Evidence dossier · candidate cand-varicella-vaccine-strain-varicella · VICP program · · DRAFT — not a determination
This is a draft research-tracking dossier, not a determination that Varicella (chickenpox) vaccine causes Vaccine Strain Varicella (Disseminated), and not an incidence or legal finding. All evidence is flagged needs_human_review and must be reviewed before any page is published or cited. Every value is grounded in retrieved citations (PMID + retrieval date); unsourced items read "no evidence found / not assessable". Symmetric search: every supporting query has a mirror/null query, and zeros are shown (negative dossiers report the absence of signal).
Claim matrix (C1–C6, computed)
Claim
Label
Status
Missing nodes
C1
Coherent clinical object exists
supported
C2
Consistent temporal window
supported
C3
Epidemiologic excess risk
insufficient_data
missing: B1 B2 B3
C4
Consistency / replication
insufficient_data
missing: B5 B6
C5
Specificity (product / dose)
supported
C6
Biological mechanism
insufficient_data
missing: E1
Two evidentiary bars apply to the epi nodes/claims (C3, C4): · VICP — preponderance of the evidence. · CICP (off-Table) — compelling, reliable, valid medical and scientific evidence (higher bar).
Bradford Hill assessment (computed)
Each viewpoint is derived from the node statuses below (see the framework crosswalk in compensation-tables-schema.md §8). Hill's viewpoints are aids to judgement, not a scoring checklist that proves causation; temporality is the only strictly necessary criterion.
Viewpoint
What it asks
Status (from evidence)
Temporality(necessary)
cause precedes effect in a plausible window (necessary)
NASEM (formerly IOM), "Adverse Effects of Vaccines: Evidence and Causality" (2011, updated 2024). Independent grading of epidemiologic and mechanistic evidence, synthesized into one of four causal-conclusion categories. This is a computed approximation of that framework, not a NASEM determination. See compensation-tables-schema.md §8bis.
Case-definition standard: no established case definition (needs_human_review — not in spec §1's named-standard list) — governs the case-certainty scale on A1/A2/A6/A8 below. See compensation-tables-schema.md §8ter.
Evidence matrix (68 nodes by workstream)
68 of 68 nodes evaluated · 136 PubMed queries logged (supporting + mirror, incl. zeros). Statuses are computed from retrieved citations; not hand-set.
Definition & attribution 24/24 evaluated
A1 · Case reportssupports
Measure: New definite object in risk window T Comparator: Pre-vaccination baseline Hit rule: Definite object present, onset in window, competing causes considered
Finding: Multiple case reports describe disseminated vaccine-strain varicella (Oka strain) after varicella vaccination in immunocompromised individuals, with onset within weeks to months post-vaccination and after consideration of competing causes.
Case-certainty distribution (no established case definition): 4 Definite. Transparency layer — does not change this node's status or feed C1–C6.
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) case report OR case series Case reports pubmed · 66212 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
15 retrieved record(s)
supports_node 39543470 · BMC infectious diseases (2024) — Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
supports_node 37286085 · American journal of transplantation : of (2023) — Disseminated vaccine-induced varicella infection in a kidney transplant recipient.
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
supports_node 24257110 · Journal of clinical virology : the offic (2014) — Disseminated vaccine-strain varicella as initial presentation of the acquired immunodeficiency syndrome: a case report and review of the literature.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
Measure: Definite object plus objective test Comparator: Reference range / diagnostic criteria Hit rule: Objective confirmation in >=1 case per the working definition
Finding: Two case reports describe disseminated vaccine-strain varicella (Oka strain) in immunocompromised patients (adolescent with Hodgkin's lymphoma; adult kidney transplant recipient), with objective confirmation via PCR/genotyping.
Case-certainty distribution (no established case definition): 3 Definite. Transparency layer — does not change this node's status or feed C1–C6.
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) case report OR case series Series with objective confirmation pubmed · 5662 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
14 retrieved record(s)
supports_node 39543470 · BMC infectious diseases (2024) — Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
supports_node 37286085 · American journal of transplantation : of (2023) — Disseminated vaccine-induced varicella infection in a kidney transplant recipient.
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
A3 · Onset histogrammixed
Measure: Distribution of onset times after dose Comparator: Pre-specified risk window Hit rule: Onset clusters inside the pre-specified window (not uniform/flat)
Finding: Multiple case reports describe disseminated Oka vaccine-strain varicella-zoster virus infection occurring in immunocompromised patients, with onset times ranging from shortly after vaccination to years later, but few reports provide precise hours-to-days onset histograms; the evidence does not uniformly confirm a tight pre-specified risk window with a non-uniform onset cluster.
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) case report OR case series Onset histogram pubmed · 18 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
21 retrieved record(s)
supports_node 39543470 · BMC infectious diseases (2024) — Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
supports_node 37286085 · American journal of transplantation : of (2023) — Disseminated vaccine-induced varicella infection in a kidney transplant recipient.
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
supports_node 24257110 · Journal of clinical virology : the offic (2014) — Disseminated vaccine-strain varicella as initial presentation of the acquired immunodeficiency syndrome: a case report and review of the literature.
does_not_resolve 20542464 · Journal of clinical virology : the offic (2010) — VZV meningitis following varicella vaccine.
supports_node 28579471 · The Journal of hospital infection (2017) — First case of vaccine-strain varicella infection as manifestation of HIV in healthcare worker: a case report and review of the literature.
does_not_resolve 41845916 · The Australasian journal of dermatology (2026) — Safety of Live and Live-Attenuated Vaccines in Patients Receiving Biologics and Small-Molecule Therapies for Dermatologic Diseases: A Systematic Review.
supports_node 22043019 · The Journal of infectious diseases (2011) — Disseminated varicella infection caused by varicella vaccine strain in a child with low invariant natural killer T cells and diminished CD1d expression.
