OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Astringent

202 flagged reaction(s) · 12,776 total co-reports · max PRR 164.6
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Joint Dislocation 151 164.6 179.1 signal
2 Wound Infection 145 152.9 165.8 signal
3 Hypercholesterolaemia 127 152.1 163.3 signal
4 Joint Range Of Motion Decreased 152 130.1 141.6 signal
5 Helicobacter Infection 109 122.2 129.8 signal
6 Pemphigus 124 113.9 122.0 signal
7 Laryngitis 98 103.0 108.7 signal
8 Pericarditis 143 97.9 106.0 signal
9 Folliculitis 83 91.6 95.8 signal
10 Red Blood Cell Sedimentation Rate Increased 87 89.4 93.8 signal
11 Sciatica 124 89.1 95.4 signal
12 Irritable Bowel Syndrome 160 85.3 93.3 signal
13 Prescribed Underdose 147 84.0 91.1 signal
14 Autoimmune Disorder 68 80.9 84.0 signal
15 Hip Arthroplasty 96 71.9 75.8 signal
16 Foot Deformity 70 71.8 74.6 signal
17 Joint Stiffness 155 67.2 73.2 signal
18 Hand Deformity 76 66.1 68.9 signal
19 Wound 156 63.8 69.6 signal
20 Synovitis 101 63.6 67.3 signal
21 Pulmonary Fibrosis 101 60.1 63.5 signal
22 Type 2 Diabetes Mellitus 178 59.9 66.2 signal
23 Prescribed Overdose 101 59.3 62.7 signal
24 Lower Limb Fracture 94 55.9 58.9 signal
25 Knee Arthroplasty 97 52.9 55.7 signal
26 Liver Function Test Increased 99 52.7 55.7 signal
27 Fibromyalgia 108 50.5 53.6 signal
28 Liver Injury 104 48.8 51.7 signal
29 Hepatic Cirrhosis 74 45.0 46.8 signal
30 Impaired Healing 129 44.6 47.9 signal
31 Osteoarthritis 154 41.2 44.8 signal
32 Glossodynia 78 39.6 41.3 signal
33 Gait Inability 115 39.4 42.0 signal
34 Psoriatic Arthropathy 136 38.4 41.3 signal
35 Osteoporosis 136 37.5 40.4 signal
36 Upper Respiratory Tract Infection 146 35.9 38.9 signal
37 Road Traffic Accident 129 35.0 37.5 signal
38 Systemic Lupus Erythematosus 109 35.0 37.1 signal
39 Disability 59 33.8 34.9 signal
40 Wheezing 158 30.3 33.0 signal
41 C-reactive Protein Increased 94 29.3 30.8 signal
42 Ear Infection 67 28.6 29.7 signal
43 Drug-induced Liver Injury 75 27.6 28.7 signal
44 Uveitis 31 26.0 26.4 signal
45 Oedema 124 26.0 27.8 signal
46 Infusion Related Reaction 149 25.6 27.7 signal
47 Sleep Disorder Due To A General Medical Condition 36 25.2 25.7 signal
48 Delirium 75 24.6 25.6 signal
49 Blood Cholesterol Increased 93 22.6 23.7 signal
50 Mobility Decreased 142 22.5 24.2 signal
51 Injury 126 20.2 21.6 signal
52 Intraocular Pressure Increased 22 19.4 19.6 signal
53 Loss Of Personal Independence In Daily Activities 77 18.3 19.1 signal
54 Sensory Disturbance 26 18.3 18.5 signal
55 Breast Cancer Stage I 15 18.1 18.2 signal
56 Poisoning 20 18.0 18.1 signal
57 Bursitis 19 17.8 18.0 signal
58 Hepatic Enzyme Increased 101 16.8 17.7 signal
59 Musculoskeletal Stiffness 130 16.8 18.0 signal
60 Obstructive Airways Disorder 16 16.2 16.4 signal
61 Stomatitis 82 15.3 16.0 signal
62 Contusion 128 15.1 16.1 signal
