OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Amantadine Hydrochloride

394 flagged reaction(s) · 11,473 total co-reports · max PRR 28.0
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Myoclonus 77 28.0 28.5 signal
2 Hallucination, Visual 134 27.7 28.5 signal
3 Neuroleptic Malignant Syndrome 67 24.4 24.8 signal
4 Dyskinesia 197 21.1 21.9 signal
5 Delusion 66 18.5 18.7 signal
6 Parkinsonism 40 17.8 17.9 signal
7 Muscle Rigidity 45 16.3 16.4 signal
8 Mitral Valve Incompetence 41 15.7 15.8 signal
9 Hallucination 254 14.7 15.4 signal
10 Micturition Urgency 38 14.5 14.6 signal
11 Speech Disorder 164 13.5 14.0 signal
12 Multiple Sclerosis 132 11.9 12.2 signal
13 Multiple Sclerosis Relapse 189 11.8 12.3 signal
14 Hallucination, Auditory 41 11.1 11.2 signal
15 Grand Mal Convulsion 24 11.1 11.1 signal
16 Dystonia 49 10.9 11.0 signal
17 Nocturia 30 10.7 10.8 signal
18 Inappropriate Antidiuretic Hormone Secretion 25 10.6 10.7 signal
19 Delirium 79 9.9 10.0 signal
20 Psychotic Disorder 67 9.8 9.9 signal
21 Dysarthria 84 9.7 9.8 signal
22 Motor Dysfunction 22 9.4 9.4 signal
23 Balance Disorder 177 8.8 9.1 signal
24 Feeling Cold 57 8.8 8.9 signal
25 Orthostatic Hypotension 35 8.7 8.7 signal
26 Aspiration 21 8.4 8.4 signal
27 Ataxia 23 8.3 8.4 signal
28 Diplopia 46 7.7 7.7 signal
29 Convulsion 102 7.6 7.7 signal
30 Economic Problem 27 7.6 7.6 signal
31 Drug Toxicity 24 7.5 7.5 signal
32 Mental Status Changes 47 7.3 7.4 signal
33 Paranoia 29 7.2 7.3 signal
34 Encephalopathy 41 7.2 7.3 signal
35 Serotonin Syndrome 32 7.2 7.3 signal
36 Pneumonia Aspiration 41 7.1 7.2 signal
37 Cognitive Disorder 75 7.0 7.1 signal
38 Incontinence 17 6.9 7.0 signal
39 Hypokinesia 23 6.8 6.9 signal
40 Dysstasia 46 6.8 6.8 signal
41 Urinary Incontinence 46 6.7 6.8 signal
42 Muscle Spasticity 19 6.6 6.6 signal
43 Gait Disturbance 288 6.5 6.8 signal
44 Neuralgia 36 6.4 6.5 signal
45 Laceration 14 6.3 6.4 signal
46 Presyncope 35 6.2 6.3 signal
47 Central Nervous System Lesion 20 6.2 6.3 signal
48 Abasia 36 6.2 6.2 signal
49 Abnormal Behaviour 57 6.2 6.2 signal
50 Urosepsis 13 6.1 6.1 signal
51 Sudden Death 15 6.1 6.1 signal
52 Tardive Dyskinesia 39 5.9 6.0 signal
53 Tremor 222 5.8 6.0 signal
54 Agitation 95 5.6 5.7 signal
55 Temperature Intolerance 13 5.5 5.5 signal
56 Movement Disorder 40 5.4 5.4 signal
57 Mania 20 5.3 5.3 signal
58 Hypotonia 12 5.2 5.2 signal
59 Dementia 33 5.1 5.1 signal
60 Fall 392 5.1 5.5 signal
61 Apathy 17 5.1 5.1 signal
62 Injection Site Haematoma 17 5.0 5.0 signal
63 Extrapyramidal Disorder 29 5.0 5.0 signal
64 Prescribed Underdose 23 5.0 5.0 signal
65 Hypercholesterolaemia 11 5.0 5.0 signal
66 Dizziness Postural 11 4.9 5.0 signal
67 Bedridden 15 4.9 4.9 signal
