Evidence dossier · candidate cand-influenza-laryngospasm · VICP program · · DRAFT — not a determination
This is a draft research-tracking dossier, not a determination that Influenza (flu) vaccine causes Laryngospasm, and not an incidence or legal finding. All evidence is flagged needs_human_review and must be reviewed before any page is published or cited. Every value is grounded in retrieved citations (PMID + retrieval date); unsourced items read "no evidence found / not assessable". Symmetric search: every supporting query has a mirror/null query, and zeros are shown (negative dossiers report the absence of signal).
Claim matrix (C1–C6, computed)
Claim
Label
Status
Missing nodes
C1
Coherent clinical object exists
insufficient_data
missing: A1 A2
C2
Consistent temporal window
insufficient_data
missing: A5
C3
Epidemiologic excess risk
insufficient_data
missing: B1 B2 B3
C4
Consistency / replication
insufficient_data
missing: B5 B6
C5
Specificity (product / dose)
insufficient_data
missing: C1n C2n
C6
Biological mechanism
insufficient_data
missing: E1
Two evidentiary bars apply to the epi nodes/claims (C3, C4): · VICP — preponderance of the evidence. · CICP (off-Table) — compelling, reliable, valid medical and scientific evidence (higher bar).
Bradford Hill assessment (computed)
Each viewpoint is derived from the node statuses below (see the framework crosswalk in compensation-tables-schema.md §8). Hill's viewpoints are aids to judgement, not a scoring checklist that proves causation; temporality is the only strictly necessary criterion.
Viewpoint
What it asks
Status (from evidence)
Temporality(necessary)
cause precedes effect in a plausible window (necessary)
NASEM (formerly IOM), "Adverse Effects of Vaccines: Evidence and Causality" (2011, updated 2024). Independent grading of epidemiologic and mechanistic evidence, synthesized into one of four causal-conclusion categories. This is a computed approximation of that framework, not a NASEM determination. See compensation-tables-schema.md §8bis.
Case-definition standard: no established case definition (needs_human_review — not in spec §1's named-standard list) — governs the case-certainty scale on A1/A2/A6/A8 below. See compensation-tables-schema.md §8ter.
Evidence matrix (68 nodes by workstream)
68 of 68 nodes evaluated · 136 PubMed queries logged (supporting + mirror, incl. zeros). Statuses are computed from retrieved citations; not hand-set.
Definition & attribution 24/24 evaluated
A1 · Case reportsno_data
Measure: New definite object in risk window T Comparator: Pre-vaccination baseline Hit rule: Definite object present, onset in window, competing causes considered
Finding: No retrieved evidence discusses laryngospasm after influenza vaccination. The retrieved studies address COVID-19 vaccine myositis, myocarditis, HPV vaccines, VITT, social media analysis, monkeypox vaccine stigma, pericarditis, poliomyelitis, and general vaccination adverse events, none of which mention laryngospasm or influenza vaccine.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm case report OR case series Case reports pubmed · 66173 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-07
9 retrieved record(s)
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 41092067 · JMIR formative research (2025) — Evaluating Large Language Models for Sentiment Analysis and Hesitancy Analysis on Vaccine Posts From Social Media: Qualitative Study.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
does_not_resolve 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A2 · Series with objective confirmationno_data
Measure: Definite object plus objective test Comparator: Reference range / diagnostic criteria Hit rule: Objective confirmation in >=1 case per the working definition
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm case report OR case series Series with objective confirmation pubmed · 5643 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-07
9 retrieved record(s)
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
Measure: Distribution of onset times after dose Comparator: Pre-specified risk window Hit rule: Onset clusters inside the pre-specified window (not uniform/flat)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm case report OR case series Onset histogram pubmed · 2 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
Measure: Onset latency vs object pathophysiology Comparator: Object's known natural latency Hit rule: Onset latency consistent with the object's pathophysiology
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm case report OR case series Temporal plausibility pubmed · 31 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-07
10 retrieved record(s)
does_not_resolve 15638050 · Clinical and experimental rheumatology (2004) — A case-series of adverse events, positive re-challenge of symptoms, and events in identical twins following hepatitis B vaccination: analysis of the Vaccine Adv
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
ambiguous 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A5 · Onset-interval documentationno_data
Measure: Onset interval documented in source Comparator: Dose date Hit rule: Onset interval is recorded (not imputed) in a primary source
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm case report OR case series Onset-interval documentation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-07
9 retrieved record(s)
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
Measure: Competing causes assessed and excluded Comparator: Likely alternative diagnoses Hit rule: Pre-specified competing causes ruled out per the working definition
