OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Brimonidine Tartrate, Timolol Maleate

272 flagged reaction(s) · 10,133 total co-reports · max PRR 74.2
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Intraocular Pressure Increased 293 74.2 77.6 signal
2 Ocular Hyperaemia 541 37.2 40.5 signal
3 Eye Irritation 524 30.2 32.7 signal
4 Glaucoma 164 27.3 28.0 signal
5 Eye Pain 470 27.3 29.3 signal
6 Eye Discharge 85 26.7 27.0 signal
7 Eye Pruritus 254 24.7 25.6 signal
8 Ocular Discomfort 65 19.1 19.3 signal
9 Lacrimation Increased 176 18.8 19.3 signal
10 Product Packaging Quantity Issue 58 17.0 17.1 signal
11 Eye Inflammation 49 16.6 16.7 signal
12 Blindness Unilateral 68 15.4 15.6 signal
13 Eye Infection 51 14.5 14.6 signal
14 Eyelid Oedema 51 13.9 14.0 signal
15 Eye Swelling 153 13.2 13.5 signal
16 Photophobia 74 12.6 12.8 signal
17 Uveitis 45 10.6 10.7 signal
18 Visual Acuity Reduced 109 10.4 10.5 signal
19 Dry Eye 138 9.1 9.3 signal
20 Cataract 160 8.6 8.8 signal
21 Vitreous Floaters 25 8.2 8.2 signal
22 Vision Blurred 337 7.9 8.2 signal
23 Conjunctivitis 45 7.8 7.8 signal
24 Eye Disorder 77 7.5 7.6 signal
25 Retinal Detachment 21 7.3 7.3 signal
26 Eye Haemorrhage 27 6.4 6.5 signal
27 Eyelid Ptosis 19 5.9 6.0 signal
28 Blindness 76 5.9 6.0 signal
29 Product Use Complaint 28 5.8 5.8 signal
30 Macular Degeneration 21 5.6 5.6 signal
31 Visual Impairment 211 5.5 5.6 signal
32 Poor Quality Product Administered 17 5.3 5.3 signal
33 Accidental Exposure To Product 157 5.0 5.1 signal
34 Dry Mouth 116 4.6 4.6 signal
35 Product Packaging Issue 13 4.5 4.5 signal
36 Heart Rate Decreased 49 4.4 4.4 signal
37 Product Storage Error 117 4.3 4.4 signal
38 Product Dose Omission 85 4.1 4.1 signal
39 Prostatic Specific Antigen Increased 17 3.9 3.9 signal
40 Body Height Decreased 13 3.8 3.8 signal
41 Product Administration Error 23 3.7 3.7 signal
42 Inappropriate Schedule Of Drug Administration 81 3.6 3.6 signal
43 Mydriasis 14 3.5 3.5 signal
44 Sluggishness 11 3.4 3.5 signal
45 Impaired Driving Ability 12 3.4 3.4 signal
46 Bradycardia 56 3.4 3.4 signal
47 Madarosis 12 3.3 3.3 signal
48 Device Use Issue 17 3.1 3.1 signal
49 Small Intestinal Obstruction 12 3.1 3.1 signal
50 End Stage Renal Disease 18 3.1 3.1 signal
51 Scab 11 3.1 3.1 signal
52 Heart Rate Irregular 22 3.1 3.1 signal
53 Blood Pressure Decreased 62 3.0 3.0 signal
54 Sinus Bradycardia 9 3.0 3.0 signal
55 Vitamin D Deficiency 9 2.9 2.9 signal
56 Blood Thyroid Stimulating Hormone Increased 8 2.8 2.8 signal
57 Expired Product Administered 28 2.7 2.7 signal
58 Hypersensitivity 156 2.7 2.7 signal
59 Blood Pressure Fluctuation 20 2.6 2.6 signal
60 Chronic Kidney Disease 62 2.6 2.6 signal
61 Diplopia 21 2.6 2.6 signal
62 Product Complaint 20 2.5 2.6 signal
63 Peripheral Coldness 11 2.5 2.5 signal
64 Dermatitis Contact 9 2.5 2.5 signal
65 Dry Throat 8 2.5 2.5 signal
66 Rhinorrhoea 50 2.5 2.5 signal
67 Sneezing 17 2.4 2.4 signal
68 Sinus Disorder 15 2.4 2.4 signal
69 Wound 21 2.4 2.4 signal
