants in Scotland, UK: a national, population-based case-control study and cohort anal
B10 · Formulation / component changeno_data
Measure: Risk tracks a formulation change
Comparator: Pre- vs post-change formulation
Hit rule: Risk change tracks a documented formulation / component change over time
Finding: The retrieved evidence includes a 2025 self-controlled case series study (PMID 40664645) that assessed Guillain-Barré syndrome following XBB.1.5-containing COVID-19 mRNA vaccines, but no retrieved study addresses risk tracking a documented formulation or component change over time for the influenza vaccine and Guillain-Barré syndrome.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Formulation / component change incidence risk cohort OR self-controlled case series
pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) no association OR null OR no increased risk Formulation / component change
pubmed · 88325 hits · run 2026-09-07
4 retrieved record(s)
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 30851046 · Biostatistics (Oxford, England) (2020) — ConvSCCS: convolutional self-controlled case series model for lagged adverse event detection.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
supports_node 41160817 · The New England journal of medicine (2025) — Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025-2026.
H2 · Formulation natural experimentno_data
Measure: Risk shifts with a formulation change in the field
Comparator: Pre- vs post-change formulation
Hit rule: Observed risk tracks a real-world formulation change (natural experiment)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Formulation natural experiment intervention OR treatment OR reversal
pubmed · 15142392 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Formulation natural experiment no effect intervention
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
1 retrieved record(s)
does_not_resolve 38189107 · Expert review of vaccines (2024) — Neoadjuvant personalized cancer vaccines: the final frontier?
H4 · Policy / pause signalno_data
Measure: Risk signal appears/disappears across a pause or policy change
Comparator: Pre- vs post-pause period
Hit rule: The signal appears or disappears coherently with a rollout / pause (H4)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Policy / pause signal intervention OR treatment OR reversal
pubmed · 15142392 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Policy / pause signal no effect intervention
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
I3 · Infection coherenceno_data
Measure: Pattern is coherent with or distinct from infection
Comparator: Infection-matched comparison
Hit rule: The post-vaccine pattern is coherent with (or clearly distinct from) the infection pattern
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Infection coherence coherence OR latency OR susceptibility
pubmed · 870069 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Infection coherence inconsistent OR contradicts
pubmed · 27612 hits · run 2026-09-07
3 retrieved record(s)
ambiguous 15578364 · Clinical infectious diseases : an offici (2004) — Varicella vaccine for susceptible adults: do it today.
does_not_resolve 19477561 · Vaccine (2009) — Genetic polymorphisms in host response to meningococcal infection: the role of susceptibility and severity genes.
does_not_resolve 2699706 · Annali italiani di chirurgia (1989) — Etiology and risk factors of melanoma.
Mediator &amp; biological gradient 24/24 evaluated24 nodes
C1n · Dose strength gradientno_data
Measure: Risk vs dose strength (dose size)
Comparator: Lower dose strength
Hit rule: Monotonic dose-response in dose strength (larger dose -> higher risk)
Finding: No retrieved evidence addresses a monotonic dose-response in dose strength (larger dose -> higher risk) for Guillain-Barré Syndrome after influenza vaccine; PMID 33137184 compares high-dose vs standard-dose influenza vaccine but reports no statistically significant increased risk and does not assess a monotonic dose-response gradient.
Cited: PMID 33137184
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Dose strength gradient dose-response OR dose effect
pubmed · 1299193 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) no dose effect OR no dose-response Dose strength gradient
pubmed · 129 hits · run 2026-09-07
5 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
ambiguous 32578447 · The Annals of pharmacotherapy (2021) — High-Dose Inactivated Influenza Vaccine Quadrivalent for Older Adults.
does_not_resolve 33373368 · PLoS medicine (2020) — Assessing the risk of ketoacidosis due to sodium-glucose cotransporter (SGLT)-2 inhibitors in patients with type 1 diabetes: A meta-analysis and meta-regression
ambiguous 37788935 · Neurology (2023) — Risk of Guillain-Barré Syndrome Following COVID-19 Vaccines: A Nationwide Self-Controlled Case Series Study.
refutes_node 33137184 · The Journal of infectious diseases (2021) — Guillain-Barré Syndrome After High-Dose Influenza Vaccine Administration in the United States, 2018-2019 Season.