Finding: Retrieved evidence contains no reports or studies linking influenza vaccine specifically to laryngospasm, nor any mention of laryngospasm as an adverse event following influenza vaccination.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm case report OR case series Differential diagnosis excluded pubmed · 427 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-07
9 retrieved record(s)
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 41092067 · JMIR formative research (2025) — Evaluating Large Language Models for Sentiment Analysis and Hesitancy Analysis on Vaccine Posts From Social Media: Qualitative Study.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
does_not_resolve 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A7 · Rechallenge / re-exposureno_data
Measure: Object recurs on a further dose Comparator: First-dose response Hit rule: Object recurs after a subsequent dose (re-exposure)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm case report OR case series Rechallenge / re-exposure pubmed · 2 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 41092067 · JMIR formative research (2025) — Evaluating Large Language Models for Sentiment Analysis and Hesitancy Analysis on Vaccine Posts From Social Media: Qualitative Study.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
does_not_resolve 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A8 · Adjudicated by criteria (no established case definition)no_data
Measure: Object adjudicated by published criteria Comparator: Published clinical / Brighton criteria Hit rule: Cases adjudicated to 'definite' by a published criterion set
Finding: no evidence found
Case-certainty distribution (no established case definition): 1 Possible/unclassifiable. Transparency layer — does not change this node's status or feed C1–C6.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm case report OR case series Adjudicated by criteria pubmed · 39 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-07
9 retrieved record(s)
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
Measure: Course matches the object's natural history Comparator: Known natural history of the object Hit rule: Clinical course (onset, peak, recovery) matches the object's natural history
Finding: No retrieved evidence addresses laryngospasm after influenza vaccine; all retrieved studies focus on COVID-19, HPV, monkeypox, polio, or rubella vaccines, or general pediatric vaccine reactions.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm case report OR case series Natural-history consistency pubmed · 103 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
Measure: Not attributable to a co-occurring condition Comparator: Co-occurring illness that could produce the object Hit rule: Object not better explained by a co-occurring condition (infection, etc.)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm case report OR case series No confounding object pubmed · 19 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-07
10 retrieved record(s)
does_not_resolve 34312836 · Clinical pharmacology and therapeutics (2022) — Angiotensin-Converting Enzyme Inhibitors Used Concomitantly with Insulin Secretagogues and the Risk of Serious Hypoglycemia.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 41092067 · JMIR formative research (2025) — Evaluating Large Language Models for Sentiment Analysis and Hesitancy Analysis on Vaccine Posts From Social Media: Qualitative Study.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
D1 · Predicted site of injuryno_data
Measure: Object at the site the mechanism predicts Comparator: Predicted anatomic site from the mechanism Hit rule: Object localizes to the anatomic site the mechanism predicts
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm anatomic localization Predicted site of injury mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm Predicted site of injury not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D2 · Spared structuresno_data
Measure: Structures the mechanism should spare are spared Comparator: Structures predicted unaffected Hit rule: Structures predicted spared by the mechanism are indeed spared
mirror: Influenza (flu) vaccine Laryngospasm Spared structures not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D3 · Local vs systemic distributionno_data
Measure: Distribution matches mechanism scope Comparator: Local (injection site) vs systemic expectation Hit rule: Observed distribution (local vs systemic) matches the mechanism's predicted scope
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm anatomic localization Local vs systemic distribution mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm Local vs systemic distribution not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D4 · Kinetics classno_data
Measure: Onset/offset kinetics match the mechanism Comparator: Expected kinetic class (acute vs chronic) Hit rule: Onset and offset kinetics are in the class the mechanism predicts
mirror: Influenza (flu) vaccine Laryngospasm Kinetics class not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
D5 · Platform-mechanism matchno_data
Measure: Mechanism is consistent with the platform Comparator: Mechanistic expectation for the platform Hit rule: The proposed mechanism is biologically consistent with the vaccine platform
mirror: Influenza (flu) vaccine Laryngospasm Platform-mechanism match not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
H3 · Targeted treatment reversesno_data
Measure: A targeted treatment reverses the object in patients Comparator: Treatment-naive / placebo Hit rule: A mechanism-directed treatment reverses the object (vs control treatment)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Targeted treatment reverses intervention OR treatment OR reversal pubmed · 15145596 hits · run 2026-09-09
does_not_resolve 38189107 · Expert review of vaccines (2024) — Neoadjuvant personalized cancer vaccines: the final frontier?
