Varicella (chickenpox) vaccine → Varicella post vaccine
Evidence dossier · candidate cand-varicella-varicella-post-vaccine · VICP program · · DRAFT — not a determination
This is a draft research-tracking dossier, not a determination that Varicella (chickenpox) vaccine causes Varicella post vaccine, and not an incidence or legal finding. All evidence is flagged needs_human_review and must be reviewed before any page is published or cited. Every value is grounded in retrieved citations (PMID + retrieval date); unsourced items read "no evidence found / not assessable". Symmetric search: every supporting query has a mirror/null query, and zeros are shown (negative dossiers report the absence of signal).
Claim matrix (C1–C6, computed)
Claim
Label
Status
Missing nodes
C1
Coherent clinical object exists
insufficient_data
missing: A2
C2
Consistent temporal window
supported
C3
Epidemiologic excess risk
insufficient_data
missing: B1 B2 B3
C4
Consistency / replication
insufficient_data
missing: B5 B6
C5
Specificity (product / dose)
insufficient_data
missing: C1n
C6
Biological mechanism
insufficient_data
missing: E1
Two evidentiary bars apply to the epi nodes/claims (C3, C4): · VICP — preponderance of the evidence. · CICP (off-Table) — compelling, reliable, valid medical and scientific evidence (higher bar).
Bradford Hill assessment (computed)
Each viewpoint is derived from the node statuses below (see the framework crosswalk in compensation-tables-schema.md §8). Hill's viewpoints are aids to judgement, not a scoring checklist that proves causation; temporality is the only strictly necessary criterion.
Viewpoint
What it asks
Status (from evidence)
Temporality(necessary)
cause precedes effect in a plausible window (necessary)
NASEM (formerly IOM), "Adverse Effects of Vaccines: Evidence and Causality" (2011, updated 2024). Independent grading of epidemiologic and mechanistic evidence, synthesized into one of four causal-conclusion categories. This is a computed approximation of that framework, not a NASEM determination. See compensation-tables-schema.md §8bis.
Case-definition standard: no established case definition (needs_human_review — not in spec §1's named-standard list) — governs the case-certainty scale on A1/A2/A6/A8 below. See compensation-tables-schema.md §8ter.
Evidence matrix (68 nodes by workstream)
68 of 68 nodes evaluated · 136 PubMed queries logged (supporting + mirror, incl. zeros). Statuses are computed from retrieved citations; not hand-set.
Definition & attribution 24/24 evaluated
A1 · Case reportsno_data
Measure: New definite object in risk window T Comparator: Pre-vaccination baseline Hit rule: Definite object present, onset in window, competing causes considered
Finding: No retrieved evidence describes new varicella post-vaccine attributed to varicella vaccine within a specified risk window after competing causes assessment; PMID 37395442 reports a case of varicella vaccine meningoencephalitis in an immunocompromised child, but this is a reactivation event, not a new varicella case meeting the node's definition.
Case-certainty distribution (no established case definition): 1 Definite, 1 Possible/unclassifiable. Transparency layer — does not change this node's status or feed C1–C6.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine case report OR case series Case reports pubmed · 66223 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-09
13 retrieved record(s)
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
ambiguous 37260797 · Medical archives (Sarajevo, Bosnia and H (2023) — Herpes Zoster Virus Reactivation in a 16 Year Old Female Post COVID-19 Vaccine. Case report and Review of the Literature.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
does_not_resolve 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
A2 · Series with objective confirmationno_data
Measure: Definite object plus objective test Comparator: Reference range / diagnostic criteria Hit rule: Objective confirmation in >=1 case per the working definition
Finding: No retrieved evidence pertains to varicella vaccine and post-vaccination varicella with objective confirmation. The only relevant citation (PMID 29047317) discusses varicella vaccine development and VZV pathogenesis, but does not report any objective confirmation of varicella post vaccine cases.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine case report OR case series Series with objective confirmation pubmed · 5673 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-09
11 retrieved record(s)
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
Measure: Distribution of onset times after dose Comparator: Pre-specified risk window Hit rule: Onset clusters inside the pre-specified window (not uniform/flat)
Finding: The retrieved evidence contains isolated case reports of vaccine-strain varicella reactivation or rash after varicella vaccination in immunocompromised or immunocompetent individuals, but provides no systematic onset-interval histogram data or population-level clustering analysis to assess whether onset times cluster inside a pre-specified risk window versus being uniformly distributed.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine case report OR case series Onset histogram pubmed · 29 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-09
17 retrieved record(s)
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
ambiguous 37260797 · Medical archives (Sarajevo, Bosnia and H (2023) — Herpes Zoster Virus Reactivation in a 16 Year Old Female Post COVID-19 Vaccine. Case report and Review of the Literature.
supports_node 34120389 · Pediatric transplantation (2021) — Lack of persisting antibody in a post-transplant patient after vaccine-strain varicella.
ambiguous 42211627 · Cureus (2026) — Zoster-Like Dermatomal Eruption Following Recombinant Zoster Vaccine: A Case Report.
does_not_resolve 41845916 · The Australasian journal of dermatology (2026) — Safety of Live and Live-Attenuated Vaccines in Patients Receiving Biologics and Small-Molecule Therapies for Dermatologic Diseases: A Systematic Review.
supports_node 21269735 · American journal of infection control (2011) — Vaccine-related varicella-zoster rash in a hospitalized immunocompetent patient.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
A4 · Temporal plausibilitysupports
Measure: Onset latency vs object pathophysiology Comparator: Object's known natural latency Hit rule: Onset latency consistent with the object's pathophysiology
Finding: A case report describes an immunocompromised child who developed vaccine-strain varicella zoster virus reactivation (herpes zoster and meningoencephalitis) after receiving the varicella vaccine, with onset consistent with known latency/reactivation pathophysiology of live attenuated varicella virus.
supporting: Varicella (chickenpox) vaccine Varicella post vaccine case report OR case series Temporal plausibility pubmed · 58 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-09
14 retrieved record(s)
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
ambiguous 37260797 · Medical archives (Sarajevo, Bosnia and H (2023) — Herpes Zoster Virus Reactivation in a 16 Year Old Female Post COVID-19 Vaccine. Case report and Review of the Literature.