70 Full Blood Count Decreased 15 2.4 2.4 signal
71 Sputum Discoloured 7 2.4 2.4 signal
72 Head Discomfort 13 2.3 2.4 signal
73 Dizziness Postural 7 2.3 2.3 signal
74 Osteopenia 11 2.3 2.3 signal
75 Hip Fracture 23 2.3 2.3 signal
76 Balance Disorder 62 2.3 2.3 signal
77 Hypotonia 7 2.2 2.2 no signal
78 Pallor 19 2.2 2.2 signal
79 Respiratory Tract Congestion 11 2.2 2.2 signal
80 Initial Insomnia 7 2.2 2.2 no signal
81 Muscular Weakness 78 2.2 2.2 signal
82 Weight Fluctuation 7 2.1 2.1 no signal
83 Tooth Disorder 15 2.1 2.1 signal
84 Full Blood Count Abnormal 7 2.1 2.1 no signal
85 Drug Administered At Inappropriate Site 7 2.1 2.1 no signal
86 Hypercalcaemia 8 2.1 2.1 no signal
87 Secretion Discharge 8 2.1 2.1 no signal
88 Lymphopenia 9 2.0 2.0 no signal
89 Seasonal Allergy 9 2.0 2.0 no signal
90 Skin Fissures 12 2.0 2.0 signal
91 Hypersomnia 18 2.0 2.0 no signal
92 Red Blood Cell Count Decreased 18 2.0 2.0 no signal
93 Pollakiuria 26 2.0 2.0 no signal
94 Micturition Urgency 7 2.0 2.0 no signal
95 Hallucination 46 2.0 2.0 no signal
96 Somnolence 122 1.9 1.9 no signal
97 Tooth Infection 8 1.9 1.9 no signal
98 Incorrect Dose Administered 136 1.9 1.9 no signal
99 Body Temperature Decreased 6 1.9 1.9 no signal
100 Fall 197 1.9 1.9 no signal
101 Ear Discomfort 6 1.9 1.9 no signal
102 Feeling Cold 16 1.8 1.8 no signal
103 Carpal Tunnel Syndrome 8 1.8 1.8 no signal
104 Frequent Bowel Movements 15 1.8 1.8 no signal
105 Atrial Fibrillation 54 1.8 1.8 no signal
106 Product Physical Issue 11 1.8 1.8 no signal
107 Hypophagia 14 1.8 1.8 no signal
108 Product Dispensing Error 12 1.8 1.8 no signal
109 Hypotension 109 1.7 1.7 no signal
110 Syncope 54 1.7 1.7 no signal
111 Dizziness 268 1.7 1.7 no signal
112 Dermatitis 11 1.7 1.7 no signal
113 Drug Dose Omission 89 1.7 1.7 no signal
114 Hallucination, Visual 11 1.7 1.7 no signal
115 Musculoskeletal Disorder 10 1.7 1.7 no signal
116 Tinnitus 24 1.7 1.7 no signal
117 Burning Sensation 36 1.6 1.6 no signal
118 Product Quality Issue 69 1.6 1.6 no signal
119 Hospice Care 5 1.6 1.6 no signal
120 Head Injury 16 1.6 1.6 no signal
121 Dementia 14 1.6 1.6 no signal
122 Bladder Disorder 5 1.6 1.6 no signal
123 Wrist Fracture 6 1.6 1.6 no signal
124 Mass 7 1.6 1.6 no signal
125 Toothache 9 1.6 1.6 no signal
126 Ovarian Cyst 5 1.6 1.6 no signal
127 Dysphonia 29 1.6 1.6 no signal
128 Sensory Disturbance 8 1.6 1.6 no signal
129 Nocturia 6 1.6 1.6 no signal
130 Rash Generalised 13 1.6 1.6 no signal
131 Fatigue 383 1.6 1.6 no signal
132 Product Dose Omission Issue 140 1.6 1.6 no signal
133 Drug Effect Incomplete 18 1.6 1.6 no signal
134 Sinusitis 50 1.5 1.6 no signal
135 Product Odour Abnormal 5 1.5 1.5 no signal
136 Skin Exfoliation 40 1.5 1.5 no signal
137 Skin Discolouration 22 1.5 1.5 no signal
138 Transient Ischaemic Attack 16 1.5 1.5 no signal
139 Mood Swings 15 1.5 1.5 no signal
140 Erythema 95 1.5 1.5 no signal
141 Faeces Discoloured 10 1.5 1.5 no signal
142 Vertigo 28 1.5 1.5 no signal
143 Pruritus Generalised 10 1.4 1.4 no signal