I1 · No internal contradictionno_data
Measure: No node's finding contradicts another Comparator: Internal consistency across nodes Hit rule: No evaluated node directly contradicts another (coherence)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm No internal contradiction coherence OR latency OR susceptibility pubmed · 870319 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm No internal contradiction inconsistent OR contradicts pubmed · 27616 hits · run 2026-09-09
I2 · Analogy to a known objectno_data
Measure: Object analogous to a well-established analog Comparator: Established analog's profile Hit rule: The object's profile matches a well-established analog on key features
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Analogy to a known object coherence OR latency OR susceptibility pubmed · 870319 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Analogy to a known object inconsistent OR contradicts pubmed · 27616 hits · run 2026-09-09
I5 · Latency coherenceno_data
Measure: Observed latency matches the mechanism's latency Comparator: Mechanism-predicted latency Hit rule: Observed onset latency is coherent with the mechanism's predicted latency
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Latency coherence coherence OR latency OR susceptibility pubmed · 870319 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Latency coherence inconsistent OR contradicts pubmed · 27616 hits · run 2026-09-09
J1 · Pre-specificationno_data
Measure: Window/hit-rule pre-specified before data Comparator: Pre-specified vs post-hoc Hit rule: The risk window, object, and hit rule were pre-specified before data were seen
Finding: No evidence was retrieved that directly addresses a pre-specified risk window or hit rule for laryngospasm following influenza vaccination; the retrieved studies focus on AI-based adjudication of immune-related adverse events and major adverse cardiovascular events, not on laryngospasm or influenza vaccine.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Pre-specification pre-specified OR adjudicated pubmed · 13561 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Pre-specification post-hoc OR hypothesis-generating only pubmed · 1712 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
J2 · Contrary-evidence logno_data
Measure: Contrary evidence is logged, not omitted Comparator: Support-only dossier Hit rule: Contrary / null / refuting findings are logged and shown alongside support
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Contrary-evidence log pre-specified OR adjudicated pubmed · 13561 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Contrary-evidence log post-hoc OR hypothesis-generating only pubmed · 1712 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
J3 · No temporality-only claimno_data
Measure: Claim not based on temporality alone Comparator: Sequence-only evidence Hit rule: The claim is not supported by temporal sequence alone (independent evidence exists)
Finding: The retrieved evidence discusses the use of large language models to identify immune-related adverse events from immune checkpoint inhibitors and AI-based adjudication of major adverse cardiovascular events in clinical trials, but does not address laryngospasm following influenza vaccination.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm No temporality-only claim pre-specified OR adjudicated pubmed · 13561 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm No temporality-only claim post-hoc OR hypothesis-generating only pubmed · 1712 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
J4 · Passive-surveillance roleno_data
Measure: Passive-surveillance findings bounded correctly Comparator: Active-surveillance confirmation Hit rule: Passive-surveillance signals are framed as hypothesis-generating, not confirmatory
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Passive-surveillance role pre-specified OR adjudicated pubmed · 13561 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Passive-surveillance role post-hoc OR hypothesis-generating only pubmed · 1712 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
J5 · Dose mappingno_data
Measure: Dose/lot exposure mapped to the object Comparator: Unmapped exposure Hit rule: Dose / lot exposure is mapped to the object where the mechanism predicts it
Finding: The retrieved evidence describes the use of large language models and artificial intelligence to identify immune-related adverse events from immune checkpoint inhibitors and to adjudicate major adverse cardiovascular events, respectively; neither study mentions influenza vaccine, laryngospasm, dose/lot exposure mapping, or any relevant evidence for this node.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Dose mapping pre-specified OR adjudicated pubmed · 13561 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Dose mapping post-hoc OR hypothesis-generating only pubmed · 1712 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
Epidemiologic chassis 13/13 evaluated
B1 · Excess vs baselineno_data
Measure: RR/IRR vs unexposed or prior window Comparator: Unvaccinated person-time or pre-vaccination window Hit rule: RR/IRR > 1 with CI excluding 1 after pre-specified confounders
Finding: No retrieved evidence directly examines the association between influenza vaccine and laryngospasm. The studies retrieved focus on other vaccines (rotavirus, COVID-19, shingles) or unrelated clinical topics (diabetes, NAFLD, sleep apnea).