supports_node 34120389 · Pediatric transplantation (2021) — Lack of persisting antibody in a post-transplant patient after vaccine-strain varicella.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
A5 · Onset-interval documentationno_data
Measure: Onset interval documented in source Comparator: Dose date Hit rule: Onset interval is recorded (not imputed) in a primary source
Finding: No retrieved evidence documents that the onset interval for varicella post-vaccine is recorded (not imputed) in a primary source.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine case report OR case series Onset-interval documentation pubmed · 27 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-09
17 retrieved record(s)
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
does_not_resolve 37260797 · Medical archives (Sarajevo, Bosnia and H (2023) — Herpes Zoster Virus Reactivation in a 16 Year Old Female Post COVID-19 Vaccine. Case report and Review of the Literature.
supports_node 34120389 · Pediatric transplantation (2021) — Lack of persisting antibody in a post-transplant patient after vaccine-strain varicella.
does_not_resolve 42211627 · Cureus (2026) — Zoster-Like Dermatomal Eruption Following Recombinant Zoster Vaccine: A Case Report.
does_not_resolve 41845916 · The Australasian journal of dermatology (2026) — Safety of Live and Live-Attenuated Vaccines in Patients Receiving Biologics and Small-Molecule Therapies for Dermatologic Diseases: A Systematic Review.
supports_node 21269735 · American journal of infection control (2011) — Vaccine-related varicella-zoster rash in a hospitalized immunocompetent patient.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
A6 · Differential diagnosis excludedno_data
Measure: Competing causes assessed and excluded Comparator: Likely alternative diagnoses Hit rule: Pre-specified competing causes ruled out per the working definition
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine case report OR case series Differential diagnosis excluded pubmed · 454 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-09
11 retrieved record(s)
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
Measure: Object recurs on a further dose Comparator: First-dose response Hit rule: Object recurs after a subsequent dose (re-exposure)
Finding: No retrieved evidence describes a recurrence of varicella post-vaccine adverse events after a subsequent (second) dose of varicella vaccine; the cited case reports involve single-dose reactivation or non-varicella vaccines.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine case report OR case series Rechallenge / re-exposure pubmed · 29 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-09
16 retrieved record(s)
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
refutes_node 37260797 · Medical archives (Sarajevo, Bosnia and H (2023) — Herpes Zoster Virus Reactivation in a 16 Year Old Female Post COVID-19 Vaccine. Case report and Review of the Literature.
supports_node 34120389 · Pediatric transplantation (2021) — Lack of persisting antibody in a post-transplant patient after vaccine-strain varicella.
supports_node 42211627 · Cureus (2026) — Zoster-Like Dermatomal Eruption Following Recombinant Zoster Vaccine: A Case Report.
does_not_resolve 41845916 · The Australasian journal of dermatology (2026) — Safety of Live and Live-Attenuated Vaccines in Patients Receiving Biologics and Small-Molecule Therapies for Dermatologic Diseases: A Systematic Review.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
A8 · Adjudicated by criteria (no established case definition)supports
Measure: Object adjudicated by published criteria Comparator: Published clinical / Brighton criteria Hit rule: Cases adjudicated to 'definite' by a published criterion set
Finding: A single case report (PMID 37395442) describes vaccine-strain varicella reactivation as meningoencephalitis in an immunocompromised child after varicella vaccination, which could be adjudicated as 'definite' by published criteria for a vaccine adverse event. Another case report (PMID 34120389) describes a post-transplant child who developed varicella rash 16 days after live attenuated varicella vaccine, consistent with vaccine-strain attribution.
Case-certainty distribution (no established case definition): 1 Definite, 1 Probable. Transparency layer — does not change this node's status or feed C1–C6.
supporting: Varicella (chickenpox) vaccine Varicella post vaccine case report OR case series Adjudicated by criteria pubmed · 66 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-09
14 retrieved record(s)
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
ambiguous 37260797 · Medical archives (Sarajevo, Bosnia and H (2023) — Herpes Zoster Virus Reactivation in a 16 Year Old Female Post COVID-19 Vaccine. Case report and Review of the Literature.
supports_node 34120389 · Pediatric transplantation (2021) — Lack of persisting antibody in a post-transplant patient after vaccine-strain varicella.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
A9 · Natural-history consistencyno_data
Measure: Course matches the object's natural history Comparator: Known natural history of the object Hit rule: Clinical course (onset, peak, recovery) matches the object's natural history
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine case report OR case series Natural-history consistency pubmed · 130 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-09
13 retrieved record(s)
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
ambiguous 37260797 · Medical archives (Sarajevo, Bosnia and H (2023) — Herpes Zoster Virus Reactivation in a 16 Year Old Female Post COVID-19 Vaccine. Case report and Review of the Literature.
does_not_resolve 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
ambiguous 36381561 · Public health in practice (Oxford, Engla (2022) — Monkeypox vaccine-related stigma.
does_not_resolve 36441403 · Current cardiology reports (2022) — COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation.
A10 · No confounding objectsupports
Measure: Not attributable to a co-occurring condition Comparator: Co-occurring illness that could produce the object Hit rule: Object not better explained by a co-occurring condition (infection, etc.)
Finding: A single case report describes varicella vaccine-strain meningoencephalitis after autologous bone marrow transplantation in a child, with onset likely related to the vaccine and not attributed to a co-occurring infection or other condition.
supporting: Varicella (chickenpox) vaccine Varicella post vaccine case report OR case series No confounding object pubmed · 46 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine alternative diagnosis OR not vaccine-related pubmed · 4054 hits · run 2026-09-09
16 retrieved record(s)
supports_node 37395442 · Pediatric transplantation (2023) — Varicella vaccine meningoencephalitis in a child receiving autologous bone marrow transplantation.
does_not_resolve 37260797 · Medical archives (Sarajevo, Bosnia and H (2023) — Herpes Zoster Virus Reactivation in a 16 Year Old Female Post COVID-19 Vaccine. Case report and Review of the Literature.
supports_node 34120389 · Pediatric transplantation (2021) — Lack of persisting antibody in a post-transplant patient after vaccine-strain varicella.
ambiguous 42211627 · Cureus (2026) — Zoster-Like Dermatomal Eruption Following Recombinant Zoster Vaccine: A Case Report.
ambiguous 41845916 · The Australasian journal of dermatology (2026) — Safety of Live and Live-Attenuated Vaccines in Patients Receiving Biologics and Small-Molecule Therapies for Dermatologic Diseases: A Systematic Review.
ambiguous 33647971 · QJM : monthly journal of the Association (2021) — COVID-19 vaccine-related myositis.
does_not_resolve 37775180 · Clinical medicine (London, England) (2023) — SARS-CoV-2 vaccines and myocarditis.
does_not_resolve 30000765 · (2006) — Human Papillomavirus Vaccines.
