Drug

Aflibercept

1,050 flagged reaction(s) · 66,553 total co-reports · max PRR 814.2

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Non-infectious Endophthalmitis	462	814.2	826.5	signal
2	Lens Capsulotomy	7	777.2	777.3	signal
3	Intra-ocular Injection Complication	113	672.1	674.5	signal
4	Vitrectomy	275	579.7	584.9	signal
5	Iris Vascular Disorder	6	499.6	499.7	signal
6	Vitreal Cells	81	465.1	466.4	signal
7	Noninfective Retinitis	8	355.3	355.4	signal
8	Subretinal Hyperreflective Exudation	9	352.7	352.8	signal
9	Polypoidal Choroidal Vasculopathy	105	346.3	347.4	signal
10	Vitreous Haze	49	316.9	317.4	signal
11	Intra-ocular Injection	17	314.6	314.7	signal
12	Retinal Fibrosis	19	253.1	253.3	signal
13	Anterior Chamber Flare	62	242.9	243.4	signal
14	Visual Acuity Reduced Transiently	81	239.8	240.4	signal
15	Subretinal Fluid	272	235.3	237.4	signal
16	Retinal Laser Coagulation	7	233.1	233.2	signal
17	Eye Infection Intraocular	20	229.7	229.9	signal
18	Vitritis	456	226.3	229.7	signal
19	Anterior Chamber Cell	180	225.8	227.1	signal
20	Vitreous Fibrin	7	222.0	222.1	signal
21	Endophthalmitis	1,409	208.1	218.0	signal
22	Macular Thickening	18	203.2	203.3	signal
23	Retinal Occlusive Vasculitis	48	196.2	196.5	signal
24	Vitreous Opacities	180	184.5	185.5	signal
25	Corneal Striae	15	181.7	181.8	signal
26	Bacterial Endophthalmitis	53	178.3	178.6	signal
27	Anterior Chamber Inflammation	117	168.3	169.0	signal
28	Neovascular Age-related Macular Degeneration	268	162.6	164.0	signal
29	Pseudoendophthalmitis	19	158.2	158.3	signal
30	Vitreous Disorder	92	154.0	154.4	signal
31	Diaphragmatic Operation	6	148.0	148.1	signal
32	Haemorrhagic Occlusive Retinal Vasculitis	13	146.8	146.8	signal
33	Detachment Of Retinal Pigment Epithelium	148	138.5	139.1	signal
34	Diabetic Retinal Oedema	85	135.5	135.8	signal
35	Macular Rupture	6	133.2	133.3	signal
36	Ocular Procedural Complication	32	132.4	132.5	signal
37	Keratic Precipitates	75	128.8	129.1	signal
38	Anterior Chamber Disorder	37	127.0	127.2	signal
39	Retinal Pigment Epithelial Tear	98	113.7	114.1	signal
40	Blindness Transient	1,040	111.3	115.1	signal
41	Retinal Oedema	266	111.2	112.1	signal
42	Posterior Capsule Rupture	11	107.8	107.8	signal
43	Hypopyon	113	106.3	106.7	signal
44	Inadequate Aseptic Technique In Use Of Product	48	105.5	105.7	signal
45	Ocular Vasculitis	23	104.9	105.0	signal
46	Hypotony Of Eye	50	91.8	91.9	signal
47	Eye Laser Surgery	70	91.1	91.3	signal
48	Macular Scar	22	87.8	87.8	signal
49	Detachment Of Macular Retinal Pigment Epithelium	6	86.9	86.9	signal
50	Epiretinal Membrane	29	85.1	85.2	signal
51	Pseudophakia	9	84.4	84.5	signal
52	Eye Infection Staphylococcal	32	83.9	84.0	signal
53	Eye Inflammation	1,008	80.9	83.6	signal
54	Retinal Perivascular Sheathing	11	79.6	79.7	signal
55	Eye Complication Associated With Device	26	79.1	79.2	signal
56	Macular Hole	139	78.5	78.8	signal
57	Retinal Scar	48	78.2	78.3	signal
58	Intraocular Pressure Decreased	55	78.0	78.1	signal
59	Choroidal Neovascularisation	86	76.3	76.5	signal
60	Retinal Neovascularisation	25	75.0	75.1	signal
61	Vitreous Haemorrhage	274	74.1	74.7	signal
62	Retinal Cyst	16	72.5	72.5	signal
63	Dry Age-related Macular Degeneration	106	71.5	71.8	signal
64	Rhegmatogenous Retinal Detachment	20	70.9	70.9	signal
65	Ocular Ischaemic Syndrome	8	70.1	70.1	signal
66	Age-related Macular Degeneration	139	67.6	67.9	signal
67	Retinal Vasculitis	107	67.0	67.2	signal
68	Intraocular Lens Implant	44	65.9	66.0	signal
69	Panophthalmitis	15	62.8	62.9	signal
70	Retinal Haemorrhage	604	62.7	64.0	signal
71	Vitreous Floaters	818	62.0	63.6	signal
72	Retinal Depigmentation	25	60.1	60.2	signal
73	Metamorphopsia	149	59.7	60.0	signal
74	Retinal Drusen	13	59.3	59.3	signal
75	Blindness Unilateral	1,089	56.6	58.7	signal
76	Sudden Visual Loss	21	54.9	54.9	signal
77	Macular Fibrosis	51	54.4	54.5	signal
78	Central Vision Loss	16	54.1	54.1	signal
79	Vitreous Adhesions	8	50.8	50.8	signal
80	Retinal Vascular Disorder	40	50.5	50.5	signal
81	Subretinal Fibrosis	13	48.1	48.1	signal
82	Retinal Exudates	61	47.1	47.2	signal
83	Tractional Retinal Detachment	7	46.2	46.2	signal
84	Retinal Artery Occlusion	161	46.1	46.3	signal
85	Eye Infection Bacterial	35	45.4	45.4	signal
86	Retinal Operation	17	44.9	45.0	signal
87	Corneal Endotheliitis	6	44.9	44.9	signal
88	Retinal Ischaemia	37	44.5	44.5	signal
89	Laser Therapy	14	44.2	44.2	signal
90	Eye Haemorrhage	817	44.0	45.1	signal
91	Intraocular Pressure Increased	781	43.8	44.9	signal
92	Vitreous Degeneration	9	43.4	43.5	signal
93	Retinal Thickening	74	43.2	43.3	signal
94	Ocular Hypertension	115	43.1	43.3	signal
95	Retinal Aneurysm	12	43.0	43.0	signal
96	Retinoschisis	8	42.3	42.3	signal
97	Retinal Deposits	12	42.1	42.1	signal
98	Retinal Vascular Occlusion	43	42.0	42.1	signal
99	Optical Coherence Tomography Abnormal	38	41.5	41.5	signal
100	Posterior Capsule Opacification	19	40.8	40.9	signal
101	Drug-device Interaction	6	40.4	40.4	signal
102	Iris Neovascularisation	7	40.2	40.2	signal
103	Retinal Degeneration	70	39.9	40.0	signal
104	Anterior Chamber Fibrin	7	38.2	38.2	signal
105	Intraocular Pressure Fluctuation	10	37.6	37.6	signal
106	Iridocyclitis	165	37.6	37.8	signal
107	Choroidal Haemorrhage	10	36.6	36.6	signal
108	Toxic Anterior Segment Syndrome	55	35.9	36.0	signal
109	Iritis	141	32.9	33.0	signal
110	Macular Oedema	258	32.6	32.9	signal
111	Tachyphylaxis	16	32.3	32.3	signal
112	Corneal Oedema	102	32.2	32.3	signal
113	Lens Disorder	13	32.1	32.1	signal
114	Chorioretinitis	29	31.9	31.9	signal
115	Deposit Eye	12	31.5	31.5	signal
116	Choroidal Detachment	24	30.6	30.6	signal
117	Lens Dislocation	9	30.3	30.3	signal
118	Idiopathic Orbital Inflammation	8	29.6	29.6	signal
119	Hyphaema	22	29.5	29.6	signal
120	Amaurosis Fugax	44	29.0	29.0	signal
