Drug
Acetaminophen And Codeine Phosphate
Important: Reactions below are the flagged terms from this drug’s
FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate
disproportionality in spontaneous reporting, not causation.
Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
| Reaction | Co-reports (a) | PRR | ROR | Signal | |
|---|---|---|---|---|---|
| 1 | Drug Toxicity | 28 | 22.6 | 22.9 | signal |
| 2 | Liver Function Test Abnormal | 39 | 14.8 | 15.1 | signal |
| 3 | Completed Suicide | 100 | 13.2 | 13.9 | signal |
| 4 | Haematemesis | 29 | 12.7 | 12.9 | signal |
| 5 | Poisoning | 14 | 12.3 | 12.4 | signal |
| 6 | Renal Failure Acute | 43 | 11.1 | 11.3 | signal |
| 7 | Pulmonary Fibrosis | 17 | 9.9 | 10.0 | signal |
| 8 | Acute Hepatic Failure | 12 | 9.8 | 9.9 | signal |
| 9 | Circulatory Collapse | 15 | 9.7 | 9.8 | signal |
| 10 | International Normalised Ratio Increased | 25 | 9.7 | 9.8 | signal |
| 11 | Glomerular Filtration Rate Decreased | 10 | 9.2 | 9.2 | signal |
| 12 | Melaena | 18 | 9.1 | 9.1 | signal |
| 13 | Toxic Epidermal Necrolysis | 12 | 8.8 | 8.9 | signal |
| 14 | Toxic Skin Eruption | 8 | 8.8 | 8.8 | signal |
| 15 | Myocardial Ischaemia | 9 | 8.7 | 8.8 | signal |
| 16 | Tenderness | 8 | 8.5 | 8.5 | signal |
| 17 | Hyperlipidaemia | 9 | 8.3 | 8.4 | signal |
| 18 | Rhabdomyolysis | 31 | 8.3 | 8.4 | signal |
| 19 | Gastric Ulcer | 14 | 8.2 | 8.2 | signal |
| 20 | Gamma-glutamyltransferase Increased | 16 | 8.0 | 8.1 | signal |
| 21 | Intentional Drug Misuse | 15 | 7.9 | 7.9 | signal |
| 22 | Multi-organ Failure | 12 | 7.6 | 7.6 | signal |
| 23 | Iron Deficiency Anaemia | 6 | 7.3 | 7.3 | signal |
| 24 | Respiratory Depression | 8 | 7.2 | 7.3 | signal |
| 25 | Blood Alkaline Phosphatase Increased | 16 | 7.1 | 7.2 | signal |
| 26 | Hepatic Encephalopathy | 6 | 7.1 | 7.2 | signal |
| 27 | Acute Myocardial Infarction | 19 | 7.1 | 7.2 | signal |
| 28 | Jaundice | 17 | 7.0 | 7.1 | signal |
| 29 | Blood Creatine Phosphokinase Increased | 18 | 6.8 | 6.9 | signal |
| 30 | Respiratory Arrest | 17 | 6.8 | 6.8 | signal |
| 31 | Fluid Overload | 9 | 6.8 | 6.8 | signal |
| 32 | Hypotonia | 6 | 6.6 | 6.7 | signal |
| 33 | Cardio-respiratory Arrest | 25 | 6.6 | 6.7 | signal |
| 34 | Upper Gastrointestinal Haemorrhage | 10 | 6.6 | 6.6 | signal |
| 35 | Skin Reaction | 8 | 6.3 | 6.3 | signal |
| 36 | Sudden Death | 6 | 6.2 | 6.3 | signal |
| 37 | Depressed Level Of Consciousness | 22 | 6.2 | 6.3 | signal |
| 38 | Gastrointestinal Haemorrhage | 46 | 6.1 | 6.2 | signal |
| 39 | Hyperkalaemia | 19 | 6.0 | 6.1 | signal |
| 40 | Unresponsive To Stimuli | 14 | 6.0 | 6.1 | signal |
| 41 | Platelet Count Increased | 7 | 6.0 | 6.0 | signal |
| 42 | Hepatic Failure | 16 | 5.9 | 5.9 | signal |
| 43 | Pallor | 14 | 5.7 | 5.7 | signal |
| 44 | Swollen Tongue | 16 | 5.7 | 5.7 | signal |
| 45 | Metabolic Acidosis | 16 | 5.6 | 5.7 | signal |
| 46 | Thirst | 9 | 5.6 | 5.6 | signal |
| 47 | Macular Degeneration | 6 | 5.6 | 5.6 | signal |
| 48 | Gout | 9 | 5.6 | 5.6 | signal |
| 49 | Mass | 7 | 5.5 | 5.6 | signal |
| 50 | Coronary Artery Disease | 15 | 5.5 | 5.5 | signal |
| 51 | Cerebral Infarction | 12 | 5.5 | 5.5 | signal |
| 52 | Neutrophil Count Increased | 5 | 5.4 | 5.4 | signal |
| 53 | Hypokinesia | 7 | 5.4 | 5.4 | signal |
| 54 | Lip Swelling | 16 | 5.3 | 5.4 | signal |
| 55 | Mouth Ulceration | 10 | 5.3 | 5.3 | signal |
| 56 | Urinary Incontinence | 14 | 5.3 | 5.3 | signal |
| 57 | Medication Error | 26 | 5.2 | 5.3 | signal |
| 58 | Haemoglobin Decreased | 48 | 5.2 | 5.3 | signal |
| 59 | Drug Exposure During Pregnancy | 16 | 5.2 | 5.2 | signal |