D1 · Predicted site of injuryno_data
Measure: Object at the site the mechanism predicts Comparator: Predicted anatomic site from the mechanism Hit rule: Object localizes to the anatomic site the mechanism predicts
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine anatomic localization Predicted site of injury mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Predicted site of injury not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
D2 · Spared structuresno_data
Measure: Structures the mechanism should spare are spared Comparator: Structures predicted unaffected Hit rule: Structures predicted spared by the mechanism are indeed spared
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Spared structures not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
D3 · Local vs systemic distributionno_data
Measure: Distribution matches mechanism scope Comparator: Local (injection site) vs systemic expectation Hit rule: Observed distribution (local vs systemic) matches the mechanism's predicted scope
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine anatomic localization Local vs systemic distribution mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Local vs systemic distribution not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
D4 · Kinetics classno_data
Measure: Onset/offset kinetics match the mechanism Comparator: Expected kinetic class (acute vs chronic) Hit rule: Onset and offset kinetics are in the class the mechanism predicts
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine anatomic localization Kinetics class mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Kinetics class not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
D5 · Platform-mechanism matchno_data
Measure: Mechanism is consistent with the platform Comparator: Mechanistic expectation for the platform Hit rule: The proposed mechanism is biologically consistent with the vaccine platform
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine anatomic localization Platform-mechanism match mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Platform-mechanism match not consistent with mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
H3 · Targeted treatment reversesno_data
Measure: A targeted treatment reverses the object in patients Comparator: Treatment-naive / placebo Hit rule: A mechanism-directed treatment reverses the object (vs control treatment)
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Targeted treatment reverses intervention OR treatment OR reversal pubmed · 15146614 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Targeted treatment reverses no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-09
I1 · No internal contradictionno_data
Measure: No node's finding contradicts another Comparator: Internal consistency across nodes Hit rule: No evaluated node directly contradicts another (coherence)
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine No internal contradiction coherence OR latency OR susceptibility pubmed · 870416 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine No internal contradiction inconsistent OR contradicts pubmed · 27618 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 8550283 · International journal of epidemiology (1995) — Minimum attack rate for measuring measles vaccine efficacy.
ambiguous 15578364 · Clinical infectious diseases : an offici (2004) — Varicella vaccine for susceptible adults: do it today.
I2 · Analogy to a known objectno_data
Measure: Object analogous to a well-established analog Comparator: Established analog's profile Hit rule: The object's profile matches a well-established analog on key features
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Analogy to a known object coherence OR latency OR susceptibility pubmed · 870416 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Analogy to a known object inconsistent OR contradicts pubmed · 27618 hits · run 2026-09-09
1 retrieved record(s)
does_not_resolve 8550283 · International journal of epidemiology (1995) — Minimum attack rate for measuring measles vaccine efficacy.
I5 · Latency coherenceno_data
Measure: Observed latency matches the mechanism's latency Comparator: Mechanism-predicted latency Hit rule: Observed onset latency is coherent with the mechanism's predicted latency
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Latency coherence coherence OR latency OR susceptibility pubmed · 870416 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Latency coherence inconsistent OR contradicts pubmed · 27618 hits · run 2026-09-09
1 retrieved record(s)
ambiguous 15578364 · Clinical infectious diseases : an offici (2004) — Varicella vaccine for susceptible adults: do it today.
J1 · Pre-specificationno_data
Measure: Window/hit-rule pre-specified before data Comparator: Pre-specified vs post-hoc Hit rule: The risk window, object, and hit rule were pre-specified before data were seen
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Pre-specification pre-specified OR adjudicated pubmed · 13562 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Pre-specification post-hoc OR hypothesis-generating only pubmed · 1719 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
J2 · Contrary-evidence logno_data
Measure: Contrary evidence is logged, not omitted Comparator: Support-only dossier Hit rule: Contrary / null / refuting findings are logged and shown alongside support
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Contrary-evidence log pre-specified OR adjudicated pubmed · 13562 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Contrary-evidence log post-hoc OR hypothesis-generating only pubmed · 1719 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
J3 · No temporality-only claimno_data
Measure: Claim not based on temporality alone Comparator: Sequence-only evidence Hit rule: The claim is not supported by temporal sequence alone (independent evidence exists)
Finding: The retrieved evidence discusses the use of large language models and artificial intelligence for adjudicating immune-related adverse events and major adverse cardiovascular events, but it does not mention varicella vaccine, varicella post-vaccine, or any temporality assessment for this specific adverse event.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine No temporality-only claim pre-specified OR adjudicated pubmed · 13562 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine No temporality-only claim post-hoc OR hypothesis-generating only pubmed · 1719 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
does_not_resolve 41493293 · Journal of the American College of Cardi (2026) — Using Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials.