121	Adenocarcinoma Metastatic	8	28.8	28.8	signal
122	Conjunctival Scar	6	28.5	28.6	signal
123	Glaucoma Surgery	10	27.5	27.5	signal
124	Eye Excision	8	27.3	27.3	signal
125	Visual Acuity Reduced	1,294	27.1	28.3	signal
126	Retinal Vein Occlusion	109	26.8	26.9	signal
127	Cataract Operation	224	26.6	26.7	signal
128	Blindness	1,492	25.7	26.9	signal
129	Vitreous Detachment	78	25.4	25.5	signal
130	Foreign Body In Eye	34	25.2	25.2	signal
131	Retinopathy Proliferative	7	24.8	24.8	signal
132	Corneal Abrasion	48	24.6	24.7	signal
133	Scleral Haemorrhage	8	24.2	24.2	signal
134	Proteus Infection	25	24.2	24.2	signal
135	Retinal Pigment Epitheliopathy	15	24.1	24.1	signal
136	Conjunctival Disorder	13	24.0	24.0	signal
137	Ophthalmological Examination Abnormal	6	23.9	23.9	signal
138	Serous Retinal Detachment	27	23.7	23.7	signal
139	Uveitis	450	23.3	23.6	signal
140	Macular Detachment	8	23.3	23.3	signal
141	Chorioretinal Atrophy	7	23.2	23.2	signal
142	Scleral Disorder	9	23.1	23.2	signal
143	Flat Anterior Chamber Of Eye	6	23.1	23.1	signal
144	Product Impurity	9	22.7	22.7	signal
145	Cardiomyopathy Acute	7	22.3	22.3	signal
146	Dyschromatopsia	26	22.3	22.3	signal
147	Visual Acuity Tests Abnormal	13	21.7	21.7	signal
148	Eye Oedema	76	21.6	21.6	signal
149	Pharyngotonsillitis	7	21.4	21.4	signal
150	Amaurosis	25	21.1	21.2	signal
151	Glare	15	20.6	20.6	signal
152	Cataract Nuclear	19	20.1	20.1	signal
153	Retinal Disorder	72	19.2	19.2	signal
154	Neovascularisation	7	19.0	19.0	signal
155	Thrombotic Cerebral Infarction	10	18.4	18.4	signal
156	Optic Disc Haemorrhage	6	18.3	18.3	signal
157	Pterygium	9	18.2	18.2	signal
158	Retinal Injury	20	18.0	18.0	signal
159	Retinal Detachment	237	17.9	18.0	signal
160	Lenticular Opacities	11	17.7	17.7	signal
161	Eye Operation	113	17.3	17.3	signal
162	Cystoid Macular Oedema	46	17.1	17.1	signal
163	Conjunctival Haemorrhage	94	17.0	17.1	signal
164	Corneal Deposits	18	16.9	16.9	signal
165	Iris Adhesions	12	16.4	16.4	signal
166	Patient Uncooperative	11	16.4	16.4	signal
167	Eye Infection	265	16.3	16.5	signal
168	Refusal Of Treatment By Patient	152	16.1	16.1	signal
169	Eye Haematoma	6	16.0	16.0	signal
170	Eye Pain	1,227	15.3	15.9	signal
171	Eye Injury	66	15.1	15.2	signal
172	Colorectal Cancer Metastatic	50	15.1	15.1	signal
173	Foreign Body Sensation In Eyes	134	14.8	14.9	signal
174	Binocular Eye Movement Disorder	6	14.7	14.8	signal
175	Injury Corneal	11	14.7	14.7	signal
176	Multiple Use Of Single-use Product	117	14.5	14.6	signal
177	Prothrombin Level Decreased	19	13.7	13.8	signal
178	Cataract Subcapsular	12	13.6	13.6	signal
179	Open Angle Glaucoma	12	13.5	13.5	signal
180	Central Serous Chorioretinopathy	12	13.4	13.4	signal
181	Retinal Vascular Thrombosis	10	13.1	13.1	signal
182	Corneal Erosion	10	13.0	13.0	signal
183	Choroidal Effusion	15	12.9	12.9	signal
184	Suspected Product Quality Issue	33	12.8	12.8	signal
185	Ocular Discomfort	202	12.8	12.9	signal
186	Superficial Injury Of Eye	19	12.2	12.2	signal
187	Visual Field Defect	128	12.2	12.2	signal
188	Cataract Operation Complication	9	12.1	12.1	signal
189	Retinal Tear	43	12.1	12.1	signal
190	Corneal Disorder	38	12.0	12.0	signal
191	Visual Impairment	2,113	11.8	12.6	signal
192	Intraocular Pressure Test Abnormal	12	11.7	11.7	signal
193	Ocular Vascular Disorder	14	11.6	11.6	signal
194	Suspected Transmission Of An Infectious Agent Via Product	20	11.1	11.1	signal
195	Corneal Opacity	22	11.1	11.1	signal
196	Photopsia	95	10.3	10.3	signal
197	Diabetic Retinopathy	51	10.3	10.3	signal
198	Corneal Dystrophy	6	9.8	9.8	signal
199	Intravascular Haemolysis	8	9.8	9.8	signal
200	Retinal Vein Thrombosis	10	9.7	9.7	signal
201	Necrotising Retinitis	9	9.7	9.7	signal
202	Corneal Scar	7	9.7	9.7	signal
203	Corneal Epithelium Defect	8	9.5	9.5	signal
204	Hypoaesthesia Eye	8	9.3	9.4	signal
205	Traumatic Fracture	10	9.3	9.3	signal
206	Macular Degeneration	161	9.2	9.3	signal
207	Scleritis	21	9.0	9.0	signal
208	Optic Nerve Injury	15	8.9	8.9	signal
209	Abnormal Sensation In Eye	55	8.8	8.8	signal
210	Puncture Site Haemorrhage	9	8.7	8.7	signal
211	Punctate Keratitis	11	8.5	8.5	signal
212	Chromatopsia	9	8.1	8.1	signal
213	Pupillary Disorder	7	7.8	7.8	signal
214	Glomerulonephritis Membranoproliferative	6	7.8	7.8	signal
215	Altered Visual Depth Perception	9	7.5	7.5	signal
216	Dyslalia	8	7.5	7.5	signal
217	Photophobia	204	7.5	7.5	signal
218	Maculopathy	39	7.5	7.5	signal
219	Eye Disorder	355	7.4	7.5	signal
220	Eye Discharge	110	7.3	7.4	signal
221	Sickle Cell Anaemia	7	7.3	7.3	signal
222	Conjunctival Oedema	11	7.3	7.3	signal
223	Induration	19	7.3	7.3	signal
224	Device Use Issue	183	7.2	7.2	signal
225	Procedural Anxiety	7	7.0	7.0	signal
226	Retinitis	17	6.9	6.9	signal
227	Eye Burns	6	6.9	6.9	signal
228	Alpha Haemolytic Streptococcal Infection	9	6.6	6.6	signal
229	Keratitis	29	6.5	6.6	signal
230	Adenocarcinoma Of Colon	18	6.5	6.5	signal
231	Colitis Microscopic	45	6.5	6.5	signal
232	Cataract	567	6.5	6.6	signal
233	Ulcerative Keratitis	26	6.5	6.5	signal
234	Glaucoma	183	6.5	6.5	signal
235	Chalazion	6	6.4	6.4	signal
236	Lacrimation Increased	279	6.4	6.4	signal
237	Death	7,874	6.2	8.0	signal
238	Embolic Cerebral Infarction	6	6.1	6.1	signal
239	Vena Cava Thrombosis	15	6.1	6.1	signal
240	Angle Closure Glaucoma	23	6.1	6.1	signal
241	Ocular Hyperaemia	419	6.1	6.2	signal
242	Vision Blurred	1,219	6.1	6.3	signal
243	Clear Cell Renal Cell Carcinoma	6	6.0	6.0	signal
244	Anastomotic Leak	6	5.9	5.9	signal
245	Blepharitis	32	5.5	5.5	signal
246	Optic Nerve Disorder	13	5.5	5.5	signal
247	Night Blindness	13	5.5	5.5	signal
248	Injection Site Discomfort	83	5.5	5.5	signal
249	Thalamus Haemorrhage	7	5.4	5.4	signal
250	Eye Colour Change	8	5.4	5.4	signal
251	Conjunctival Hyperaemia	28	5.3	5.3	signal
252	Corneal Transplant	6	5.3	5.3	signal