A4 · Temporal plausibilitysupports
Measure: Onset latency vs object pathophysiology Comparator: Object's known natural latency Hit rule: Onset latency consistent with the object's pathophysiology
Finding: Multiple case reports describe disseminated vaccine-strain varicella-zoster virus (Oka strain) reactivation in immunocompromised individuals, with onset latencies consistent with the pathophysiology of reactivation (e.g., weeks to months after vaccination, often after immunosuppressive therapy or in immunodeficiency).
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) case report OR case series Temporal plausibility pubmed · 47 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
16 retrieved record(s)
supports_node 39543470 · BMC infectious diseases (2024) — Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
supports_node 37286085 · American journal of transplantation : of (2023) — Disseminated vaccine-induced varicella infection in a kidney transplant recipient.
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
supports_node 24257110 · Journal of clinical virology : the offic (2014) — Disseminated vaccine-strain varicella as initial presentation of the acquired immunodeficiency syndrome: a case report and review of the literature.
does_not_resolve 20542464 · Journal of clinical virology : the offic (2010) — VZV meningitis following varicella vaccine.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
A5 · Onset-interval documentationsupports
Measure: Onset interval documented in source Comparator: Dose date Hit rule: Onset interval is recorded (not imputed) in a primary source
Finding: Several case reports document disseminated vaccine-strain varicella infection with onset intervals explicitly recorded as weeks after vaccination (e.g., 3 weeks, 5 weeks), meeting the definition of an onset interval documented in a primary source.
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) case report OR case series Onset-interval documentation pubmed · 16 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
21 retrieved record(s)
supports_node 39543470 · BMC infectious diseases (2024) — Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
supports_node 37286085 · American journal of transplantation : of (2023) — Disseminated vaccine-induced varicella infection in a kidney transplant recipient.
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
supports_node 24257110 · Journal of clinical virology : the offic (2014) — Disseminated vaccine-strain varicella as initial presentation of the acquired immunodeficiency syndrome: a case report and review of the literature.
supports_node 28579471 · The Journal of hospital infection (2017) — First case of vaccine-strain varicella infection as manifestation of HIV in healthcare worker: a case report and review of the literature.
supports_node 14513412 · The Journal of infectious diseases (2003) — Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells.
does_not_resolve 20542464 · Journal of clinical virology : the offic (2010) — VZV meningitis following varicella vaccine.
does_not_resolve 41845916 · The Australasian journal of dermatology (2026) — Safety of Live and Live-Attenuated Vaccines in Patients Receiving Biologics and Small-Molecule Therapies for Dermatologic Diseases: A Systematic Review.
A6 · Differential diagnosis excludedno_data
Measure: Competing causes assessed and excluded Comparator: Likely alternative diagnoses Hit rule: Pre-specified competing causes ruled out per the working definition
Finding: A single case report describes disseminated Oka vaccine-strain varicella in an adolescent with secondary immunodeficiency (Hodgkin's lymphoma) after chemotherapy, but the report does not explicitly state that all pre-specified competing causes were ruled out per a working definition.
Case-certainty distribution (no established case definition): 1 Probable. Transparency layer — does not change this node's status or feed C1–C6.
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) case report OR case series Differential diagnosis excluded pubmed · 443 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
12 retrieved record(s)
supports_node 39543470 · BMC infectious diseases (2024) — Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
ambiguous 7114977 · Archives of internal medicine (1982) — Vaccine-related poliomyelitis.
A7 · Rechallenge / re-exposureno_data
Measure: Object recurs on a further dose Comparator: First-dose response Hit rule: Object recurs after a subsequent dose (re-exposure)
Finding: The retrieved evidence includes only case reports of disseminated vaccine-strain varicella after a single dose of varicella vaccine, with no reports of recurrence after a subsequent (second) dose of the same vaccine.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) case report OR case series Rechallenge / re-exposure pubmed · 18 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
20 retrieved record(s)
supports_node 39543470 · BMC infectious diseases (2024) — Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
supports_node 37286085 · American journal of transplantation : of (2023) — Disseminated vaccine-induced varicella infection in a kidney transplant recipient.
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
supports_node 24257110 · Journal of clinical virology : the offic (2014) — Disseminated vaccine-strain varicella as initial presentation of the acquired immunodeficiency syndrome: a case report and review of the literature.
supports_node 14513412 · The Journal of infectious diseases (2003) — Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells.
does_not_resolve 20542464 · Journal of clinical virology : the offic (2010) — VZV meningitis following varicella vaccine.
supports_node 28579471 · The Journal of hospital infection (2017) — First case of vaccine-strain varicella infection as manifestation of HIV in healthcare worker: a case report and review of the literature.
does_not_resolve 41845916 · The Australasian journal of dermatology (2026) — Safety of Live and Live-Attenuated Vaccines in Patients Receiving Biologics and Small-Molecule Therapies for Dermatologic Diseases: A Systematic Review.
A8 · Adjudicated by criteria (no established case definition)no_data
Measure: Object adjudicated by published criteria Comparator: Published clinical / Brighton criteria Hit rule: Cases adjudicated to 'definite' by a published criterion set
Finding: The retrieved evidence includes multiple case reports of disseminated vaccine-strain varicella (Oka strain) in immunocompromised patients, with PCR or genotyping confirmation, meeting criteria for vaccine-strain attribution. However, these are individual case reports, not systematic adjudication by a published criterion set as specified for this node.