J4 · Passive-surveillance roleno_data
Measure: Passive-surveillance findings bounded correctly Comparator: Active-surveillance confirmation Hit rule: Passive-surveillance signals are framed as hypothesis-generating, not confirmatory
Finding: This study evaluates LLMs for detecting immune-related adverse events from immune checkpoint inhibitors, not for varicella vaccine adverse events; no evidence addresses varicella post-vaccine or passive surveillance signals for that outcome.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Passive-surveillance role pre-specified OR adjudicated pubmed · 13562 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Passive-surveillance role post-hoc OR hypothesis-generating only pubmed · 1719 hits · run 2026-09-09
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
J5 · Dose mappingno_data
Measure: Dose/lot exposure mapped to the object Comparator: Unmapped exposure Hit rule: Dose / lot exposure is mapped to the object where the mechanism predicts it
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Dose mapping pre-specified OR adjudicated pubmed · 13562 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Dose mapping post-hoc OR hypothesis-generating only pubmed · 1719 hits · run 2026-09-09
1 retrieved record(s)
does_not_resolve 39226489 · Journal of clinical oncology : official (2024) — Enhancing Precision in Detecting Severe Immune-Related Adverse Events: Comparative Analysis of Large Language Models and International Classification of Disease
Epidemiologic chassis 13/13 evaluated
B1 · Excess vs baselineno_data
Measure: RR/IRR vs unexposed or prior window Comparator: Unvaccinated person-time or pre-vaccination window Hit rule: RR/IRR > 1 with CI excluding 1 after pre-specified confounders
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Excess vs baseline incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine no association OR null OR no increased risk Excess vs baseline pubmed · 88608 hits · run 2026-09-09
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
ambiguous 34806766 · The Cochrane database of systematic revi (2021) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 32309885 · The Cochrane database of systematic revi (2020) — Vaccines for measles, mumps, rubella, and varicella in children.
B2 · SCCSno_data
Measure: Self-controlled case series risk ratio Comparator: Individuals' own risk intervals (no-event) Hit rule: SCCS risk ratio > 1 in the post-vaccination window, CI excluding 1
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine SCCS incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine no association OR null OR no increased risk SCCS pubmed · 88717 hits · run 2026-09-09
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 34806766 · The Cochrane database of systematic revi (2021) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 32309885 · The Cochrane database of systematic revi (2020) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 39795956 · International journal of molecular scien (2024) — The Potential Metalloestrogenic Effect of Aluminum on Breast Cancer Risk for Antiperspirant Users.
B3 · Cohort / risk-intervalno_data
Measure: Incidence rate ratio in defined window Comparator: Pre-specified risk vs comparison interval Hit rule: IRR > 1 in the pre-specified window, CI excluding 1, stratified by age/sex
Finding: The retrieved evidence includes studies on various vaccines (Shingrix, COVID-19, rotavirus, MMR/V) but no study directly examined the incidence rate ratio of varicella post-vaccine after varicella (chickenpox) vaccination in a pre-specified risk window with age/sex stratification. The evidence is not applicable to this specific node.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Cohort / risk-interval incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine no association OR null OR no increased risk Cohort / risk-interval pubmed · 88217 hits · run 2026-09-09
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
ambiguous 34806766 · The Cochrane database of systematic revi (2021) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 32309885 · The Cochrane database of systematic revi (2020) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 16989624 · Expert review of vaccines (2006) — Prevention of shingles by varicella zoster virus vaccination.
B4 · Meta-analysis / poolingno_data
Measure: Pooled effect across studies Comparator: Pooled estimate with heterogeneity Hit rule: Pooled estimate > 1 (or < 1) with quantified heterogeneity (I2)
Finding: No retrieved evidence provides a pooled meta-analysis estimate with quantified heterogeneity (I2) for varicella post-vaccine following varicella (chickenpox) vaccine; the studies focus on herpes zoster vaccine safety or background risk of stroke after zoster, not post-varicella vaccine outcomes.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Meta-analysis / pooling incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine no association OR null OR no increased risk Meta-analysis / pooling pubmed · 112075 hits · run 2026-09-09
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 24700656 · Clinical infectious diseases : an offici (2014) — Risk of stroke following herpes zoster: a self-controlled case-series study.
does_not_resolve 34806766 · The Cochrane database of systematic revi (2021) — Vaccines for measles, mumps, rubella, and varicella in children.
ambiguous 32309885 · The Cochrane database of systematic revi (2020) — Vaccines for measles, mumps, rubella, and varicella in children.
B5 · Negative-control outcomesno_data
Measure: No excess for outcomes the vaccine should not cause Comparator: Negative-control outcomes (unaffected by mechanism) Hit rule: Null for negative-control outcomes while target outcome is positive (specificity)
Finding: No retrieved evidence addresses varicella (chickenpox) vaccine as a cause of new varicella post-vaccine, or provides null findings for this specific negative-control outcome. The cited studies focus on Shingrix, MMR, rotavirus, COVID-19 vaccines, valproate, or general SCCS methods, not on varicella vaccine causing varicella disease.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Negative-control outcomes incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine no association OR null OR no increased risk Negative-control outcomes pubmed · 88418 hits · run 2026-09-09
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 34806766 · The Cochrane database of systematic revi (2021) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 32309885 · The Cochrane database of systematic revi (2020) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 38833248 · JAMA network open (2024) — Valproate Use During Spermatogenesis and Risk to Offspring.
B6 · Other-antigen comparisonno_data
Measure: Risk vs a different-antigen comparator Comparator: Comparator product with a different antigen Hit rule: Risk specific to the target antigen, not shared with the comparator antigen
Finding: The retrieved evidence does not address a comparison of varicella post-vaccine risk between varicella vaccine and a different-antigen comparator. Studies focus on zoster vaccine safety, rotavirus vaccine, COVID-19 vaccines, or general varicella disease burden, not the specific antigen-comparison risk question.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Other-antigen comparison incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine no association OR null OR no increased risk Other-antigen comparison pubmed · 88181 hits · run 2026-09-09
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 24700656 · Clinical infectious diseases : an offici (2014) — Risk of stroke following herpes zoster: a self-controlled case-series study.
does_not_resolve 34806766 · The Cochrane database of systematic revi (2021) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 32309885 · The Cochrane database of systematic revi (2020) — Vaccines for measles, mumps, rubella, and varicella in children.
B7 · Absolute riskno_data
Measure: Per-100k risk in window Comparator: Absolute incidence per 100k Hit rule: Absolute risk reported and stable across the window (not an artifact of rarity)
Finding: No retrieved evidence addresses the absolute risk of varicella post-vaccine (breakthrough varicella) following varicella (chickenpox) vaccination. The provided studies focus on herpes zoster (shingles) after recombinant zoster vaccine or zoster vaccine live, stroke after herpes zoster, and other unrelated outcomes, none of which report per-100k risk of varicella after varicella vaccine.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Absolute risk incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine no association OR null OR no increased risk Absolute risk pubmed · 111475 hits · run 2026-09-09
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 24700656 · Clinical infectious diseases : an offici (2014) — Risk of stroke following herpes zoster: a self-controlled case-series study.
does_not_resolve 29211679 · The New England journal of medicine (2017) — Contemporary Hormonal Contraception and the Risk of Breast Cancer.
does_not_resolve 34806766 · The Cochrane database of systematic revi (2021) — Vaccines for measles, mumps, rubella, and varicella in children.
