OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Acetaminophen,caffeine

131 flagged reaction(s) · 7,459 total co-reports · max PRR 498.0
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Blood Calcium Decreased 216 498.0 675.1 signal
2 Orthostatic Hypotension 216 319.7 433.3 signal
3 Sedation 212 209.1 281.5 signal
4 Hand Deformity 101 198.4 226.1 signal
5 Folliculitis 72 179.0 196.1 signal
6 Helicobacter Infection 69 173.8 189.6 signal
7 Depressed Level Of Consciousness 215 139.7 188.8 signal
8 Pemphigus 67 138.2 150.4 signal
9 Cognitive Disorder 219 120.7 164.1 signal
10 Drug Level Increased 67 103.6 112.7 signal
11 Pericarditis 65 99.9 108.4 signal
12 Mobility Decreased 275 98.3 147.3 signal
13 Synovitis 67 95.0 103.4 signal
14 Sciatica 54 87.1 93.2 signal
15 Glossodynia 70 80.1 87.5 signal
16 Contraindicated Product Administered 93 78.9 88.8 signal
17 Irritable Bowel Syndrome 61 73.0 78.8 signal
18 Joint Range Of Motion Decreased 37 70.8 74.1 signal
19 Wound Infection 28 65.9 68.2 signal
20 Balance Disorder 218 64.4 87.3 signal
21 Systemic Lupus Erythematosus 81 58.5 64.8 signal
22 Autoimmune Disorder 21 56.1 57.5 signal
23 Muscle Spasticity 27 55.7 57.5 signal
24 Bursitis 26 55.1 56.8 signal
25 Impaired Healing 69 53.7 58.5 signal
26 Electrocardiogram Qt Prolonged 67 47.6 51.7 signal
27 Wound 51 46.9 49.9 signal
28 Lower Respiratory Tract Infection 81 45.7 50.6 signal
29 Prescribed Overdose 32 42.2 43.9 signal
30 Deformity 15 40.9 41.6 signal
31 Fibromyalgia 38 40.0 41.9 signal
32 Therapeutic Product Effect Decreased 68 39.1 42.6 signal
33 Hypercholesterolaemia 13 34.7 35.2 signal
34 Arthropathy 74 33.9 37.1 signal
35 Liver Injury 32 33.8 35.1 signal
36 Obesity 21 33.6 34.5 signal
37 Bladder Disorder 13 33.4 33.9 signal
38 Blister 73 33.3 36.4 signal
39 Ear Pain 25 32.8 33.8 signal
40 Night Sweats 41 32.5 34.2 signal
41 Red Blood Cell Sedimentation Rate Increased 14 32.2 32.8 signal
42 Toxicity To Various Agents 200 30.4 39.9 signal
43 Impaired Quality Of Life 17 30.2 30.8 signal
44 Infusion Related Reaction 77 29.8 32.7 signal
45 Discomfort 69 29.1 31.6 signal
46 Hip Arthroplasty 17 28.6 29.2 signal
47 Laryngitis 12 28.2 28.6 signal
48 Hypotension 220 28.1 37.9 signal
49 Type 2 Diabetes Mellitus 37 28.0 29.2 signal
50 Ill-defined Disorder 66 27.7 30.1 signal
51 Frequent Bowel Movements 29 27.5 28.5 signal
52 Hepatic Enzyme Increased 72 27.1 29.6 signal
53 Stomatitis 63 26.5 28.6 signal
54 Pregnancy 21 26.5 27.2 signal
55 Respiratory Disorder 31 26.4 27.4 signal
56 Constipation 223 26.3 35.7 signal
57 Body Temperature Increased 21 26.2 26.9 signal
58 Lower Limb Fracture 19 25.4 26.0 signal
59 Foot Deformity 11 25.3 25.6 signal
60 Medication Error 55 25.3 27.0 signal
61 Tubulointerstitial Nephritis 18 24.5 25.1 signal
62 Treatment Failure 73 22.7 24.8 signal
63 Sinusitis 91 22.6 25.3 signal