253	Adenocarcinoma	17	5.1	5.1	signal
254	Giant Cell Arteritis	6	5.1	5.1	signal
255	Iiird Nerve Paralysis	6	5.0	5.0	signal
256	Clostridial Infection	25	5.0	5.0	signal
257	Rectal Tenesmus	9	5.0	5.0	signal
258	Stoma Site Haemorrhage	11	4.9	4.9	signal
259	Product Contamination	25	4.8	4.8	signal
260	Periodontal Disease	10	4.8	4.8	signal
261	Halo Vision	8	4.8	4.8	signal
262	Asthenopia	38	4.7	4.8	signal
263	Herpes Ophthalmic	9	4.7	4.7	signal
264	Injection Related Reaction	11	4.6	4.6	signal
265	Necrotising Fasciitis	24	4.6	4.6	signal
266	Eyelid Pain	13	4.6	4.6	signal
267	Eye Contusion	14	4.5	4.5	signal
268	Ocular Toxicity	7	4.5	4.5	signal
269	Colour Blindness	6	4.4	4.4	signal
270	Renal Atrophy	8	4.3	4.3	signal
271	Drug Effect Less Than Expected	90	4.3	4.3	signal
272	Injury Associated With Device	126	4.3	4.3	signal
273	Diabetic Complication	16	4.2	4.2	signal
274	Intentional Dose Omission	168	4.2	4.2	signal
275	Multiple-drug Resistance	19	4.2	4.2	signal
276	Eyelid Disorder	14	4.1	4.1	signal
277	Colon Adenoma	6	4.1	4.1	signal
278	Embolism Arterial	7	4.0	4.0	signal
279	Pharyngeal Inflammation	7	3.9	3.9	signal
280	Klebsiella Infection	29	3.9	3.9	signal
281	Syringe Issue	101	3.9	3.9	signal
282	Eye Irritation	314	3.8	3.9	signal
283	Proteinuria	106	3.8	3.8	signal
284	Ophthalmic Herpes Zoster	10	3.8	3.8	signal
285	Fear Of Injection	39	3.8	3.8	signal
286	Optic Atrophy	9	3.7	3.7	signal
287	Swelling Of Eyelid	32	3.6	3.6	signal
288	Hordeolum	22	3.5	3.5	signal
289	Eye Allergy	8	3.5	3.5	signal
290	Diabetic Metabolic Decompensation	7	3.4	3.4	signal
291	Skin Toxicity	28	3.4	3.4	signal
292	Eye Swelling	178	3.3	3.3	signal
293	Focal Segmental Glomerulosclerosis	7	3.0	3.0	signal
294	Nephrotic Syndrome	30	3.0	3.0	signal
295	Optic Neuropathy	9	2.9	2.9	signal
296	Cerebral Infarction	104	2.9	2.9	signal
297	Staphylococcus Test Positive	9	2.9	2.9	signal
298	Cerebellar Haemorrhage	6	2.8	2.8	signal
299	Product Monitoring Error	6	2.8	2.8	signal
300	Chorioretinopathy	6	2.8	2.8	signal
301	Immune-mediated Adverse Reaction	6	2.8	2.8	signal
302	Therapeutic Product Ineffective	16	2.8	2.8	signal
303	Blood Lactic Acid Increased	21	2.7	2.7	signal
304	Product Dose Omission Issue	1,136	2.7	2.8	signal
305	Sudden Hearing Loss	8	2.7	2.7	signal
306	Optic Ischaemic Neuropathy	14	2.7	2.7	signal
307	Papilloedema	17	2.5	2.5	signal
308	Slow Speech	9	2.5	2.5	signal
309	Periodontitis	8	2.5	2.5	signal
310	Carotid Artery Stenosis	13	2.5	2.5	signal
311	Neutrophilia	21	2.5	2.5	signal
312	Hypertensive Crisis	41	2.5	2.5	signal
313	Retinopathy	13	2.4	2.4	signal
314	Injection Site Inflammation	17	2.3	2.3	signal
315	Pupil Fixed	6	2.3	2.3	no signal
316	Hemiplegia	28	2.3	2.3	signal
317	Vascular Occlusion	7	2.2	2.2	no signal
318	Rectal Cancer	10	2.2	2.2	signal
319	Streptococcal Infection	18	2.2	2.2	signal
320	Intercepted Product Preparation Error	39	2.2	2.2	signal
321	Sudden Death	34	2.2	2.2	signal
322	Diabetic Nephropathy	7	2.1	2.1	no signal
323	Embolic Stroke	11	2.1	2.1	signal
324	Cytomegalovirus Chorioretinitis	6	2.1	2.1	no signal
325	Ventricular Dysfunction	8	2.1	2.1	no signal
326	Product Dose Omission	203	2.1	2.1	signal
327	Infarction	21	2.1	2.1	signal
328	Hypoacusis	128	2.0	2.0	signal
329	Conjunctivitis	54	2.0	2.0	no signal
330	Invasive Ductal Breast Carcinoma	8	2.0	2.0	no signal
331	Lacunar Infarction	7	2.0	2.0	no signal
332	Dry Eye	141	2.0	2.0	no signal
333	Impaired Driving Ability	33	2.0	2.0	no signal
334	Transient Ischaemic Attack	98	2.0	2.0	no signal
335	Acute Coronary Syndrome	24	1.9	1.9	no signal
336	Viith Nerve Paralysis	10	1.9	1.9	no signal
337	Incorrect Dosage Administered	14	1.9	1.9	no signal
338	Angiopathy	16	1.9	1.9	no signal
339	Proctalgia	18	1.9	1.9	no signal
340	Metastases To Peritoneum	7	1.9	1.9	no signal
341	Gastrointestinal Toxicity	13	1.9	1.9	no signal
342	Monoplegia	12	1.9	1.9	no signal
343	Pulmonary Function Test Decreased	12	1.8	1.8	no signal
344	Hiccups	22	1.8	1.8	no signal
345	Neutropenic Sepsis	19	1.8	1.8	no signal
346	Anaesthetic Complication	7	1.8	1.8	no signal
347	Eyelids Pruritus	8	1.8	1.8	no signal
348	Pustule	6	1.8	1.8	no signal
349	Ischaemia	12	1.8	1.8	no signal
350	Migraine With Aura	7	1.7	1.7	no signal
351	Peripheral Sensory Neuropathy	15	1.7	1.7	no signal
352	Mucosal Inflammation	66	1.7	1.7	no signal
353	Myopia	6	1.7	1.7	no signal
354	Metastases To Lung	29	1.7	1.7	no signal
355	Eye Pruritus	82	1.7	1.7	no signal
356	Procedural Complication	19	1.7	1.7	no signal
357	Angina Unstable	16	1.7	1.7	no signal
358	Vascular Graft	7	1.6	1.6	no signal
359	Disease Progression	284	1.6	1.6	no signal
360	Rhinitis	19	1.6	1.6	no signal
361	Facial Pain	21	1.6	1.6	no signal
362	Product Temperature Excursion Issue	11	1.6	1.6	no signal
363	Intestinal Perforation	26	1.6	1.6	no signal
364	Functional Gastrointestinal Disorder	8	1.6	1.6	no signal
365	Blood Chloride Decreased	6	1.6	1.6	no signal
366	Fibrosis	7	1.5	1.5	no signal
367	Hospitalisation	346	1.5	1.5	no signal
368	Cerebral Haemorrhage	79	1.5	1.5	no signal
369	Product Prescribing Issue	44	1.5	1.5	no signal
370	Ischaemic Stroke	38	1.4	1.4	no signal
371	Cholecystitis Acute	12	1.4	1.4	no signal
372	Cardiac Operation	18	1.4	1.4	no signal
373	Dementia	59	1.4	1.4	no signal
374	Cerebral Ischaemia	11	1.4	1.4	no signal
375	Cerebrovascular Accident	359	1.4	1.4	no signal
376	Tenderness	22	1.4	1.4	no signal
377	Purulent Discharge	9	1.4	1.4	no signal
378	Drug Effective For Unapproved Indication	61	1.4	1.4	no signal
379	Lung Cancer Metastatic	6	1.4	1.4	no signal
380	Paronychia	9	1.4	1.4	no signal
381	Left Ventricular Failure	7	1.4	1.4	no signal
382	Eyelid Oedema	24	1.4	1.4	no signal
383	Haemorrhagic Stroke	16	1.4	1.4	no signal
384	Arterial Occlusive Disease	16	1.4	1.4	no signal
385	Large Intestine Perforation	14	1.4	1.4	no signal