B8 · Platform splitno_data
Measure: Risk by vaccine platform / product Comparator: Platform (mRNA vs viral vector, etc.) Hit rule: Risk attributable to a specific platform, not to 'a vaccine' generally
Finding: No retrieved evidence directly addresses the risk of varicella post vaccine (shingles) specifically attributed to varicella (chickenpox) vaccine (as opposed to shingles vaccine or other platforms). The available studies focus on RZV, MMR/V, rotavirus, or COVID-19 vaccines, and none provide platform-specific risk estimates for varicella vaccine causing varicella post vaccine.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Platform split incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine no association OR null OR no increased risk Platform split pubmed · 88246 hits · run 2026-09-09
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 34806766 · The Cochrane database of systematic revi (2021) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 32309885 · The Cochrane database of systematic revi (2020) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 16989624 · Expert review of vaccines (2006) — Prevention of shingles by varicella zoster virus vaccination.
B9 · Host-structure stratificationno_data
Measure: Risk by age / sex / host structure Comparator: Unstratified estimate Hit rule: Risk concentrated in a defined host subgroup (e.g. young males), stable across sources
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Host-structure stratification incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine no association OR null OR no increased risk Host-structure stratification pubmed · 88179 hits · run 2026-09-09
does_not_resolve 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 40440921 · Vaccine (2025) — Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A multinational self-controlled case series study.
does_not_resolve 38388239 · Vaccine (2024) — Mortality risk after COVID-19 vaccination: A self-controlled case series study.
does_not_resolve 34806766 · The Cochrane database of systematic revi (2021) — Vaccines for measles, mumps, rubella, and varicella in children.
ambiguous 32309885 · The Cochrane database of systematic revi (2020) — Vaccines for measles, mumps, rubella, and varicella in children.
B10 · Formulation / component changeno_data
Measure: Risk tracks a formulation change Comparator: Pre- vs post-change formulation Hit rule: Risk change tracks a documented formulation / component change over time
Finding: The retrieved evidence does not address a formulation/component change for the Varicella vaccine or its association with Varicella post vaccine; all cited studies focus on other vaccines (e.g., Shingrix, zoster vaccine live, rotavirus vaccine, MMR, COVID-19 mRNA vaccines) or on general zoster/varicella burden without evaluating formulation-related risk changes.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Formulation / component change incidence risk cohort OR self-controlled case series pubmed · 948 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine no association OR null OR no increased risk Formulation / component change pubmed · 88341 hits · run 2026-09-09
does_not_resolve 37468475 · Nature communications (2023) — Herpes zoster vaccine safety in the Aotearoa New Zealand population: a self-controlled case series study.
ambiguous 34937500 · Expert review of vaccines (2022) — Self-controlled case series design in vaccine safety: a systematic review.
does_not_resolve 38875047 · The International journal of risk & safe (2024) — Self-controlled risk interval study of rotavirus vaccine safety: Findings and implications.
does_not_resolve 40664645 · Nature communications (2025) — Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
does_not_resolve 24700656 · Clinical infectious diseases : an offici (2014) — Risk of stroke following herpes zoster: a self-controlled case-series study.
does_not_resolve 34806766 · The Cochrane database of systematic revi (2021) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 32309885 · The Cochrane database of systematic revi (2020) — Vaccines for measles, mumps, rubella, and varicella in children.
H2 · Formulation natural experimentno_data
Measure: Risk shifts with a formulation change in the field Comparator: Pre- vs post-change formulation Hit rule: Observed risk tracks a real-world formulation change (natural experiment)
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Formulation natural experiment intervention OR treatment OR reversal pubmed · 15146614 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Formulation natural experiment no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-09
H4 · Policy / pause signalno_data
Measure: Risk signal appears/disappears across a pause or policy change Comparator: Pre- vs post-pause period Hit rule: The signal appears or disappears coherently with a rollout / pause (H4)
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Policy / pause signal intervention OR treatment OR reversal pubmed · 15146614 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Policy / pause signal no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-09
I3 · Infection coherenceno_data
Measure: Pattern is coherent with or distinct from infection Comparator: Infection-matched comparison Hit rule: The post-vaccine pattern is coherent with (or clearly distinct from) the infection pattern
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Infection coherence coherence OR latency OR susceptibility pubmed · 870416 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Infection coherence inconsistent OR contradicts pubmed · 27618 hits · run 2026-09-09
1 retrieved record(s)
does_not_resolve 8550283 · International journal of epidemiology (1995) — Minimum attack rate for measuring measles vaccine efficacy.
Mediator & biological gradient 24/24 evaluated
C1n · Dose strength gradientno_data
Measure: Risk vs dose strength (dose size) Comparator: Lower dose strength Hit rule: Monotonic dose-response in dose strength (larger dose -> higher risk)
Finding: No evidence in the retrieved set addresses a monotonic dose-response gradient between varicella vaccine dose strength and risk of varicella post-vaccine adverse events.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Dose strength gradient dose-response OR dose effect pubmed · 1299586 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine no dose effect OR no dose-response Dose strength gradient pubmed · 210 hits · run 2026-09-09
10 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 34806766 · The Cochrane database of systematic revi (2021) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 37967254 · Human vaccines & immunotherapeutics (2023) — Effectiveness and safety of recombinant zoster vaccine: A review of real-world evidence.
does_not_resolve 32309885 · The Cochrane database of systematic revi (2020) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 22859715 · British medical bulletin (2012) — Varicella vaccines.
does_not_resolve 34893015 · Human vaccines & immunotherapeutics (2021) — Effectiveness of varicella vaccine as post-exposure prophylaxis: a meta-analysis.
ambiguous 22890288 · Bone marrow transplantation (2013) — Live (vaccines) from New York.
ambiguous 40916263 · Vaccine (2025) — Safety, immunogenicity and efficacy of the Shingrix vaccine in immunocompromised varicella zoster virus naïve pediatric patients.
