OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Alendronate Sodium And Cholecalciferol

397 flagged reaction(s) · 25,399 total co-reports · max PRR 360.1
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Femur Fracture 1,407 360.1 732.2 signal
2 Vitamin D Deficiency 260 207.9 229.3 signal
3 Hyperlipidaemia 304 197.4 221.6 signal
4 Intervertebral Disc Degeneration 214 178.5 193.4 signal
5 Hypercholesterolaemia 201 162.7 175.4 signal
6 Bursitis 228 146.1 159.1 signal
7 Osteopenia 260 131.5 145.0 signal
8 Osteoarthritis 655 118.8 155.3 signal
9 Dental Caries 157 109.3 115.8 signal
10 Foot Fracture 232 93.7 102.2 signal
11 Bone Disorder 215 89.8 97.3 signal
12 Tooth Disorder 258 88.6 97.6 signal
13 Tooth Fracture 124 86.3 90.3 signal
14 Osteoporosis 428 79.6 94.0 signal
15 Rotator Cuff Syndrome 130 77.3 81.0 signal
16 Ligament Sprain 88 68.2 70.4 signal
17 Device Failure 135 68.1 71.5 signal
18 Impaired Healing 265 61.7 68.1 signal
19 Tooth Extraction 99 60.8 63.0 signal
20 Wrist Fracture 95 60.6 62.7 signal
21 Rib Fracture 160 59.6 63.2 signal
22 Osteonecrosis Of Jaw 190 58.3 62.5 signal
23 Hiatus Hernia 95 55.9 57.9 signal
24 Foot Deformity 80 55.1 56.7 signal
25 Cholecystectomy 80 53.8 55.3 signal
26 Haemorrhoids 123 48.0 50.2 signal
27 Hypothyroidism 200 47.9 51.6 signal
28 Osteomyelitis 113 47.7 49.6 signal
29 Spinal Disorder 59 47.4 48.4 signal
30 Sciatica 95 45.7 47.3 signal
31 Intervertebral Disc Protrusion 129 44.9 47.0 signal
32 Increased Tendency To Bruise 54 44.7 45.5 signal
33 Atelectasis 55 43.3 44.1 signal
34 Body Height Decreased 61 43.0 44.0 signal
35 Osteonecrosis 184 42.3 45.3 signal
36 Hip Arthroplasty 84 42.2 43.5 signal
37 Tooth Abscess 56 41.8 42.6 signal
38 Gastrooesophageal Reflux Disease 437 41.6 49.2 signal
39 Tendonitis 84 41.2 42.4 signal
40 Laceration 51 40.8 41.5 signal
41 Carpal Tunnel Syndrome 71 38.5 39.5 signal
42 Ankle Fracture 78 38.3 39.4 signal
43 Iron Deficiency Anaemia 44 36.5 37.1 signal
44 Blood Cholesterol Increased 223 36.4 39.5 signal
45 Joint Dislocation 50 36.2 36.8 signal
46 Transfusion 49 35.5 36.1 signal
47 Joint Injury 94 33.5 34.6 signal
48 Mitral Valve Incompetence 48 32.3 32.8 signal
49 Hip Fracture 124 29.4 30.7 signal
50 Cyst 48 29.4 29.9 signal
51 Bone Loss 54 27.1 27.6 signal
52 Emphysema 36 27.1 27.4 signal
53 Sleep Apnoea Syndrome 68 27.1 27.7 signal
54 Knee Arthroplasty 74 27.0 27.7 signal
55 Fracture 67 26.9 27.6 signal
56 Upper Limb Fracture 70 26.6 27.3 signal
57 Skeletal Injury 36 26.2 26.5 signal
58 Gastritis 90 26.0 26.9 signal
59 Ovarian Cyst 34 25.7 26.0 signal
60 Arthropathy 185 25.2 27.0 signal
61 Bone Density Decreased 105 25.2 26.2 signal