386	Diplopia	52	1.4	1.4	no signal
387	Azotaemia	8	1.3	1.3	no signal
388	Intracranial Aneurysm	8	1.3	1.3	no signal
389	Inflammation	102	1.3	1.3	no signal
390	Post Procedural Complication	38	1.3	1.3	no signal
391	Cerebrovascular Disorder	6	1.3	1.3	no signal
392	Phlebitis	10	1.3	1.3	no signal
393	Concomitant Disease Aggravated	12	1.3	1.3	no signal
394	Product Use Issue	363	1.3	1.3	no signal
395	Renal Transplant	7	1.3	1.3	no signal
396	Inappropriate Schedule Of Drug Administration	138	1.3	1.3	no signal
397	Dialysis	27	1.3	1.3	no signal
398	Off Label Use	1,645	1.3	1.3	no signal
399	Non-cardiac Chest Pain	6	1.3	1.3	no signal
400	Candida Infection	31	1.3	1.3	no signal
401	Neurotoxicity	32	1.2	1.2	no signal
402	Hypertension	390	1.2	1.2	no signal
403	Injection Site Injury	10	1.2	1.2	no signal
404	Dermatitis Acneiform	11	1.2	1.2	no signal
405	Blood Pressure Inadequately Controlled	11	1.2	1.2	no signal
406	Coagulopathy	30	1.2	1.2	no signal
407	Procedural Haemorrhage	7	1.2	1.2	no signal
408	Posterior Reversible Encephalopathy Syndrome	17	1.2	1.2	no signal
409	Colitis Ischaemic	12	1.2	1.2	no signal
410	Facial Paralysis	15	1.2	1.2	no signal
411	Cerebral Disorder	13	1.2	1.2	no signal
412	Autoimmune Haemolytic Anaemia	6	1.2	1.2	no signal
413	Unevaluable Event	133	1.2	1.2	no signal
414	Intercepted Product Storage Error	6	1.2	1.2	no signal
415	Peripheral Ischaemia	7	1.2	1.2	no signal
416	Product Administration Error	34	1.2	1.2	no signal
417	Leg Amputation	7	1.1	1.1	no signal
418	Erythema Of Eyelid	9	1.1	1.1	no signal
419	Embolism	14	1.1	1.1	no signal
420	Inappropriate Schedule Of Product Administration	295	1.1	1.1	no signal
421	Metastases To Liver	29	1.1	1.1	no signal
422	Cardiac Failure Chronic	7	1.1	1.1	no signal
423	Facial Bones Fracture	6	1.1	1.1	no signal
424	Deafness Unilateral	9	1.1	1.1	no signal
425	Neutropenia	220	1.1	1.1	no signal
426	Metastatic Neoplasm	7	1.1	1.1	no signal
427	Cholangitis	10	1.1	1.1	no signal
428	Chemotherapy	6	1.1	1.1	no signal
429	Therapeutic Response Decreased	97	1.1	1.1	no signal
430	Therapeutic Product Effect Decreased	71	1.1	1.1	no signal
431	Coronary Artery Stenosis	8	1.1	1.1	no signal
432	Pelvic Fracture	12	1.0	1.0	no signal
433	Palmar-plantar Erythrodysaesthesia Syndrome	36	1.0	1.0	no signal
434	Wrong Technique In Product Usage Process	310	1.0	1.0	no signal
435	Odynophagia	9	1.0	1.0	no signal
436	Hospice Care	15	1.0	1.0	no signal
437	Cardiac Pacemaker Insertion	9	1.0	1.0	no signal
438	Rash Pustular	11	1.0	1.0	no signal
439	Incorrect Route Of Product Administration	25	1.0	1.0	no signal
440	Organ Failure	6	1.0	1.0	no signal
441	Hypovolaemic Shock	7	1.0	1.0	no signal
442	Pulmonary Thrombosis	16	1.0	1.0	no signal
443	Periorbital Swelling	8	1.0	1.0	no signal
444	Hyperthermia	11	1.0	1.0	no signal
445	Acute Myocardial Infarction	43	1.0	1.0	no signal
446	Stomatitis	88	1.0	1.0	no signal
447	Eosinophil Count Increased	12	1.0	1.0	no signal
448	Leukocytosis	26	1.0	1.0	no signal
449	Needle Issue	41	1.0	1.0	no signal
450	Polyneuropathy	17	1.0	1.0	no signal
451	Inflammatory Marker Increased	7	1.0	1.0	no signal
452	Acute Pulmonary Oedema	8	1.0	1.0	no signal
453	Myocardial Infarction	247	0.9	0.9	no signal
454	General Physical Health Deterioration	161	0.9	0.9	no signal
455	Erysipelas	7	0.9	0.9	no signal
456	Eyelid Ptosis	14	0.9	0.9	no signal
457	Product Preparation Issue	8	0.9	0.9	no signal
458	Hip Fracture	44	0.9	0.9	no signal
459	Melanocytic Naevus	6	0.9	0.9	no signal
460	Drug Resistance	35	0.9	0.9	no signal
461	Hyperbilirubinaemia	14	0.9	0.9	no signal
462	Abdominal Abscess	6	0.9	0.9	no signal
463	Diabetes Mellitus Inadequate Control	24	0.9	0.9	no signal
464	Peripheral Vascular Disorder	7	0.9	0.9	no signal
465	Ill-defined Disorder	82	0.9	0.9	no signal
466	Varicose Vein	7	0.9	0.9	no signal
467	Troponin Increased	10	0.9	0.9	no signal
468	Angina Pectoris	38	0.9	0.9	no signal
469	Eye Movement Disorder	9	0.9	0.9	no signal
470	Ileus	16	0.9	0.9	no signal
471	Subarachnoid Haemorrhage	13	0.9	0.9	no signal
472	Drug Dose Omission	213	0.9	0.9	no signal
473	Enteritis	8	0.9	0.9	no signal
474	Mydriasis	16	0.8	0.8	no signal
475	Stent Placement	10	0.8	0.8	no signal
476	Enterococcal Infection	6	0.8	0.8	no signal
477	Hemiparesis	21	0.8	0.8	no signal
478	Polyp	8	0.8	0.8	no signal
479	Surgery	70	0.8	0.8	no signal
480	Hydronephrosis	9	0.8	0.8	no signal
481	Wrong Product Administered	8	0.8	0.8	no signal
482	Pulmonary Embolism	115	0.8	0.8	no signal
483	Body Height Decreased	13	0.8	0.8	no signal
484	Drug Ineffective For Unapproved Indication	67	0.8	0.8	no signal
485	Neoplasm Malignant	80	0.8	0.8	no signal
486	Product Packaging Quantity Issue	13	0.8	0.8	no signal
487	Coronary Arterial Stent Insertion	6	0.8	0.8	no signal
488	Hypoalbuminaemia	9	0.8	0.8	no signal
489	Metastases To Central Nervous System	15	0.8	0.8	no signal
490	Injection Site Pain	352	0.8	0.8	no signal
491	Cardiac Failure	93	0.8	0.8	no signal
492	Large Intestine Polyp	8	0.8	0.8	no signal
493	Pulmonary Haemorrhage	9	0.8	0.8	no signal
494	Thrombotic Microangiopathy	11	0.8	0.8	no signal
495	Myocardial Ischaemia	13	0.8	0.8	no signal
496	Adverse Reaction	15	0.8	0.8	no signal
497	Atrial Flutter	9	0.8	0.8	no signal
498	Anal Abscess	6	0.8	0.8	no signal
499	Deafness	29	0.7	0.7	no signal
500	Epistaxis	82	0.7	0.7	no signal
501	Coronary Artery Occlusion	15	0.7	0.7	no signal
502	Rhinorrhoea	70	0.7	0.7	no signal
503	Therapeutic Response Shortened	34	0.7	0.7	no signal
504	Dermatitis Contact	12	0.7	0.7	no signal
505	Cardiac Failure Acute	7	0.7	0.7	no signal
506	Left Ventricular Dysfunction	7	0.7	0.7	no signal
507	Scar	18	0.7	0.7	no signal
508	Aortic Aneurysm	8	0.7	0.7	no signal
509	Osteonecrosis Of Jaw	26	0.7	0.7	no signal
510	Adverse Drug Reaction	93	0.7	0.7	no signal