64 Prescribed Underdose 17 21.8 22.2 signal
65 Drug Interaction 132 21.2 25.1 signal
66 Gastrointestinal Disorder 73 21.1 23.0 signal
67 Rheumatoid Arthritis 93 21.0 23.5 signal
68 Joint Swelling 96 20.3 22.9 signal
69 Psoriatic Arthropathy 32 20.3 21.1 signal
70 Sleep Disorder 55 20.1 21.4 signal
71 Pulmonary Fibrosis 15 20.0 20.4 signal
72 Knee Arthroplasty 16 19.6 20.0 signal
73 Disability 15 19.4 19.7 signal
74 Oedema 41 19.3 20.3 signal
75 Osteoarthritis 32 19.2 20.0 signal
76 Swelling 69 18.9 20.5 signal
77 Drug Intolerance 69 18.3 19.9 signal
78 Blood Cholesterol Increased 33 18.1 18.8 signal
79 Fall 235 18.0 24.9 signal
80 Delirium 24 17.7 18.2 signal
81 Subarachnoid Haemorrhage 7 17.5 17.6 signal
82 Contusion 64 17.0 18.3 signal
83 Gait Inability 22 17.0 17.4 signal
84 Impaired Work Ability 14 16.7 16.9 signal
85 Colitis Ulcerative 29 16.6 17.2 signal
86 Intentional Product Use Issue 57 16.5 17.7 signal
87 Hepatic Encephalopathy 6 16.4 16.5 signal
88 Hepatic Cirrhosis 12 16.4 16.6 signal
89 Liver Disorder 28 16.1 16.7 signal
90 Rectal Haemorrhage 27 16.0 16.5 signal
91 Myocarditis 7 15.8 15.9 signal
92 Dementia 17 15.6 15.9 signal
93 Wheezing 36 15.5 16.2 signal
94 Injury 42 15.2 15.9 signal
95 Abdominal Discomfort 98 15.0 16.9 signal
96 Swollen Tongue 18 14.7 15.0 signal
97 Joint Stiffness 15 14.6 14.8 signal
98 Joint Dislocation 6 14.5 14.6 signal
99 Loss Of Personal Independence In Daily Activities 27 14.5 14.9 signal
100 Pain 343 14.2 23.7 signal
101 Musculoskeletal Pain 29 14.0 14.5 signal
102 Peripheral Swelling 84 14.0 15.4 signal
103 Musculoskeletal Stiffness 47 13.7 14.5 signal
104 Migraine 50 13.5 14.3 signal
105 Maternal Exposure During Pregnancy 46 13.3 14.0 signal
106 Blood Pressure Systolic Increased 10 13.0 13.2 signal
107 Inflammation 26 12.9 13.3 signal
108 Body Temperature Decreased 5 12.9 12.9 signal
109 Road Traffic Accident 21 12.8 13.1 signal
110 Injection Site Reaction 34 12.6 13.1 signal
111 Accidental Overdose 18 12.6 12.8 signal
112 Nightmare 17 12.5 12.7 signal
113 Drug Abuse 40 12.2 12.8 signal
114 Incorrect Route Of Product Administration 8 12.1 12.3 signal
115 Musculoskeletal Disorder 9 12.0 12.1 signal
116 Nasopharyngitis 82 11.3 12.5 signal
117 Exposure During Pregnancy 27 11.1 11.4 signal
118 Face Oedema 7 10.5 10.6 signal
119 Injection Site Extravasation 5 10.2 10.3 signal
120 Alopecia 72 9.3 10.1 signal
121 Eczema 17 8.6 8.8 signal
122 Eye Inflammation 3 8.1 8.1 signal
123 Adverse Event 29 8.0 8.3 signal
124 Eye Discharge 3 7.5 7.5 signal
125 Sleep Disorder Due To A General Medical Condition 4 6.3 6.3 signal
126 Overdose 51 6.0 6.3 signal
127 Intentional Overdose 14 5.6 5.7 signal
128 Intentional Self-injury 4 5.1 5.1 signal
129 Suicide Attempt 11 4.6 4.7 signal
130 Completed Suicide 13 3.9 4.0 signal
131 Device Dislocation 5 2.9 3.0 signal