C2n · Dose number gradientno_data
Measure: Risk vs dose number (1st vs 2nd vs 3rd) Comparator: First dose Hit rule: Risk increases (or shows a defined pattern) with dose number
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Dose number gradient dose-response OR dose effect pubmed · 1299586 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine no dose effect OR no dose-response Dose number gradient pubmed · 655 hits · run 2026-09-09
12 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 34806766 · The Cochrane database of systematic revi (2021) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 37967254 · Human vaccines & immunotherapeutics (2023) — Effectiveness and safety of recombinant zoster vaccine: A review of real-world evidence.
does_not_resolve 32309885 · The Cochrane database of systematic revi (2020) — Vaccines for measles, mumps, rubella, and varicella in children.
ambiguous 22859715 · British medical bulletin (2012) — Varicella vaccines.
does_not_resolve 34893015 · Human vaccines & immunotherapeutics (2021) — Effectiveness of varicella vaccine as post-exposure prophylaxis: a meta-analysis.
does_not_resolve 22890288 · Bone marrow transplantation (2013) — Live (vaccines) from New York.
ambiguous 40916263 · Vaccine (2025) — Safety, immunogenicity and efficacy of the Shingrix vaccine in immunocompromised varicella zoster virus naïve pediatric patients.
C3n · Measured-exposure tertilesno_data
Measure: Risk vs measured exposure tertile Comparator: Lowest-exposure tertile Hit rule: Risk ordered by measured-exposure tertile (high > mid > low)
Finding: No retrieved evidence examines risk of varicella post-vaccine across measured-exposure tertiles (high > mid > low).
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Measured-exposure tertiles dose-response OR dose effect pubmed · 1299586 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine no dose effect OR no dose-response Measured-exposure tertiles pubmed · 99 hits · run 2026-09-09
13 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
ambiguous 34806766 · The Cochrane database of systematic revi (2021) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 37967254 · Human vaccines & immunotherapeutics (2023) — Effectiveness and safety of recombinant zoster vaccine: A review of real-world evidence.
refutes_node 32309885 · The Cochrane database of systematic revi (2020) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 22859715 · British medical bulletin (2012) — Varicella vaccines.
does_not_resolve 34893015 · Human vaccines & immunotherapeutics (2021) — Effectiveness of varicella vaccine as post-exposure prophylaxis: a meta-analysis.
does_not_resolve 22890288 · Bone marrow transplantation (2013) — Live (vaccines) from New York.
ambiguous 40916263 · Vaccine (2025) — Safety, immunogenicity and efficacy of the Shingrix vaccine in immunocompromised varicella zoster virus naïve pediatric patients.
C4n · Organoid concentration curveno_data
Measure: Effect vs antigen concentration in organoid Comparator: Vehicle / zero antigen Hit rule: Dose-dependent effect across a graded concentration curve
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Organoid concentration curve dose-response OR dose effect pubmed · 1299586 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine no dose effect OR no dose-response Organoid concentration curve pubmed · 110 hits · run 2026-09-09
12 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 34806766 · The Cochrane database of systematic revi (2021) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 37967254 · Human vaccines & immunotherapeutics (2023) — Effectiveness and safety of recombinant zoster vaccine: A review of real-world evidence.
does_not_resolve 32309885 · The Cochrane database of systematic revi (2020) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 22859715 · British medical bulletin (2012) — Varicella vaccines.
does_not_resolve 34893015 · Human vaccines & immunotherapeutics (2021) — Effectiveness of varicella vaccine as post-exposure prophylaxis: a meta-analysis.
does_not_resolve 22890288 · Bone marrow transplantation (2013) — Live (vaccines) from New York.
does_not_resolve 40916263 · Vaccine (2025) — Safety, immunogenicity and efficacy of the Shingrix vaccine in immunocompromised varicella zoster virus naïve pediatric patients.
C5n · EC50 vs Cmax coherenceno_data
Measure: Measured exposure reaches effect threshold Comparator: Pharmacokinetic Cmax vs EC50 Hit rule: Achieved exposure (Cmax/tissue) plausibly reaches the in-vitro EC50
Finding: No retrieved evidence reports measured exposure (Cmax/tissue) or in-vitro EC50 values for varicella vaccine, nor any coherence assessment between achieved exposure and effect thresholds for varicella post-vaccine events.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine EC50 vs Cmax coherence dose-response OR dose effect pubmed · 1299586 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine no dose effect OR no dose-response EC50 vs Cmax coherence pubmed · 99 hits · run 2026-09-09
13 retrieved record(s)
does_not_resolve 39082700 · The Journal of infectious diseases (2025) — Effectiveness of MenB-4C Vaccine Against Gonorrhea: A Systematic Review and Meta-analysis.
does_not_resolve 34806766 · The Cochrane database of systematic revi (2021) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 37967254 · Human vaccines & immunotherapeutics (2023) — Effectiveness and safety of recombinant zoster vaccine: A review of real-world evidence.
does_not_resolve 32309885 · The Cochrane database of systematic revi (2020) — Vaccines for measles, mumps, rubella, and varicella in children.
does_not_resolve 22859715 · British medical bulletin (2012) — Varicella vaccines.
does_not_resolve 34893015 · Human vaccines & immunotherapeutics (2021) — Effectiveness of varicella vaccine as post-exposure prophylaxis: a meta-analysis.
does_not_resolve 22890288 · Bone marrow transplantation (2013) — Live (vaccines) from New York.
ambiguous 40916263 · Vaccine (2025) — Safety, immunogenicity and efficacy of the Shingrix vaccine in immunocompromised varicella zoster virus naïve pediatric patients.
