OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Avacopan

147 flagged reaction(s) · 5,740 total co-reports · max PRR 31.9
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Dialysis 136 31.9 32.6 signal
2 Hospitalisation 931 20.3 23.6 signal
3 Vasculitis 67 19.1 19.3 signal
4 Pneumocystis Jirovecii Pneumonia 45 14.9 15.0 signal
5 Therapy Interrupted 291 14.0 14.6 signal
6 Drug-induced Liver Injury 108 11.6 11.8 signal
7 Hepatic Function Abnormal 114 10.2 10.4 signal
8 Liver Disorder 122 9.1 9.3 signal
9 Jaundice 74 9.1 9.2 signal
10 Cytomegalovirus Infection 43 8.6 8.6 signal
11 Liver Function Test Increased 53 8.2 8.3 signal
12 Cholestasis 41 7.1 7.1 signal
13 Hospice Care 17 5.7 5.7 signal
14 Hepatic Cytolysis 21 5.7 5.7 signal
15 Covid-19 Pneumonia 20 5.6 5.6 signal
16 Glomerular Filtration Rate Decreased 19 5.2 5.2 signal
17 Bacteraemia 18 5.1 5.1 signal
18 Hepatic Enzyme Increased 95 4.6 4.7 signal
19 Therapy Cessation 71 4.6 4.6 signal
20 Intentional Dose Omission 38 4.6 4.6 signal
21 Unevaluable Event 105 4.6 4.7 signal
22 Pharyngeal Swelling 13 4.5 4.5 signal
23 Renal Disorder 56 4.0 4.0 signal
24 Cytopenia 14 3.9 3.9 signal
25 Therapy Change 11 3.8 3.8 signal
26 Illness 114 3.8 3.8 signal
27 Product Dose Omission In Error 30 3.7 3.7 signal
28 Proteinuria 20 3.5 3.5 signal
29 Hepatocellular Injury 15 3.5 3.5 signal
30 Surgery 60 3.4 3.4 signal
31 End Stage Renal Disease 19 3.4 3.4 signal
32 Urosepsis 9 3.2 3.2 signal
33 Covid-19 172 3.2 3.3 signal
34 Product Use Complaint 15 3.2 3.2 signal
35 Blood Pressure Abnormal 19 3.2 3.2 signal
36 Increased Appetite 18 3.2 3.2 signal
37 Infection 138 3.2 3.2 signal
38 Renal Impairment 80 3.2 3.2 signal
39 Lower Respiratory Tract Infection 43 3.1 3.2 signal
40 Sinus Disorder 17 2.8 2.8 signal
41 Hepatotoxicity 19 2.8 2.8 signal
42 Liver Function Test Abnormal 25 2.8 2.8 signal
43 Interstitial Lung Disease 41 2.8 2.8 signal
44 Aspartate Aminotransferase Increased 44 2.7 2.8 signal
45 Fungal Infection 27 2.7 2.7 signal
46 Localised Infection 19 2.6 2.6 signal
47 Lung Disorder 38 2.6 2.6 signal
48 Osteomyelitis 14 2.6 2.6 signal
49 Arteriosclerosis 7 2.5 2.5 signal
50 Aspiration 8 2.4 2.4 signal
51 Swelling Face 48 2.4 2.5 signal
52 Autoimmune Disorder 7 2.4 2.4 signal
53 Alanine Aminotransferase Increased 44 2.4 2.4 signal
54 Lymphopenia 10 2.4 2.4 signal
55 Blood Creatinine Increased 46 2.3 2.3 signal
56 Hyperthyroidism 10 2.3 2.3 signal
57 Pneumonia 223 2.3 2.3 signal
58 Immune System Disorder 9 2.3 2.3 signal
59 Pneumonia Aspiration 17 2.3 2.3 signal
60 Insurance Issue 10 2.2 2.2 signal
61 Pulmonary Mass 10 2.2 2.2 signal
62 Knee Arthroplasty 14 2.2 2.2 signal
63 Transfusion 7 2.2 2.2 no signal
64 Hepatitis 17 2.2 2.2 signal
65 Clostridium Difficile Colitis 7 2.2 2.2 no signal
66 Cerebral Infarction 16 2.2 2.2 signal
67 Device Related Infection 10 2.1 2.1 signal
68 Staphylococcal Infection 21 2.1 2.1 signal
69 Blood Bilirubin Increased 17 2.1 2.1 signal
70 Intestinal Perforation 7 2.1 2.1 no signal
71 Chromaturia 14 2.0 2.1 signal
72 Blood Potassium Increased 10 2.0 2.0 signal
73 Herpes Zoster 35 2.0 2.0 signal
74 Leukopenia 30 2.0 2.0 no signal
75 Abdominal Discomfort 98 1.9 2.0 no signal