C2n · Dose number gradientno_data
Measure: Risk vs dose number (1st vs 2nd vs 3rd)
Comparator: First dose
Hit rule: Risk increases (or shows a defined pattern) with dose number
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Dose number gradient dose-response OR dose effect
pubmed · 1299193 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) no dose effect OR no dose-response Dose number gradient
pubmed · 573 hits · run 2026-09-07
4 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
ambiguous 32578447 · The Annals of pharmacotherapy (2021) — High-Dose Inactivated Influenza Vaccine Quadrivalent for Older Adults.
does_not_resolve 34703927 · Heliyon (2021) — Development of a protective inactivated vaccine against Crimean-Congo hemorrhagic fever infection.
supports_node 37788935 · Neurology (2023) — Risk of Guillain-Barré Syndrome Following COVID-19 Vaccines: A Nationwide Self-Controlled Case Series Study.
C3n · Measured-exposure tertilesno_data
Measure: Risk vs measured exposure tertile
Comparator: Lowest-exposure tertile
Hit rule: Risk ordered by measured-exposure tertile (high > mid > low)
Finding: No retrieved studies directly measure risk of Guillain-Barré syndrome after influenza vaccine by measured-exposure tertile. The only study mentioning GBS after influenza vaccine (PMID 33137184) uses high-dose vs standard-dose comparison, not exposure tertiles.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Measured-exposure tertiles dose-response OR dose effect
pubmed · 1299193 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) no dose effect OR no dose-response Measured-exposure tertiles
pubmed · 18 hits · run 2026-09-07
11 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 32578447 · The Annals of pharmacotherapy (2021) — High-Dose Inactivated Influenza Vaccine Quadrivalent for Older Adults.
does_not_resolve 37788935 · Neurology (2023) — Risk of Guillain-Barré Syndrome Following COVID-19 Vaccines: A Nationwide Self-Controlled Case Series Study.
refutes_node 33137184 · The Journal of infectious diseases (2021) — Guillain-Barré Syndrome After High-Dose Influenza Vaccine Administration in the United States, 2018-2019 Season.
does_not_resolve 32565346 · Vaccine (2020) — Comparative safety of high-dose versus standard-dose influenza vaccination in patients with end-stage renal disease.
ambiguous 31122853 · Vaccine (2019) — Surveillance for Guillain-Barré syndrome after influenza vaccination among U.S. Medicare beneficiaries during the 2017-2018 season.
does_not_resolve 40845790 · Vaccine (2025) — Safety monitoring of health outcomes following influenza vaccination during the 2023-2024 season among U.S. Commercially-insured individuals aged 6 months throu
ambiguous 31515146 · Vaccine (2019) — Surveillance for Guillain-Barré syndrome after 2015-2016 and 2016-2017 influenza vaccination of Medicare beneficiaries.
C4n · Organoid concentration curveno_data
Measure: Effect vs antigen concentration in organoid
Comparator: Vehicle / zero antigen
Hit rule: Dose-dependent effect across a graded concentration curve
Finding: No retrieved evidence addresses a dose-dependent effect of influenza vaccine antigen concentration in an organoid model on Guillain-Barré Syndrome incidence.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Organoid concentration curve dose-response OR dose effect
pubmed · 1299193 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) no dose effect OR no dose-response Organoid concentration curve
pubmed · 29 hits · run 2026-09-07
8 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
ambiguous 32578447 · The Annals of pharmacotherapy (2021) — High-Dose Inactivated Influenza Vaccine Quadrivalent for Older Adults.
ambiguous 37788935 · Neurology (2023) — Risk of Guillain-Barré Syndrome Following COVID-19 Vaccines: A Nationwide Self-Controlled Case Series Study.
refutes_node 33137184 · The Journal of infectious diseases (2021) — Guillain-Barré Syndrome After High-Dose Influenza Vaccine Administration in the United States, 2018-2019 Season.
ambiguous 40845790 · Vaccine (2025) — Safety monitoring of health outcomes following influenza vaccination during the 2023-2024 season among U.S. Commercially-insured individuals aged 6 months throu
does_not_resolve 32565346 · Vaccine (2020) — Comparative safety of high-dose versus standard-dose influenza vaccination in patients with end-stage renal disease.
refutes_node 31122853 · Vaccine (2019) — Surveillance for Guillain-Barré syndrome after influenza vaccination among U.S. Medicare beneficiaries during the 2017-2018 season.
ambiguous 31515146 · Vaccine (2019) — Surveillance for Guillain-Barré syndrome after 2015-2016 and 2016-2017 influenza vaccination of Medicare beneficiaries.