E1 · Mediator identified in casesno_data
Measure: Mediator present in affected tissue/cells Comparator: Unaffected tissue / control Hit rule: The hypothesized mediator is detected in the affected compartment and not (or less) in control
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine mechanism Mediator identified in cases in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Mediator identified in cases not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
E2 · Mediator in healthy vaccineesno_data
Measure: Mediator detectable after vaccination Comparator: Pre-vaccination baseline Hit rule: Mediator appears after vaccination and tracks the exposure window
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine mechanism Mediator in healthy vaccinees in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Mediator in healthy vaccinees not associated mechanism pubmed · 2 hits · run 2026-09-09
E3 · Infection contrastno_data
Measure: Mediator absent/low after natural infection Comparator: Recovered natural infection Hit rule: Mediator signal is specific to vaccination vs a comparable natural-infection control
Finding: The retrieved evidence does not address a comparator of natural infection control for varicella post-vaccine cases; the studies focus on immunogenicity, vaccine effectiveness, or correlates of response without assessing mediator signals that are absent or low after natural varicella infection.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine mechanism Infection contrast in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Infection contrast not associated mechanism pubmed · 5 hits · run 2026-09-09
4 retrieved record(s)
does_not_resolve 31345639 · Vaccine (2019) — Long-term immunogenicity of measles, mumps and rubella-containing vaccines in healthy young children: A 10-year follow-up.
does_not_resolve 24485548 · Lancet (London, England) (2014) — Protection against varicella with two doses of combined measles-mumps-rubella-varicella vaccine versus one dose of monovalent varicella vaccine: a multicentre,
does_not_resolve 40592255 · Vaccine (2025) — AS01-adjuvanted vaccine alters baseline correlates of T cell response to varicella zoster virus in older adults.
does_not_resolve 26554449 · BMC infectious diseases (2015) — Antibody induced by one-dose varicella vaccine soon became weak in children: evidence from a cross-sectional seroepidemiological survey in Beijing, PRC.
E4 · Transfer to recipientno_data
Measure: Phenotype/mediator transferred to a recipient system Comparator: Control transfer Hit rule: The effect / mediator transfers to a naive recipient system
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine mechanism Transfer to recipient in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Transfer to recipient not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
E5 · Transfer specificityno_data
Measure: Transfer requires the specific mediator Comparator: Transfer with mediator present Hit rule: Transfer effect is lost when the specific mediator is removed
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine mechanism Transfer specificity in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Transfer specificity not associated mechanism pubmed · 2 hits · run 2026-09-09
1 retrieved record(s)
does_not_resolve 11101557 · Journal of clinical microbiology (2000) — Rapid genotyping of varicella-zoster virus vaccine and wild-type strains with fluorophore-labeled hybridization probes.
E6 · Depletion / knockdownno_data
Measure: Removing the mediator reduces the effect Comparator: Non-targeted knockdown Hit rule: Knockdown / depletion of the mediator reduces the phenotype
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine mechanism Depletion / knockdown in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Depletion / knockdown not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
E7 · Add-back rescueno_data
Measure: Adding the mediator restores the effect Comparator: Add-back of a control protein Hit rule: Adding back the mediator (not a control) restores the phenotype
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine mechanism Add-back rescue in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Add-back rescue not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
E8 · Neutralizationno_data
Measure: Neutralizing the mediator blocks the effect Comparator: Isotype control Hit rule: Neutralization of the mediator (not an isotype control) blocks the phenotype
Finding: The study measured neutralizing antibody titers (NATb) post-vaccination, but did not report neutralization blocking the phenotype of varicella post-vaccine adverse events.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine mechanism Neutralization in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Neutralization not associated mechanism pubmed · 3 hits · run 2026-09-09
2 retrieved record(s)
does_not_resolve 30481106 · Human vaccines & immunotherapeutics (2019) — Safety, immunogenicity, and lot-to-lot consistency of live attenuated varicella vaccine in 1-3 years old children: a double-blind, randomized phase III trial.
does_not_resolve 8585290 · Vaccine (1995) — Boosting immune response with a candidate varicella-zoster virus glycoprotein subunit vaccine.
E9 · Isotype controlno_data
Measure: Isotype control does not reproduce the effect Comparator: Active antibody Hit rule: An isotype control fails to reproduce the block/activation
Finding: The retrieved evidence does not discuss isotype controls or their failure to reproduce a block/activation effect in the context of varicella vaccine and varicella post-vaccine events.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine mechanism Isotype control in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Isotype control not associated mechanism pubmed · 17 hits · run 2026-09-09
7 retrieved record(s)
does_not_resolve 40916263 · Vaccine (2025) — Safety, immunogenicity and efficacy of the Shingrix vaccine in immunocompromised varicella zoster virus naïve pediatric patients.
does_not_resolve 41225196 · Pediatric nephrology (Berlin, Germany) (2026) — Risk factors for loss of Varicella immunity after pediatric kidney transplantation.
supports_node 39411866 · Human vaccines & immunotherapeutics (2024) — Analysis of antibody dynamics in Chinese children aged 1-3 years after single-dose varicella vaccination: A 42 months prospective study.
does_not_resolve 41703694 · The Pediatric infectious disease journal (2026) — Immunogenicity and Safety of Two-dose Schedules With Different Intervals of an ORF7-deficient Live Vaccine Candidate for Varicella: A Randomized, Double-blind,
does_not_resolve 40464766 · Human vaccines & immunotherapeutics (2025) — Seroepidemiological survey of the population 10 years after the implementation of the varicella vaccine 2-dose immunization strategy.
does_not_resolve 19403475 · Pediatrics (2009) — Validity of reported varicella history as a marker for varicella zoster virus immunity among unvaccinated children, adolescents, and young adults in the post-va
supports_node 8018498 · Pediatric nephrology (Berlin, Germany) (1994) — Attenuated varicella virus vaccine in children with renal transplants.