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Excess vs baseline incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm no association OR null OR no increased risk Excess vs baseline pubmed · 88474 hits · run 2026-09-07
8 retrieved record(s)
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34672967 · Lancet (London, England) (2021) — Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, pha
does_not_resolve 34489307 · Gut (2022) — Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: results from a nationwide histology cohort.
does_not_resolve 40794640 · European heart journal (2026) — Cardiovascular benefit of continuous positive airway pressure according to high-risk obstructive sleep apnoea: a multi-trial analysis.
B2 · SCCSno_data
Measure: Self-controlled case series risk ratio Comparator: Individuals' own risk intervals (no-event) Hit rule: SCCS risk ratio > 1 in the post-vaccination window, CI excluding 1
Finding: No retrieved evidence directly addresses the association between influenza vaccine and laryngospasm. The retrieved studies cover shingles post-Shingrix vaccination, rotavirus vaccine safety, COVID-19 vaccine safety, arrhythmias post-COVID-19, Guillain-Barré syndrome after influenza vaccine, aluminum's metalloestrogenic effect, and rurality and heart failure, but none report on laryngospasm as an outcome.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm SCCS incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm no association OR null OR no increased risk SCCS pubmed · 88582 hits · run 2026-09-07
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 32098853 · Neurology (2020) — Seasonal influenza vaccine and Guillain-Barré syndrome: A self-controlled case series study.
does_not_resolve 39795956 · International journal of molecular scien (2024) — The Potential Metalloestrogenic Effect of Aluminum on Breast Cancer Risk for Antiperspirant Users.
does_not_resolve 36696094 · JAMA cardiology (2023) — Association of Rurality With Risk of Heart Failure.
B3 · Cohort / risk-intervalno_data
Measure: Incidence rate ratio in defined window Comparator: Pre-specified risk vs comparison interval Hit rule: IRR > 1 in the pre-specified window, CI excluding 1, stratified by age/sex
Finding: The retrieved evidence provides no direct study evaluating the incidence rate ratio (IRR) for laryngospasm specifically after influenza vaccination using a cohort or risk-interval design. The cited studies address other vaccines, other outcomes, or methodological reviews, but none report data for the pair 'influenza vaccine -> laryngospasm'.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Cohort / risk-interval incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm no association OR null OR no increased risk Cohort / risk-interval pubmed · 88083 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 32098853 · Neurology (2020) — Seasonal influenza vaccine and Guillain-Barré syndrome: A self-controlled case series study.
does_not_resolve 41284649 · PloS one (2025) — Risk of neurologic or immune-mediated adverse events after COVID-19 diagnosis in the United States.
does_not_resolve 32568572 · Annals of internal medicine (2020) — Risk for Subdeltoid Bursitis After Influenza Vaccination: A Population-Based Cohort Study.
B4 · Meta-analysis / poolingno_data
Measure: Pooled effect across studies Comparator: Pooled estimate with heterogeneity Hit rule: Pooled estimate > 1 (or < 1) with quantified heterogeneity (I2)
Finding: No retrieved evidence addresses a pooled estimate with quantified heterogeneity for an association between influenza vaccine and laryngospasm. The retrieved studies focus on other vaccines (Shingrix, rotavirus, COVID-19, RZV) or non-vaccine risk factors (shingles, mobile phones, falls, stroke, diabetes, GSTT1), and none report meta-analyses or pooled effect sizes for influenza vaccine and laryngospasm.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Meta-analysis / pooling incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm no association OR null OR no increased risk Meta-analysis / pooling pubmed · 111921 hits · run 2026-09-07
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 29402646 · Journal of the American Medical Director (2018) — Fall-Risk-Increasing Drugs: A Systematic Review and Meta-analysis: III. Others.
does_not_resolve 28230042 · Journal of cancer research and therapeut (2016) — Meta-analysis of association between mobile phone use and glioma risk.
does_not_resolve 28270112 · BMC infectious diseases (2017) — A meta-analysis of stroke risk following herpes zoster infection.