511	Coronary Artery Bypass	6	0.7	0.7	no signal
512	Atrioventricular Block	8	0.7	0.7	no signal
513	Brain Oedema	13	0.7	0.7	no signal
514	Deep Vein Thrombosis	67	0.7	0.7	no signal
515	Thrombocytopenia	114	0.7	0.7	no signal
516	Electrocardiogram Abnormal	8	0.7	0.7	no signal
517	Anal Incontinence	9	0.7	0.7	no signal
518	Dysarthria	38	0.7	0.7	no signal
519	Cholecystitis	12	0.7	0.7	no signal
520	Sinus Disorder	20	0.7	0.7	no signal
521	Oesophagitis	11	0.7	0.7	no signal
522	Neuropathy Peripheral	95	0.7	0.7	no signal
523	Therapeutic Product Effect Incomplete	71	0.7	0.7	no signal
524	Therapy Partial Responder	15	0.7	0.7	no signal
525	Lower Limb Fracture	19	0.7	0.7	no signal
526	Cardiac Disorder	93	0.7	0.7	no signal
527	Gangrene	6	0.7	0.7	no signal
528	Skin Cancer	21	0.7	0.7	no signal
529	Blood Pressure Increased	149	0.7	0.7	no signal
530	Ventricular Extrasystoles	10	0.6	0.6	no signal
531	Aphasia	29	0.6	0.6	no signal
532	Arteriosclerosis	9	0.6	0.6	no signal
533	Hallucination, Visual	20	0.6	0.6	no signal
534	Rectal Haemorrhage	41	0.6	0.6	no signal
535	Injection Site Irritation	12	0.6	0.6	no signal
536	Lower Gastrointestinal Haemorrhage	7	0.6	0.6	no signal
537	Staphylococcal Infection	31	0.6	0.6	no signal
538	Mass	13	0.6	0.6	no signal
539	Muscle Strain	8	0.6	0.6	no signal
540	Product Storage Error	80	0.6	0.6	no signal
541	Accident	11	0.6	0.6	no signal
542	Haemorrhoids	18	0.6	0.6	no signal
543	Haemorrhage	96	0.6	0.6	no signal
544	Drug Ineffective	1,205	0.6	0.6	no signal
545	Atrial Fibrillation	89	0.6	0.6	no signal
546	Neoplasm Progression	32	0.6	0.6	no signal
547	Intestinal Obstruction	34	0.6	0.6	no signal
548	Paralysis	13	0.6	0.6	no signal
549	Blood Sodium Decreased	17	0.6	0.6	no signal
550	Incorrect Product Storage	12	0.6	0.6	no signal
551	Malnutrition	10	0.6	0.6	no signal
552	Renal Disorder	42	0.6	0.6	no signal
553	Upper Limb Fracture	18	0.6	0.6	no signal
554	Lung Disorder	44	0.6	0.6	no signal
555	Basal Cell Carcinoma	14	0.6	0.6	no signal
556	Generalised Oedema	11	0.6	0.6	no signal
557	Dysphonia	52	0.6	0.6	no signal
558	Myasthenia Gravis	7	0.6	0.6	no signal
559	Lung Infection	14	0.6	0.6	no signal
560	General Physical Condition Abnormal	6	0.6	0.6	no signal
561	Product Administered At Inappropriate Site	16	0.6	0.6	no signal
562	Pulmonary Mass	13	0.6	0.6	no signal
563	Lung Neoplasm Malignant	36	0.6	0.6	no signal
564	Colon Cancer	13	0.6	0.6	no signal
565	Brain Neoplasm	8	0.6	0.6	no signal
566	Frustration Tolerance Decreased	7	0.6	0.6	no signal
567	Fall	289	0.6	0.6	no signal
568	Localised Infection	21	0.6	0.6	no signal
569	Renal Failure	116	0.6	0.6	no signal
570	Discomfort	52	0.6	0.6	no signal
571	Injection Site Haemorrhage	68	0.6	0.6	no signal
572	Diarrhoea Haemorrhagic	8	0.6	0.6	no signal
573	Photosensitivity Reaction	14	0.6	0.6	no signal
574	Intentional Product Use Issue	74	0.6	0.6	no signal
575	Acute Respiratory Failure	16	0.6	0.6	no signal
576	Wrist Fracture	10	0.6	0.6	no signal
577	Diverticulum	6	0.6	0.6	no signal
578	Panic Reaction	6	0.6	0.6	no signal
579	Cardio-respiratory Arrest	35	0.6	0.6	no signal
580	Therapy Non-responder	37	0.6	0.6	no signal
581	Ear Pain	16	0.6	0.6	no signal
582	Product Preparation Error	17	0.6	0.6	no signal
583	Illness	82	0.6	0.6	no signal
584	Pemphigoid	6	0.5	0.5	no signal
585	Arrhythmia	38	0.5	0.5	no signal
586	C-reactive Protein Increased	29	0.5	0.5	no signal
587	Hypomagnesaemia	11	0.5	0.5	no signal
588	Toxic Skin Eruption	8	0.5	0.5	no signal
589	Labelled Drug-drug Interaction Medication Error	7	0.5	0.5	no signal
590	Thrombosis	63	0.5	0.5	no signal
591	Seasonal Allergy	11	0.5	0.5	no signal
592	Tuberculosis	10	0.5	0.5	no signal
593	No Adverse Event	137	0.5	0.5	no signal
594	Vasculitis	9	0.5	0.5	no signal
595	Blood Pressure Systolic Increased	15	0.5	0.5	no signal
596	Circulatory Collapse	13	0.5	0.5	no signal
597	Blood Pressure Abnormal	15	0.5	0.5	no signal
598	Haematotoxicity	7	0.5	0.5	no signal
599	Gastroenteritis	11	0.5	0.5	no signal
600	Bacterial Infection	14	0.5	0.5	no signal
601	Blood Creatine Phosphokinase Increased	22	0.5	0.5	no signal
602	Viral Infection	25	0.5	0.5	no signal
603	Hepatic Encephalopathy	7	0.5	0.5	no signal
604	Personality Change	7	0.5	0.5	no signal
605	Condition Aggravated	226	0.5	0.5	no signal
606	Blood Disorder	6	0.5	0.5	no signal
607	Cardiomyopathy	11	0.5	0.5	no signal
608	Nocturia	9	0.5	0.5	no signal
609	Hypocalcaemia	14	0.5	0.5	no signal
610	Depressed Mood	39	0.5	0.5	no signal
611	Neutrophil Count Decreased	30	0.5	0.5	no signal
612	Post Procedural Infection	6	0.5	0.5	no signal
613	Back Injury	8	0.5	0.5	no signal
614	Spinal Disorder	7	0.5	0.5	no signal
615	Diarrhoea	472	0.5	0.5	no signal
616	Small Intestinal Obstruction	9	0.5	0.5	no signal
617	Polyuria	6	0.5	0.5	no signal
618	Cyst	9	0.5	0.5	no signal
619	Knee Arthroplasty	15	0.5	0.5	no signal
620	Aphonia	10	0.5	0.5	no signal
621	Device Related Infection	11	0.5	0.5	no signal
622	Anaemia	136	0.5	0.5	no signal
623	Disorientation	28	0.5	0.5	no signal
624	Bladder Disorder	7	0.5	0.5	no signal
625	Limb Injury	19	0.5	0.5	no signal
626	Head Injury	22	0.5	0.5	no signal
627	Headache	435	0.5	0.5	no signal
628	Febrile Neutropenia	46	0.5	0.5	no signal
629	Neoplasm	8	0.5	0.5	no signal
630	Sciatica	11	0.5	0.5	no signal
631	Diabetes Mellitus	53	0.5	0.5	no signal
632	Orthostatic Hypotension	12	0.5	0.5	no signal
633	Gastritis	18	0.5	0.5	no signal
634	Adverse Event	63	0.5	0.5	no signal
635	Acute Kidney Injury	104	0.5	0.5	no signal
636	Rib Fracture	14	0.5	0.5	no signal
637	Hernia	13	0.5	0.5	no signal
638	Asthenia	253	0.5	0.4	no signal
639	Hepatic Failure	20	0.4	0.4	no signal
640	Urinary Tract Infection	112	0.4	0.4	no signal
641	Skin Ulcer	17	0.4	0.4	no signal
642	Optic Neuritis	6	0.4	0.4	no signal
643	Gastrointestinal Carcinoma	6	0.4	0.4	no signal