F1 · Full product reproducesno_data
Measure: Full vaccine product reproduces the effect Comparator: No-product control Hit rule: The full product (not a subcomponent) reproduces the effect
Finding: The retrieved evidence describes virus-vectored vaccines for influenza, measles, rabies, and cancer, but contains no mention of varicella vaccine, varicella post-vaccine adverse events, or any reproduction of varicella disease by a full varicella vaccine product.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Full product reproduces component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Full product reproduces no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-09
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F2 · Empty vector / particleno_data
Measure: Vector/particle without antigen reproduces (or not) Comparator: Full product Hit rule: Effect attributed to (or excluded from) the vector/particle backbone alone
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Empty vector / particle component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Empty vector / particle no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-09
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F4 · Irrelevant cargono_data
Measure: Irrelevant cargo does not reproduce the effect Comparator: Vector with the target antigen Hit rule: Irrelevant cargo fails to reproduce the effect (specificity)
Finding: The retrieved evidence does not discuss varicella vaccine or varicella post-vaccine adverse events; it focuses on viral and bacterial vaccine vectors for influenza, measles, rabies, and cancer vaccines, with no mention of varicella vaccine safety.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Irrelevant cargo component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Irrelevant cargo no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-09
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F5 · Infection preparationno_data
Measure: Infection preparation vs product comparison Comparator: Product-derived preparation Hit rule: Effect compares correctly between infection and product preparations
Finding: No retrieved evidence discusses varicella vaccine, varicella post-vaccine adverse events, or comparisons between infection and vaccine preparations; the evidence focuses on influenza, measles, rabies, and cancer vaccine vectors.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Infection preparation component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Infection preparation no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-09
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F6 · Cytokine / adjuvant mixno_data
Measure: Cytokine/adjuvant mix alone reproduces (or not) Comparator: Individual components Hit rule: The effect is (or is not) reproducible by the cytokine/adjuvant mix alone
Finding: No retrieved evidence discusses varicella vaccine, varicella post-vaccine adverse events, or the specific role of a cytokine/adjuvant mix in reproducing such events. The evidence focuses on virus-vectored, live bacterial, and lentiviral vector vaccines for influenza, measles, rabies, and cancer, with no mention of varicella or post-vaccine varicella.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Cytokine / adjuvant mix component OR antigen OR vector pubmed · 2045722 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Cytokine / adjuvant mix no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-09
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
F7 · Component combinationno_data
Measure: Defined component combination reproduces the effect Comparator: Single components Hit rule: A defined combination reproduces the effect that single components do not
Finding: No retrieved evidence directly addresses varicella vaccine causing varicella post-vaccine disease through a defined component combination effect.
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Component combination component OR antigen OR vector pubmed · 2045728 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Component combination no effect component isolation pubmed · 0 hits (0 hits — negative) · run 2026-09-09
does_not_resolve 25876176 · Human vaccines & immunotherapeutics (2015) — Progress on adenovirus-vectored universal influenza vaccines.
does_not_resolve 40857335 · PLoS neglected tropical diseases (2025) — Novel rabies vaccine candidates development based on pseudotyped lentiviral vectors with rabies virus glycoprotein.
does_not_resolve 21952287 · Cancer journal (Sudbury, Mass.) (2011) — Viral vector-based therapeutic cancer vaccines.
G1 · 2D human cellsno_data
Measure: Effect reproduced in 2D human cell culture Comparator: Untreated / control cells Hit rule: Effect reproduced in 2D primary human cells
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine 2D human cells animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine 2D human cells not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G2 · Organoid / chipno_data
Measure: Effect reproduced in organoid / organ-on-chip Comparator: Unexposed organoid Hit rule: Effect reproduced in a 3D organoid / organ-on-chip system
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Organoid / chip animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Organoid / chip not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
H1 · Block in vitro / in vivono_data
Measure: Blocking the mediator/mechanism prevents the effect Comparator: Control intervention Hit rule: Blocking the mechanism prevents or reverses the effect (not with a control intervention)
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Block in vitro / in vivo intervention OR treatment OR reversal pubmed · 15146614 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Block in vitro / in vivo no effect intervention pubmed · 0 hits (0 hits — negative) · run 2026-09-09
Clinical / animal / host 7/7 evaluated
E10 · Host-line dependenceno_data
Measure: Effect depends on host line/cell type Comparator: Susceptible host line Hit rule: Effect is restricted to a defined host line / genotype, not universal
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine mechanism Host-line dependence in vitro OR patient-derived pubmed · 29266 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Host-line dependence not associated mechanism pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G3 · Animal, clinical routeno_data
Measure: Effect in animal via the clinical route of administration Comparator: Vehicle, same route Hit rule: Effect reproduced in an animal using the clinical route of administration
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Animal, clinical route animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Animal, clinical route not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G4 · Susceptible animalno_data
Measure: Effect in a susceptible animal model Comparator: Non-susceptible model Hit rule: Effect in a defined susceptible animal model
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Susceptible animal animal OR organoid OR cell model pubmed · 1819355 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Susceptible animal not reproduced model pubmed · 1 hits · run 2026-09-09
G5 · Replication across labsno_data
Measure: Effect replicated in an independent lab Comparator: Original result Hit rule: The key effect is replicated in an independent laboratory
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Replication across labs animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Replication across labs not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G6 · Blinded scoringno_data
Measure: Outcomes scored blinded Comparator: Unblinded reference Hit rule: Primary outcomes scored by a blinded assessor
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Blinded scoring animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Blinded scoring not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
G7 · Experimental time courseno_data
Measure: Effect follows a defined experimental time course Comparator: No-exposure time course Hit rule: The effect's onset/offset follows a defined experimental time course
Finding: no evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Experimental time course animal OR organoid OR cell model pubmed · 1819354 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Experimental time course not reproduced model pubmed · 0 hits (0 hits — negative) · run 2026-09-09
I4 · Susceptibility traitno_data
Measure: A host trait / marker defines susceptibility Comparator: Trait-negative hosts Hit rule: A defined host trait / marker enriches for susceptibility
Finding: No evidence found
Cited: (none)
supporting: Varicella (chickenpox) vaccine Varicella post vaccine Susceptibility trait coherence OR latency OR susceptibility pubmed · 870416 hits · run 2026-09-09
mirror: Varicella (chickenpox) vaccine Varicella post vaccine Susceptibility trait inconsistent OR contradicts pubmed · 27618 hits · run 2026-09-09
1 retrieved record(s)
ambiguous 15578364 · Clinical infectious diseases : an offici (2004) — Varicella vaccine for susceptible adults: do it today.
How this was built
Per node: a supporting and a mirror PubMed query built from the node's measure / population / comparator / hit_rule; top hits fetched (title + abstract); each record classified (supports / refutes / ambiguous) by xAI with a heuristic fallback; a per-node synthesis is generated strictly from the retrieved PMIDs; the node status is then rolled up to C1–C6. Full query provenance is shown per node above. Reproduce the build: python -m evidence_run. Data: data/evidence_run/state.json.