OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Bupivacaine Hydrochloride

318 flagged reaction(s) · 13,469 total co-reports · max PRR 28.3
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Joint Injury 204 28.3 29.1 signal
2 Joint Range Of Motion Decreased 127 28.2 28.6 signal
3 Helicobacter Infection 84 24.4 24.7 signal
4 Hypercholesterolaemia 61 18.8 19.0 signal
5 Musculoskeletal Pain 267 14.9 15.5 signal
6 Musculoskeletal Discomfort 85 14.6 14.7 signal
7 Activities Of Daily Living Impaired 88 12.9 13.1 signal
8 Incorrect Route Of Product Administration 73 12.8 12.9 signal
9 Musculoskeletal Disorder 75 11.5 11.7 signal
10 Folliculitis 38 10.8 10.9 signal
11 Fibromyalgia 82 9.9 10.0 signal
12 Respiratory Depression 41 9.8 9.9 signal
13 Neurotoxicity 56 9.5 9.6 signal
14 Drug Effect Incomplete 117 9.3 9.5 signal
15 Caesarean Section 37 9.3 9.3 signal
16 Paralysis 45 9.2 9.3 signal
17 Myoclonus 37 9.1 9.2 signal
18 Foot Deformity 32 8.5 8.5 signal
19 Maternal Exposure During Pregnancy 241 8.0 8.3 signal
20 Sciatica 43 8.0 8.0 signal
21 Osteoarthritis 112 7.8 7.9 signal
22 Bursitis 30 7.3 7.3 signal
23 Hand Deformity 32 7.2 7.2 signal
24 Rotator Cuff Syndrome 30 6.8 6.9 signal
25 No Therapeutic Response 28 6.7 6.7 signal
26 Bradycardia 120 6.6 6.7 signal
27 Premature Delivery 35 6.4 6.5 signal
28 Type 2 Diabetes Mellitus 72 6.3 6.3 signal
29 Post Procedural Complication 41 6.3 6.3 signal
30 Motor Dysfunction 21 6.1 6.1 signal
31 Hypoxia 72 6.0 6.1 signal
32 Autoimmune Disorder 19 5.8 5.8 signal
33 Unresponsive To Stimuli 51 5.8 5.9 signal
34 Drug Ineffective 2,609 5.8 8.6 signal
35 Ventricular Fibrillation 21 5.5 5.6 signal
36 Hepatic Cirrhosis 35 5.5 5.5 signal
37 C-reactive Protein Increased 65 5.3 5.3 signal
38 Prescribed Overdose 34 5.2 5.2 signal
39 Anaphylactic Shock 45 5.2 5.2 signal
40 Ventricular Tachycardia 29 5.1 5.2 signal
41 Wound Infection 19 5.1 5.2 signal
42 Sensory Disturbance 28 5.1 5.1 signal
43 Joint Dislocation 18 5.0 5.0 signal
44 Grand Mal Convulsion 16 5.0 5.0 signal
45 Hypoaesthesia 255 5.0 5.2 signal
46 Tachypnoea 23 5.0 5.0 signal
47 Muscle Spasticity 21 5.0 5.0 signal
48 Cardiac Arrest 140 5.0 5.0 signal
49 Hypothermia 17 4.9 4.9 signal
50 Lower Limb Fracture 32 4.9 4.9 signal
51 Circulatory Collapse 28 4.8 4.8 signal
52 Nerve Injury 18 4.7 4.8 signal
53 Glossodynia 36 4.7 4.8 signal
54 Drug Toxicity 22 4.7 4.7 signal
55 Incorrect Product Storage 21 4.6 4.6 signal
56 Euphoric Mood 16 4.6 4.6 signal
57 Sinus Tachycardia 22 4.6 4.6 signal
58 Synovitis 28 4.6 4.6 signal
59 Staphylococcal Infection 51 4.5 4.6 signal
60 Blood Cholesterol Increased 71 4.5 4.5 signal
61 Drug Exposure During Pregnancy 52 4.4 4.5 signal
62 Drug Effect Decreased 82 4.4 4.5 signal
63 Anaphylactic Reaction 81 4.3 4.4 signal
64 Laryngitis 16 4.3 4.3 signal
65 Pemphigus 18 4.3 4.3 signal
66 Atelectasis 14 4.2 4.2 signal
67 Pericarditis 24 4.2 4.2 signal
68 Drug-induced Liver Injury 44 4.2 4.2 signal
69 Impaired Healing 46 4.1 4.1 signal
70 Incorrect Route Of Drug Administration 50 4.1 4.1 signal