C5n · EC50 vs Cmax coherenceno_data
Measure: Measured exposure reaches effect threshold
Comparator: Pharmacokinetic Cmax vs EC50
Hit rule: Achieved exposure (Cmax/tissue) plausibly reaches the in-vitro EC50
Finding: No retrieved evidence directly reports measured influenza vaccine exposure concentrations (Cmax/tissue) reaching in-vitro EC50 values for Guillain-Barré syndrome induction; the available studies are epidemiological safety surveillance or immunogenicity reviews, not pharmacokinetic/pharmacodynamic bridging experiments.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) EC50 vs Cmax coherence dose-response OR dose effect
pubmed · 1299193 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) no dose effect OR no dose-response EC50 vs Cmax coherence
pubmed · 18 hits · run 2026-09-07
11 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 32578447 · The Annals of pharmacotherapy (2021) — High-Dose Inactivated Influenza Vaccine Quadrivalent for Older Adults.
ambiguous 37788935 · Neurology (2023) — Risk of Guillain-Barré Syndrome Following COVID-19 Vaccines: A Nationwide Self-Controlled Case Series Study.
refutes_node 33137184 · The Journal of infectious diseases (2021) — Guillain-Barré Syndrome After High-Dose Influenza Vaccine Administration in the United States, 2018-2019 Season.
ambiguous 40845790 · Vaccine (2025) — Safety monitoring of health outcomes following influenza vaccination during the 2023-2024 season among U.S. Commercially-insured individuals aged 6 months throu
does_not_resolve 32565346 · Vaccine (2020) — Comparative safety of high-dose versus standard-dose influenza vaccination in patients with end-stage renal disease.
does_not_resolve 31122853 · Vaccine (2019) — Surveillance for Guillain-Barré syndrome after influenza vaccination among U.S. Medicare beneficiaries during the 2017-2018 season.
ambiguous 31515146 · Vaccine (2019) — Surveillance for Guillain-Barré syndrome after 2015-2016 and 2016-2017 influenza vaccination of Medicare beneficiaries.
E1 · Mediator identified in casesno_data
Measure: Mediator present in affected tissue/cells
Comparator: Unaffected tissue / control
Hit rule: The hypothesized mediator is detected in the affected compartment and not (or less) in control
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) mechanism Mediator identified in cases in vitro OR patient-derived
pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Mediator identified in cases not associated mechanism
pubmed · 1 hits · run 2026-09-07
E2 · Mediator in healthy vaccineesno_data
Measure: Mediator detectable after vaccination
Comparator: Pre-vaccination baseline
Hit rule: Mediator appears after vaccination and tracks the exposure window
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) mechanism Mediator in healthy vaccinees in vitro OR patient-derived
pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Mediator in healthy vaccinees not associated mechanism
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E3 · Infection contrastno_data
Measure: Mediator absent/low after natural infection
Comparator: Recovered natural infection
Hit rule: Mediator signal is specific to vaccination vs a comparable natural-infection control
Finding: The retrieved evidence does not include a comparator with natural influenza infection; the studies assess GBS risk after vaccination versus control periods or other vaccines, but not a natural-infection contrast. No mediator signal specific to vaccination versus natural infection is reported.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) mechanism Infection contrast in vitro OR patient-derived
pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Infection contrast not associated mechanism
pubmed · 6 hits · run 2026-09-07
4 retrieved record(s)
ambiguous 42198362 · Pharmaceuticals (Basel, Switzerland) (2026) — Disproportionality Analysis and Timing of Drug-Associated Guillain-Barré Syndrome Onset Based on the Japanese Adverse Drug Event Report Database.
refutes_node 32098853 · Neurology (2020) — Seasonal influenza vaccine and Guillain-Barré syndrome: A self-controlled case series study.
refutes_node 19033158 · American journal of epidemiology (2009) — Investigation of the temporal association of Guillain-Barre syndrome with influenza vaccine and influenzalike illness using the United Kingdom General Practice
supports_node 23209624 · PloS one (2012) — Ontology-based combinatorial comparative analysis of adverse events associated with killed and live influenza vaccines.