644	Chronic Obstructive Pulmonary Disease	34	0.4	0.4	no signal
645	Septic Shock	28	0.4	0.4	no signal
646	Oedema	35	0.4	0.4	no signal
647	Ankle Fracture	10	0.4	0.4	no signal
648	Road Traffic Accident	27	0.4	0.4	no signal
649	Cardiomegaly	8	0.4	0.4	no signal
650	Haematuria	22	0.4	0.4	no signal
651	Ear Infection	17	0.4	0.4	no signal
652	Nephropathy	6	0.4	0.4	no signal
653	Leukaemia	6	0.4	0.4	no signal
654	Expired Product Administered	21	0.4	0.4	no signal
655	Swelling Face	41	0.4	0.4	no signal
656	Nervousness	33	0.4	0.4	no signal
657	Blood Bilirubin Increased	17	0.4	0.4	no signal
658	Sepsis	70	0.4	0.4	no signal
659	Blood Creatinine Increased	41	0.4	0.4	no signal
660	Sneezing	14	0.4	0.4	no signal
661	Malaise	275	0.4	0.4	no signal
662	Herpes Zoster	36	0.4	0.4	no signal
663	Head Discomfort	11	0.4	0.4	no signal
664	Hyponatraemia	35	0.4	0.4	no signal
665	Myocarditis	7	0.4	0.4	no signal
666	Knee Operation	6	0.4	0.4	no signal
667	Cardiac Failure Congestive	50	0.4	0.4	no signal
668	Dyspnoea Exertional	23	0.4	0.4	no signal
669	Kidney Infection	12	0.4	0.4	no signal
670	Colitis	23	0.4	0.4	no signal
671	Renal Tubular Necrosis	6	0.4	0.4	no signal
672	Bedridden	8	0.4	0.4	no signal
673	Vertigo	37	0.4	0.4	no signal
674	Brain Injury	6	0.4	0.4	no signal
675	Loss Of Consciousness	76	0.4	0.4	no signal
676	Sinus Congestion	8	0.4	0.4	no signal
677	Acute Hepatic Failure	8	0.4	0.4	no signal
678	Ataxia	7	0.4	0.4	no signal
679	Poor Quality Product Administered	6	0.4	0.4	no signal
680	Ear Discomfort	6	0.4	0.4	no signal
681	Influenza	65	0.4	0.4	no signal
682	Pulmonary Oedema	26	0.4	0.4	no signal
683	Syncope	58	0.4	0.4	no signal
684	Dermatitis	12	0.4	0.4	no signal
685	Therapeutic Response Unexpected	26	0.4	0.4	no signal
686	Gait Inability	19	0.4	0.4	no signal
687	Decreased Appetite	132	0.4	0.4	no signal
688	Drug Effect Incomplete	21	0.4	0.4	no signal
689	Abdominal Pain	132	0.4	0.4	no signal
690	Tendon Rupture	7	0.4	0.4	no signal
691	Tinnitus	26	0.4	0.4	no signal
692	Tooth Extraction	7	0.4	0.4	no signal
693	Chills	66	0.4	0.4	no signal
694	Pneumonia	181	0.4	0.4	no signal
695	Coronary Artery Disease	17	0.4	0.4	no signal
696	Subdural Haematoma	8	0.4	0.4	no signal
697	Skin Haemorrhage	8	0.4	0.4	no signal
698	Clostridium Difficile Infection	12	0.4	0.4	no signal
699	Fear	15	0.4	0.4	no signal
700	Osteomyelitis	10	0.4	0.4	no signal
701	Laryngitis	6	0.4	0.4	no signal
702	Impaired Healing	18	0.4	0.4	no signal
703	Blood Glucose Fluctuation	6	0.4	0.4	no signal
704	Hyperkalaemia	19	0.4	0.4	no signal
705	End Stage Renal Disease	10	0.4	0.4	no signal
706	Balance Disorder	47	0.4	0.4	no signal
707	Stress	39	0.4	0.4	no signal
708	Incorrect Product Administration Duration	11	0.4	0.4	no signal
709	Hepatotoxicity	12	0.4	0.4	no signal
710	Leukopenia	27	0.4	0.4	no signal
711	Urinary Retention	18	0.4	0.4	no signal
712	Ovarian Cancer	5	0.4	0.4	no signal
713	Hypersensitivity	100	0.4	0.4	no signal
714	Product Packaging Issue	5	0.4	0.4	no signal
715	Nephropathy Toxic	6	0.4	0.4	no signal
716	Pancytopenia	30	0.4	0.4	no signal
717	Bronchitis	40	0.4	0.4	no signal
718	Drug Hypersensitivity	104	0.4	0.4	no signal
719	Hypoaesthesia Oral	8	0.4	0.4	no signal
720	Hip Arthroplasty	8	0.4	0.4	no signal
721	Pulmonary Hypertension	11	0.4	0.4	no signal
722	Laceration	5	0.4	0.4	no signal
723	Disease Recurrence	25	0.4	0.4	no signal
724	Musculoskeletal Disorder	10	0.4	0.4	no signal
725	Autoimmune Disorder	5	0.4	0.4	no signal
726	Pneumonia Aspiration	13	0.4	0.4	no signal
727	Quality Of Life Decreased	7	0.4	0.4	no signal
728	Amnesia	34	0.4	0.4	no signal
729	Cardiac Arrest	43	0.4	0.3	no signal
730	Therapy Change	5	0.4	0.4	no signal
731	Osteoarthritis	22	0.3	0.3	no signal
732	Pneumonitis	14	0.3	0.3	no signal
733	Tachycardia	46	0.3	0.3	no signal
734	Eosinophilia	9	0.3	0.3	no signal
735	Post Procedural Haemorrhage	6	0.3	0.3	no signal
736	Ejection Fraction Decreased	8	0.3	0.3	no signal
737	Spinal Pain	6	0.3	0.3	no signal
738	Inability To Afford Medication	5	0.3	0.3	no signal
739	Cardiovascular Disorder	13	0.3	0.3	no signal
740	Ligament Sprain	5	0.3	0.3	no signal
741	Pneumothorax	8	0.3	0.3	no signal
742	Haemoptysis	14	0.3	0.3	no signal
743	Malignant Neoplasm Progression	51	0.3	0.3	no signal
744	Coordination Abnormal	7	0.3	0.3	no signal
745	Motor Dysfunction	5	0.3	0.3	no signal
746	Confusional State	80	0.3	0.3	no signal
747	Blood Cholesterol Increased	23	0.3	0.3	no signal
748	Hypothermia	5	0.3	0.3	no signal
749	Back Disorder	8	0.3	0.3	no signal
750	Encephalopathy	12	0.3	0.3	no signal
751	Dysuria	18	0.3	0.3	no signal
752	Product Use In Unapproved Indication	119	0.3	0.3	no signal
753	Impaired Quality Of Life	7	0.3	0.3	no signal
754	Blood Glucose Abnormal	9	0.3	0.3	no signal
755	Limb Discomfort	15	0.3	0.3	no signal
756	Blood Alkaline Phosphatase Increased	12	0.3	0.3	no signal
757	Drug Administration Error	15	0.3	0.3	no signal
758	Dehydration	64	0.3	0.3	no signal
759	Hypokalaemia	22	0.3	0.3	no signal
760	Speech Disorder	25	0.3	0.3	no signal
761	Skin Fissures	9	0.3	0.3	no signal
762	Upper Gastrointestinal Haemorrhage	8	0.3	0.3	no signal
763	Foot Fracture	9	0.3	0.3	no signal
764	Abdominal Pain Lower	12	0.3	0.3	no signal
765	Face Oedema	8	0.3	0.3	no signal
766	Cystitis	15	0.3	0.3	no signal
767	Poor Quality Sleep	10	0.3	0.3	no signal
768	Musculoskeletal Discomfort	8	0.3	0.3	no signal
769	Lower Respiratory Tract Infection	21	0.3	0.3	no signal
770	Pyrexia	160	0.3	0.3	no signal
771	Wound Infection	5	0.3	0.3	no signal
772	Blood Pressure Fluctuation	11	0.3	0.3	no signal
773	Drug Eruption	8	0.3	0.3	no signal
774	Neuralgia	11	0.3	0.3	no signal
775	Hepatic Cancer	11	0.3	0.3	no signal
776	Alopecia	89	0.3	0.3	no signal
777	Cognitive Disorder	21	0.3	0.3	no signal
778	Neck Pain	25	0.3	0.3	no signal
779	Gout	8	0.3	0.3	no signal
