Drug

Brigatinib

88 flagged reaction(s) · 3,359 total co-reports · max PRR 111.2

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Metastases To Central Nervous System	242	111.2	119.1	signal
2	Blood Creatine Phosphokinase Increased	222	44.2	47.0	signal
3	Lung Neoplasm Malignant	225	31.6	33.7	signal
4	Neoplasm Progression	180	29.8	31.3	signal
5	Metastases To Liver	61	20.2	20.5	signal
6	Brain Neoplasm	30	18.9	19.1	signal
7	Pneumonitis	74	15.9	16.2	signal
8	Photosensitivity Reaction	43	15.1	15.3	signal
9	Hypercholesterolaemia	17	10.3	10.3	signal
10	Metastases To Bone	29	10.3	10.3	signal
11	Central Nervous System Lesion	22	9.2	9.3	signal
12	Pericardial Effusion	34	8.5	8.6	signal
13	Metastases To Lung	17	8.5	8.6	signal
14	Drug Resistance	36	8.1	8.2	signal
15	Brain Oedema	16	7.3	7.4	signal
16	Pleural Effusion	77	7.3	7.4	signal
17	Hepatotoxicity	28	7.3	7.4	signal
18	Hepatic Cytolysis	15	7.1	7.1	signal
19	Liver Function Test Increased	25	6.8	6.8	signal
20	Neoplasm	13	6.5	6.5	signal
21	Haemoptysis	29	6.0	6.0	signal
22	Transaminases Increased	23	6.0	6.0	signal
23	Hepatic Function Abnormal	38	5.9	6.0	signal
24	Disease Progression	120	5.9	6.1	signal
25	Aspartate Aminotransferase Increased	51	5.6	5.6	signal
26	Taste Disorder	19	5.5	5.5	signal
27	Interstitial Lung Disease	43	5.1	5.2	signal
28	Therapy Partial Responder	13	5.0	5.0	signal
29	Malignant Neoplasm Progression	84	4.8	4.9	signal
30	Lung Disorder	40	4.7	4.8	signal
31	Blood Lactate Dehydrogenase Increased	12	4.3	4.4	signal
32	Pancytopenia	41	4.3	4.3	signal
33	Therapy Change	7	4.2	4.2	signal
34	Aphonia	10	4.1	4.2	signal
35	Product Dose Omission Issue	204	4.1	4.3	signal
36	Alanine Aminotransferase Increased	44	4.1	4.2	signal
37	Inability To Afford Medication	7	4.1	4.1	signal
38	Hepatic Enzyme Increased	48	4.1	4.1	signal
39	Renal Impairment	57	3.9	4.0	signal
40	Blood Pressure Increased	104	3.9	4.0	signal
41	Ascites	19	3.7	3.7	signal
42	Cerebral Haemorrhage	22	3.6	3.6	signal
43	Hyperglycaemia	22	3.5	3.5	signal
44	Deafness	15	3.3	3.3	signal
45	Product Prescribing Issue	11	3.1	3.1	signal
46	Seizure	60	3.0	3.1	signal
47	Dizziness Postural	5	3.0	3.0	signal
48	Death	431	2.9	3.1	signal
49	Toxic Skin Eruption	5	2.9	2.9	signal
50	Hepatocellular Injury	7	2.8	2.8	signal
51	Hyperbilirubinaemia	5	2.8	2.8	signal
52	Face Oedema	8	2.7	2.7	signal
53	Decreased Activity	5	2.7	2.7	no signal
54	Platelet Count Increased	6	2.7	2.7	signal
55	Blood Pressure Abnormal	9	2.6	2.6	signal
56	Gamma-glutamyltransferase Increased	10	2.6	2.6	signal
57	Illness	45	2.6	2.6	signal
58	Adverse Drug Reaction	39	2.5	2.5	signal
59	Retinal Detachment	4	2.5	2.5	no signal
60	Pancreatitis	23	2.5	2.5	signal
61	Appendicitis	4	2.5	2.5	no signal
62	Covid-19 Pneumonia	5	2.4	2.4	no signal
63	Cholestasis	8	2.4	2.4	signal
64	Cerebral Infarction	10	2.4	2.4	signal
65	Product Administration Error	8	2.3	2.3	signal
66	Brain Injury	4	2.3	2.3	no signal
67	Dry Throat	4	2.3	2.3	no signal
68	Tuberculosis	5	2.2	2.2	no signal
69	Rhabdomyolysis	16	2.2	2.2	signal
70	Blood Glucose Abnormal	7	2.2	2.2	no signal
71	Nephropathy Toxic	4	2.1	2.1	no signal
72	Myocarditis	4	2.0	2.0	no signal
73	Hypoacusis	15	2.0	2.0	signal
74	Increased Tendency To Bruise	3	1.9	1.9	no signal
75	Erythema Multiforme	3	1.9	1.9	no signal
76	Sars-cov-2 Test Positive	4	1.7	1.7	no signal
77	No Adverse Event	50	1.6	1.6	no signal
78	Status Epilepticus	3	1.5	1.5	no signal
79	Product Dose Omission In Error	7	1.5	1.5	no signal
80	Gastric Haemorrhage	3	1.5	1.5	no signal
81	Lymphoma	4	1.5	1.5	no signal
82	Product Physical Issue	5	1.4	1.4	no signal
83	Drug Reaction With Eosinophilia And Systemic Symptoms	6	1.4	1.4	no signal
84	Meningioma	3	1.2	1.2	no signal
85	Amenorrhoea	3	1.0	1.0	no signal
86	Palmar-plantar Erythrodysaesthesia Syndrome	4	1.0	1.0	no signal
87	Acne	13	1.0	1.0	no signal
88	Pancreatic Carcinoma	3	0.6	0.6	no signal