68 Activities Of Daily Living Impaired 22 4.7 4.7 signal
69 Unresponsive To Stimuli 28 4.7 4.7 signal
70 Lymphocyte Count Decreased 19 4.6 4.7 signal
71 Blood Urea Increased 18 4.6 4.6 signal
72 Disorientation 42 4.6 4.6 signal
73 Restless Legs Syndrome 19 4.5 4.5 signal
74 Ankle Fracture 16 4.5 4.5 signal
75 Brain Oedema 13 4.4 4.5 signal
76 Dysphagia 96 4.4 4.4 signal
77 Bladder Disorder 10 4.3 4.3 signal
78 Cystitis 32 4.3 4.3 signal
79 Hyperlipidaemia 12 4.3 4.3 signal
80 Muscular Weakness 113 4.3 4.4 signal
81 Malnutrition 11 4.3 4.3 signal
82 Sluggishness 10 4.3 4.3 signal
83 Confusional State 159 4.2 4.3 signal
84 Urinary Tract Infection 167 4.2 4.4 signal
85 Iron Deficiency Anaemia 9 4.2 4.2 signal
86 Hypersomnia 28 4.2 4.2 signal
87 Ventricular Extrasystoles 10 4.2 4.2 signal
88 Acute Respiratory Failure 18 4.1 4.1 signal
89 Aggression 47 4.0 4.1 signal
90 Eating Disorder 20 4.0 4.1 signal
91 Depression 213 4.0 4.2 signal
92 Influenza Like Illness 77 4.0 4.1 signal
93 Skin Laceration 10 4.0 4.0 signal
94 Rib Fracture 19 4.0 4.0 signal
95 Coordination Abnormal 13 4.0 4.0 signal
96 Aphasia 28 4.0 4.0 signal
97 Fear 25 4.0 4.0 signal
98 Head Injury 29 4.0 4.0 signal
99 Depressed Level Of Consciousness 36 3.9 4.0 signal
100 Therapeutic Response Shortened 29 3.9 4.0 signal
101 Flushing 93 3.9 4.0 signal
102 Dysphonia 53 3.9 3.9 signal
103 Gait Inability 30 3.9 3.9 signal
104 Disturbance In Attention 49 3.9 3.9 signal
105 Musculoskeletal Stiffness 79 3.9 3.9 signal
106 Salivary Hypersecretion 9 3.9 3.9 signal
107 Blood Lactate Dehydrogenase Increased 14 3.8 3.8 signal
108 Coronary Artery Occlusion 12 3.8 3.8 signal
109 Sensory Disturbance 14 3.7 3.8 signal
110 Mobility Decreased 62 3.7 3.8 signal
111 Pollakiuria 36 3.7 3.8 signal
112 Vasculitis 10 3.7 3.7 signal
113 Haematocrit Decreased 17 3.7 3.7 signal
114 Ventricular Tachycardia 14 3.6 3.7 signal
115 Blood Alkaline Phosphatase Increased 21 3.6 3.7 signal
116 Paralysis 12 3.6 3.6 signal
117 Cardiomegaly 10 3.5 3.5 signal
118 Neurotoxicity 14 3.5 3.5 signal
119 Renal Failure Acute 34 3.4 3.4 signal
120 Gastric Ulcer 15 3.4 3.4 signal
121 Blood Creatine Phosphokinase Increased 23 3.4 3.4 signal
122 Carpal Tunnel Syndrome 11 3.4 3.4 signal
123 Infusion Site Pain 10 3.4 3.4 signal
124 Psychomotor Hyperactivity 13 3.4 3.4 signal
125 Depressed Mood 41 3.4 3.4 signal
126 Leukocytosis 14 3.3 3.3 signal
127 Nervous System Disorder 24 3.3 3.3 signal
128 Gamma-glutamyltransferase Increased 17 3.3 3.3 signal
129 Subdural Haematoma 11 3.3 3.3 signal
130 Memory Impairment 103 3.2 3.3 signal
131 Constipation 161 3.2 3.3 signal
132 Cardiomyopathy 11 3.2 3.2 signal
133 Muscle Tightness 12 3.2 3.2 signal
134 Cerebral Infarction 18 3.2 3.2 signal
135 Amnesia 48 3.2 3.2 signal