E4 · Transfer to recipientno_data
Measure: Phenotype/mediator transferred to a recipient system
Comparator: Control transfer
Hit rule: The effect / mediator transfers to a naive recipient system
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) mechanism Transfer to recipient in vitro OR patient-derived
pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Transfer to recipient not associated mechanism
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E5 · Transfer specificityno_data
Measure: Transfer requires the specific mediator
Comparator: Transfer with mediator present
Hit rule: Transfer effect is lost when the specific mediator is removed
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) mechanism Transfer specificity in vitro OR patient-derived
pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Transfer specificity not associated mechanism
pubmed · 1 hits · run 2026-09-07
E6 · Depletion / knockdownno_data
Measure: Removing the mediator reduces the effect
Comparator: Non-targeted knockdown
Hit rule: Knockdown / depletion of the mediator reduces the phenotype
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) mechanism Depletion / knockdown in vitro OR patient-derived
pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Depletion / knockdown not associated mechanism
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E7 · Add-back rescueno_data
Measure: Adding the mediator restores the effect
Comparator: Add-back of a control protein
Hit rule: Adding back the mediator (not a control) restores the phenotype
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) mechanism Add-back rescue in vitro OR patient-derived
pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Add-back rescue not associated mechanism
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E8 · Neutralizationno_data
Measure: Neutralizing the mediator blocks the effect
Comparator: Isotype control
Hit rule: Neutralization of the mediator (not an isotype control) blocks the phenotype
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) mechanism Neutralization in vitro OR patient-derived
pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Neutralization not associated mechanism
pubmed · 5 hits · run 2026-09-07
2 retrieved record(s)
does_not_resolve 29298885 · Journal of virology (2018) — Recombinant Chimpanzee Adenovirus Vaccine AdC7-M/E Protects against Zika Virus Infection and Testis Damage.
does_not_resolve 29555345 · Microbes and infection (2018) — Rapid response to an emerging infectious disease - Lessons learned from development of a synthetic DNA vaccine targeting Zika virus.
E9 · Isotype controlno_data
Measure: Isotype control does not reproduce the effect
Comparator: Active antibody
Hit rule: An isotype control fails to reproduce the block/activation
Finding: A single case report describes chronic inflammatory demyelinating polyneuropathy (CIDP) after influenza vaccine, which is a related but distinct condition from Guillain-Barré syndrome (GBS); no evidence is provided regarding an isotype control experiment or its failure to reproduce an effect.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) mechanism Isotype control in vitro OR patient-derived
pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Isotype control not associated mechanism
pubmed · 2 hits · run 2026-09-07
1 retrieved record(s)
ambiguous 17993473 · Age and ageing (2008) — Post-influenza vaccine chronic inflammatory demyelinating polyneuropathy.
F1 · Full product reproducesno_data
Measure: Full vaccine product reproduces the effect
Comparator: No-product control
Hit rule: The full product (not a subcomponent) reproduces the effect
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Full product reproduces component OR antigen OR vector
pubmed · 2045311 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Full product reproduces no effect component isolation
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
7 retrieved record(s)
does_not_resolve 34816398 · Methods in molecular biology (Clifton, N (2022) — Avian Paramyxoviruses as Vectors for Vaccine Development.
does_not_resolve 31300111 · Comparative immunology, microbiology and (2019) — Construction of recombinant capripoxviruses as vaccine vectors for delivering foreign antigens: Methodology and application.
does_not_resolve 42172979 · Virology (2026) — Towards the development of a mucosal vectored vaccine against enterovirus D68.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 23707160 · Vaccine (2013) — Prospects for oral replicating adenovirus-vectored vaccines.
does_not_resolve 15853721 · Current HIV research (2005) — Non-replicating viral vector-based AIDS vaccines: interplay between viral vectors and the immune system.
does_not_resolve 22683663 · Vaccine (2012) — Malaria vaccines: focus on adenovirus based vectors.