B5 · Negative-control outcomesno_data
Measure: No excess for outcomes the vaccine should not cause Comparator: Negative-control outcomes (unaffected by mechanism) Hit rule: Null for negative-control outcomes while target outcome is positive (specificity)
Finding: The retrieved evidence describes self-controlled case series (SCCS) study designs and analyses for various vaccine-outcome pairs (e.g., rotavirus vaccine and intussusception, COVID-19 mRNA vaccines and adverse events, influenza vaccine and Guillain-Barré syndrome, shingles vaccine and shingles) but does not provide any data, analysis, or mention of laryngospasm following influenza vaccination.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Negative-control outcomes incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm no association OR null OR no increased risk Negative-control outcomes pubmed · 88285 hits · run 2026-09-07
7 retrieved record(s)
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 32098853 · Neurology (2020) — Seasonal influenza vaccine and Guillain-Barré syndrome: A self-controlled case series study.
does_not_resolve 38833248 · JAMA network open (2024) — Valproate Use During Spermatogenesis and Risk to Offspring.
B6 · Other-antigen comparisonno_data
Measure: Risk vs a different-antigen comparator Comparator: Comparator product with a different antigen Hit rule: Risk specific to the target antigen, not shared with the comparator antigen
Finding: The retrieved evidence includes studies on self-controlled case series designs and various vaccine safety topics, but none address laryngospasm following influenza vaccination or compare risk across different antigens.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Other-antigen comparison incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm no association OR null OR no increased risk Other-antigen comparison pubmed · 88047 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 32098853 · Neurology (2020) — Seasonal influenza vaccine and Guillain-Barré syndrome: A self-controlled case series study.
does_not_resolve 23296494 · Molecular biology reports (2013) — Assessment of the association between GSTM1 null genotype and risk of type 2 diabetes.
does_not_resolve 23949879 · Tumour biology : the journal of the Inte (2014) — Meta-analysis of the association between GSTT1 null genotype and risk of nasopharyngeal carcinoma in Chinese.
B7 · Absolute riskno_data
Measure: Per-100k risk in window Comparator: Absolute incidence per 100k Hit rule: Absolute risk reported and stable across the window (not an artifact of rarity)
Finding: No evidence found for an association between influenza vaccine and laryngospasm.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Absolute risk incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm no association OR null OR no increased risk Absolute risk pubmed · 111321 hits · run 2026-09-07
11 retrieved record(s)
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 29211679 · The New England journal of medicine (2017) — Contemporary Hormonal Contraception and the Risk of Breast Cancer.
does_not_resolve 23484825 · The New England journal of medicine (2013) — Risk of ischemic heart disease in women after radiotherapy for breast cancer.
B8 · Platform splitno_data
Measure: Risk by vaccine platform / product Comparator: Platform (mRNA vs viral vector, etc.) Hit rule: Risk attributable to a specific platform, not to 'a vaccine' generally
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Platform split incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm no association OR null OR no increased risk Platform split pubmed · 88112 hits · run 2026-09-07
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 32098853 · Neurology (2020) — Seasonal influenza vaccine and Guillain-Barré syndrome: A self-controlled case series study.
does_not_resolve 36370744 · The Lancet. Child & adolescent health (2023) — Cancer risk with topical calcineurin inhibitors, pimecrolimus and tacrolimus, for atopic dermatitis: a systematic review and meta-analysis.
does_not_resolve 23296494 · Molecular biology reports (2013) — Assessment of the association between GSTM1 null genotype and risk of type 2 diabetes.
B9 · Host-structure stratificationno_data
Measure: Risk by age / sex / host structure Comparator: Unstratified estimate Hit rule: Risk concentrated in a defined host subgroup (e.g. young males), stable across sources
Finding: No retrieved evidence addresses laryngospasm after influenza vaccine or any host-structure stratification of risk for that outcome.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Host-structure stratification incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm no association OR null OR no increased risk Host-structure stratification pubmed · 88045 hits · run 2026-09-07
9 retrieved record(s)
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 32098853 · Neurology (2020) — Seasonal influenza vaccine and Guillain-Barré syndrome: A self-controlled case series study.
does_not_resolve 23296494 · Molecular biology reports (2013) — Assessment of the association between GSTM1 null genotype and risk of type 2 diabetes.
does_not_resolve 23949879 · Tumour biology : the journal of the Inte (2014) — Meta-analysis of the association between GSTT1 null genotype and risk of nasopharyngeal carcinoma in Chinese.