| 60 | Rash Generalised | 12 | 5.1 | 5.1 | signal |
| 61 | Cyanosis | 7 | 4.9 | 4.9 | signal |
| 62 | Lower Respiratory Tract Infection | 20 | 4.9 | 4.9 | signal |
| 63 | Scab | 5 | 4.9 | 4.9 | signal |
| 64 | Cardiovascular Disorder | 11 | 4.8 | 4.8 | signal |
| 65 | Poisoning Deliberate | 4 | 4.8 | 4.8 | signal |
| 66 | Vasculitis | 5 | 4.8 | 4.8 | signal |
| 67 | Erectile Dysfunction | 11 | 4.7 | 4.8 | signal |
| 68 | Caesarean Section | 5 | 4.7 | 4.7 | signal |
| 69 | Bronchospasm | 6 | 4.7 | 4.7 | signal |
| 70 | Dizziness Postural | 4 | 4.6 | 4.6 | signal |
| 71 | Angina Pectoris | 12 | 4.6 | 4.6 | signal |
| 72 | Pancreatitis | 22 | 4.6 | 4.7 | signal |
| 73 | Faeces Discoloured | 9 | 4.6 | 4.6 | signal |
| 74 | Parkinsonism | 4 | 4.6 | 4.6 | signal |
| 75 | Stevens-johnson Syndrome | 9 | 4.5 | 4.5 | signal |
| 76 | Pancreatitis Acute | 9 | 4.5 | 4.5 | signal |
| 77 | Anaphylactic Reaction | 22 | 4.4 | 4.5 | signal |
| 78 | Chromaturia | 9 | 4.4 | 4.4 | signal |
| 79 | Cholestasis | 7 | 4.1 | 4.1 | signal |
| 80 | Red Blood Cell Sedimentation Rate Increased | 4 | 4.0 | 4.0 | signal |
| 81 | Eosinophilia | 6 | 3.8 | 3.8 | signal |
| 82 | Eyelid Oedema | 4 | 3.8 | 3.8 | signal |
| 83 | Myoclonus | 4 | 3.7 | 3.7 | signal |
| 84 | Hallucination, Visual | 7 | 3.7 | 3.7 | signal |
| 85 | Delusion | 5 | 3.6 | 3.6 | signal |
| 86 | Drug Dispensing Error | 5 | 3.6 | 3.6 | signal |
| 87 | Erythema Multiforme | 3 | 3.6 | 3.6 | no signal |
| 88 | Drug Administration Error | 10 | 3.6 | 3.6 | signal |
| 89 | Diarrhoea Haemorrhagic | 3 | 3.6 | 3.6 | no signal |
| 90 | Angioedema | 14 | 3.5 | 3.5 | signal |
| 91 | Convulsion | 18 | 3.4 | 3.5 | signal |
| 92 | Ankylosing Spondylitis | 4 | 3.4 | 3.4 | signal |
| 93 | Sopor | 4 | 3.3 | 3.3 | signal |
| 94 | Pregnancy | 6 | 3.3 | 3.3 | signal |
| 95 | Helicobacter Infection | 3 | 3.3 | 3.3 | no signal |
| 96 | Lymphopenia | 4 | 3.2 | 3.2 | no signal |
| 97 | Irritability | 17 | 3.1 | 3.2 | signal |
| 98 | Aggression | 14 | 3.1 | 3.1 | signal |
| 99 | Extrapyramidal Disorder | 7 | 3.1 | 3.1 | signal |
| 100 | Pharyngitis Streptococcal | 3 | 3.1 | 3.1 | no signal |
| 101 | Pelvic Pain | 5 | 3.1 | 3.1 | signal |
| 102 | Psychotic Disorder | 8 | 3.0 | 3.0 | signal |
| 103 | Drug Abuse | 22 | 2.9 | 2.9 | signal |
| 104 | Myocardial Infarction | 46 | 2.9 | 3.0 | signal |
| 105 | Metastases To Lung | 3 | 2.9 | 2.9 | no signal |
| 106 | Dependence | 14 | 2.8 | 2.8 | signal |
| 107 | Abnormal Behaviour | 10 | 2.8 | 2.8 | signal |
| 108 | Activities Of Daily Living Impaired | 5 | 2.8 | 2.8 | signal |
| 109 | Thyroid Cancer | 3 | 2.8 | 2.8 | no signal |
| 110 | Mania | 4 | 2.7 | 2.7 | no signal |
| 111 | Libido Decreased | 3 | 2.7 | 2.7 | no signal |
| 112 | Osteonecrosis | 8 | 2.7 | 2.7 | signal |
| 113 | Abasia | 6 | 2.7 | 2.7 | signal |
| 114 | Tuberculosis | 3 | 2.6 | 2.6 | no signal |
| 115 | Anorexia | 3 | 2.5 | 2.6 | no signal |
| 116 | Hepatocellular Injury | 3 | 2.3 | 2.3 | no signal |
| 117 | Withdrawal Syndrome | 8 | 2.1 | 2.1 | no signal |
| 118 | Tardive Dyskinesia | 5 | 1.9 | 2.0 | no signal |
| 119 | Suicide Attempt | 10 | 1.8 | 1.8 | no signal |
| 120 | Intentional Overdose | 10 | 1.7 | 1.7 | no signal |
| 121 | Dystonia | 3 | 1.7 | 1.7 | no signal |
| 122 | Abortion Spontaneous | 6 | 1.7 | 1.7 | no signal |
| 123 | Pancreatic Carcinoma | 3 | 1.1 | 1.1 | no signal |
| 124 | Oesophageal Carcinoma | 3 | 1.1 | 1.1 | no signal |
| 125 | Drug Withdrawal Syndrome | 7 | 0.9 | 0.9 | no signal |
| 126 | Drug Dependence | 11 | 0.8 | 0.7 | no signal |