144 Thyroid Disorder 7 1.4 1.4 no signal
145 Drug Hypersensitivity 88 1.4 1.4 no signal
146 Diabetes Mellitus Inadequate Control 8 1.4 1.4 no signal
147 Ankle Fracture 7 1.4 1.4 no signal
148 Red Blood Cell Sedimentation Rate Increased 5 1.4 1.4 no signal
149 Treatment Failure 37 1.4 1.4 no signal
150 Upper Limb Fracture 9 1.4 1.4 no signal
151 Arthropathy 25 1.4 1.4 no signal
152 Quality Of Life Decreased 6 1.4 1.4 no signal
153 Therapeutic Response Unexpected 20 1.4 1.4 no signal
154 Accidental Overdose 16 1.4 1.4 no signal
155 Diverticulitis 12 1.4 1.4 no signal
156 Increased Tendency To Bruise 4 1.4 1.4 no signal
157 Amnesia 28 1.4 1.4 no signal
158 Coronary Artery Disease 13 1.4 1.4 no signal
159 Intentional Product Misuse 37 1.4 1.4 no signal
160 Leukaemia 4 1.3 1.3 no signal
161 Spinal Disorder 4 1.3 1.3 no signal
162 Eating Disorder 9 1.3 1.3 no signal
163 Covid-19 Pneumonia 5 1.3 1.3 no signal
164 Bronchospasm 6 1.3 1.3 no signal
165 Hypoacusis 18 1.3 1.3 no signal
166 Therapy Change 4 1.3 1.3 no signal
167 Therapeutic Response Decreased 25 1.3 1.3 no signal
168 Skin Irritation 19 1.3 1.3 no signal
169 Flatulence 23 1.3 1.3 no signal
170 Movement Disorder 13 1.3 1.3 no signal
171 Intentional Dose Omission 11 1.3 1.3 no signal
172 Nervousness 21 1.3 1.3 no signal
173 Therapy Partial Responder 6 1.3 1.3 no signal
174 Temperature Intolerance 4 1.2 1.2 no signal
175 Inappropriate Schedule Of Product Administration 69 1.2 1.2 no signal
176 Dry Skin 51 1.2 1.2 no signal
177 Poor Venous Access 4 1.2 1.2 no signal
178 Folliculitis 4 1.2 1.2 no signal
179 Scratch 4 1.2 1.2 no signal
180 Drug Administration Error 12 1.2 1.2 no signal
181 Nodule 5 1.2 1.2 no signal
182 Angina Pectoris 11 1.2 1.2 no signal
183 Middle Insomnia 7 1.2 1.2 no signal
184 Extra Dose Administered 15 1.2 1.2 no signal
185 Incorrect Product Storage 5 1.2 1.2 no signal
186 Product Dose Omission In Error 10 1.2 1.2 no signal
187 Skin Cancer 8 1.2 1.2 no signal
188 Renal Injury 11 1.2 1.2 no signal
189 Pulmonary Thrombosis 4 1.2 1.2 no signal
190 Hernia 7 1.2 1.2 no signal
191 Dysgeusia 27 1.1 1.2 no signal
192 No Adverse Event 64 1.1 1.1 no signal
193 Device Occlusion 5 1.1 1.1 no signal
194 Oral Discomfort 5 1.1 1.1 no signal
195 Throat Irritation 16 1.1 1.1 no signal
196 Upper Gastrointestinal Haemorrhage 6 1.1 1.1 no signal
197 Fistula 4 1.1 1.1 no signal
198 Disability 7 1.1 1.1 no signal
199 Wrong Technique In Product Usage Process 71 1.1 1.1 no signal
200 Spinal Fracture 7 1.1 1.1 no signal
201 Activities Of Daily Living Impaired 7 1.1 1.1 no signal
202 Subdural Haematoma 5 1.1 1.1 no signal
203 Therapy Interrupted 24 1.1 1.1 no signal
204 Impaired Quality Of Life 5 1.1 1.1 no signal
205 Hot Flush 26 1.1 1.1 no signal
206 Apathy 5 1.1 1.1 no signal
207 Spinal Pain 4 1.1 1.1 no signal
208 Haemorrhage Intracranial 5 1.1 1.1 no signal
209 Spinal Operation 4 1.1 1.1 no signal
210 Influenza Like Illness 27 1.0 1.0 no signal
211 Nerve Compression 3 1.0 1.0 no signal