F2 · Empty vector / particleno_data
Measure: Vector/particle without antigen reproduces (or not)
Comparator: Full product
Hit rule: Effect attributed to (or excluded from) the vector/particle backbone alone
Finding: No retrieved evidence discusses Guillain-Barré Syndrome or any adverse event attributed to an empty vector or particle backbone of an influenza vaccine.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Empty vector / particle component OR antigen OR vector
pubmed · 2045311 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Empty vector / particle no effect component isolation
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
8 retrieved record(s)
does_not_resolve 30917500 · Viruses (2019) — Innovation in Newcastle Disease Virus Vectored Avian Influenza Vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 16914237 · Vaccine (2007) — Viral vectors for malaria vaccine development.
does_not_resolve 33640142 · Vaccine (2022) — Biosecurity risks associated with vaccine platform technologies.
does_not_resolve 34816398 · Methods in molecular biology (Clifton, N (2022) — Avian Paramyxoviruses as Vectors for Vaccine Development.
does_not_resolve 15174971 · Expert opinion on biological therapy (2004) — Particle-mediated DNA vaccine delivery to the skin.
does_not_resolve 29550258 · Immunology letters (2018) — Live bacterial vaccine vector and delivery strategies of heterologous antigen: A review.
does_not_resolve 31300111 · Comparative immunology, microbiology and (2019) — Construction of recombinant capripoxviruses as vaccine vectors for delivering foreign antigens: Methodology and application.
F3 · Antigen alone reproducesno_data
Measure: Isolated antigen reproduces the effect
Comparator: Vehicle
Hit rule: The isolated antigen (not the full product) reproduces the effect
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Antigen alone reproduces component OR antigen OR vector
pubmed · 2045311 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Antigen alone reproduces no effect component isolation
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
8 retrieved record(s)
does_not_resolve 20218334 · Uirusu (2009) — [Measles vaccine].
does_not_resolve 30917500 · Viruses (2019) — Innovation in Newcastle Disease Virus Vectored Avian Influenza Vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 16914237 · Vaccine (2007) — Viral vectors for malaria vaccine development.
does_not_resolve 33640142 · Vaccine (2022) — Biosecurity risks associated with vaccine platform technologies.
does_not_resolve 34816398 · Methods in molecular biology (Clifton, N (2022) — Avian Paramyxoviruses as Vectors for Vaccine Development.
does_not_resolve 15174971 · Expert opinion on biological therapy (2004) — Particle-mediated DNA vaccine delivery to the skin.
does_not_resolve 29550258 · Immunology letters (2018) — Live bacterial vaccine vector and delivery strategies of heterologous antigen: A review.
F4 · Irrelevant cargono_data
Measure: Irrelevant cargo does not reproduce the effect
Comparator: Vector with the target antigen
Hit rule: Irrelevant cargo fails to reproduce the effect (specificity)
Finding: The retrieved evidence contains no mention of Guillain-Barré Syndrome or any adverse event related to influenza vaccine or its irrelevant cargo; it discusses development and vector technologies for measles, avian influenza, rabies, malaria, and other vaccines, but none address the specified node.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Irrelevant cargo component OR antigen OR vector
pubmed · 2045311 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Irrelevant cargo no effect component isolation
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
8 retrieved record(s)
does_not_resolve 20218334 · Uirusu (2009) — [Measles vaccine].
does_not_resolve 30917500 · Viruses (2019) — Innovation in Newcastle Disease Virus Vectored Avian Influenza Vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 16914237 · Vaccine (2007) — Viral vectors for malaria vaccine development.
does_not_resolve 33640142 · Vaccine (2022) — Biosecurity risks associated with vaccine platform technologies.
does_not_resolve 34816398 · Methods in molecular biology (Clifton, N (2022) — Avian Paramyxoviruses as Vectors for Vaccine Development.
does_not_resolve 15174971 · Expert opinion on biological therapy (2004) — Particle-mediated DNA vaccine delivery to the skin.
does_not_resolve 29550258 · Immunology letters (2018) — Live bacterial vaccine vector and delivery strategies of heterologous antigen: A review.