Case-certainty distribution (no established case definition): 2 Definite, 3 Probable. Transparency layer — does not change this node's status or feed C1–C6.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) case report OR case series Adjudicated by criteria pubmed · 55 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
16 retrieved record(s)
supports_node 39543470 · BMC infectious diseases (2024) — Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
supports_node 37286085 · American journal of transplantation : of (2023) — Disseminated vaccine-induced varicella infection in a kidney transplant recipient.
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
supports_node 24257110 · Journal of clinical virology : the offic (2014) — Disseminated vaccine-strain varicella as initial presentation of the acquired immunodeficiency syndrome: a case report and review of the literature.
refutes_node 20542464 · Journal of clinical virology : the offic (2010) — VZV meningitis following varicella vaccine.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
A9 · Natural-history consistencysupports
Measure: Course matches the object's natural history Comparator: Known natural history of the object Hit rule: Clinical course (onset, peak, recovery) matches the object's natural history
Finding: Multiple case reports describe disseminated vaccine-strain varicella (Oka strain) in immunocompromised patients, with clinical courses including onset after vaccination, disseminated rash, and recovery consistent with natural history of disseminated VZV infection.
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) case report OR case series Natural-history consistency pubmed · 119 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
15 retrieved record(s)
supports_node 39543470 · BMC infectious diseases (2024) — Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
supports_node 37286085 · American journal of transplantation : of (2023) — Disseminated vaccine-induced varicella infection in a kidney transplant recipient.
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
supports_node 24257110 · Journal of clinical virology : the offic (2014) — Disseminated vaccine-strain varicella as initial presentation of the acquired immunodeficiency syndrome: a case report and review of the literature.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
ambiguous 30000765 · (2006) — Human Papillomavirus Vaccines.
Measure: Not attributable to a co-occurring condition Comparator: Co-occurring illness that could produce the object Hit rule: Object not better explained by a co-occurring condition (infection, etc.)
Finding: Multiple case reports describe disseminated vaccine-strain varicella (Oka strain) occurring in immunocompromised patients (e.g., with Hodgkin's lymphoma, kidney transplant, HIV, or autologous bone marrow transplant) after varicella vaccination, supporting a causal link when no other co-occurring infection is present.
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) case report OR case series No confounding object pubmed · 35 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) alternative diagnosis OR not vaccine-related pubmed · 4053 hits · run 2026-09-09
18 retrieved record(s)
supports_node 39543470 · BMC infectious diseases (2024) — Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
supports_node 37286085 · American journal of transplantation : of (2023) — Disseminated vaccine-induced varicella infection in a kidney transplant recipient.
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
supports_node 24257110 · Journal of clinical virology : the offic (2014) — Disseminated vaccine-strain varicella as initial presentation of the acquired immunodeficiency syndrome: a case report and review of the literature.
does_not_resolve 20542464 · Journal of clinical virology : the offic (2010) — VZV meningitis following varicella vaccine.
supports_node 28579471 · The Journal of hospital infection (2017) — First case of vaccine-strain varicella infection as manifestation of HIV in healthcare worker: a case report and review of the literature.
does_not_resolve 41845916 · The Australasian journal of dermatology (2026) — Safety of Live and Live-Attenuated Vaccines in Patients Receiving Biologics and Small-Molecule Therapies for Dermatologic Diseases: A Systematic Review.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
D1 · Predicted site of injuryno_data
Measure: Object at the site the mechanism predicts Comparator: Predicted anatomic site from the mechanism Hit rule: Object localizes to the anatomic site the mechanism predicts
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) anatomic localization Predicted site of injury mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Predicted site of injury not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
D2 · Spared structuresno_data
Measure: Structures the mechanism should spare are spared Comparator: Structures predicted unaffected Hit rule: Structures predicted spared by the mechanism are indeed spared
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Spared structures not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
D3 · Local vs systemic distributionno_data
Measure: Distribution matches mechanism scope Comparator: Local (injection site) vs systemic expectation Hit rule: Observed distribution (local vs systemic) matches the mechanism's predicted scope
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) anatomic localization Local vs systemic distribution mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Local vs systemic distribution not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
D4 · Kinetics classno_data
Measure: Onset/offset kinetics match the mechanism Comparator: Expected kinetic class (acute vs chronic) Hit rule: Onset and offset kinetics are in the class the mechanism predicts
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Kinetics class not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
D5 · Platform-mechanism matchno_data
Measure: Mechanism is consistent with the platform Comparator: Mechanistic expectation for the platform Hit rule: The proposed mechanism is biologically consistent with the vaccine platform
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Platform-mechanism match not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
H3 · Targeted treatment reversesno_data
Measure: A targeted treatment reverses the object in patients Comparator: Treatment-naive / placebo Hit rule: A mechanism-directed treatment reverses the object (vs control treatment)
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Targeted treatment reverses intervention OR treatment OR reversal pubmed · 15146614 hits · run 2026-09-09
does_not_resolve 38189107 · Expert review of vaccines (2024) — Neoadjuvant personalized cancer vaccines: the final frontier?
I1 · No internal contradictionno_data
Measure: No node's finding contradicts another Comparator: Internal consistency across nodes Hit rule: No evaluated node directly contradicts another (coherence)
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) No internal contradiction coherence OR latency OR susceptibility pubmed · 870416 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) No internal contradiction inconsistent OR contradicts pubmed · 27618 hits · run 2026-09-09
1 retrieved record(s)
does_not_resolve 25187623 · Reproduction (Cambridge, England) (2014) — Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment.