62 Abscess 52 24.8 25.3 signal
63 Hypercalcaemia 40 24.7 25.0 signal
64 Tooth Infection 42 24.2 24.6 signal
65 Arthritis 250 24.1 26.4 signal
66 Back Disorder 51 23.8 24.2 signal
67 Glaucoma 60 23.7 24.2 signal
68 Arteriosclerosis 29 23.4 23.6 signal
69 Multiple Fractures 50 22.9 23.3 signal
70 Coronary Artery Disease 91 22.7 23.4 signal
71 Nocturia 36 22.6 22.9 signal
72 Restless Legs Syndrome 54 22.6 23.0 signal
73 Gingival Bleeding 40 22.2 22.6 signal
74 Cardiomegaly 36 22.1 22.3 signal
75 Cataract 169 21.7 23.0 signal
76 Macular Degeneration 33 21.1 21.3 signal
77 Toothache 50 21.0 21.4 signal
78 Bladder Disorder 27 20.6 20.8 signal
79 Musculoskeletal Chest Pain 42 20.6 20.9 signal
80 Urinary Incontinence 80 20.5 21.1 signal
81 Gallbladder Disorder 47 20.0 20.3 signal
82 Lower Limb Fracture 50 19.9 20.3 signal
83 Hypertension 552 19.8 24.5 signal
84 Leukocytosis 47 19.8 20.1 signal
85 Fibromyalgia 62 19.4 19.8 signal
86 Sinus Disorder 50 19.2 19.5 signal
87 Back Injury 27 19.0 19.1 signal
88 Chronic Obstructive Pulmonary Disease 130 19.0 19.8 signal
89 Irritable Bowel Syndrome 53 18.9 19.2 signal
90 Fall 809 18.5 25.7 signal
91 Limb Injury 65 18.2 18.7 signal
92 Spinal Fracture 47 17.9 18.2 signal
93 Haematoma 60 17.5 17.9 signal
94 Cellulitis 116 17.5 18.2 signal
95 Micturition Urgency 26 17.4 17.6 signal
96 Thyroid Disorder 35 17.3 17.5 signal
97 Knee Operation 22 17.2 17.3 signal
98 Pain In Jaw 64 17.2 17.5 signal
99 Oesophagitis 24 16.7 16.8 signal
100 Adverse Event 202 16.7 17.9 signal
101 Type 2 Diabetes Mellitus 74 16.6 17.1 signal
102 Musculoskeletal Discomfort 37 16.3 16.6 signal
103 Road Traffic Accident 89 16.2 16.7 signal
104 Musculoskeletal Pain 111 16.0 16.6 signal
105 Malnutrition 23 15.7 15.9 signal
106 Hypokalaemia 95 15.7 16.3 signal
107 Basal Cell Carcinoma 32 15.6 15.7 signal
108 Dermatitis Contact 23 15.4 15.5 signal
109 Nephrolithiasis 91 15.1 15.6 signal
110 Nerve Compression 18 14.8 14.9 signal
111 Fistula 22 14.8 14.9 signal
112 Pulmonary Mass 28 14.3 14.4 signal
113 Supraventricular Tachycardia 18 14.3 14.4 signal
114 Musculoskeletal Disorder 36 14.3 14.5 signal
115 Hyperthyroidism 27 14.2 14.3 signal
116 Ear Pain 36 14.1 14.2 signal
117 Ventricular Extrasystoles 19 13.9 14.0 signal
118 Tooth Loss 38 13.8 14.0 signal
119 Mass 25 13.6 13.7 signal
120 Depression 404 13.4 15.6 signal
121 Bronchitis 131 13.4 14.0 signal
122 Synovitis 31 13.0 13.2 signal
123 Gastroenteritis 25 13.0 13.1 signal
124 Obesity 27 12.9 13.0 signal
125 Blood Calcium Decreased 19 12.8 12.9 signal
126 Bone Pain 98 12.7 13.1 signal
127 Back Pain 388 12.7 14.6 signal
128 Haematocrit Decreased 33 12.6 12.7 signal