780	Rash Papular	10	0.3	0.3	no signal
781	Renal Impairment	37	0.3	0.3	no signal
782	Scab	5	0.3	0.3	no signal
783	Rebound Effect	5	0.3	0.3	no signal
784	Cholecystectomy	5	0.3	0.3	no signal
785	Pelvic Pain	8	0.3	0.3	no signal
786	Hypotension	88	0.3	0.3	no signal
787	Incorrect Dose Administered	98	0.3	0.3	no signal
788	Diverticulitis	12	0.3	0.3	no signal
789	Nerve Compression	4	0.3	0.3	no signal
790	Sensory Disturbance	7	0.3	0.3	no signal
791	Increased Tendency To Bruise	4	0.3	0.3	no signal
792	Delirium	15	0.3	0.3	no signal
793	Hypophagia	11	0.3	0.3	no signal
794	Bradycardia	23	0.3	0.3	no signal
795	Blood Potassium Increased	7	0.3	0.3	no signal
796	Contraindicated Product Administered	13	0.3	0.3	no signal
797	Weight Decreased	120	0.3	0.3	no signal
798	Blood Iron Decreased	5	0.3	0.3	no signal
799	Respiratory Tract Infection	11	0.3	0.3	no signal
800	Haematoma	11	0.3	0.3	no signal
801	Productive Cough	20	0.3	0.3	no signal
802	Gait Disturbance	80	0.3	0.3	no signal
803	Nervous System Disorder	13	0.3	0.3	no signal
804	Treatment Failure	34	0.3	0.3	no signal
805	Fluid Retention	21	0.3	0.3	no signal
806	Spinal Operation	5	0.3	0.3	no signal
807	Choking	8	0.3	0.3	no signal
808	Dizziness	205	0.3	0.3	no signal
809	Underdose	30	0.3	0.3	no signal
810	Chest Pain	76	0.3	0.3	no signal
811	Gamma-glutamyltransferase Increased	9	0.3	0.3	no signal
812	Lactic Acidosis	13	0.3	0.3	no signal
813	Treatment Noncompliance	22	0.3	0.3	no signal
814	Pallor	11	0.3	0.3	no signal
815	Feeding Disorder	8	0.3	0.3	no signal
816	Dermatitis Allergic	5	0.3	0.3	no signal
817	Blood Potassium Decreased	12	0.3	0.3	no signal
818	Lymphocyte Count Decreased	7	0.3	0.3	no signal
819	Infection	57	0.3	0.3	no signal
820	Contusion	38	0.3	0.3	no signal
821	Mobility Decreased	28	0.3	0.3	no signal
822	Cough	109	0.3	0.3	no signal
823	Thyroid Disorder	6	0.3	0.3	no signal
824	Product Use Complaint	6	0.3	0.3	no signal
825	Femur Fracture	12	0.3	0.3	no signal
826	Respiratory Failure	28	0.3	0.3	no signal
827	Feeling Abnormal	92	0.3	0.3	no signal
828	Agranulocytosis	7	0.3	0.3	no signal
829	Pancreatic Carcinoma	11	0.3	0.3	no signal
830	Muscular Weakness	43	0.3	0.3	no signal
831	Peripheral Swelling	58	0.3	0.3	no signal
832	Cellulitis	19	0.3	0.3	no signal
833	Oedema Peripheral	46	0.3	0.3	no signal
834	Vomiting	176	0.3	0.2	no signal
835	Blood Glucose Increased	71	0.3	0.3	no signal
836	Blood Glucose Decreased	18	0.3	0.3	no signal
837	Covid-19	66	0.3	0.3	no signal
838	Upper Respiratory Tract Infection	17	0.2	0.2	no signal
839	Fatigue	285	0.2	0.2	no signal
840	Metastases To Bone	6	0.2	0.2	no signal
841	Memory Impairment	50	0.2	0.2	no signal
842	Blood Pressure Decreased	24	0.2	0.2	no signal
843	Rash Maculo-papular	8	0.2	0.2	no signal
844	Medication Error	20	0.2	0.2	no signal
845	Ageusia	9	0.2	0.2	no signal
846	Lymphopenia	5	0.2	0.2	no signal
847	Skin Reaction	5	0.2	0.2	no signal
848	Disability	7	0.2	0.2	no signal
849	Chronic Kidney Disease	27	0.2	0.2	no signal
850	Gastric Cancer	9	0.2	0.2	no signal
851	Anaphylactic Shock	9	0.2	0.2	no signal
852	Spinal Fracture	7	0.2	0.2	no signal
853	Haemoglobin Decreased	36	0.2	0.2	no signal
854	Drug Effect Decreased	19	0.2	0.2	no signal
855	Pericardial Effusion	8	0.2	0.2	no signal
856	Platelet Count Decreased	37	0.2	0.2	no signal
857	Pain	213	0.2	0.2	no signal
858	Muscle Twitching	8	0.2	0.2	no signal
859	Pleural Effusion	21	0.2	0.2	no signal
860	Mental Disorder	15	0.2	0.2	no signal
861	Hypoxia	12	0.2	0.2	no signal
862	Nasopharyngitis	63	0.2	0.2	no signal
863	Heart Rate Decreased	12	0.2	0.2	no signal
864	Ascites	10	0.2	0.2	no signal
865	Dyspnoea	192	0.2	0.2	no signal
866	Influenza Like Illness	28	0.2	0.2	no signal
867	Respiratory Disorder	10	0.2	0.2	no signal
868	Device Issue	29	0.2	0.2	no signal
869	Nephrolithiasis	15	0.2	0.2	no signal
870	Anxiety	93	0.2	0.2	no signal
871	Procedural Pain	9	0.2	0.2	no signal
872	Nasal Congestion	19	0.2	0.2	no signal
873	Faeces Discoloured	7	0.2	0.2	no signal
874	Feeling Cold	9	0.2	0.2	no signal
875	Injection Site Discolouration	4	0.2	0.2	no signal
876	Device Dislocation	14	0.2	0.2	no signal
877	Abdominal Pain Upper	66	0.2	0.2	no signal
878	Depression	73	0.2	0.2	no signal
879	Pruritus Generalised	7	0.2	0.2	no signal
880	Glycosylated Haemoglobin Increased	8	0.2	0.2	no signal
881	Maternal Exposure During Pregnancy	28	0.2	0.2	no signal
882	Arthritis	25	0.2	0.2	no signal
883	Melaena	7	0.2	0.2	no signal
884	Poisoning	4	0.2	0.2	no signal
885	Rash Macular	11	0.2	0.2	no signal
886	Loss Of Personal Independence In Daily Activities	15	0.2	0.2	no signal
887	Hypoaesthesia	47	0.2	0.2	no signal
888	International Normalised Ratio Increased	9	0.2	0.2	no signal
889	Agitation	23	0.2	0.2	no signal
890	Interstitial Lung Disease	15	0.2	0.2	no signal
891	Back Pain	72	0.2	0.2	no signal
892	Nausea	244	0.2	0.2	no signal
893	Musculoskeletal Pain	16	0.2	0.2	no signal
894	Complication Associated With Device	4	0.2	0.2	no signal
895	Crying	11	0.2	0.2	no signal
896	Drug Intolerance	29	0.2	0.2	no signal
897	Lip Swelling	10	0.2	0.2	no signal
898	Skin Exfoliation	25	0.2	0.2	no signal
899	Haematocrit Decreased	6	0.2	0.2	no signal
900	Ovarian Cyst	3	0.2	0.2	no signal
901	Malignant Melanoma	4	0.2	0.2	no signal
902	Erythema	61	0.2	0.2	no signal
903	Angioedema	13	0.2	0.2	no signal
904	Prostatic Specific Antigen Increased	4	0.2	0.2	no signal
905	Seizure	33	0.2	0.2	no signal
906	Gastrooesophageal Reflux Disease	23	0.2	0.2	no signal
907	Arthropathy	16	0.2	0.2	no signal
908	White Blood Cell Count Decreased	31	0.2	0.2	no signal
909	Dysphagia	27	0.2	0.2	no signal
910	Injection Site Erythema	35	0.2	0.2	no signal
911	Hypothyroidism	9	0.2	0.2	no signal
912	Dysgeusia	21	0.2	0.2	no signal
913	Joint Injury	6	0.2	0.2	no signal
914	Hypersomnia	8	0.2	0.2	no signal
915	Abasia	7	0.2	0.2	no signal