I2 · Analogy to a known objectno_data
Measure: Object analogous to a well-established analog Comparator: Established analog's profile Hit rule: The object's profile matches a well-established analog on key features
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Analogy to a known object coherence OR latency OR susceptibility pubmed · 870416 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Analogy to a known object inconsistent OR contradicts pubmed · 27618 hits · run 2026-09-09
I5 · Latency coherenceno_data
Measure: Observed latency matches the mechanism's latency Comparator: Mechanism-predicted latency Hit rule: Observed onset latency is coherent with the mechanism's predicted latency
Finding: No evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Latency coherence coherence OR latency OR susceptibility pubmed · 870416 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Latency coherence inconsistent OR contradicts pubmed · 27618 hits · run 2026-09-09
1 retrieved record(s)
does_not_resolve 25187623 · Reproduction (Cambridge, England) (2014) — Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment.
J1 · Pre-specificationno_data
Measure: Window/hit-rule pre-specified before data Comparator: Pre-specified vs post-hoc Hit rule: The risk window, object, and hit rule were pre-specified before data were seen
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Pre-specification pre-specified OR adjudicated pubmed · 13562 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Pre-specification post-hoc OR hypothesis-generating only pubmed · 1719 hits · run 2026-09-09
J2 · Contrary-evidence logno_data
Measure: Contrary evidence is logged, not omitted Comparator: Support-only dossier Hit rule: Contrary / null / refuting findings are logged and shown alongside support
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Contrary-evidence log pre-specified OR adjudicated pubmed · 13562 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Contrary-evidence log post-hoc OR hypothesis-generating only pubmed · 1719 hits · run 2026-09-09
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
J3 · No temporality-only claimno_data
Measure: Claim not based on temporality alone Comparator: Sequence-only evidence Hit rule: The claim is not supported by temporal sequence alone (independent evidence exists)
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) No temporality-only claim pre-specified OR adjudicated pubmed · 13562 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) No temporality-only claim post-hoc OR hypothesis-generating only pubmed · 1719 hits · run 2026-09-09
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
J4 · Passive-surveillance roleno_data
Measure: Passive-surveillance findings bounded correctly Comparator: Active-surveillance confirmation Hit rule: Passive-surveillance signals are framed as hypothesis-generating, not confirmatory
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Passive-surveillance role pre-specified OR adjudicated pubmed · 13562 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Passive-surveillance role post-hoc OR hypothesis-generating only pubmed · 1719 hits · run 2026-09-09
2 retrieved record(s)
ambiguous 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
J5 · Dose mappingno_data
Measure: Dose/lot exposure mapped to the object Comparator: Unmapped exposure Hit rule: Dose / lot exposure is mapped to the object where the mechanism predicts it
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Dose mapping pre-specified OR adjudicated pubmed · 13562 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Dose mapping post-hoc OR hypothesis-generating only pubmed · 1719 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
Epidemiologic chassis 13/13 evaluated
B1 · Excess vs baselineno_data
Measure: RR/IRR vs unexposed or prior window Comparator: Unvaccinated person-time or pre-vaccination window Hit rule: RR/IRR > 1 with CI excluding 1 after pre-specified confounders
Finding: No retrieved evidence directly addresses the excess risk of disseminated vaccine strain varicella after varicella vaccination using the specified hit rule (RR/IRR > 1 with CI excluding 1 after confounders). The available papers discuss self-controlled case series methods, rotavirus vaccine safety, COVID-19 vaccine safety, shingles risk after Shingrix, and unrelated clinical topics; none report on varicella vaccine strain disseminated disease.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Excess vs baseline incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) no association OR null OR no increased risk Excess vs baseline pubmed · 88512 hits · run 2026-09-09
9 retrieved record(s)
does_not_resolve 24013203 · American journal of epidemiology (2013) — A new self-controlled case series method for analyzing spontaneous reports of adverse events after vaccination.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 34672967 · Lancet (London, England) (2021) — Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, pha
does_not_resolve 34489307 · Gut (2022) — Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: results from a nationwide histology cohort.
B2 · SCCSno_data
Measure: Self-controlled case series risk ratio Comparator: Individuals' own risk intervals (no-event) Hit rule: SCCS risk ratio > 1 in the post-vaccination window, CI excluding 1
Finding: The retrieved evidence includes methodological papers and studies on SCCS design for vaccine safety, but none specifically evaluate the risk of disseminated varicella due to varicella vaccine strain using SCCS. No direct evidence was found for this node.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) SCCS incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) no association OR null OR no increased risk SCCS pubmed · 88622 hits · run 2026-09-09
10 retrieved record(s)
does_not_resolve 24013203 · American journal of epidemiology (2013) — A new self-controlled case series method for analyzing spontaneous reports of adverse events after vaccination.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 39795956 · International journal of molecular scien (2024) — The Potential Metalloestrogenic Effect of Aluminum on Breast Cancer Risk for Antiperspirant Users.
