OpenPV Signal Explorer
FAERS disproportionality dashboard
← All drugs
Drug

Brimonidine

230 flagged reaction(s) · 8,940 total co-reports · max PRR 95.7
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Treatment Failure 2,763 95.7 149.5 signal
2 Intraocular Pressure Increased 231 50.3 51.9 signal
3 Glaucoma 145 20.8 21.2 signal
4 Eye Inflammation 44 12.9 12.9 signal
5 Ocular Hyperaemia 186 11.0 11.2 signal
6 Eye Irritation 190 9.4 9.6 signal
7 Vitreous Floaters 31 8.8 8.8 signal
8 Eye Pain 172 8.6 8.8 signal
9 Uveitis 42 8.6 8.6 signal
10 Hypotonia 31 8.5 8.5 signal
11 Blindness Unilateral 43 8.4 8.5 signal
12 Hypothermia 27 7.3 7.4 signal
13 Retinal Detachment 23 6.9 6.9 signal
14 Product Packaging Quantity Issue 26 6.6 6.6 signal
15 Hypersensitivity 441 6.6 6.9 signal
16 Conjunctivitis 39 5.8 5.9 signal
17 Ocular Discomfort 23 5.8 5.8 signal
18 Eye Pruritus 69 5.8 5.8 signal
19 Eye Discharge 21 5.7 5.7 signal
20 Visual Acuity Reduced 64 5.3 5.3 signal
21 Photophobia 34 5.0 5.0 signal
22 End Stage Renal Disease 31 4.6 4.6 signal
23 Dry Eye 80 4.5 4.6 signal
24 Lacrimation Increased 49 4.5 4.5 signal
25 Vasculitis 19 4.5 4.5 signal
26 Nocturia 17 3.9 3.9 signal
27 Cataract 78 3.6 3.6 signal
28 Eye Disorder 42 3.5 3.5 signal
29 Vision Blurred 174 3.5 3.6 signal
30 Eye Haemorrhage 17 3.5 3.5 signal
31 Macular Degeneration 15 3.5 3.5 signal
32 Dizziness Postural 12 3.4 3.4 signal
33 Blindness 50 3.4 3.4 signal
34 Eye Infection 12 2.9 2.9 signal
35 Chronic Kidney Disease 82 2.9 3.0 signal
36 Product Use Complaint 16 2.8 2.8 signal
37 Visual Impairment 126 2.8 2.8 signal
38 Renal Tubular Necrosis 10 2.8 2.8 signal
39 Hemiparesis 17 2.7 2.7 signal
40 Blood Pressure Fluctuation 24 2.7 2.7 signal
41 Subarachnoid Haemorrhage 10 2.7 2.7 signal
42 Product Packaging Issue 9 2.7 2.7 signal
43 Therapy Non-responder 43 2.7 2.7 signal
44 Muscle Atrophy 12 2.6 2.6 signal
45 Eyelid Oedema 11 2.6 2.6 signal
46 Hypomagnesaemia 13 2.6 2.6 signal
47 Eyelid Ptosis 9 2.4 2.4 signal
48 Electrolyte Imbalance 10 2.4 2.4 signal
49 Urosepsis 8 2.4 2.4 signal
50 Ischaemic Stroke 15 2.3 2.3 signal
51 Eye Swelling 31 2.3 2.3 signal
52 Skin Laceration 9 2.3 2.3 signal
53 Bradycardia 44 2.3 2.3 signal
54 Hospice Care 8 2.2 2.2 signal
55 Haematemesis 20 2.2 2.2 signal
56 Body Height Decreased 8 2.0 2.0 no signal
57 Respiratory Depression 9 2.0 2.0 no signal
58 Dry Mouth 59 2.0 2.0 signal
59 Drug Hypersensitivity 139 2.0 2.0 no signal
60 Incorrect Route Of Product Administration 12 2.0 2.0 no signal
61 Blood Calcium Decreased 8 1.9 1.9 no signal
62 Product Administration Error 14 1.9 1.9 no signal
63 Dry Throat 7 1.9 1.9 no signal
64 Hypocalcaemia 13 1.9 1.9 no signal
65 Inflammation 35 1.9 1.9 no signal
66 Drug Intolerance 65 1.9 1.9 no signal
67 Gout 12 1.8 1.8 no signal
68 Transfusion 7 1.8 1.8 no signal
69 Localised Infection 16 1.8 1.8 no signal
70 Hallucination 49 1.8 1.8 no signal
71 Iron Deficiency Anaemia 6 1.8 1.8 no signal
72 Haemoptysis 18 1.8 1.8 no signal
73 Oesophagitis 7 1.8 1.8 no signal
74 Hepatocellular Injury 9 1.7 1.7 no signal
75 Blood Urine Present 12 1.7 1.7 no signal
76 Mydriasis 8 1.7 1.7 no signal
77 Unresponsive To Stimuli 16 1.7 1.7 no signal
78 Intentional Dose Omission 17 1.7 1.7 no signal
79 Sinus Bradycardia 6 1.7 1.7 no signal
80 Ear Pain 12 1.7 1.7 no signal
81 Depressed Level Of Consciousness 24 1.7 1.7 no signal
82 Acute Kidney Injury 91 1.6 1.6 no signal