76 Ear Discomfort 6 1.9 1.9 no signal
77 Multiple Organ Dysfunction Syndrome 16 1.9 1.9 no signal
78 Deafness 15 1.9 1.9 no signal
79 Paraesthesia Oral 8 1.8 1.8 no signal
80 Gastroenteritis 8 1.8 1.8 no signal
81 Product Dose Omission Issue 155 1.8 1.8 no signal
82 Haemoptysis 15 1.8 1.8 no signal
83 Erythema Multiforme 5 1.8 1.8 no signal
84 Gastrointestinal Disorder 47 1.8 1.8 no signal
85 Adverse Reaction 7 1.7 1.7 no signal
86 Neutropenia 71 1.7 1.7 no signal
87 Dizziness Postural 5 1.7 1.7 no signal
88 Underdose 38 1.7 1.7 no signal
89 Aphonia 7 1.7 1.7 no signal
90 Taste Disorder 10 1.6 1.7 no signal
91 Hip Fracture 16 1.6 1.6 no signal
92 Gastroenteritis Viral 9 1.6 1.6 no signal
93 Liver Injury 12 1.6 1.6 no signal
94 Spinal Operation 6 1.6 1.6 no signal
95 Fluid Retention 25 1.6 1.6 no signal
96 Agranulocytosis 9 1.6 1.6 no signal
97 Hyperbilirubinaemia 5 1.6 1.6 no signal
98 Brain Fog 7 1.6 1.6 no signal
99 Peripheral Swelling 73 1.6 1.6 no signal
100 Laboratory Test Abnormal 14 1.6 1.6 no signal
101 Hepatic Failure 14 1.5 1.5 no signal
102 Pulmonary Thrombosis 5 1.5 1.5 no signal
103 Head Discomfort 8 1.5 1.5 no signal
104 Sars-cov-2 Test Positive 6 1.5 1.5 no signal
105 Thrombosis 36 1.5 1.5 no signal
106 Drug Effective For Unapproved Indication 13 1.5 1.5 no signal
107 Death 381 1.5 1.5 no signal
108 Toothache 8 1.5 1.5 no signal
109 Cholecystectomy 5 1.5 1.5 no signal
110 Ageusia 11 1.5 1.5 no signal
111 Diabetes Mellitus 33 1.4 1.4 no signal
112 Blood Test Abnormal 6 1.4 1.4 no signal
113 Tubulointerstitial Nephritis 8 1.4 1.4 no signal
114 Photosensitivity Reaction 7 1.4 1.4 no signal
115 Blood Urine Present 8 1.4 1.4 no signal
116 Deep Vein Thrombosis 27 1.4 1.4 no signal
117 Gamma-glutamyltransferase Increased 9 1.3 1.3 no signal
118 Product Administration Error 8 1.3 1.3 no signal
119 Tuberculosis 5 1.3 1.3 no signal
120 White Blood Cell Count Decreased 42 1.3 1.3 no signal
121 Scratch 4 1.3 1.3 no signal
122 Peritonitis 8 1.3 1.3 no signal
123 Disease Recurrence 18 1.2 1.2 no signal
124 Acute Hepatic Failure 5 1.2 1.2 no signal
125 Osteonecrosis 12 1.2 1.2 no signal
126 Red Blood Cell Sedimentation Rate Increased 4 1.2 1.2 no signal
127 Nephropathy Toxic 4 1.2 1.2 no signal
128 Internal Haemorrhage 4 1.2 1.2 no signal
129 Ill-defined Disorder 21 1.1 1.1 no signal
130 Gastric Haemorrhage 4 1.1 1.1 no signal
131 Wrist Fracture 4 1.1 1.1 no signal
132 Hip Arthroplasty 5 1.1 1.1 no signal
133 Tooth Extraction 4 1.1 1.1 no signal
134 Posterior Reversible Encephalopathy Syndrome 3 1.0 1.0 no signal
135 Feeling Jittery 6 1.0 1.0 no signal
136 No Adverse Event 55 1.0 1.0 no signal
137 Thrombotic Microangiopathy 3 1.0 1.0 no signal
138 Poor Venous Access 3 1.0 1.0 no signal
139 Lung Neoplasm Malignant 12 1.0 1.0 no signal
140 Cardiac Disorder 26 0.9 0.9 no signal
141 Blood Glucose Abnormal 5 0.9 0.9 no signal
142 Product Physical Issue 5 0.8 0.8 no signal
143 Ankylosing Spondylitis 3 0.8 0.8 no signal
144 Circumstance Or Information Capable Of Leading To Medication Error 7 0.7 0.7 no signal
145 Product Storage Error 9 0.3 0.3 no signal
146 Myelosuppression 3 0.3 0.3 no signal
147 Bladder Cancer 3 0.2 0.2 no signal