63 Psoriasis 174 15.1 16.5 signal
64 Arthropathy 73 14.8 15.4 signal
65 Completed Suicide 107 14.4 15.2 signal
66 Blister 71 14.3 14.9 signal
67 Sinusitis 129 14.2 15.2 signal
68 Visual Impairment 153 14.1 15.3 signal
69 Infection 178 14.0 15.4 signal
70 Poor Quality Sleep 25 13.2 13.4 signal
71 Amnesia 76 13.2 13.7 signal
72 Discomfort 69 12.9 13.3 signal
73 Pulmonary Congestion 15 12.8 12.9 signal
74 Tachycardia 100 12.7 13.4 signal
75 Urticaria 184 12.5 13.8 signal
76 Hypoaesthesia 165 12.5 13.6 signal
77 Erectile Dysfunction 28 12.3 12.5 signal
78 Oedema Peripheral 131 12.1 13.0 signal
79 Muscular Weakness 120 12.0 12.7 signal
80 Peripheral Swelling 156 11.5 12.5 signal
81 Back Injury 11 11.5 11.6 signal
82 Asthma 110 11.1 11.7 signal
83 Toxicity To Various Agents 162 10.9 11.9 signal
84 General Physical Health Deterioration 109 10.7 11.3 signal
85 Joint Swelling 114 10.7 11.3 signal
86 Swelling 88 10.7 11.1 signal
87 Rheumatoid Arthritis 104 10.4 11.0 signal
88 Coeliac Disease 9 10.4 10.4 signal
89 Bronchitis 67 10.2 10.5 signal
90 Obesity 14 9.9 10.0 signal
91 Ear Pain 17 9.9 10.0 signal
92 Visual Acuity Reduced 29 9.8 9.9 signal
93 Arthritis 68 9.8 10.1 signal
94 Hypertension 181 9.7 10.6 signal
95 Nasopharyngitis 155 9.5 10.3 signal
96 Rash Macular 29 9.4 9.6 signal
97 Hypersensitivity 154 9.4 10.2 signal
98 Weight Increased 183 9.3 10.2 signal
99 Dysuria 30 9.2 9.3 signal
100 Dyspepsia 79 9.1 9.5 signal
101 Intentional Product Use Issue 69 8.9 9.2 signal
102 Poor Quality Product Administered 8 8.9 8.9 signal
103 Memory Impairment 107 8.8 9.3 signal
104 Therapeutic Product Effect Incomplete 55 8.8 9.0 signal
105 Sleep Disorder 54 8.7 9.0 signal
106 Contraindicated Product Administered 22 8.3 8.3 signal
107 Skin Discolouration 33 8.1 8.3 signal
108 Drug Intolerance 69 8.1 8.4 signal
109 Scab 8 8.0 8.0 signal
110 Abdominal Discomfort 116 7.9 8.3 signal
111 Skin Haemorrhage 10 7.8 7.9 signal
112 Scratch 7 7.7 7.7 signal
113 Weight Decreased 188 7.6 8.4 signal
114 Lower Respiratory Tract Infection 30 7.5 7.6 signal
115 Hypoglycaemia 32 7.5 7.6 signal
116 Incorrect Route Of Product Administration 11 7.4 7.4 signal
117 Drug Toxicity 9 7.4 7.4 signal
118 Skin Fissures 12 7.2 7.2 signal
119 Productive Cough 30 7.2 7.3 signal
120 Eye Pain 35 7.2 7.3 signal
121 Neurotoxicity 11 7.2 7.2 signal
122 Heart Rate Decreased 22 7.1 7.1 signal
123 Micturition Urgency 7 7.0 7.0 signal
124 Renal Tubular Necrosis 6 6.9 6.9 signal
125 Condition Aggravated 184 6.9 7.5 signal
126 Confusional State 98 6.8 7.2 signal
127 Metabolic Acidosis 19 6.8 6.9 signal
128 Chest Pain 110 6.7 7.1 signal
129 Pain In Extremity 169 6.5 7.0 signal
130 Epilepsy 17 6.3 6.4 signal
131 Renal Disorder 26 6.3 6.4 signal
132 Brain Oedema 7 6.3 6.3 signal
133 Taste Disorder 11 6.2 6.2 signal
134 Inflammation 28 6.2 6.3 signal
135 Immunodeficiency 8 6.1 6.2 signal
