Drug
Bupivacaine Hydrochloride And Epinephrine Bitartrate
Important: Reactions below are the flagged terms from this drug’s
FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate
disproportionality in spontaneous reporting, not causation.
Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
| Reaction | Co-reports (a) | PRR | ROR | Signal | |
|---|---|---|---|---|---|
| 1 | Joint Range Of Motion Decreased | 98 | 50.0 | 51.6 | signal |
| 2 | Joint Injury | 135 | 43.0 | 44.9 | signal |
| 3 | Musculoskeletal Pain | 203 | 26.1 | 27.9 | signal |
| 4 | Musculoskeletal Discomfort | 56 | 22.1 | 22.5 | signal |
| 5 | Rotator Cuff Syndrome | 23 | 12.1 | 12.2 | signal |
| 6 | Caesarean Section | 19 | 11.0 | 11.0 | signal |
| 7 | Drug Effect Incomplete | 56 | 10.3 | 10.5 | signal |
| 8 | Musculoskeletal Disorder | 29 | 10.3 | 10.4 | signal |
| 9 | Sensory Disturbance | 20 | 8.4 | 8.5 | signal |
| 10 | No Therapeutic Response | 15 | 8.2 | 8.3 | signal |
| 11 | Post Procedural Complication | 23 | 8.1 | 8.2 | signal |
| 12 | Bursitis | 12 | 6.7 | 6.8 | signal |
| 13 | Osteoarthritis | 42 | 6.7 | 6.8 | signal |
| 14 | Motor Dysfunction | 10 | 6.7 | 6.7 | signal |
| 15 | Anaphylactic Shock | 25 | 6.6 | 6.7 | signal |
| 16 | Status Epilepticus | 11 | 6.6 | 6.6 | signal |
| 17 | Staphylococcal Infection | 32 | 6.5 | 6.6 | signal |
| 18 | Paralysis | 13 | 6.1 | 6.2 | signal |
| 19 | Drug Effect Decreased | 47 | 5.8 | 5.9 | signal |
| 20 | Disseminated Intravascular Coagulation | 12 | 5.8 | 5.8 | signal |
| 21 | Drug Ineffective | 1,097 | 5.6 | 8.2 | signal |
| 22 | End Stage Renal Disease | 15 | 5.5 | 5.5 | signal |
| 23 | Nerve Injury | 9 | 5.5 | 5.5 | signal |
| 24 | Neurotoxicity | 14 | 5.5 | 5.5 | signal |
| 25 | Blood Calcium Decreased | 9 | 5.4 | 5.4 | signal |
| 26 | Movement Disorder | 24 | 5.0 | 5.1 | signal |
| 27 | Laceration | 7 | 5.0 | 5.0 | signal |
| 28 | Device Failure | 11 | 4.9 | 4.9 | signal |
| 29 | Drug Toxicity | 10 | 4.9 | 4.9 | signal |
| 30 | Pharmaceutical Product Complaint | 19 | 4.9 | 4.9 | signal |
| 31 | Economic Problem | 11 | 4.8 | 4.8 | signal |
| 32 | Cardiac Arrest | 59 | 4.8 | 4.9 | signal |
| 33 | Cyanosis | 11 | 4.7 | 4.7 | signal |
| 34 | Activities Of Daily Living Impaired | 14 | 4.7 | 4.7 | signal |
| 35 | Drug Exposure During Pregnancy | 24 | 4.7 | 4.7 | signal |
| 36 | Anaphylactic Reaction | 37 | 4.6 | 4.6 | signal |
| 37 | Muscle Spasticity | 8 | 4.4 | 4.4 | signal |
| 38 | Intervertebral Disc Degeneration | 6 | 4.4 | 4.4 | signal |
| 39 | Abscess | 10 | 4.2 | 4.3 | signal |
| 40 | Procedural Pain | 17 | 4.2 | 4.2 | signal |
| 41 | Ventricular Tachycardia | 10 | 4.1 | 4.1 | signal |
| 42 | Incorrect Product Storage | 8 | 4.1 | 4.1 | signal |
| 43 | Eyelid Oedema | 7 | 4.1 | 4.1 | signal |
| 44 | Brain Injury | 6 | 4.0 | 4.1 | signal |
| 45 | Hypoaesthesia Oral | 9 | 4.0 | 4.1 | signal |
| 46 | Circulatory Collapse | 10 | 4.0 | 4.0 | signal |
| 47 | Bradycardia | 31 | 4.0 | 4.0 | signal |
| 48 | Unresponsive To Stimuli | 15 | 3.9 | 4.0 | signal |
| 49 | Scar | 10 | 3.9 | 4.0 | signal |
| 50 | Ventricular Extrasystoles | 6 | 3.9 | 3.9 | signal |
| 51 | Drug Effect Less Than Expected | 8 | 3.8 | 3.9 | signal |
| 52 | Cardiogenic Shock | 8 | 3.8 | 3.8 | signal |
| 53 | Synovitis | 10 | 3.8 | 3.8 | signal |
| 54 | Injury | 39 | 3.7 | 3.8 | signal |
| 55 | Convulsion | 32 | 3.7 | 3.8 | signal |
| 56 | Dental Caries | 6 | 3.7 | 3.7 | signal |