F5 · Infection preparationno_data
Measure: Infection preparation vs product comparison
Comparator: Product-derived preparation
Hit rule: Effect compares correctly between infection and product preparations
Finding: The retrieved evidence discusses vaccine vector development for measles, avian paramyxoviruses, and live bacterial vaccines, but contains no mention of Guillain-Barré Syndrome, influenza vaccine, or immune-mediated adverse events relevant to infection preparation comparisons.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Infection preparation component OR antigen OR vector
pubmed · 2045311 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Infection preparation no effect component isolation
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
3 retrieved record(s)
does_not_resolve 20218334 · Uirusu (2009) — [Measles vaccine].
does_not_resolve 34816398 · Methods in molecular biology (Clifton, N (2022) — Avian Paramyxoviruses as Vectors for Vaccine Development.
does_not_resolve 29550258 · Immunology letters (2018) — Live bacterial vaccine vector and delivery strategies of heterologous antigen: A review.
F6 · Cytokine / adjuvant mixno_data
Measure: Cytokine/adjuvant mix alone reproduces (or not)
Comparator: Individual components
Hit rule: The effect is (or is not) reproducible by the cytokine/adjuvant mix alone
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Cytokine / adjuvant mix component OR antigen OR vector
pubmed · 2045311 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Cytokine / adjuvant mix no effect component isolation
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
2 retrieved record(s)
does_not_resolve 20218334 · Uirusu (2009) — [Measles vaccine].
does_not_resolve 34816398 · Methods in molecular biology (Clifton, N (2022) — Avian Paramyxoviruses as Vectors for Vaccine Development.
F7 · Component combinationno_data
Measure: Defined component combination reproduces the effect
Comparator: Single components
Hit rule: A defined combination reproduces the effect that single components do not
Finding: No retrieved evidence addresses a defined component combination of influenza vaccine reproducing Guillain-Barré Syndrome that single components do not; the retrieved literature discusses measles vaccine strains, avian paramyxovirus vectors, capripoxvirus vectors, and NDV-based enterovirus D68 vaccine development, none of which involve influenza vaccine or GBS.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Component combination component OR antigen OR vector
pubmed · 2045311 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Component combination no effect component isolation
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
5 retrieved record(s)
does_not_resolve 20218334 · Uirusu (2009) — [Measles vaccine].
does_not_resolve 34816398 · Methods in molecular biology (Clifton, N (2022) — Avian Paramyxoviruses as Vectors for Vaccine Development.
does_not_resolve 31300111 · Comparative immunology, microbiology and (2019) — Construction of recombinant capripoxviruses as vaccine vectors for delivering foreign antigens: Methodology and application.
does_not_resolve 42172979 · Virology (2026) — Towards the development of a mucosal vectored vaccine against enterovirus D68.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
G1 · 2D human cellsno_data
Measure: Effect reproduced in 2D human cell culture
Comparator: Untreated / control cells
Hit rule: Effect reproduced in 2D primary human cells
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) 2D human cells animal OR organoid OR cell model
pubmed · 1818663 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) 2D human cells not reproduced model
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G2 · Organoid / chipno_data
Measure: Effect reproduced in organoid / organ-on-chip
Comparator: Unexposed organoid
Hit rule: Effect reproduced in a 3D organoid / organ-on-chip system
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Organoid / chip animal OR organoid OR cell model
pubmed · 1818663 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Organoid / chip not reproduced model
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
H1 · Block in vitro / in vivono_data
Measure: Blocking the mediator/mechanism prevents the effect
Comparator: Control intervention
Hit rule: Blocking the mechanism prevents or reverses the effect (not with a control intervention)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Block in vitro / in vivo intervention OR treatment OR reversal
pubmed · 15142392 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Block in vitro / in vivo no effect intervention
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
1 retrieved record(s)
does_not_resolve 38189107 · Expert review of vaccines (2024) — Neoadjuvant personalized cancer vaccines: the final frontier?