136 Pruritus 205 6.1 6.8 signal
137 Gait Disturbance 104 6.1 6.4 signal
138 Skin Infection 6 6.1 6.1 signal
139 Immune System Disorder 7 6.0 6.0 signal
140 Lung Disorder 26 6.0 6.1 signal
141 Alopecia 104 6.0 6.3 signal
142 Spinal Disorder 5 6.0 6.0 signal
143 Posterior Reversible Encephalopathy Syndrome 5 5.9 6.0 signal
144 Ankle Fracture 8 5.8 5.9 signal
145 Post Procedural Haemorrhage 6 5.8 5.8 signal
146 Acute Respiratory Distress Syndrome 9 5.8 5.8 signal
147 Hypomagnesaemia 7 5.7 5.7 signal
148 Wrong Technique In Device Usage Process 23 5.7 5.8 signal
149 Gallbladder Disorder 9 5.7 5.7 signal
150 Movement Disorder 16 5.6 5.7 signal
151 Back Disorder 8 5.5 5.6 signal
152 Cataract 29 5.5 5.6 signal
153 Acne 37 5.5 5.6 signal
154 Pain Of Skin 13 5.4 5.5 signal
155 Cardio-respiratory Arrest 20 5.4 5.4 signal
156 Scar 8 5.3 5.3 signal
157 Adverse Event 42 5.2 5.3 signal
158 Quality Of Life Decreased 6 5.1 5.1 signal
159 Device Defective 7 4.9 4.9 signal
160 Squamous Cell Carcinoma 4 4.8 4.8 signal
161 Product Prescribing Error 10 4.8 4.8 signal
162 Nasal Congestion 24 4.6 4.7 signal
163 Inflammatory Bowel Disease 4 4.6 4.6 signal
164 Fluid Overload 6 4.6 4.6 signal
165 Therapeutic Product Effect Decreased 18 4.6 4.6 signal
166 Adverse Drug Reaction 36 4.6 4.6 signal
167 Respiratory Arrest 11 4.5 4.5 signal
168 Limb Discomfort 12 4.4 4.4 signal
169 Treatment Failure 31 4.3 4.3 signal
170 Jaundice 10 4.2 4.2 signal
171 Fracture 7 4.2 4.2 signal
172 Therapeutic Response Decreased 22 4.1 4.2 signal
173 Pruritus Generalised 8 4.1 4.1 signal
174 Maternal Exposure During Pregnancy 31 4.0 4.0 signal
175 Pregnancy 7 3.9 3.9 signal
176 Spinal Pain 4 3.9 3.9 signal
177 Accident 4 3.8 3.8 signal
178 Product Dispensing Error 7 3.6 3.7 signal
179 Product Complaint 8 3.6 3.6 signal
180 Ill-defined Disorder 19 3.5 3.6 signal
181 Drug Abuse 26 3.5 3.6 signal
182 Malignant Melanoma 4 3.4 3.4 signal
183 Injection Site Urticaria 7 3.3 3.3 signal
184 Colitis Ulcerative 12 3.0 3.1 signal
185 Intentional Overdose 17 3.0 3.0 signal
186 Haemorrhage Intracranial 4 3.0 3.0 no signal
187 Status Epilepticus 3 3.0 3.0 no signal
188 Cytokine Release Syndrome 5 3.0 3.0 signal
189 Tendon Rupture 3 2.7 2.7 no signal
190 Muscle Spasticity 3 2.7 2.7 no signal
191 Extrapyramidal Disorder 6 2.7 2.7 signal
192 Injection Site Reaction 15 2.5 2.5 signal
193 Prostatic Specific Antigen Increased 3 2.4 2.5 no signal
194 Incorrect Product Administration Duration 4 2.2 2.2 no signal
195 Product Storage Error 13 1.7 1.7 no signal
196 Needle Issue 4 1.6 1.6 no signal
197 Device Difficult To Use 9 1.5 1.5 no signal
198 Device Malfunction 7 1.2 1.2 no signal
199 Dermatitis Atopic 5 1.1 1.1 no signal
200 Drug Exposure During Pregnancy 3 1.0 1.0 no signal
201 Drug Withdrawal Syndrome 7 0.9 0.9 no signal
202 Bladder Cancer 3 0.6 0.6 no signal