83 Heart Rate Decreased 21 1.6 1.6 no signal
84 Mass 8 1.6 1.6 no signal
85 Lymphopenia 8 1.6 1.6 no signal
86 Cellulitis 28 1.5 1.5 no signal
87 Pulmonary Thrombosis 6 1.5 1.5 no signal
88 Gastroenteritis 8 1.5 1.5 no signal
89 Feeling Cold 15 1.5 1.5 no signal
90 Metabolic Acidosis 17 1.5 1.5 no signal
91 Sneezing 12 1.5 1.5 no signal
92 Rib Fracture 11 1.5 1.5 no signal
93 Upper Gastrointestinal Haemorrhage 9 1.5 1.5 no signal
94 Atrial Fibrillation 52 1.5 1.5 no signal
95 Renal Injury 16 1.5 1.5 no signal
96 Squamous Cell Carcinoma 5 1.5 1.5 no signal
97 Internal Haemorrhage 6 1.4 1.4 no signal
98 Autoimmune Disorder 5 1.4 1.4 no signal
99 Therapy Change 5 1.4 1.4 no signal
100 Tachypnoea 7 1.4 1.4 no signal
101 Ankle Fracture 8 1.4 1.4 no signal
102 Orthostatic Hypotension 9 1.4 1.4 no signal
103 Balance Disorder 44 1.4 1.4 no signal
104 Peripheral Coldness 7 1.4 1.4 no signal
105 Covid-19 Pneumonia 6 1.4 1.4 no signal
106 Skin Ulcer 13 1.4 1.4 no signal
107 Dementia 14 1.4 1.4 no signal
108 Blood Test Abnormal 7 1.4 1.4 no signal
109 Back Disorder 8 1.3 1.3 no signal
110 Red Blood Cell Count Decreased 14 1.3 1.3 no signal
111 Impaired Quality Of Life 7 1.3 1.3 no signal
112 International Normalised Ratio Increased 14 1.3 1.3 no signal
113 Fall 161 1.3 1.3 no signal
114 Frequent Bowel Movements 13 1.3 1.3 no signal
115 Pharyngitis 6 1.3 1.3 no signal
116 Weight Fluctuation 5 1.3 1.3 no signal
117 Hallucination, Visual 10 1.3 1.3 no signal
118 Cholestasis 9 1.3 1.3 no signal
119 Post Procedural Complication 9 1.3 1.3 no signal
120 Haemorrhage Intracranial 7 1.3 1.3 no signal
121 Blood Pressure Systolic Increased 9 1.3 1.3 no signal
122 Economic Problem 7 1.2 1.2 no signal
123 Basal Cell Carcinoma 7 1.2 1.2 no signal
124 Asthma 50 1.2 1.2 no signal
125 Hair Texture Abnormal 6 1.2 1.2 no signal
126 Impaired Driving Ability 5 1.2 1.2 no signal
127 Drug Ineffective 575 1.2 1.2 no signal
128 Personality Change 4 1.2 1.2 no signal
129 Toxicity To Various Agents 71 1.2 1.2 no signal
130 Polyneuropathy 5 1.2 1.2 no signal
131 Renal Failure Acute 18 1.1 1.1 no signal
132 Pharyngeal Swelling 4 1.1 1.1 no signal
133 Haematochezia 23 1.1 1.1 no signal
134 Electrocardiogram Qt Prolonged 15 1.1 1.1 no signal
135 Affect Lability 4 1.1 1.1 no signal
136 Pulmonary Arterial Hypertension 6 1.1 1.1 no signal
137 Inability To Afford Medication 4 1.1 1.1 no signal
138 Lactic Acidosis 13 1.1 1.1 no signal
139 Treatment Noncompliance 22 1.1 1.1 no signal
140 Throat Irritation 18 1.1 1.1 no signal
141 Cyst 5 1.1 1.1 no signal
142 Dermatitis Allergic 5 1.1 1.1 no signal
143 Rash Papular 9 1.1 1.1 no signal
144 Upper Limb Fracture 8 1.1 1.1 no signal
145 Hot Flush 30 1.1 1.1 no signal
146 Product Prescribing Issue 8 1.1 1.1 no signal
147 Helicobacter Infection 4 1.1 1.1 no signal
148 Injection Site Discomfort 4 1.1 1.1 no signal
149 Product Dose Omission Issue 110 1.1 1.1 no signal
150 Dermatitis 8 1.1 1.1 no signal
151 Ejection Fraction Decreased 6 1.1 1.1 no signal
152 Nodule 5 1.1 1.1 no signal
153 Platelet Count Increased 5 1.1 1.1 no signal
154 Full Blood Count Abnormal 4 1.0 1.0 no signal
155 Respiratory Tract Congestion 6 1.0 1.0 no signal
156 Middle Insomnia 7 1.0 1.0 no signal
157 Blood Creatine Phosphokinase Increased 11 1.0 1.0 no signal
158 Hip Fracture 12 1.0 1.0 no signal
159 Malignant Melanoma 5 1.0 1.0 no signal