| 57 | Urinary Incontinence | 16 | 3.7 | 3.7 | signal |
| 58 | Diplopia | 14 | 3.7 | 3.7 | signal |
| 59 | Hypoaesthesia | 80 | 3.6 | 3.7 | signal |
| 60 | Therapeutic Product Effect Decreased | 23 | 3.5 | 3.5 | signal |
| 61 | Product Quality Issue | 69 | 3.5 | 3.5 | signal |
| 62 | Cold Sweat | 9 | 3.5 | 3.5 | signal |
| 63 | Blood Triglycerides Increased | 9 | 3.4 | 3.4 | signal |
| 64 | Carpal Tunnel Syndrome | 7 | 3.4 | 3.4 | signal |
| 65 | Skin Reaction | 7 | 3.4 | 3.4 | signal |
| 66 | Hypothermia | 5 | 3.3 | 3.3 | signal |
| 67 | Ear Discomfort | 5 | 3.3 | 3.3 | signal |
| 68 | Impaired Quality Of Life | 7 | 3.3 | 3.3 | signal |
| 69 | Brain Oedema | 6 | 3.2 | 3.2 | signal |
| 70 | Respiratory Arrest | 13 | 3.2 | 3.2 | signal |
| 71 | Presyncope | 11 | 3.1 | 3.1 | signal |
| 72 | Discomfort | 27 | 3.0 | 3.0 | signal |
| 73 | Therapeutic Response Shortened | 14 | 3.0 | 3.0 | signal |
| 74 | Muscle Tightness | 7 | 2.9 | 2.9 | signal |
| 75 | Splenomegaly | 5 | 2.9 | 2.9 | signal |
| 76 | Deformity | 4 | 2.9 | 2.9 | no signal |
| 77 | Incorrect Route Of Drug Administration | 15 | 2.8 | 2.8 | signal |
| 78 | Affect Lability | 4 | 2.8 | 2.8 | no signal |
| 79 | Hypotonia | 4 | 2.7 | 2.7 | no signal |
| 80 | Eyelid Ptosis | 4 | 2.7 | 2.7 | no signal |
| 81 | Temperature Intolerance | 4 | 2.7 | 2.7 | no signal |
| 82 | Intraocular Pressure Increased | 5 | 2.6 | 2.6 | no signal |
| 83 | Euphoric Mood | 4 | 2.6 | 2.6 | no signal |
| 84 | Tendonitis | 6 | 2.6 | 2.6 | signal |
| 85 | Pharyngeal Oedema | 6 | 2.6 | 2.6 | signal |
| 86 | Nervous System Disorder | 12 | 2.6 | 2.6 | signal |
| 87 | Complication Associated With Device | 5 | 2.6 | 2.6 | no signal |
| 88 | Blindness | 15 | 2.5 | 2.5 | signal |
| 89 | Back Disorder | 6 | 2.5 | 2.5 | no signal |
| 90 | Arthropathy | 20 | 2.4 | 2.4 | signal |
| 91 | Product Administration Error | 7 | 2.4 | 2.4 | signal |
| 92 | Bronchospasm | 5 | 2.4 | 2.4 | no signal |
| 93 | Metastases To Lung | 4 | 2.3 | 2.3 | no signal |
| 94 | Neuroleptic Malignant Syndrome | 4 | 2.3 | 2.3 | no signal |
| 95 | Renal Injury | 10 | 2.3 | 2.3 | signal |
| 96 | Respiratory Depression | 4 | 2.2 | 2.2 | no signal |
| 97 | Tendon Rupture | 4 | 2.2 | 2.2 | no signal |
| 98 | Drug Withdrawal Syndrome | 28 | 2.1 | 2.1 | signal |
| 99 | Ovarian Cyst | 3 | 2.0 | 2.0 | no signal |
| 100 | Exposure During Pregnancy | 18 | 2.0 | 2.0 | no signal |
| 101 | Paranoia | 5 | 2.0 | 2.0 | no signal |
| 102 | Skeletal Injury | 3 | 1.9 | 1.9 | no signal |
| 103 | Abasia | 7 | 1.9 | 1.9 | no signal |
| 104 | Osteonecrosis | 9 | 1.8 | 1.8 | no signal |
| 105 | Withdrawal Syndrome | 11 | 1.8 | 1.8 | no signal |
| 106 | Dystonia | 5 | 1.7 | 1.7 | no signal |
| 107 | Emotional Distress | 30 | 1.7 | 1.7 | no signal |
| 108 | Osteonecrosis Of Jaw | 6 | 1.6 | 1.6 | no signal |
| 109 | Tooth Loss | 5 | 1.6 | 1.6 | no signal |
| 110 | Cytokine Release Syndrome | 4 | 1.4 | 1.4 | no signal |
| 111 | Injection Site Warmth | 4 | 1.3 | 1.3 | no signal |
| 112 | Injection Site Swelling | 13 | 1.2 | 1.2 | no signal |
| 113 | Bone Density Decreased | 5 | 1.1 | 1.1 | no signal |
| 114 | Incorrect Dose Administered By Device | 4 | 1.1 | 1.1 | no signal |
| 115 | Extrapyramidal Disorder | 3 | 0.8 | 0.8 | no signal |
| 116 | Device Leakage | 4 | 0.6 | 0.6 | no signal |
| 117 | Device Dislocation | 4 | 0.6 | 0.6 | no signal |
| 118 | Device Issue | 8 | 0.6 | 0.6 | no signal |