71 Hypotension 276 4.1 4.2 signal
72 Red Blood Cell Sedimentation Rate Increased 15 4.0 4.0 signal
73 Generalised Tonic-clonic Seizure 22 4.0 4.0 signal
74 Road Traffic Accident 56 3.9 4.0 signal
75 Movement Disorder 43 3.9 3.9 signal
76 Status Epilepticus 15 3.9 3.9 signal
77 Exposure During Pregnancy 82 3.9 3.9 signal
78 Arthropathy 73 3.8 3.9 signal
79 Respiratory Arrest 36 3.8 3.8 signal
80 Premature Baby 39 3.8 3.8 signal
81 Urinary Incontinence 38 3.8 3.8 signal
82 Delirium 44 3.7 3.8 signal
83 Hepatic Enzyme Increased 86 3.7 3.8 signal
84 Sinus Bradycardia 12 3.6 3.6 signal
85 Discomfort 74 3.6 3.6 signal
86 Irritable Bowel Syndrome 26 3.6 3.6 signal
87 Urinary Retention 40 3.5 3.5 signal
88 Gait Inability 38 3.4 3.4 signal
89 Blood Pressure Decreased 75 3.3 3.3 signal
90 Abscess 18 3.3 3.3 signal
91 Back Injury 12 3.3 3.3 signal
92 Swelling 103 3.2 3.3 signal
93 Hypotonia 11 3.2 3.2 signal
94 Respiratory Distress 30 3.2 3.2 signal
95 Neuralgia 26 3.1 3.2 signal
96 Disseminated Intravascular Coagulation 15 3.1 3.1 signal
97 Injury 73 3.0 3.1 signal
98 Mobility Decreased 73 3.0 3.0 signal
99 Infusion Related Reaction 67 3.0 3.0 signal
100 Oxygen Saturation Decreased 56 2.9 3.0 signal
101 Prescribed Underdose 20 2.9 3.0 signal
102 Blood Calcium Decreased 11 2.9 2.9 signal
103 Convulsion 56 2.8 2.9 signal
104 Ventricular Extrasystoles 10 2.8 2.8 signal
105 Cyanosis 15 2.8 2.8 signal
106 Epilepsy 29 2.8 2.8 signal
107 Laceration 9 2.8 2.8 signal
108 Supraventricular Tachycardia 9 2.8 2.8 signal
109 Scar 16 2.7 2.7 signal
110 Hypoaesthesia Oral 14 2.7 2.7 signal
111 Sedation 24 2.7 2.7 signal
112 Joint Stiffness 24 2.7 2.7 signal
113 Pharmaceutical Product Complaint 24 2.7 2.7 signal
114 Mental Status Changes 25 2.6 2.6 signal
115 Therapeutic Product Effect Incomplete 63 2.6 2.6 signal
116 Eyelid Ptosis 9 2.6 2.6 signal
117 End Stage Renal Disease 16 2.6 2.6 signal
118 Loss Of Consciousness 111 2.5 2.6 signal
119 Muscle Tightness 14 2.5 2.5 signal
120 Coma 41 2.5 2.5 signal
121 Mydriasis 11 2.5 2.5 signal
122 Hip Arthroplasty 13 2.5 2.5 signal
123 Osteoporosis 35 2.5 2.5 signal
124 Stomatitis 51 2.5 2.5 signal
125 Depressed Level Of Consciousness 33 2.5 2.5 signal
126 Wound 23 2.4 2.4 signal
127 Liver Injury 20 2.4 2.4 signal
128 Coeliac Disease 8 2.4 2.4 signal
129 Obesity 13 2.4 2.4 signal
130 Therapeutic Product Effect Decreased 36 2.4 2.4 signal
131 General Physical Health Deterioration 93 2.4 2.4 signal
132 Product Quality Issue 108 2.4 2.4 signal
133 Nervous System Disorder 25 2.3 2.3 signal
134 Mitral Valve Incompetence 9 2.3 2.3 signal
135 Device Failure 12 2.3 2.3 signal
136 Pulmonary Fibrosis 15 2.3 2.3 signal
137 Sleep Apnoea Syndrome 15 2.3 2.3 signal
138 Metastases To Lung 9 2.3 2.3 signal
139 Economic Problem 12 2.3 2.3 signal
140 Cardiogenic Shock 11 2.3 2.3 signal
141 Psoriatic Arthropathy 31 2.3 2.3 signal
142 Transfusion 8 2.2 2.2 signal
143 Pneumothorax 12 2.2 2.2 signal
144 Tachycardia 67 2.2 2.2 signal
145 Product Administration Error 15 2.2 2.2 signal