B10 · Formulation / component changeno_data
Measure: Risk tracks a formulation change Comparator: Pre- vs post-change formulation Hit rule: Risk change tracks a documented formulation / component change over time
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Formulation / component change incidence risk cohort OR self-controlled case series pubmed · 945 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm no association OR null OR no increased risk Formulation / component change pubmed · 88207 hits · run 2026-09-07
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38089855 · European heart journal open (2023) — Risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
does_not_resolve 41092926 · Lancet (London, England) (2025) — Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 su
H2 · Formulation natural experimentno_data
Measure: Risk shifts with a formulation change in the field Comparator: Pre- vs post-change formulation Hit rule: Observed risk tracks a real-world formulation change (natural experiment)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Formulation natural experiment intervention OR treatment OR reversal pubmed · 15145596 hits · run 2026-09-09
Measure: Risk signal appears/disappears across a pause or policy change Comparator: Pre- vs post-pause period Hit rule: The signal appears or disappears coherently with a rollout / pause (H4)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Policy / pause signal intervention OR treatment OR reversal pubmed · 15145596 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Policy / pause signal no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-09
I3 · Infection coherenceno_data
Measure: Pattern is coherent with or distinct from infection Comparator: Infection-matched comparison Hit rule: The post-vaccine pattern is coherent with (or clearly distinct from) the infection pattern
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Infection coherence coherence OR latency OR susceptibility pubmed · 870319 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Infection coherence inconsistent OR contradicts pubmed · 27616 hits · run 2026-09-09
Mediator & biological gradient 24/24 evaluated
C1n · Dose strength gradientno_data
Measure: Risk vs dose strength (dose size) Comparator: Lower dose strength Hit rule: Monotonic dose-response in dose strength (larger dose -> higher risk)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Dose strength gradient dose-response OR dose effect pubmed · 1299208 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm no dose effect OR no dose-response Dose strength gradient pubmed · 111 hits · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
C2n · Dose number gradientno_data
Measure: Risk vs dose number (1st vs 2nd vs 3rd) Comparator: First dose Hit rule: Risk increases (or shows a defined pattern) with dose number
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Dose number gradient dose-response OR dose effect pubmed · 1299208 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm no dose effect OR no dose-response Dose number gradient pubmed · 555 hits · run 2026-09-07
4 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
does_not_resolve 42488947 · Hypertension (Dallas, Tex. : 1979) (2026) — Clinical Modifiers of Salt Sensitivity: A Meta-Regression and Risk Translation Study.
does_not_resolve 30316563 · Radiotherapy and oncology : journal of t (2019) — Volume effects of radiotherapy on the risk of second primary cancers: A systematic review of clinical and epidemiological studies.
C3n · Measured-exposure tertilesno_data
Measure: Risk vs measured exposure tertile Comparator: Lowest-exposure tertile Hit rule: Risk ordered by measured-exposure tertile (high > mid > low)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Measured-exposure tertiles dose-response OR dose effect pubmed · 1299208 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm no dose effect OR no dose-response Measured-exposure tertiles pubmed · 0 hits (0 hits — negative) · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
C4n · Organoid concentration curveno_data
Measure: Effect vs antigen concentration in organoid Comparator: Vehicle / zero antigen Hit rule: Dose-dependent effect across a graded concentration curve
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Organoid concentration curve dose-response OR dose effect pubmed · 1299208 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm no dose effect OR no dose-response Organoid concentration curve pubmed · 11 hits · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
C5n · EC50 vs Cmax coherenceno_data
Measure: Measured exposure reaches effect threshold Comparator: Pharmacokinetic Cmax vs EC50 Hit rule: Achieved exposure (Cmax/tissue) plausibly reaches the in-vitro EC50
Finding: No evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm EC50 vs Cmax coherence dose-response OR dose effect pubmed · 1299208 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm no dose effect OR no dose-response EC50 vs Cmax coherence pubmed · 0 hits (0 hits — negative) · run 2026-09-07
2 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
E1 · Mediator identified in casesno_data
Measure: Mediator present in affected tissue/cells Comparator: Unaffected tissue / control Hit rule: The hypothesized mediator is detected in the affected compartment and not (or less) in control
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm mechanism Mediator identified in cases in vitro OR patient-derived pubmed · 29245 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm Mediator identified in cases not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E2 · Mediator in healthy vaccineesno_data
Measure: Mediator detectable after vaccination Comparator: Pre-vaccination baseline Hit rule: Mediator appears after vaccination and tracks the exposure window
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm mechanism Mediator in healthy vaccinees in vitro OR patient-derived pubmed · 29245 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm Mediator in healthy vaccinees not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E3 · Infection contrastno_data
