Licensed vaccine product
Prevnar 20: side effects, ingredients & package insert
Pfizer Inc. · pneumococcal (PCV) vaccine · conjugate · intramuscular · 0.5 mL
Prevnar 20 ingredients (FDA package insert, Section 11)
Per-dose composition as stated in the prescribing information; verified 2026-07-09. Click an ingredient for every vaccine that contains it.
| Role | Ingredient | Amount per dose |
|---|---|---|
| Antigen | Pneumococcal capsular polysaccharides (20 serotypes) conjugated to CRM197 | 2.2 mcg each of 19 serotypes + 4.4 mcg serotype 6B (typical PCV20 labeling) |
| Adjuvant | Aluminum phosphate | |
| Preservative | None (preservative-free) | Single-dose presentation; label states no preservative. |
| surfactant | Polysorbate 80 | ≈100 mcg |
| buffer | Succinate buffer | ≈295 mcg |
| buffer | Sodium chloride | label quantity |
| culture_medium_residual | Yeast / growth medium residuals | trace |
Source: Manufacturer prescribing information. Formulations change — re-verify before clinical use.
Prevnar 20 side effects: where the data is
Reported reactions for Prevnar 20 and the other pneumococcal (PCV) products are compiled on the pneumococcal (PCV) vaccine page: pre-licensure trial reactogenicity, VAERS report counts, and international databases (Canada Vigilance, EudraVigilance, Lareb, VigiAccess). Those counts are spontaneous reports with no denominator — a report does not establish that the vaccine caused the event.
Prevnar 20 lot number lookup
VAERS report counts are available by lot for Pneumococcal (PCV) vaccines. Use the pneumococcal (PCV) lot number lookup or search any lot directly in the lot explorer. Lot numbers are printed on the vaccination record card and the vial label.
Schedule and age range
Licensed ages and the recommended series for pneumococcal (PCV) vaccines are on the pneumococcal (PCV) vaccine page; how 31 countries schedule it is on pneumococcal (PCV) schedule by country. Always confirm the product-specific age range in the current package insert.
Common questions about Prevnar 20
What are the side effects of Prevnar 20?
Common reactions listed in the Prevnar 20 package insert are injection-site pain, redness or swelling and short-lived systemic symptoms such as fever, tiredness or irritability. Rarer events and the reported counts from VAERS and international databases are on the pneumococcal (PCV) vaccine page; counts are reports, not rates, and do not prove the vaccine caused the event.
What is in Prevnar 20?
Prevnar 20 contains Pneumococcal capsular polysaccharides (20 serotypes) conjugated to CRM197 as antigen; adjuvant: Aluminum phosphate; it is preservative-free. Excipients: Polysorbate 80, Succinate buffer, Sodium chloride, Yeast / growth medium residuals. Amounts per dose are in the table above, taken from Section 11 of the FDA package insert (verified 2026-07-09).
Where is the Prevnar 20 package insert?
The FDA-licensed prescribing information for Prevnar 20 is published by Pfizer Inc. and the FDA; the source used for this page is https://labeling.pfizer.com/ShowLabeling.aspx?id=15428. Formulations change, so re-verify the current insert before clinical use.
Reviewed 2026-10-08 · Matthew Thomas J Halma, Founder, Open Source Medicine Foundation. Informational, not medical advice.