B3 · Cohort / risk-intervalno_data
Measure: Incidence rate ratio in defined window Comparator: Pre-specified risk vs comparison interval Hit rule: IRR > 1 in the pre-specified window, CI excluding 1, stratified by age/sex
Finding: No retrieved evidence directly studies an incidence rate ratio for Vaccine Strain Varicella (Disseminated) after varicella vaccination using a self-controlled case series or cohort design with a pre-specified risk window and age/sex stratification.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Cohort / risk-interval incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) no association OR null OR no increased risk Cohort / risk-interval pubmed · 88121 hits · run 2026-09-09
12 retrieved record(s)
does_not_resolve 24013203 · American journal of epidemiology (2013) — A new self-controlled case series method for analyzing spontaneous reports of adverse events after vaccination.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 41284649 · PloS one (2025) — Risk of neurologic or immune-mediated adverse events after COVID-19 diagnosis in the United States.
B4 · Meta-analysis / poolingno_data
Measure: Pooled effect across studies Comparator: Pooled estimate with heterogeneity Hit rule: Pooled estimate > 1 (or < 1) with quantified heterogeneity (I2)
Finding: No retrieved evidence evaluates a pooled estimate (meta-analysis) of disseminated vaccine-strain varicella following varicella vaccination; the retrieved studies address unrelated vaccines (Shingrix, rotavirus, COVID-19, influenza) or unrelated outcomes (falls, cancer, glioma, stroke after herpes zoster).
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Meta-analysis / pooling incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) no association OR null OR no increased risk Meta-analysis / pooling pubmed · 111979 hits · run 2026-09-09
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 29402646 · Journal of the American Medical Director (2018) — Fall-Risk-Increasing Drugs: A Systematic Review and Meta-analysis: III. Others.
does_not_resolve 41435370 · JMIR research protocols (2025) — Antidepressant and Antipsychotic Drug Use and Cancer Risk: Protocol for an Overview of Systematic Reviews and Meta-Analyses.
B5 · Negative-control outcomesno_data
Measure: No excess for outcomes the vaccine should not cause Comparator: Negative-control outcomes (unaffected by mechanism) Hit rule: Null for negative-control outcomes while target outcome is positive (specificity)
Finding: No evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Negative-control outcomes incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) no association OR null OR no increased risk Negative-control outcomes pubmed · 88323 hits · run 2026-09-09
9 retrieved record(s)
does_not_resolve 41143862 · Age and ageing (2025) — Overactive bladder medications and risk of emergency hospital admissions with delirium in adults without dementia: self-controlled case series.
does_not_resolve 24013203 · American journal of epidemiology (2013) — A new self-controlled case series method for analyzing spontaneous reports of adverse events after vaccination.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 38833248 · JAMA network open (2024) — Valproate Use During Spermatogenesis and Risk to Offspring.
B6 · Other-antigen comparisonno_data
Measure: Risk vs a different-antigen comparator Comparator: Comparator product with a different antigen Hit rule: Risk specific to the target antigen, not shared with the comparator antigen
Finding: No retrieved evidence addresses the risk of Vaccine Strain Varicella (Disseminated) after varicella vaccine compared with a different-antigen comparator. The retrieved articles focus on other vaccines (e.g., rotavirus, COVID-19, Shingrix, overactive bladder medications) or genetic associations, not on varicella vaccine or disseminated varicella.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Other-antigen comparison incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) no association OR null OR no increased risk Other-antigen comparison pubmed · 88085 hits · run 2026-09-09
10 retrieved record(s)
does_not_resolve 41143862 · Age and ageing (2025) — Overactive bladder medications and risk of emergency hospital admissions with delirium in adults without dementia: self-controlled case series.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 23296494 · Molecular biology reports (2013) — Assessment of the association between GSTM1 null genotype and risk of type 2 diabetes.
does_not_resolve 23949879 · Tumour biology : the journal of the Inte (2014) — Meta-analysis of the association between GSTT1 null genotype and risk of nasopharyngeal carcinoma in Chinese.
B7 · Absolute riskno_data
Measure: Per-100k risk in window Comparator: Absolute incidence per 100k Hit rule: Absolute risk reported and stable across the window (not an artifact of rarity)
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Absolute risk incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) no association OR null OR no increased risk Absolute risk pubmed · 111379 hits · run 2026-09-09
11 retrieved record(s)
does_not_resolve 41143862 · Age and ageing (2025) — Overactive bladder medications and risk of emergency hospital admissions with delirium in adults without dementia: self-controlled case series.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 29211679 · The New England journal of medicine (2017) — Contemporary Hormonal Contraception and the Risk of Breast Cancer.
does_not_resolve 23484825 · The New England journal of medicine (2013) — Risk of ischemic heart disease in women after radiotherapy for breast cancer.
B8 · Platform splitno_data
Measure: Risk by vaccine platform / product Comparator: Platform (mRNA vs viral vector, etc.) Hit rule: Risk attributable to a specific platform, not to 'a vaccine' generally
Finding: Retrieved evidence discusses self-controlled case series methods for vaccine safety but contains no studies evaluating risk of vaccine strain varicella (disseminated) specifically attributed to varicella vaccine, or any assessment of platform-specific risk for this outcome.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Platform split incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) no association OR null OR no increased risk Platform split pubmed · 88150 hits · run 2026-09-09
9 retrieved record(s)
does_not_resolve 24013203 · American journal of epidemiology (2013) — A new self-controlled case series method for analyzing spontaneous reports of adverse events after vaccination.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 36370744 · The Lancet. Child & adolescent health (2023) — Cancer risk with topical calcineurin inhibitors, pimecrolimus and tacrolimus, for atopic dermatitis: a systematic review and meta-analysis.
