Abatacept vs Ipilimumab: side effects in FDA adverse event reports
At a glance
| Abatacept | Ipilimumab | |
|---|---|---|
| Drug class | Selective T Cell Costimulation Modulator | CTLA-4-directed Blocking Antibody |
| Brand names | Orencia | Yervoy |
| FAERS reports | 137,367 | 42,905 |
| Serious | 60% | 89% |
| Death outcome | 9,239 | 9,586 |
| Boxed warning | No | No |
Signals both drugs share
No strong shared signal after removing coding and lab terms.
Labeled signals distinctive to Abatacept
- None stood out among the strongest labeled signals.
Labeled signals distinctive to Ipilimumab
- Immune-mediated enterocolitis — n=1,121, PRR 228.7 Labeled adverse reaction
- Hypophysitis — n=1,074, PRR 566.7 Labeled adverse reaction
- Immune-mediated hepatitis — n=521, PRR 176.9 Labeled adverse reaction
- Hypopituitarism — n=430, PRR 160.4 Labeled adverse reaction
- Immune-mediated hepatic disorder — n=399, PRR 129.0 Labeled (related wording)
- Immune-mediated lung disease — n=362, PRR 127.8 Labeled (related wording)
- Autoimmune colitis — n=283, PRR 386.9 Labeled (related wording)
- Immune-mediated dermatitis — n=281, PRR 210.3 Labeled (related wording)
Common questions
Which has more reported side effects, Abatacept or Ipilimumab?
Abatacept has 137,367 FAERS reports and Ipilimumab 42,905. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (60% vs 89%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Abatacept and Ipilimumab share?
They share no strong flagged signal after artifacts and lab terms are removed.
Is Abatacept or Ipilimumab safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.