Measure: Mediator absent/low after natural infection Comparator: Recovered natural infection Hit rule: Mediator signal is specific to vaccination vs a comparable natural-infection control
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm mechanism Infection contrast in vitro OR patient-derived pubmed · 29245 hits · run 2026-09-07
Measure: Phenotype/mediator transferred to a recipient system Comparator: Control transfer Hit rule: The effect / mediator transfers to a naive recipient system
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm mechanism Transfer to recipient in vitro OR patient-derived pubmed · 29245 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm Transfer to recipient not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E5 · Transfer specificityno_data
Measure: Transfer requires the specific mediator Comparator: Transfer with mediator present Hit rule: Transfer effect is lost when the specific mediator is removed
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm mechanism Transfer specificity in vitro OR patient-derived pubmed · 29245 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm Transfer specificity not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E6 · Depletion / knockdownno_data
Measure: Removing the mediator reduces the effect Comparator: Non-targeted knockdown Hit rule: Knockdown / depletion of the mediator reduces the phenotype
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm mechanism Depletion / knockdown in vitro OR patient-derived pubmed · 29245 hits · run 2026-09-07
Measure: Adding the mediator restores the effect Comparator: Add-back of a control protein Hit rule: Adding back the mediator (not a control) restores the phenotype
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm mechanism Add-back rescue in vitro OR patient-derived pubmed · 29245 hits · run 2026-09-07
Measure: Neutralizing the mediator blocks the effect Comparator: Isotype control Hit rule: Neutralization of the mediator (not an isotype control) blocks the phenotype
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm mechanism Neutralization in vitro OR patient-derived pubmed · 29245 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm Neutralization not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
E9 · Isotype controlno_data
Measure: Isotype control does not reproduce the effect Comparator: Active antibody Hit rule: An isotype control fails to reproduce the block/activation
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm mechanism Isotype control in vitro OR patient-derived pubmed · 29245 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm Isotype control not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-07
F1 · Full product reproducesno_data
Measure: Full vaccine product reproduces the effect Comparator: No-product control Hit rule: The full product (not a subcomponent) reproduces the effect
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Full product reproduces component OR antigen OR vector pubmed · 2045333 hits · run 2026-09-07
mirror: Influenza (flu) vaccine Laryngospasm Full product reproduces no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-07
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F2 · Empty vector / particleno_data
Measure: Vector/particle without antigen reproduces (or not) Comparator: Full product Hit rule: Effect attributed to (or excluded from) the vector/particle backbone alone
Finding: No evidence found for an association between the empty vector/particle backbone of influenza vaccines and laryngospasm.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Empty vector / particle component OR antigen OR vector pubmed · 2045333 hits · run 2026-09-07
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F3 · Antigen alone reproducesno_data
Measure: Isolated antigen reproduces the effect Comparator: Vehicle Hit rule: The isolated antigen (not the full product) reproduces the effect
Finding: The retrieved evidence discusses virus-vectored and bacterial-vectored influenza vaccines, recombinant antigen delivery, and universal vaccine strategies, but none of the abstracts describe or test whether isolated influenza antigen alone reproduces laryngospasm in any model or clinical setting.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Antigen alone reproduces component OR antigen OR vector pubmed · 2045333 hits · run 2026-09-07
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F4 · Irrelevant cargono_data
Measure: Irrelevant cargo does not reproduce the effect Comparator: Vector with the target antigen Hit rule: Irrelevant cargo fails to reproduce the effect (specificity)
Finding: The retrieved evidence discusses development of influenza vaccines using viral vectors (e.g., adenovirus, measles virus) and bacterial vectors, but no study reports or evaluates laryngospasm as an adverse event following influenza vaccination, nor does any evidence link the vaccine to laryngospasm.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Irrelevant cargo component OR antigen OR vector pubmed · 2045333 hits · run 2026-09-07
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F5 · Infection preparationno_data
Measure: Infection preparation vs product comparison Comparator: Product-derived preparation Hit rule: Effect compares correctly between infection and product preparations
Finding: The retrieved evidence discusses viral vector-based influenza vaccines and live bacterial vaccine vectors, but none of the abstracts describe laryngospasm as an adverse event following influenza vaccination or provide any data on infection preparation vs product comparison for this outcome.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Infection preparation component OR antigen OR vector pubmed · 2045333 hits · run 2026-09-07
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F6 · Cytokine / adjuvant mixno_data
Measure: Cytokine/adjuvant mix alone reproduces (or not) Comparator: Individual components Hit rule: The effect is (or is not) reproducible by the cytokine/adjuvant mix alone
Finding: The retrieved evidence discusses various viral vector-based influenza vaccines and their design principles, but does not address whether the cytokine/adjuvant mix alone can reproduce laryngospasm following influenza vaccination.