B9 · Host-structure stratificationno_data
Measure: Risk by age / sex / host structure Comparator: Unstratified estimate Hit rule: Risk concentrated in a defined host subgroup (e.g. young males), stable across sources
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Host-structure stratification incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) no association OR null OR no increased risk Host-structure stratification pubmed · 88083 hits · run 2026-09-09
11 retrieved record(s)
does_not_resolve 41143862 · Age and ageing (2025) — Overactive bladder medications and risk of emergency hospital admissions with delirium in adults without dementia: self-controlled case series.
does_not_resolve 24013203 · American journal of epidemiology (2013) — A new self-controlled case series method for analyzing spontaneous reports of adverse events after vaccination.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
ambiguous 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 23296494 · Molecular biology reports (2013) — Assessment of the association between GSTM1 null genotype and risk of type 2 diabetes.
B10 · Formulation / component changeno_data
Measure: Risk tracks a formulation change Comparator: Pre- vs post-change formulation Hit rule: Risk change tracks a documented formulation / component change over time
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Formulation / component change incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) no association OR null OR no increased risk Formulation / component change pubmed · 88245 hits · run 2026-09-09
8 retrieved record(s)
does_not_resolve 41143862 · Age and ageing (2025) — Overactive bladder medications and risk of emergency hospital admissions with delirium in adults without dementia: self-controlled case series.
does_not_resolve 24013203 · American journal of epidemiology (2013) — A new self-controlled case series method for analyzing spontaneous reports of adverse events after vaccination.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 41092926 · Lancet (London, England) (2025) — Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 su
H2 · Formulation natural experimentno_data
Measure: Risk shifts with a formulation change in the field Comparator: Pre- vs post-change formulation Hit rule: Observed risk tracks a real-world formulation change (natural experiment)
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Formulation natural experiment intervention OR treatment OR reversal pubmed · 15146614 hits · run 2026-09-09
does_not_resolve 38189107 · Expert review of vaccines (2024) — Neoadjuvant personalized cancer vaccines: the final frontier?
H4 · Policy / pause signalno_data
Measure: Risk signal appears/disappears across a pause or policy change Comparator: Pre- vs post-pause period Hit rule: The signal appears or disappears coherently with a rollout / pause (H4)
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Policy / pause signal intervention OR treatment OR reversal pubmed · 15146614 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Policy / pause signal no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-09
1 retrieved record(s)
does_not_resolve 38189107 · Expert review of vaccines (2024) — Neoadjuvant personalized cancer vaccines: the final frontier?
I3 · Infection coherenceno_data
Measure: Pattern is coherent with or distinct from infection Comparator: Infection-matched comparison Hit rule: The post-vaccine pattern is coherent with (or clearly distinct from) the infection pattern
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Infection coherence coherence OR latency OR susceptibility pubmed · 870416 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Infection coherence inconsistent OR contradicts pubmed · 27618 hits · run 2026-09-09
Mediator & biological gradient 24/24 evaluated
C1n · Dose strength gradientno_data
Measure: Risk vs dose strength (dose size) Comparator: Lower dose strength Hit rule: Monotonic dose-response in dose strength (larger dose -> higher risk)
Finding: A single case report describes disseminated Oka vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency after prior varicella vaccination, but no dose-response data or dose strength gradient information is reported.
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) no dose effect OR no dose-response Dose strength gradient pubmed · 113 hits · run 2026-09-09
3 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
supports_node 39543470 · BMC infectious diseases (2024) — Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
C2n · Dose number gradientno_data
Measure: Risk vs dose number (1st vs 2nd vs 3rd) Comparator: First dose Hit rule: Risk increases (or shows a defined pattern) with dose number
Finding: A single case report (PMID 39543470) describes disseminated Oka-strain varicella-zoster virus reactivation in an immunocompromised adolescent after prior vaccination, but does not assess dose number or provide a dose-response gradient.
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Dose number gradient dose-response OR dose effect pubmed · 1299586 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) no dose effect OR no dose-response Dose number gradient pubmed · 558 hits · run 2026-09-09
5 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
supports_node 39543470 · BMC infectious diseases (2024) — Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
does_not_resolve 30316563 · Radiotherapy and oncology : journal of t (2019) — Volume effects of radiotherapy on the risk of second primary cancers: A systematic review of clinical and epidemiological studies.
does_not_resolve 42106826 · The international journal of behavioral (2026) — Physical activity, falls, and dementia risk in adults aged ≥ 60: evidence from three cohorts.
C3n · Measured-exposure tertilesno_data
Measure: Risk vs measured exposure tertile Comparator: Lowest-exposure tertile Hit rule: Risk ordered by measured-exposure tertile (high > mid > low)
Finding: No retrieved evidence directly investigates the risk of disseminated vaccine-strain varicella (Oka strain) across tertiles of measured exposure to varicella vaccine. One case report (PMID 39543470) describes a single case of disseminated vaccine-strain varicella reactivation in an immunocompromised adolescent, but does not provide any exposure tertile risk ordering or measured-exposure analysis.
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) no dose effect OR no dose-response Measured-exposure tertiles pubmed · 2 hits · run 2026-09-09
3 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
supports_node 39543470 · BMC infectious diseases (2024) — Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
C4n · Organoid concentration curveno_data
Measure: Effect vs antigen concentration in organoid Comparator: Vehicle / zero antigen Hit rule: Dose-dependent effect across a graded concentration curve
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) no dose effect OR no dose-response Organoid concentration curve pubmed · 13 hits · run 2026-09-09
3 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
supports_node 39543470 · BMC infectious diseases (2024) — Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
C5n · EC50 vs Cmax coherenceno_data
Measure: Measured exposure reaches effect threshold Comparator: Pharmacokinetic Cmax vs EC50 Hit rule: Achieved exposure (Cmax/tissue) plausibly reaches the in-vitro EC50
Finding: A single case report describes disseminated Oka vaccine-strain varicella-zoster virus reactivation in an immunocompromised adolescent, but no evidence of measured in-vitro EC50 or Cmax/tissue exposure levels relevant to the EC50 vs Cmax coherence node was found.