129 Contusion 158 12.5 13.2 signal
130 Seasonal Allergy 23 12.4 12.5 signal
131 Myocardial Ischaemia 18 11.9 12.0 signal
132 Transient Ischaemic Attack 53 11.9 12.1 signal
133 Gout 28 11.8 11.9 signal
134 Device Related Infection 24 11.8 11.9 signal
135 Post Procedural Haemorrhage 18 11.7 11.8 signal
136 Pollakiuria 64 11.7 11.9 signal
137 Nodule 20 11.6 11.7 signal
138 Skin Cancer 33 11.6 11.8 signal
139 Cholelithiasis 50 11.6 11.8 signal
140 Breast Pain 16 11.4 11.5 signal
141 Spinal Operation 18 11.3 11.4 signal
142 Upper Respiratory Tract Infection 68 11.2 11.4 signal
143 Neck Pain 82 11.1 11.4 signal
144 Surgery 82 10.7 11.0 signal
145 Deafness 37 10.7 10.9 signal
146 Anxiety 402 10.7 12.4 signal
147 Adverse Drug Reaction 126 10.7 11.2 signal
148 Oedema Peripheral 171 10.6 11.2 signal
149 Head Injury 44 10.6 10.7 signal
150 Oral Pain 31 10.5 10.6 signal
151 Incorrect Product Administration Duration 28 10.5 10.6 signal
152 Pain In Extremity 396 10.2 11.7 signal
153 Sinus Tachycardia 19 10.2 10.2 signal
154 Diverticulitis 37 10.2 10.3 signal
155 Anaemia 253 10.1 11.0 signal
156 Ulcer 21 10.0 10.1 signal
157 Tendon Rupture 16 9.8 9.9 signal
158 Appendicitis 12 9.8 9.8 signal
159 Laryngitis 14 9.8 9.8 signal
160 Urinary Tract Infection 219 9.8 10.5 signal
161 Squamous Cell Carcinoma 12 9.7 9.7 signal
162 Vertigo 77 9.6 9.8 signal
163 Red Blood Cell Sedimentation Rate Increased 14 9.6 9.6 signal
164 Gastric Ulcer 24 9.6 9.6 signal
165 Nerve Injury 14 9.5 9.6 signal
166 Bacterial Infection 23 9.4 9.5 signal
167 Incontinence 13 9.3 9.4 signal
168 Small Intestinal Obstruction 15 9.3 9.3 signal
169 Deep Vein Thrombosis 79 9.2 9.4 signal
170 Herpes Zoster 69 9.1 9.3 signal
171 Dyspnoea Exertional 44 8.9 9.0 signal
172 Fungal Infection 39 8.9 9.0 signal
173 Pelvic Pain 21 8.8 8.8 signal
174 Ileus 14 8.6 8.7 signal
175 Sinus Bradycardia 11 8.6 8.7 signal
176 Hepatic Steatosis 21 8.6 8.6 signal
177 Arthralgia 466 8.5 10.1 signal
178 Pharyngitis 14 8.5 8.6 signal
179 Skin Lesion 30 8.4 8.4 signal
180 Cholecystitis 13 8.3 8.3 signal
181 Mouth Ulceration 23 8.3 8.4 signal
182 Conjunctivitis 20 8.3 8.3 signal
183 Retinal Detachment 10 8.3 8.3 signal
184 Asthma 121 8.2 8.5 signal
185 Nephropathy 10 8.1 8.1 signal
186 Tinnitus 49 8.1 8.2 signal
187 Tenderness 11 8.0 8.0 signal
188 Joint Range Of Motion Decreased 14 7.9 8.0 signal
189 Muscular Weakness 119 7.9 8.3 signal
190 Electrolyte Imbalance 12 7.9 7.9 signal
191 Dyspepsia 102 7.9 8.2 signal
192 Neuropathy Peripheral 98 7.9 8.1 signal
193 Sinus Congestion 14 7.9 7.9 signal
194 Muscle Atrophy 13 7.8 7.9 signal
195 Oral Herpes 20 7.8 7.9 signal