136 Sleep Apnoea Syndrome 14 3.2 3.2 signal
137 Somnolence 147 3.2 3.2 signal
138 Intervertebral Disc Protrusion 16 3.2 3.2 signal
139 Affect Lability 7 3.1 3.1 signal
140 Abnormal Dreams 20 3.1 3.1 signal
141 Pulmonary Hypertension 15 3.1 3.1 signal
142 Blindness Unilateral 10 3.1 3.1 signal
143 Status Epilepticus 8 3.1 3.1 signal
144 Ejection Fraction Decreased 11 3.0 3.1 signal
145 Hemiparesis 12 3.0 3.0 signal
146 Impaired Driving Ability 8 3.0 3.0 signal
147 Cholelithiasis 23 3.0 3.0 signal
148 Drug Interaction 111 3.0 3.1 signal
149 Myocardial Ischaemia 8 3.0 3.0 signal
150 Urinary Retention 23 3.0 3.0 signal
151 Subarachnoid Haemorrhage 7 3.0 3.0 signal
152 Acute Respiratory Distress Syndrome 12 2.9 2.9 signal
153 Post Procedural Complication 13 2.9 2.9 signal
154 Hypophagia 17 2.9 2.9 signal
155 Choking 13 2.9 2.9 signal
156 Wrist Fracture 8 2.9 2.9 signal
157 Tachypnoea 9 2.9 2.9 signal
158 Restlessness 24 2.8 2.8 signal
159 Hip Fracture 21 2.8 2.8 signal
160 Dehydration 87 2.8 2.8 signal
161 Ileus 8 2.8 2.8 signal
162 Thyroid Disorder 10 2.8 2.8 signal
163 Loss Of Consciousness 83 2.8 2.8 signal
164 No Therapeutic Response 8 2.8 2.8 signal
165 Appendicitis 6 2.8 2.8 signal
166 Intervertebral Disc Degeneration 6 2.8 2.8 signal
167 Thinking Abnormal 12 2.8 2.8 signal
168 Drug Effect Decreased 35 2.8 2.8 signal
169 Basal Cell Carcinoma 10 2.8 2.8 signal
170 Drug Effect Less Than Expected 9 2.8 2.8 signal
171 Staphylococcal Infection 21 2.7 2.7 signal
172 Hypoaesthesia 95 2.7 2.8 signal
173 Foot Deformity 7 2.7 2.7 signal
174 Oedema Peripheral 77 2.7 2.7 signal
175 Impaired Gastric Emptying 8 2.7 2.7 signal
176 Mydriasis 8 2.7 2.7 signal
177 Sinus Bradycardia 6 2.7 2.7 signal
178 Hypotension 124 2.7 2.7 signal
179 Myocarditis 7 2.7 2.7 signal
180 Gastroenteritis 9 2.7 2.7 signal
181 Vitamin D Deficiency 6 2.7 2.7 signal
182 Blood Pressure Systolic Increased 12 2.6 2.6 signal
183 Kidney Infection 12 2.6 2.6 signal
184 Generalised Tonic-clonic Seizure 10 2.6 2.6 signal
185 Drug Level Increased 10 2.6 2.6 signal
186 Altered State Of Consciousness 13 2.6 2.6 signal
187 Colon Cancer 9 2.6 2.6 signal
188 Blood Potassium Decreased 18 2.6 2.6 signal
189 Dry Mouth 48 2.6 2.6 signal
190 Vertigo 36 2.5 2.6 signal
191 Cholecystitis 7 2.5 2.5 signal
192 Tooth Abscess 6 2.5 2.5 signal
193 Body Temperature Increased 12 2.5 2.5 signal
194 Akathisia 8 2.5 2.5 signal
195 Neutrophil Count Increased 6 2.5 2.5 signal
196 Insomnia 155 2.5 2.6 signal
197 Rhabdomyolysis 24 2.5 2.5 signal
198 Schizophrenia 7 2.5 2.5 signal
199 Chromaturia 13 2.5 2.5 signal
200 Joint Dislocation 6 2.5 2.5 no signal
201 Pharmaceutical Product Complaint 15 2.5 2.5 signal
202 Nephrolithiasis 26 2.5 2.5 signal