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) EC50 vs Cmax coherence dose-response OR dose effect pubmed · 1299586 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) no dose effect OR no dose-response EC50 vs Cmax coherence pubmed · 2 hits · run 2026-09-09
3 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 36090988 · Frontiers in immunology (2022) — A comprehensive analysis of the efficacy and effectiveness of COVID-19 vaccines.
supports_node 39543470 · BMC infectious diseases (2024) — Disseminated vaccine-strain varicella-zoster virus reactivation in an adolescent with secondary immunodeficiency: a case report and literature review.
E1 · Mediator identified in casesno_data
Measure: Mediator present in affected tissue/cells Comparator: Unaffected tissue / control Hit rule: The hypothesized mediator is detected in the affected compartment and not (or less) in control
Finding: The retrieved evidence addresses safety of live vaccinations in immunosuppressed patients but does not specifically describe detection of vaccine strain varicella virus in affected tissues or cases of disseminated varicella attributed to varicella vaccine.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) mechanism Mediator identified in cases in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Mediator identified in cases not associated mechanism pubmed · 1 hits · run 2026-09-09
1 retrieved record(s)
does_not_resolve 28162821 · Vaccine (2017) — Safety of live vaccinations on immunosuppressive therapy in patients with immune-mediated inflammatory diseases, solid organ transplantation or after bone-marro
E2 · Mediator in healthy vaccineesno_data
Measure: Mediator detectable after vaccination Comparator: Pre-vaccination baseline Hit rule: Mediator appears after vaccination and tracks the exposure window
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) mechanism Mediator in healthy vaccinees in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Mediator in healthy vaccinees not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
E3 · Infection contrastno_data
Measure: Mediator absent/low after natural infection Comparator: Recovered natural infection Hit rule: Mediator signal is specific to vaccination vs a comparable natural-infection control
Finding: The retrieved evidence describes a PCR assay that distinguishes vaccine strain from wild-type VZV in vaccinees with breakthrough varicella or zoster, but it does not compare mediator levels after vaccination versus natural infection, nor does it address the specific node condition of disseminated vaccine strain varicella with onset within a predefined risk window after competing causes are assessed.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) mechanism Infection contrast in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Infection contrast not associated mechanism pubmed · 1 hits · run 2026-09-09
1 retrieved record(s)
does_not_resolve 11099082 · The Pediatric infectious disease journal (2000) — Viral strain identification in varicella vaccinees with disseminated rashes.
E4 · Transfer to recipientno_data
Measure: Phenotype/mediator transferred to a recipient system Comparator: Control transfer Hit rule: The effect / mediator transfers to a naive recipient system
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) mechanism Transfer to recipient in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Transfer to recipient not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
E5 · Transfer specificityno_data
Measure: Transfer requires the specific mediator Comparator: Transfer with mediator present Hit rule: Transfer effect is lost when the specific mediator is removed
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) mechanism Transfer specificity in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Transfer specificity not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
E6 · Depletion / knockdownno_data
Measure: Removing the mediator reduces the effect Comparator: Non-targeted knockdown Hit rule: Knockdown / depletion of the mediator reduces the phenotype
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) mechanism Depletion / knockdown in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
Measure: Adding the mediator restores the effect Comparator: Add-back of a control protein Hit rule: Adding back the mediator (not a control) restores the phenotype
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) mechanism Add-back rescue in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
Measure: Neutralizing the mediator blocks the effect Comparator: Isotype control Hit rule: Neutralization of the mediator (not an isotype control) blocks the phenotype
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) mechanism Neutralization in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
Measure: Isotype control does not reproduce the effect Comparator: Active antibody Hit rule: An isotype control fails to reproduce the block/activation
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) mechanism Isotype control in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Isotype control not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
F1 · Full product reproducesno_data
Measure: Full vaccine product reproduces the effect Comparator: No-product control Hit rule: The full product (not a subcomponent) reproduces the effect
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Full product reproduces component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Full product reproduces no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-09
does_not_resolve 28420073 · International journal of molecular scien (2017) — Future Prospects for the Development of Cost-Effective Adenovirus Vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 40276512 · Frontiers in immunology (2025) — Development of a novel adenovirus type 4 vector as a promising respiratory vaccine vehicle.
F2 · Empty vector / particleno_data
Measure: Vector/particle without antigen reproduces (or not) Comparator: Full product Hit rule: Effect attributed to (or excluded from) the vector/particle backbone alone
Finding: No retrieved evidence addresses vaccine strain varicella (disseminated) attributed to a varicella vaccine vector/particle backbone alone; all retrieved articles discuss unrelated viral vectors for other pathogens (measles, influenza, Newcastle disease, malaria, rabies, adenovirus, paramyxoviruses) or bacterial vectors.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Empty vector / particle component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 28420073 · International journal of molecular scien (2017) — Future Prospects for the Development of Cost-Effective Adenovirus Vaccines.
does_not_resolve 40276512 · Frontiers in immunology (2025) — Development of a novel adenovirus type 4 vector as a promising respiratory vaccine vehicle.