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Cytokine / adjuvant mix component OR antigen OR vector pubmed · 2045628 hits · run 2026-09-09
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
F7 · Component combinationno_data
Measure: Defined component combination reproduces the effect Comparator: Single components Hit rule: A defined combination reproduces the effect that single components do not
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Component combination component OR antigen OR vector pubmed · 2045628 hits · run 2026-09-09
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
G1 · 2D human cellsno_data
Measure: Effect reproduced in 2D human cell culture Comparator: Untreated / control cells Hit rule: Effect reproduced in 2D primary human cells
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm 2D human cells animal OR organoid OR cell model pubmed · 1819226 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm 2D human cells not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G2 · Organoid / chipno_data
Measure: Effect reproduced in organoid / organ-on-chip Comparator: Unexposed organoid Hit rule: Effect reproduced in a 3D organoid / organ-on-chip system
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Organoid / chip animal OR organoid OR cell model pubmed · 1819226 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Organoid / chip not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
H1 · Block in vitro / in vivono_data
Measure: Blocking the mediator/mechanism prevents the effect Comparator: Control intervention Hit rule: Blocking the mechanism prevents or reverses the effect (not with a control intervention)
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Block in vitro / in vivo intervention OR treatment OR reversal pubmed · 15145596 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Block in vitro / in vivo no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-09
Clinical / animal / host 7/7 evaluated
E10 · Host-line dependenceno_data
Measure: Effect depends on host line/cell type Comparator: Susceptible host line Hit rule: Effect is restricted to a defined host line / genotype, not universal
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm mechanism Host-line dependence in vitro OR patient-derived pubmed · 29245 hits · run 2026-09-07
Measure: Effect in animal via the clinical route of administration Comparator: Vehicle, same route Hit rule: Effect reproduced in an animal using the clinical route of administration
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Animal, clinical route animal OR organoid OR cell model pubmed · 1819226 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Animal, clinical route not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G4 · Susceptible animalno_data
Measure: Effect in a susceptible animal model Comparator: Non-susceptible model Hit rule: Effect in a defined susceptible animal model
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Susceptible animal animal OR organoid OR cell model pubmed · 1819226 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Susceptible animal not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G5 · Replication across labsno_data
Measure: Effect replicated in an independent lab Comparator: Original result Hit rule: The key effect is replicated in an independent laboratory
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Replication across labs animal OR organoid OR cell model pubmed · 1819226 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Replication across labs not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G6 · Blinded scoringno_data
Measure: Outcomes scored blinded Comparator: Unblinded reference Hit rule: Primary outcomes scored by a blinded assessor
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Blinded scoring animal OR organoid OR cell model pubmed · 1819226 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Blinded scoring not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G7 · Experimental time courseno_data
Measure: Effect follows a defined experimental time course Comparator: No-exposure time course Hit rule: The effect's onset/offset follows a defined experimental time course
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Experimental time course animal OR organoid OR cell model pubmed · 1819226 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Experimental time course not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
I4 · Susceptibility traitno_data
Measure: A host trait / marker defines susceptibility Comparator: Trait-negative hosts Hit rule: A defined host trait / marker enriches for susceptibility
Finding: no evidence found
Cited: (none)
supporting: Influenza (flu) vaccine Laryngospasm Susceptibility trait coherence OR latency OR susceptibility pubmed · 870319 hits · run 2026-09-09
mirror: Influenza (flu) vaccine Laryngospasm Susceptibility trait inconsistent OR contradicts pubmed · 27616 hits · run 2026-09-09
How this was built
Per node: a supporting and a mirror PubMed query built from the node's measure / population / comparator / hit_rule; top hits fetched (title + abstract); each record classified (supports / refutes / ambiguous) by xAI with a heuristic fallback; a per-node synthesis is generated strictly from the retrieved PMIDs; the node status is then rolled up to C1–C6. Full query provenance is shown per node above. Reproduce the build: python -m evidence_run. Data: data/evidence_run/state.json.