203 Visual Acuity Reduced 19 2.4 2.5 signal
204 Libido Decreased 7 2.4 2.4 signal
205 Asthenia 212 2.4 2.5 signal
206 Type 2 Diabetes Mellitus 19 2.4 2.4 signal
207 Muscle Twitching 13 2.4 2.4 signal
208 Joint Injury 12 2.4 2.4 signal
209 Product Dose Omission In Error 15 2.4 2.4 signal
210 Coronary Artery Disease 17 2.4 2.4 signal
211 Condition Aggravated 168 2.4 2.5 signal
212 Lethargy 32 2.4 2.4 signal
213 Poisoning 7 2.4 2.4 signal
214 Pharyngitis Streptococcal 6 2.4 2.4 no signal
215 Pulmonary Thrombosis 6 2.4 2.4 no signal
216 Bipolar Disorder 6 2.4 2.4 no signal
217 Respiratory Distress 15 2.3 2.3 signal
218 Blood Pressure Decreased 36 2.3 2.4 signal
219 Hiatus Hernia 7 2.3 2.3 signal
220 Respiratory Arrest 15 2.3 2.3 signal
221 Hypoglycaemia 26 2.3 2.3 signal
222 Cellulitis 27 2.3 2.3 signal
223 Gastritis 14 2.3 2.3 signal
224 Lower Limb Fracture 10 2.3 2.3 signal
225 Quality Of Life Decreased 7 2.2 2.3 no signal
226 Nightmare 18 2.2 2.2 signal
227 Femur Fracture 16 2.2 2.2 signal
228 Pulmonary Embolism 49 2.2 2.2 signal
229 Peripheral Coldness 7 2.2 2.2 no signal
230 Body Temperature Decreased 5 2.2 2.2 no signal
231 Transient Ischaemic Attack 17 2.2 2.2 signal
232 Muscle Spasms 92 2.2 2.2 signal
233 Product Dose Omission 33 2.2 2.2 signal
234 Ovarian Cyst 5 2.1 2.1 no signal
235 Spinal Operation 6 2.1 2.1 no signal
236 Hyperglycaemia 18 2.1 2.1 signal
237 Emphysema 5 2.1 2.1 no signal
238 Crying 18 2.1 2.1 signal
239 Anxiety 140 2.1 2.2 signal
240 Initial Insomnia 5 2.1 2.1 no signal
241 Back Disorder 8 2.1 2.1 no signal
242 Cyst 6 2.1 2.1 no signal
243 Shock 11 2.1 2.1 signal
244 Mental Disorder 21 2.1 2.1 signal
245 Petechiae 5 2.1 2.1 no signal
246 Liver Function Test Abnormal 14 2.1 2.1 signal
247 Muscle Atrophy 6 2.1 2.1 no signal
248 Cerebral Haemorrhage 17 2.1 2.1 signal
249 Withdrawal Syndrome 20 2.0 2.0 signal
250 Foot Fracture 9 2.0 2.0 no signal
251 Electrocardiogram Qt Prolonged 17 2.0 2.0 signal
252 Diabetes Mellitus 36 2.0 2.0 signal
253 Syncope 47 2.0 2.0 signal
254 Scar 8 2.0 2.0 no signal
255 Erectile Dysfunction 12 2.0 2.0 signal
256 Hypoaesthesia Oral 7 2.0 2.0 no signal
257 Back Injury 5 2.0 2.0 no signal
258 Hepatic Function Abnormal 17 2.0 2.0 no signal
259 Mental Impairment 11 2.0 2.0 no signal
260 Dental Caries 5 2.0 2.0 no signal
261 Limb Discomfort 14 2.0 2.0 no signal
262 Emotional Disorder 14 1.9 2.0 no signal
263 Toxicity To Various Agents 75 1.9 1.9 no signal
264 Jaundice 12 1.9 1.9 no signal
265 Cyanosis 7 1.9 1.9 no signal
266 Suicidal Ideation 40 1.9 1.9 no signal
267 Retinal Detachment 4 1.9 1.9 no signal
268 Interstitial Lung Disease 21 1.9 1.9 no signal
269 Ovarian Cancer 4 1.9 1.9 no signal
270 Chest Discomfort 44 1.9 1.9 no signal