F3 · Antigen alone reproducesno_data
Measure: Isolated antigen reproduces the effect Comparator: Vehicle Hit rule: The isolated antigen (not the full product) reproduces the effect
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Antigen alone reproduces component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 28420073 · International journal of molecular scien (2017) — Future Prospects for the Development of Cost-Effective Adenovirus Vaccines.
does_not_resolve 40276512 · Frontiers in immunology (2025) — Development of a novel adenovirus type 4 vector as a promising respiratory vaccine vehicle.
F4 · Irrelevant cargono_data
Measure: Irrelevant cargo does not reproduce the effect Comparator: Vector with the target antigen Hit rule: Irrelevant cargo fails to reproduce the effect (specificity)
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Irrelevant cargo component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
does_not_resolve 28420073 · International journal of molecular scien (2017) — Future Prospects for the Development of Cost-Effective Adenovirus Vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 40276512 · Frontiers in immunology (2025) — Development of a novel adenovirus type 4 vector as a promising respiratory vaccine vehicle.
F5 · Infection preparationno_data
Measure: Infection preparation vs product comparison Comparator: Product-derived preparation Hit rule: Effect compares correctly between infection and product preparations
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Infection preparation component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
does_not_resolve 28420073 · International journal of molecular scien (2017) — Future Prospects for the Development of Cost-Effective Adenovirus Vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 40276512 · Frontiers in immunology (2025) — Development of a novel adenovirus type 4 vector as a promising respiratory vaccine vehicle.
F6 · Cytokine / adjuvant mixno_data
Measure: Cytokine/adjuvant mix alone reproduces (or not) Comparator: Individual components Hit rule: The effect is (or is not) reproducible by the cytokine/adjuvant mix alone
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Cytokine / adjuvant mix component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
does_not_resolve 28420073 · International journal of molecular scien (2017) — Future Prospects for the Development of Cost-Effective Adenovirus Vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 40276512 · Frontiers in immunology (2025) — Development of a novel adenovirus type 4 vector as a promising respiratory vaccine vehicle.
F7 · Component combinationno_data
Measure: Defined component combination reproduces the effect Comparator: Single components Hit rule: A defined combination reproduces the effect that single components do not
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Component combination component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 28420073 · International journal of molecular scien (2017) — Future Prospects for the Development of Cost-Effective Adenovirus Vaccines.
does_not_resolve 40276512 · Frontiers in immunology (2025) — Development of a novel adenovirus type 4 vector as a promising respiratory vaccine vehicle.
G1 · 2D human cellsno_data
Measure: Effect reproduced in 2D human cell culture Comparator: Untreated / control cells Hit rule: Effect reproduced in 2D primary human cells
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) 2D human cells animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) 2D human cells not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G2 · Organoid / chipno_data
Measure: Effect reproduced in organoid / organ-on-chip Comparator: Unexposed organoid Hit rule: Effect reproduced in a 3D organoid / organ-on-chip system
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Organoid / chip animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Organoid / chip not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
H1 · Block in vitro / in vivono_data
Measure: Blocking the mediator/mechanism prevents the effect Comparator: Control intervention Hit rule: Blocking the mechanism prevents or reverses the effect (not with a control intervention)
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Block in vitro / in vivo intervention OR treatment OR reversal pubmed · 15146614 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Block in vitro / in vivo no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-09
1 retrieved record(s)
does_not_resolve 38189107 · Expert review of vaccines (2024) — Neoadjuvant personalized cancer vaccines: the final frontier?
Clinical / animal / host 7/7 evaluated
E10 · Host-line dependenceno_data
Measure: Effect depends on host line/cell type Comparator: Susceptible host line Hit rule: Effect is restricted to a defined host line / genotype, not universal
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) mechanism Host-line dependence in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
Measure: Effect in animal via the clinical route of administration Comparator: Vehicle, same route Hit rule: Effect reproduced in an animal using the clinical route of administration
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Animal, clinical route animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Animal, clinical route not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G4 · Susceptible animalno_data
Measure: Effect in a susceptible animal model Comparator: Non-susceptible model Hit rule: Effect in a defined susceptible animal model
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Susceptible animal animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Susceptible animal not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G5 · Replication across labsno_data
Measure: Effect replicated in an independent lab Comparator: Original result Hit rule: The key effect is replicated in an independent laboratory
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Replication across labs animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Replication across labs not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G6 · Blinded scoringno_data
Measure: Outcomes scored blinded Comparator: Unblinded reference Hit rule: Primary outcomes scored by a blinded assessor
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Blinded scoring animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Blinded scoring not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G7 · Experimental time courseno_data
Measure: Effect follows a defined experimental time course Comparator: No-exposure time course Hit rule: The effect's onset/offset follows a defined experimental time course
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Experimental time course animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Experimental time course not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
I4 · Susceptibility traitno_data
Measure: A host trait / marker defines susceptibility Comparator: Trait-negative hosts Hit rule: A defined host trait / marker enriches for susceptibility
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Susceptibility trait coherence OR latency OR susceptibility pubmed · 870416 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Vaccine Strain Varicella (Disseminated) Susceptibility trait inconsistent OR contradicts pubmed · 27618 hits · run 2026-09-09
How this was built
Per node: a supporting and a mirror PubMed query built from the node's measure / population / comparator / hit_rule; top hits fetched (title + abstract); each record classified (supports / refutes / ambiguous) by xAI with a heuristic fallback; a per-node synthesis is generated strictly from the retrieved PMIDs; the node status is then rolled up to C1–C6. Full query provenance is shown per node above. Reproduce the build: python -m evidence_run. Data: data/evidence_run/state.json.