212 Blood Glucose Abnormal 6 1.0 1.0 no signal
213 Cardiac Failure Congestive 26 1.0 1.0 no signal
214 Hair Colour Changes 4 1.0 1.0 no signal
215 Glycosylated Haemoglobin Increased 8 1.0 1.0 no signal
216 Fracture 6 1.0 1.0 no signal
217 Eructation 6 1.0 1.0 no signal
218 Drug Reaction With Eosinophilia And Systemic Symptoms 8 1.0 1.0 no signal
219 Circumstance Or Information Capable Of Leading To Medication Error 10 0.9 0.9 no signal
220 Product Taste Abnormal 4 0.9 0.9 no signal
221 Gynaecomastia 9 0.9 0.9 no signal
222 Metastases To Liver 5 0.9 0.9 no signal
223 Incorrect Drug Administration Duration 8 0.9 0.9 no signal
224 Pulmonary Arterial Hypertension 4 0.9 0.9 no signal
225 Wrong Technique In Drug Usage Process 10 0.9 0.9 no signal
226 Fluid Overload 4 0.9 0.9 no signal
227 Blood Glucose Increased 49 0.8 0.8 no signal
228 Drug Prescribing Error 5 0.8 0.8 no signal
229 Palmar-plantar Erythrodysaesthesia Syndrome 6 0.8 0.8 no signal
230 Neoplasm Progression 9 0.8 0.8 no signal
231 Abnormal Behaviour 10 0.8 0.8 no signal
232 Osteonecrosis Of Jaw 6 0.8 0.8 no signal
233 Abasia 6 0.8 0.8 no signal
234 Plasma Cell Myeloma 9 0.7 0.7 no signal
235 Ankylosing Spondylitis 3 0.7 0.7 no signal
236 Myocardial Infarction 40 0.7 0.7 no signal
237 Complication Associated With Device 3 0.7 0.7 no signal
238 Malignant Neoplasm Progression 23 0.7 0.7 no signal
239 Product Availability Issue 5 0.7 0.7 no signal
240 Hair Texture Abnormal 3 0.7 0.7 no signal
241 Exposure Via Skin Contact 5 0.7 0.7 no signal
242 Product Administered At Inappropriate Site 4 0.7 0.7 no signal
243 Drug Dispensing Error 3 0.6 0.6 no signal
244 Psoriasis 25 0.6 0.6 no signal
245 Multiple Fractures 3 0.6 0.6 no signal
246 Injection Site Reaction 12 0.6 0.6 no signal
247 Device Issue 15 0.5 0.5 no signal
248 Injection Site Pruritus 11 0.5 0.5 no signal
249 Injection Site Bruising 13 0.5 0.5 no signal
250 Drug Effect Decreased 9 0.5 0.5 no signal
251 Device Malfunction 11 0.5 0.5 no signal
252 Therapeutic Response Shortened 5 0.5 0.5 no signal
253 Application Site Erythema 4 0.5 0.5 no signal
254 Multiple Sclerosis 7 0.5 0.5 no signal
255 Skin Burning Sensation 10 0.4 0.4 no signal
256 Injection Site Haemorrhage 11 0.4 0.4 no signal
257 Device Dislocation 6 0.4 0.4 no signal
258 Injection Site Mass 5 0.4 0.4 no signal
259 Application Site Pruritus 3 0.4 0.4 no signal
260 Injection Site Pain 40 0.4 0.4 no signal
261 Multiple Sclerosis Relapse 9 0.4 0.4 no signal
262 Dermatitis Atopic 6 0.4 0.4 no signal
263 Device Delivery System Issue 3 0.4 0.4 no signal
264 Injection Site Erythema 14 0.4 0.4 no signal
265 Incorrect Route Of Drug Administration 4 0.4 0.4 no signal
266 Wrong Technique In Device Usage Process 5 0.3 0.3 no signal
267 Breast Cancer 10 0.3 0.3 no signal
268 Device Breakage 4 0.3 0.3 no signal
269 Prostate Cancer 8 0.3 0.3 no signal
270 Device Leakage 4 0.3 0.3 no signal
271 Device Difficult To Use 6 0.3 0.3 no signal
272 Renal Cancer 3 0.2 0.2 no signal