Drug

Aldesleukin

75 flagged reaction(s) · 1,325 total co-reports · max PRR 28.7

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Cytokine Release Syndrome	32	28.7	29.4	signal
2	Device Related Infection	25	27.6	28.2	signal
3	Hypoxia	54	26.3	27.4	signal
4	Myocarditis	15	22.6	22.9	signal
5	Lymphopenia	18	21.8	22.1	signal
6	Clostridium Difficile Colitis	13	20.9	21.1	signal
7	Metastases To Lung	13	19.2	19.4	signal
8	Ejection Fraction Decreased	16	17.5	17.7	signal
9	Mental Status Changes	28	17.2	17.6	signal
10	Anorexia	13	17.0	17.1	signal
11	Splenomegaly	11	16.0	16.2	signal
12	Metastases To Central Nervous System	12	16.0	16.1	signal
13	Sinus Tachycardia	13	15.6	15.8	signal
14	Pulmonary Oedema	40	15.2	15.7	signal
15	Acute Respiratory Failure	17	15.1	15.3	signal
16	Haemorrhage Intracranial	13	14.8	14.9	signal
17	Cytopenia	10	14.3	14.4	signal
18	Myelodysplastic Syndrome	12	14.1	14.3	signal
19	Malignant Melanoma	11	14.0	14.1	signal
20	Blood Bilirubin Increased	22	13.8	14.1	signal
21	Drug Toxicity	11	13.6	13.7	signal
22	Febrile Neutropenia	51	13.1	13.7	signal
23	Thrombocytopenia	83	12.7	13.5	signal
24	Quality Of Life Decreased	10	12.7	12.8	signal
25	Tachypnoea	10	12.6	12.7	signal
26	Pancytopenia	37	11.3	11.6	signal
27	Unresponsive To Stimuli	17	11.3	11.4	signal
28	Encephalopathy	16	11.1	11.3	signal
29	Hypomagnesaemia	9	11.1	11.1	signal
30	Hypercalcaemia	8	11.1	11.1	signal
31	Pleural Effusion	39	10.9	11.2	signal
32	Supraventricular Tachycardia	6	10.7	10.7	signal
33	Blood Lactate Dehydrogenase Increased	10	10.7	10.8	signal
34	Electrolyte Imbalance	7	10.4	10.4	signal
35	Bacterial Infection	11	10.1	10.2	signal
36	Rash Maculo-papular	13	10.0	10.1	signal
37	Renal Failure Acute	25	9.9	10.1	signal
38	Hypotension	111	9.4	10.3	signal
39	Blood Creatinine Increased	36	9.4	9.6	signal
40	Respiratory Failure	39	9.1	9.4	signal
41	Cerebral Infarction	13	9.1	9.1	signal
42	Chills	62	9.0	9.4	signal
43	Posterior Reversible Encephalopathy Syndrome	5	9.0	9.0	signal
44	Uveitis	7	8.8	8.9	signal
45	Multi-organ Failure	9	8.7	8.8	signal
46	Multiple Organ Dysfunction Syndrome	14	8.5	8.6	signal
47	Hypotonia	5	8.5	8.5	signal
48	Generalised Tonic-clonic Seizure	8	8.3	8.4	signal
49	Hyperbilirubinaemia	5	8.3	8.3	signal
50	Hypocalcaemia	9	8.1	8.2	signal
51	Brain Oedema	6	8.1	8.1	signal
52	Acute Myeloid Leukaemia	7	7.7	7.7	signal
53	Disease Progression	52	7.5	7.8	signal
54	Eyelid Oedema	5	7.3	7.3	signal
55	Disseminated Intravascular Coagulation	6	7.2	7.3	signal
56	Cardiogenic Shock	6	7.2	7.2	signal
57	Thrombotic Microangiopathy	4	7.0	7.1	signal
58	Malignant Neoplasm Progression	42	7.0	7.2	signal
59	Neurotoxicity	7	6.9	6.9	signal
60	Tooth Extraction	5	6.8	6.9	signal
61	Eosinophilia	7	6.8	6.9	signal
62	Shock	9	6.7	6.8	signal
63	Neoplasm Progression	13	6.3	6.4	signal
64	Neutrophil Count Decreased	15	6.3	6.4	signal
65	Hyperthyroidism	5	5.9	5.9	signal
66	Metastases To Liver	6	5.8	5.9	signal
67	Bone Marrow Failure	7	5.8	5.9	signal
68	Fluid Overload	5	5.8	5.8	signal
69	Inappropriate Antidiuretic Hormone Secretion	3	5.0	5.0	signal
70	Injection Site Discomfort	3	5.0	5.0	signal
71	Status Epilepticus	3	4.5	4.5	signal
72	Diabetic Ketoacidosis	6	4.3	4.3	signal
73	Osteonecrosis	7	3.6	3.6	signal
74	Myelosuppression	7	3.5	3.5	signal
75	Injection Site Erythema	15	2.1	2.1	signal