Clinical / animal / host 7/7 evaluated7 nodes
E10 · Host-line dependenceno_data
Measure: Effect depends on host line/cell type
Comparator: Susceptible host line
Hit rule: Effect is restricted to a defined host line / genotype, not universal
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) mechanism Host-line dependence in vitro OR patient-derived
pubmed · 29244 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Host-line dependence not associated mechanism
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G3 · Animal, clinical routeno_data
Measure: Effect in animal via the clinical route of administration
Comparator: Vehicle, same route
Hit rule: Effect reproduced in an animal using the clinical route of administration
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Animal, clinical route animal OR organoid OR cell model
pubmed · 1818663 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Animal, clinical route not reproduced model
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G4 · Susceptible animalmixed
Measure: Effect in a susceptible animal model
Comparator: Non-susceptible model
Hit rule: Effect in a defined susceptible animal model
Finding: The 1976 swine flu vaccine was associated with GBS and induced anti-ganglioside antibodies in susceptible animal models, but subsequent influenza vaccines have not shown a proven association with GBS, and no defined susceptible animal model evidence for current influenza vaccines is reported.
Cited: PMID 29880241 PMID 18522505
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Susceptible animal animal OR organoid OR cell model
pubmed · 1818665 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Susceptible animal not reproduced model
pubmed · 2 hits · run 2026-09-07
2 retrieved record(s)
supports_node 29880241 · Vaccine (2019) — Vaccine-preventable diseases, vaccines and Guillain-Barre' syndrome.
ambiguous 18522505 · The Journal of infectious diseases (2008) — Anti-ganglioside antibody induction by swine (A/NJ/1976/H1N1) and other influenza vaccines: insights into vaccine-associated Guillain-Barré syndrome.
G5 · Replication across labsno_data
Measure: Effect replicated in an independent lab
Comparator: Original result
Hit rule: The key effect is replicated in an independent laboratory
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Replication across labs animal OR organoid OR cell model
pubmed · 1818663 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Replication across labs not reproduced model
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G6 · Blinded scoringno_data
Measure: Outcomes scored blinded
Comparator: Unblinded reference
Hit rule: Primary outcomes scored by a blinded assessor
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Blinded scoring animal OR organoid OR cell model
pubmed · 1818663 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Blinded scoring not reproduced model
pubmed · 0 hits (0 hits — negative) · run 2026-09-07
G7 · Experimental time courseno_data
Measure: Effect follows a defined experimental time course
Comparator: No-exposure time course
Hit rule: The effect's onset/offset follows a defined experimental time course
Finding: The retrieved evidence describes a preclinical murine model of a combined influenza and Group B Streptococcus vaccine and does not report any experimental time course data on Guillain-Barré Syndrome onset or offset following influenza vaccination in humans.
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Experimental time course animal OR organoid OR cell model
pubmed · 1818664 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Experimental time course not reproduced model
pubmed · 1 hits · run 2026-09-07
1 retrieved record(s)
does_not_resolve 31237893 · PloS one (2019) — Mucosal vaccine based on attenuated influenza virus and the group B Streptococcus recombinant peptides protected mice from influenza and S. pneumoniae infection
I4 · Susceptibility traitno_data
Measure: A host trait / marker defines susceptibility
Comparator: Trait-negative hosts
Hit rule: A defined host trait / marker enriches for susceptibility
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Susceptibility trait coherence OR latency OR susceptibility
pubmed · 870068 hits · run 2026-09-07
mirror: Influenza (flu) vaccine ("Guillain-Barre" OR "Guillain Barre" OR GBS OR polyradiculoneuropathy) Susceptibility trait inconsistent OR contradicts
pubmed · 27612 hits · run 2026-09-07

How this was built

Per node: a supporting and a mirror PubMed query built from the node's measure / population / comparator / hit_rule; top hits fetched (title + abstract); each record classified (supports / refutes / ambiguous) by xAI with a heuristic fallback; a per-node synthesis is generated strictly from the retrieved PMIDs; the node status is then rolled up to C1–C6. Full query provenance is shown per node above. Data: data/evidence_run/state.json.