196 Rectal Haemorrhage 44 7.7 7.9 signal
197 Constipation 219 7.7 8.3 signal
198 Hypomagnesaemia 14 7.7 7.7 signal
199 Cystitis 32 7.6 7.7 signal
200 Pulmonary Fibrosis 19 7.5 7.6 signal
201 Muscle Tightness 16 7.5 7.5 signal
202 Chest Pain 183 7.5 7.9 signal
203 Eyelid Ptosis 10 7.5 7.5 signal
204 Poor Quality Sleep 21 7.4 7.5 signal
205 Hyponatraemia 55 7.4 7.6 signal
206 Sleep Disorder 68 7.4 7.5 signal
207 Malignant Melanoma 13 7.4 7.4 signal
208 Flank Pain 9 7.3 7.3 signal
209 Liver Function Test Abnormal 28 7.3 7.3 signal
210 Hypocalcaemia 18 7.2 7.3 signal
211 Joint Stiffness 25 7.2 7.3 signal
212 Neuralgia 23 7.2 7.2 signal
213 Device Breakage 37 7.1 7.2 signal
214 Clostridium Difficile Colitis 10 7.1 7.2 signal
215 Sinusitis 96 7.1 7.3 signal
216 Atrial Fibrillation 91 7.1 7.3 signal
217 Skin Disorder 31 7.1 7.1 signal
218 Urinary Retention 31 7.1 7.1 signal
219 Pulmonary Hypertension 19 6.9 6.9 signal
220 Local Swelling 16 6.9 6.9 signal
221 Dysuria 33 6.8 6.9 signal
222 Myalgia 152 6.8 7.1 signal
223 Helicobacter Infection 9 6.7 6.7 signal
224 Dermatitis Allergic 11 6.7 6.7 signal
225 Hyperglycaemia 32 6.7 6.8 signal
226 Gait Disturbance 169 6.7 7.1 signal
227 Diabetes Mellitus 67 6.6 6.8 signal
228 Breast Cancer 82 6.6 6.8 signal
229 Abdominal Pain Lower 22 6.6 6.6 signal
230 Muscle Spasms 159 6.6 6.9 signal
231 Inappropriate Schedule Of Drug Administration 62 6.5 6.6 signal
232 Spinal Pain 10 6.5 6.5 signal
233 Migraine 80 6.4 6.6 signal
234 Angina Pectoris 24 6.3 6.4 signal
235 Presyncope 20 6.3 6.3 signal
236 Bipolar Disorder 9 6.2 6.3 signal
237 Dermatitis 17 6.2 6.3 signal
238 Rheumatoid Arthritis 92 6.2 6.4 signal
239 Palpitations 95 6.2 6.3 signal
240 Libido Decreased 10 6.1 6.1 signal
241 Skin Infection 9 6.1 6.1 signal
242 Metastases To Bone 13 6.0 6.1 signal
243 Eye Disorder 26 6.0 6.1 signal
244 Lymphadenopathy 28 6.0 6.0 signal
245 Staphylococcal Infection 26 6.0 6.0 signal
246 Temperature Intolerance 8 5.9 6.0 signal
247 Coagulopathy 13 5.9 6.0 signal
248 Dysphagia 74 5.9 6.1 signal
249 Neoplasm 9 5.9 5.9 signal
250 Hypoacusis 33 5.8 5.9 signal
251 Haematuria 26 5.8 5.8 signal
252 Respiratory Tract Congestion 12 5.7 5.7 signal
253 Balance Disorder 65 5.7 5.8 signal
254 Oedema 40 5.6 5.7 signal
255 Wound Infection 8 5.6 5.6 signal
256 Arrhythmia 35 5.6 5.6 signal
257 Infection 106 5.6 5.8 signal
258 Autoimmune Disorder 7 5.5 5.6 signal
259 Hernia 14 5.5 5.5 signal
260 Stress 52 5.5 5.6 signal
261 Coeliac Disease 7 5.4 5.4 signal
262 Gastrointestinal Disorder 62 5.3 5.4 signal
263 Skin Ulcer 18 5.3 5.3 signal
264 Activities Of Daily Living Impaired 14 5.3 5.3 signal