271 Visual Impairment 53 1.9 1.9 no signal
272 Middle Insomnia 8 1.9 1.9 no signal
273 Sexual Dysfunction 5 1.8 1.8 no signal
274 Completed Suicide 36 1.8 1.9 no signal
275 Personality Change 4 1.8 1.8 no signal
276 Splenomegaly 5 1.8 1.8 no signal
277 Deformity 4 1.8 1.8 no signal
278 Lymphopenia 6 1.8 1.8 no signal
279 Intentional Drug Misuse 9 1.8 1.8 no signal
280 Pain In Jaw 12 1.8 1.8 no signal
281 Fracture 8 1.8 1.8 no signal
282 Irritable Bowel Syndrome 9 1.8 1.8 no signal
283 Diabetic Ketoacidosis 10 1.8 1.8 no signal
284 Skin Discolouration 19 1.8 1.8 no signal
285 Prescribed Overdose 8 1.8 1.8 no signal
286 Decreased Immune Responsiveness 4 1.8 1.8 no signal
287 Respiratory Depression 5 1.8 1.8 no signal
288 Limb Injury 11 1.8 1.8 no signal
289 Ligament Sprain 4 1.7 1.7 no signal
290 Influenza 45 1.7 1.7 no signal
291 Rash Macular 14 1.7 1.7 no signal
292 Therapeutic Response Unexpected 18 1.7 1.7 no signal
293 Coma 19 1.7 1.7 no signal
294 Hepatic Failure 12 1.7 1.7 no signal
295 Cold Sweat 7 1.7 1.7 no signal
296 Injection Site Irritation 5 1.7 1.7 no signal
297 Blood Triglycerides Increased 7 1.7 1.7 no signal
298 Hypothermia 4 1.7 1.7 no signal
299 Blindness 16 1.7 1.7 no signal
300 Rotator Cuff Syndrome 5 1.7 1.7 no signal
301 Panic Attack 14 1.7 1.7 no signal
302 Knee Arthroplasty 8 1.7 1.7 no signal
303 Nodule 5 1.7 1.7 no signal
304 Dysmenorrhoea 5 1.6 1.7 no signal
305 Road Traffic Accident 16 1.6 1.7 no signal
306 Injury 27 1.6 1.7 no signal
307 Myocardial Infarction 67 1.6 1.7 no signal
308 Rash Generalised 10 1.6 1.6 no signal
309 Tooth Infection 5 1.6 1.6 no signal
310 Sopor 5 1.6 1.6 no signal
311 Breast Cancer Metastatic 4 1.6 1.6 no signal
312 Hunger 5 1.6 1.6 no signal
313 Hot Flush 28 1.6 1.6 no signal
314 Body Height Decreased 4 1.6 1.6 no signal
315 Melaena 8 1.6 1.6 no signal
316 Emotional Distress 44 1.6 1.6 no signal
317 Red Blood Cell Sedimentation Rate Increased 4 1.6 1.6 no signal
318 Therapeutic Product Effect Decreased 16 1.6 1.6 no signal
319 Product Availability Issue 8 1.5 1.5 no signal
320 Rebound Effect 4 1.5 1.5 no signal
321 Menorrhagia 7 1.5 1.5 no signal
322 Spinal Fracture 7 1.5 1.5 no signal
323 Upper Limb Fracture 7 1.5 1.5 no signal
324 Drug Withdrawal Syndrome 31 1.5 1.5 no signal
325 Bronchospasm 5 1.5 1.5 no signal
326 Inappropriate Schedule Of Drug Administration 25 1.5 1.5 no signal
327 Gastric Haemorrhage 4 1.5 1.5 no signal
328 Cerebrovascular Accident 58 1.5 1.5 no signal
329 Polyneuropathy 4 1.5 1.5 no signal
330 Nerve Compression 3 1.4 1.4 no signal
331 Blood Count Abnormal 5 1.4 1.4 no signal
332 Drug Dispensing Error 5 1.4 1.4 no signal
333 Pharyngeal Oedema 5 1.4 1.4 no signal
334 Musculoskeletal Disorder 6 1.4 1.4 no signal