916	Rash Pruritic	15	0.2	0.2	no signal
917	Feeling Hot	17	0.2	0.2	no signal
918	Asthma	31	0.2	0.2	no signal
919	Anosmia	4	0.2	0.2	no signal
920	Hyperglycaemia	10	0.2	0.2	no signal
921	Chest Discomfort	28	0.2	0.2	no signal
922	Therapy Cessation	14	0.2	0.2	no signal
923	Intervertebral Disc Protrusion	6	0.2	0.2	no signal
924	Gastrointestinal Haemorrhage	23	0.2	0.2	no signal
925	Restlessness	10	0.2	0.2	no signal
926	Pain In Extremity	80	0.2	0.2	no signal
927	Skin Disorder	9	0.2	0.2	no signal
928	Urinary Incontinence	8	0.2	0.2	no signal
929	Hypoglycaemia	13	0.2	0.2	no signal
930	Hallucination	20	0.2	0.2	no signal
931	Type 2 Diabetes Mellitus	9	0.2	0.2	no signal
932	Eructation	5	0.2	0.2	no signal
933	Sinusitis	27	0.2	0.2	no signal
934	Internal Haemorrhage	3	0.2	0.2	no signal
935	Lethargy	15	0.2	0.2	no signal
936	Gastric Haemorrhage	3	0.2	0.2	no signal
937	Overdose	56	0.2	0.2	no signal
938	Eczema	13	0.2	0.2	no signal
939	Delusion	4	0.2	0.2	no signal
940	Lymphoma	4	0.2	0.2	no signal
941	Palpitations	30	0.2	0.2	no signal
942	Swollen Tongue	8	0.2	0.2	no signal
943	Dyspepsia	25	0.2	0.2	no signal
944	Device Breakage	10	0.2	0.2	no signal
945	Migraine	24	0.2	0.2	no signal
946	Product Quality Issue	34	0.2	0.2	no signal
947	Musculoskeletal Stiffness	22	0.2	0.2	no signal
948	Toxicity To Various Agents	42	0.2	0.2	no signal
949	Accidental Exposure To Product	25	0.2	0.2	no signal
950	Arthralgia	103	0.2	0.2	no signal
951	Oropharyngeal Pain	23	0.2	0.2	no signal
952	Flatulence	14	0.2	0.2	no signal
953	Mental Impairment	6	0.2	0.2	no signal
954	Pain In Jaw	7	0.2	0.2	no signal
955	Bone Marrow Failure	5	0.2	0.2	no signal
956	Cholelithiasis	8	0.2	0.2	no signal
957	Peritonitis	5	0.2	0.2	no signal
958	Disturbance In Attention	13	0.2	0.2	no signal
959	Constipation	52	0.2	0.2	no signal
960	Pruritus	90	0.2	0.2	no signal
961	Anaphylactic Reaction	13	0.2	0.2	no signal
962	Incorrect Dose Administered By Device	6	0.2	0.2	no signal
963	Haematemesis	6	0.2	0.2	no signal
964	Dry Mouth	19	0.2	0.2	no signal
965	Oesophageal Carcinoma	7	0.2	0.2	no signal
966	Oxygen Saturation Decreased	13	0.2	0.2	no signal
967	Therapy Interrupted	16	0.2	0.2	no signal
968	Rash	100	0.2	0.2	no signal
969	Device Difficult To Use	15	0.2	0.2	no signal
970	Systemic Lupus Erythematosus	8	0.2	0.2	no signal
971	Swelling	21	0.2	0.2	no signal
972	Injection Site Swelling	17	0.2	0.2	no signal
973	Product Availability Issue	5	0.2	0.2	no signal
974	Panic Attack	8	0.1	0.1	no signal
975	Osteoporosis	9	0.1	0.1	no signal
976	Osteonecrosis	7	0.1	0.1	no signal
977	Hepatocellular Injury	3	0.1	0.1	no signal
978	Accidental Underdose	3	0.1	0.1	no signal
979	Injection Site Haematoma	3	0.1	0.1	no signal
980	Injection Site Reaction	14	0.1	0.1	no signal
981	Gastric Disorder	7	0.1	0.1	no signal
982	Product Physical Issue	4	0.1	0.1	no signal
983	Lymphadenopathy	7	0.1	0.1	no signal
984	Prostate Cancer	16	0.1	0.1	no signal
985	Epilepsy	6	0.1	0.1	no signal
986	Blood Count Abnormal	3	0.1	0.1	no signal
987	Myalgia	33	0.1	0.1	no signal
988	Somnolence	39	0.1	0.1	no signal
989	Hyperhidrosis	25	0.1	0.1	no signal
990	Abdominal Distension	20	0.1	0.1	no signal
991	Tooth Loss	4	0.1	0.1	no signal
992	Accidental Overdose	7	0.1	0.1	no signal
993	Premature Delivery	3	0.1	0.1	no signal
994	Insomnia	50	0.1	0.1	no signal
995	Renal Cancer	9	0.1	0.1	no signal
996	Hot Flush	14	0.1	0.1	no signal
997	Abdominal Discomfort	31	0.1	0.1	no signal
998	Heart Rate Increased	18	0.1	0.1	no signal
999	Gastrointestinal Disorder	16	0.1	0.1	no signal
1000	Tremor	30	0.1	0.1	no signal
1001	Urticaria	30	0.1	0.1	no signal
1002	Blister	10	0.1	0.1	no signal
1003	Exposure Via Skin Contact	4	0.1	0.1	no signal
1004	Skin Discolouration	8	0.1	0.1	no signal
1005	Abortion Spontaneous	7	0.1	0.1	no signal
1006	Burning Sensation	12	0.1	0.1	no signal
1007	Rash Erythematous	8	0.1	0.1	no signal
1008	Bone Pain	10	0.1	0.1	no signal
1009	Pollakiuria	7	0.1	0.1	no signal
1010	Bladder Cancer	10	0.1	0.1	no signal
1011	Diabetic Ketoacidosis	4	0.1	0.1	no signal
1012	Drug Interaction	26	0.1	0.1	no signal
1013	Haematochezia	9	0.1	0.1	no signal
1014	Paraesthesia	25	0.1	0.1	no signal
1015	Sleep Disorder	11	0.1	0.1	no signal
1016	Depressed Level Of Consciousness	6	0.1	0.1	no signal
1017	Pancreatitis	8	0.1	0.1	no signal
1018	Dyskinesia	6	0.1	0.1	no signal
1019	Coma	7	0.1	0.1	no signal
1020	Dry Skin	19	0.1	0.1	no signal
1021	Suicidal Ideation	13	0.1	0.1	no signal
1022	Joint Swelling	17	0.1	0.1	no signal
1023	Injection Site Bruising	11	0.1	0.1	no signal
1024	Renal Failure Acute	6	0.1	0.1	no signal
1025	Application Site Pain	3	0.1	0.1	no signal
1026	Liver Disorder	6	0.1	0.1	no signal
1027	Irritability	8	0.1	0.1	no signal
1028	Aspartate Aminotransferase Increased	7	0.1	0.1	no signal
1029	Emotional Distress	16	0.1	0.1	no signal
1030	Muscle Spasms	24	0.1	0.1	no signal
1031	Alanine Aminotransferase Increased	8	0.1	0.1	no signal
1032	Weight Increased	29	0.1	0.1	no signal
1033	Psoriasis	16	0.1	0.1	no signal
1034	Product Complaint	3	0.1	0.1	no signal
1035	Aggression	6	0.1	0.1	no signal
1036	Wheezing	7	0.1	0.1	no signal
1037	Breast Cancer	11	0.1	0.1	no signal
1038	Intentional Product Misuse	10	0.1	0.1	no signal
1039	Injury	8	0.1	0.1	no signal
1040	Breast Cancer Female	3	0.1	0.1	no signal
1041	Wrong Technique In Drug Usage Process	4	0.1	0.1	no signal
1042	Rheumatoid Arthritis	12	0.1	0.1	no signal
1043	Convulsion	6	0.1	0.1	no signal
1044	Injection Site Pruritus	6	0.1	0.1	no signal
1045	Wrong Technique In Device Usage Process	4	0.1	0.1	no signal
1046	Completed Suicide	7	0.1	0.1	no signal
1047	Incorrect Route Of Drug Administration	3	0.1	0.1	no signal
1048	Colorectal Cancer	4	0.1	0.1	no signal
1049	Drug Dose Omission By Device	6	0.1	0.1	no signal
1050	Flushing	7	0.0	0.0	no signal