265 Proteinuria 13 5.2 5.3 signal
266 Cardiac Disorder 64 5.2 5.3 signal
267 Complication Associated With Device 9 5.2 5.2 signal
268 Acute Respiratory Failure 13 5.2 5.2 signal
269 Cardiac Failure Congestive 55 5.1 5.2 signal
270 Diabetes Mellitus Inadequate Control 12 5.1 5.2 signal
271 Colon Cancer 10 5.1 5.1 signal
272 Drug Hypersensitivity 130 5.1 5.3 signal
273 Blood Thyroid Stimulating Hormone Increased 6 4.9 4.9 signal
274 Inflammation 33 4.9 4.9 signal
275 Breast Cancer Stage I 6 4.8 4.9 signal
276 Insomnia 169 4.8 5.1 signal
277 Blood Potassium Decreased 19 4.8 4.8 signal
278 Syncope 63 4.8 4.9 signal
279 Bronchospasm 9 4.8 4.8 signal
280 Obstructive Airways Disorder 7 4.8 4.8 signal
281 Dry Eye 30 4.7 4.7 signal
282 Dementia 17 4.6 4.7 signal
283 Adverse Reaction 8 4.6 4.6 signal
284 Hypoaesthesia 89 4.5 4.6 signal
285 Ear Discomfort 6 4.4 4.5 signal
286 Haemoglobin Decreased 60 4.4 4.5 signal
287 Renal Failure Acute 25 4.4 4.4 signal
288 Drug Administration Error 18 4.4 4.4 signal
289 Mental Status Changes 16 4.4 4.4 signal
290 Gastric Disorder 20 4.4 4.4 signal
291 Ear Infection 15 4.3 4.3 signal
292 Blood Triglycerides Increased 10 4.3 4.3 signal
293 Stomatitis 34 4.3 4.3 signal
294 Fear 15 4.2 4.2 signal
295 Injury 39 4.2 4.2 signal
296 Panic Attack 20 4.2 4.2 signal
297 Gastrointestinal Pain 6 4.2 4.2 signal
298 Urosepsis 5 4.1 4.1 signal
299 Hypertensive Crisis 6 4.1 4.1 signal
300 Eye Infection 6 4.1 4.1 signal
301 Hand Deformity 7 4.1 4.1 signal
302 Colitis 20 4.0 4.1 signal
303 Pulmonary Congestion 7 4.0 4.0 signal
304 Heart Rate Irregular 12 4.0 4.0 signal
305 Limb Discomfort 16 3.9 3.9 signal
306 Paraesthesia 81 3.9 4.0 signal
307 Vitreous Floaters 5 3.9 3.9 signal
308 Hypophagia 13 3.9 3.9 signal
309 Cardiovascular Disorder 13 3.9 3.9 signal
310 Accident 6 3.8 3.8 signal
311 Ataxia 6 3.8 3.8 signal
312 Vaginal Discharge 5 3.8 3.8 signal
313 Renal Disorder 23 3.7 3.8 signal
314 Subdural Haematoma 7 3.7 3.7 signal
315 Myelodysplastic Syndrome 7 3.7 3.7 signal
316 Blood Urine Present 9 3.6 3.6 signal
317 Fluid Retention 24 3.6 3.6 signal
318 Cough 132 3.6 3.7 signal
319 Post Procedural Complication 9 3.5 3.6 signal
320 Scar 8 3.5 3.5 signal
321 Night Sweats 15 3.5 3.5 signal
322 Pain 281 3.5 3.7 signal
323 Localised Infection 11 3.4 3.5 signal
324 Hot Flush 34 3.4 3.5 signal
325 Visual Acuity Reduced 15 3.4 3.4 signal
326 Weight Increased 99 3.4 3.5 signal
327 Treatment Noncompliance 24 3.4 3.4 signal
328 Joint Swelling 53 3.3 3.4 signal
329 Abasia 11 3.3 3.3 signal
330 Haematemesis 11 3.3 3.3 signal
331 Wound 12 3.3 3.3 signal
332 Oral Discomfort 6 3.3 3.3 signal
333 Deformity 4 3.2 3.2 signal