335 Cardiovascular Disorder 8 1.3 1.3 no signal
336 Injection Site Induration 4 1.3 1.3 no signal
337 Application Site Pruritus 7 1.3 1.3 no signal
338 Sedation 8 1.3 1.3 no signal
339 Anorexia 4 1.3 1.3 no signal
340 Sars-cov-2 Test Positive 4 1.3 1.3 no signal
341 Eye Haemorrhage 4 1.3 1.3 no signal
342 Malignant Melanoma 4 1.3 1.3 no signal
343 Suicide Attempt 18 1.3 1.3 no signal
344 Therapy Cessation 15 1.3 1.3 no signal
345 Device Occlusion 4 1.2 1.2 no signal
346 Skeletal Injury 3 1.2 1.2 no signal
347 Diabetes Mellitus Inadequate Control 5 1.2 1.2 no signal
348 Irritability 17 1.2 1.2 no signal
349 Skin Cancer 6 1.2 1.2 no signal
350 Product Dispensing Error 6 1.2 1.2 no signal
351 Injection Site Erythema 34 1.2 1.2 no signal
352 Injection Site Mass 10 1.2 1.2 no signal
353 Haemorrhage Intracranial 4 1.2 1.2 no signal
354 Application Site Erythema 7 1.1 1.1 no signal
355 Cholecystectomy 3 1.1 1.1 no signal
356 Device Dislocation 11 1.1 1.1 no signal
357 Mood Swings 8 1.1 1.1 no signal
358 Injection Site Discolouration 3 1.0 1.0 no signal
359 Tooth Loss 5 1.0 1.0 no signal
360 Anger 8 1.0 1.0 no signal
361 Underdose 17 1.0 1.0 no signal
362 Device Use Issue 4 1.0 1.0 no signal
363 Complication Associated With Device 3 1.0 1.0 no signal
364 Local Swelling 4 1.0 1.0 no signal
365 Product Taste Abnormal 3 1.0 1.0 no signal
366 Overdose 46 0.9 0.9 no signal
367 Incorrect Drug Administration Duration 6 0.9 0.9 no signal
368 Drug Effective For Unapproved Indication 6 0.9 0.9 no signal
369 Meningioma 3 0.9 0.9 no signal
370 Pregnancy 4 0.9 0.9 no signal
371 Device Issue 17 0.8 0.8 no signal
372 Injection Site Warmth 4 0.8 0.8 no signal
373 Drug Administration Error 6 0.8 0.8 no signal
374 Drug Dose Omission 31 0.8 0.8 no signal
375 Extra Dose Administered 7 0.8 0.8 no signal
376 Injection Site Reaction 12 0.8 0.8 no signal
377 Drug Abuse 14 0.7 0.7 no signal
378 Intentional Overdose 10 0.7 0.7 no signal
379 Menstruation Irregular 4 0.7 0.6 no signal
380 Injection Site Bruising 11 0.6 0.6 no signal
381 Injection Site Pain 42 0.6 0.6 no signal
382 Wrong Technique In Device Usage Process 6 0.6 0.6 no signal
383 Device Breakage 5 0.5 0.5 no signal
384 Abortion Spontaneous 5 0.5 0.5 no signal
385 Product Complaint 3 0.5 0.5 no signal
386 Injection Site Swelling 9 0.5 0.5 no signal
387 Incorrect Dose Administered By Device 3 0.5 0.5 no signal
388 Breast Cancer Female 3 0.5 0.5 no signal
389 Injection Site Haemorrhage 8 0.4 0.4 no signal
390 Injection Site Rash 3 0.4 0.4 no signal
391 Incorrect Route Of Drug Administration 3 0.4 0.4 no signal
392 Drug Dependence 13 0.3 0.3 no signal
393 Prostate Cancer 6 0.3 0.3 no signal
394 Drug Dose Omission By Device 3 0.2 0.2 no signal