160 Hypoacusis 16 1.0 1.0 no signal
161 Hypoglycaemia 18 1.0 1.0 no signal
162 Gastrointestinal Haemorrhage 31 1.0 1.0 no signal
163 Injection Site Nodule 4 1.0 1.0 no signal
164 Melaena 8 1.0 1.0 no signal
165 Therapeutic Response Unexpected 16 1.0 1.0 no signal
166 Rebound Effect 4 1.0 1.0 no signal
167 Post Procedural Haemorrhage 4 0.9 0.9 no signal
168 Spinal Pain 4 0.9 0.9 no signal
169 Insurance Issue 5 0.9 0.9 no signal
170 Wrist Fracture 4 0.9 0.9 no signal
171 Blood Thyroid Stimulating Hormone Increased 3 0.9 0.9 no signal
172 Cardiac Failure Congestive 26 0.9 0.9 no signal
173 Cytokine Release Syndrome 6 0.9 0.9 no signal
174 Drug Effective For Unapproved Indication 9 0.8 0.8 no signal
175 Ankylosing Spondylitis 4 0.8 0.8 no signal
176 Therapy Interrupted 21 0.8 0.8 no signal
177 Product Quality Issue 41 0.8 0.8 no signal
178 Expired Product Administered 10 0.8 0.8 no signal
179 Product Dose Omission In Error 8 0.8 0.8 no signal
180 Product Odour Abnormal 3 0.8 0.8 no signal
181 Product Substitution Issue 16 0.8 0.8 no signal
182 Product Administered At Inappropriate Site 5 0.8 0.8 no signal
183 Fluid Overload 4 0.7 0.7 no signal
184 Blood Glucose Decreased 13 0.7 0.7 no signal
185 Myocarditis 3 0.7 0.7 no signal
186 Underdose 19 0.7 0.7 no signal
187 Product Dose Omission 17 0.7 0.7 no signal
188 Plasma Cell Myeloma 10 0.7 0.7 no signal
189 Product Physical Issue 5 0.7 0.7 no signal
190 Extra Dose Administered 10 0.7 0.7 no signal
191 Drug Effect Incomplete 9 0.7 0.7 no signal
192 Dry Skin 32 0.7 0.7 no signal
193 Incorrect Dose Administered By Device 6 0.6 0.6 no signal
194 Device Use Issue 4 0.6 0.6 no signal
195 Incorrect Product Storage 3 0.6 0.6 no signal
196 Drug Administration Error 7 0.6 0.6 no signal
197 Lung Neoplasm Malignant 9 0.6 0.6 no signal
198 Device Occlusion 3 0.6 0.6 no signal
199 Accidental Exposure To Product 21 0.6 0.6 no signal
200 Diabetic Ketoacidosis 5 0.6 0.6 no signal
201 Dermatitis Atopic 10 0.5 0.5 no signal
202 Incorrect Dose Administered 45 0.5 0.5 no signal
203 Injury Associated With Device 4 0.5 0.5 no signal
204 Glycosylated Haemoglobin Increased 5 0.5 0.5 no signal
205 Psoriasis 25 0.5 0.5 no signal
206 Injection Site Mass 7 0.5 0.5 no signal
207 Bone Density Decreased 6 0.5 0.5 no signal
208 No Adverse Event 33 0.5 0.5 no signal
209 Product Dispensing Error 4 0.5 0.5 no signal
210 Wrong Technique In Product Usage Process 37 0.5 0.5 no signal
211 Injection Site Pruritus 12 0.5 0.5 no signal
212 Inappropriate Schedule Of Drug Administration 13 0.5 0.5 no signal
213 Needle Issue 5 0.5 0.5 no signal
214 Palmar-plantar Erythrodysaesthesia Syndrome 4 0.5 0.5 no signal
215 Device Issue 14 0.4 0.4 no signal
216 Extrapyramidal Disorder 4 0.4 0.4 no signal
217 Skin Irritation 7 0.4 0.4 no signal
218 Device Dislocation 6 0.4 0.4 no signal
219 Incorrect Route Of Drug Administration 5 0.4 0.4 no signal
220 Exposure Via Skin Contact 3 0.4 0.4 no signal
221 Drug Dose Omission 22 0.4 0.4 no signal
222 Product Storage Error 11 0.3 0.3 no signal
223 Product Complaint 3 0.3 0.3 no signal
224 Device Delivery System Issue 3 0.3 0.3 no signal
225 Injection Site Haemorrhage 9 0.3 0.3 no signal
226 Pancreatic Carcinoma 3 0.3 0.3 no signal
227 Device Difficult To Use 6 0.2 0.2 no signal
228 Drug Withdrawal Syndrome 7 0.2 0.2 no signal
229 Device Leakage 3 0.2 0.2 no signal
230 Wrong Technique In Device Usage Process 3 0.2 0.2 no signal