334 Blindness Unilateral 6 3.2 3.2 signal
335 Flatulence 24 3.2 3.2 signal
336 Polyneuropathy 5 3.2 3.2 signal
337 Hypokinesia 6 3.1 3.1 signal
338 Hemiparesis 7 3.1 3.1 signal
339 Melaena 9 3.1 3.1 signal
340 Kidney Infection 8 3.1 3.1 signal
341 Meningioma 6 3.1 3.1 signal
342 Inflammatory Bowel Disease 4 3.1 3.1 no signal
343 Fluid Overload 6 3.1 3.1 signal
344 No Therapeutic Response 5 3.1 3.1 signal
345 Inappropriate Antidiuretic Hormone Secretion 4 3.0 3.0 no signal
346 Tuberculosis 5 2.9 3.0 signal
347 Folliculitis 4 2.9 2.9 no signal
348 Sedation 10 2.9 2.9 signal
349 Dysmenorrhoea 5 2.9 2.9 signal
350 Middle Insomnia 7 2.9 2.9 signal
351 Nervousness 19 2.7 2.8 signal
352 Prostatic Specific Antigen Increased 5 2.7 2.7 no signal
353 Eczema 18 2.7 2.7 signal
354 Gastric Haemorrhage 4 2.6 2.6 no signal
355 Neoplasm Malignant 23 2.6 2.6 signal
356 Thyroid Cancer 4 2.5 2.5 no signal
357 Product Packaging Issue 3 2.5 2.5 no signal
358 Muscle Spasticity 4 2.4 2.4 no signal
359 Personality Change 3 2.4 2.4 no signal
360 Grand Mal Convulsion 3 2.4 2.4 no signal
361 Leukaemia 3 2.4 2.4 no signal
362 Eructation 6 2.4 2.4 no signal
363 Hallucination, Auditory 5 2.4 2.4 no signal
364 Erectile Dysfunction 8 2.4 2.4 signal
365 Interstitial Lung Disease 15 2.4 2.4 signal
366 Convulsion 18 2.4 2.4 signal
367 Myocardial Infarction 54 2.3 2.4 signal
368 Disability 6 2.3 2.3 no signal
369 Uveitis 4 2.2 2.2 no signal
370 Metrorrhagia 5 2.2 2.2 no signal
371 Emotional Distress 35 2.2 2.2 signal
372 Systemic Lupus Erythematosus 10 2.1 2.1 signal
373 Breast Cancer Metastatic 3 2.1 2.1 no signal
374 Device Dislocation 12 2.1 2.1 signal
375 Cerebrovascular Accident 47 2.1 2.1 signal
376 Anosmia 4 2.1 2.1 no signal
377 Hepatitis C 3 1.9 1.9 no signal
378 Vaginal Haemorrhage 10 1.8 1.8 no signal
379 Overdose 50 1.8 1.8 no signal
380 Ankylosing Spondylitis 3 1.7 1.7 no signal
381 Blood Glucose Abnormal 4 1.6 1.6 no signal
382 Acne 16 1.6 1.6 no signal
383 Pulmonary Arterial Hypertension 3 1.6 1.6 no signal
384 Menorrhagia 4 1.5 1.5 no signal
385 Amenorrhoea 3 1.4 1.4 no signal
386 Psoriasis 23 1.3 1.3 no signal
387 Psoriatic Arthropathy 7 1.3 1.3 no signal
388 Lung Neoplasm Malignant 7 1.3 1.3 no signal
389 Gastric Cancer 4 1.2 1.2 no signal
390 Bladder Cancer 9 1.1 1.1 no signal
391 Injury Associated With Device 3 1.1 1.1 no signal
392 Incorrect Drug Administration Duration 4 1.1 1.1 no signal
393 Drug Exposure During Pregnancy 4 0.9 0.9 no signal
394 Breast Cancer Female 3 0.8 0.8 no signal
395 Wrong Technique In Drug Usage Process 4 0.8 0.8 no signal
396 Drug Dependence 12 0.6 0.6 no signal
397 Renal Cancer 3 0.5 0.5 no signal