146 Skin Laceration 8 2.2 2.2 no signal
147 Muscular Weakness 83 2.1 2.2 signal
148 Contraindicated Product Administered 22 2.1 2.1 signal
149 Ear Infection 19 2.1 2.1 signal
150 Mass 10 2.1 2.1 signal
151 Renal Tubular Necrosis 7 2.1 2.1 no signal
152 Hypertension 150 2.1 2.1 signal
153 Medication Error 39 2.1 2.1 signal
154 Bronchospasm 10 2.1 2.1 signal
155 Brain Injury 7 2.0 2.0 no signal
156 Tinnitus 32 2.0 2.0 signal
157 Diplopia 18 2.0 2.0 signal
158 Hypokinesia 10 2.0 2.0 signal
159 Drug Withdrawal Syndrome 61 2.0 2.0 signal
160 Procedural Pain 19 2.0 2.0 signal
161 Eyelid Oedema 8 2.0 2.0 no signal
162 Restlessness 25 2.0 2.0 signal
163 Drug Intolerance 64 2.0 2.0 no signal
164 Inflammation 34 1.9 1.9 no signal
165 Therapy Non-responder 29 1.9 1.9 no signal
166 Device Related Infection 10 1.9 1.9 no signal
167 Intervertebral Disc Degeneration 6 1.9 1.9 no signal
168 Pharyngeal Oedema 10 1.9 1.9 no signal
169 Adverse Event 59 1.9 1.9 no signal
170 Drug Effect Less Than Expected 9 1.9 1.9 no signal
171 Adverse Drug Reaction 57 1.9 1.9 no signal
172 Dental Caries 7 1.9 1.9 no signal
173 Subdural Haematoma 9 1.8 1.8 no signal
174 Hepatitis 16 1.8 1.8 no signal
175 Blister 35 1.8 1.8 no signal
176 Cold Sweat 11 1.8 1.8 no signal
177 Presyncope 15 1.8 1.8 no signal
178 Deep Vein Thrombosis 40 1.8 1.8 no signal
179 Osteomyelitis 11 1.8 1.8 no signal
180 Disability 12 1.8 1.8 no signal
181 Altered State Of Consciousness 13 1.8 1.8 no signal
182 Intentional Product Use Issue 53 1.8 1.8 no signal
183 Heart Rate Decreased 21 1.7 1.7 no signal
184 Cellulitis 30 1.7 1.7 no signal
185 Aphasia 18 1.7 1.7 no signal
186 Neuroleptic Malignant Syndrome 7 1.7 1.7 no signal
187 Muscle Rigidity 7 1.7 1.7 no signal
188 Dysstasia 17 1.7 1.7 no signal
189 Cholestasis 11 1.7 1.7 no signal
190 Shock 13 1.7 1.7 no signal
191 Carpal Tunnel Syndrome 8 1.7 1.7 no signal
192 Systemic Lupus Erythematosus 20 1.7 1.7 no signal
193 Acute Respiratory Distress Syndrome 10 1.7 1.7 no signal
194 Breast Cancer Metastatic 6 1.6 1.6 no signal
195 Night Sweats 18 1.6 1.6 no signal
196 Impaired Quality Of Life 8 1.6 1.6 no signal
197 Back Disorder 9 1.6 1.6 no signal
198 Condition Aggravated 165 1.6 1.6 no signal
199 Blindness 22 1.6 1.6 no signal
200 Paraesthesia 85 1.6 1.6 no signal
201 Pain 325 1.6 1.6 no signal
202 Seizure 60 1.5 1.5 no signal
203 Withdrawal Syndrome 22 1.5 1.5 no signal
204 Hypersensitivity 96 1.5 1.5 no signal
205 Affect Lability 5 1.5 1.5 no signal
206 Cognitive Disorder 24 1.5 1.5 no signal
207 Blood Triglycerides Increased 9 1.5 1.5 no signal
208 Drug Hypersensitivity 97 1.5 1.5 no signal
209 Cardio-respiratory Arrest 21 1.5 1.5 no signal
210 Sinusitis 51 1.5 1.5 no signal
211 Dyskinesia 20 1.4 1.4 no signal
212 Temperature Intolerance 5 1.4 1.4 no signal
213 Anxiety 139 1.4 1.4 no signal
214 Chromaturia 11 1.4 1.4 no signal
215 Hyperbilirubinaemia 5 1.4 1.4 no signal
216 Musculoskeletal Stiffness 42 1.4 1.4 no signal
217 Abdominal Discomfort 80 1.4 1.4 no signal
218 Brain Oedema 6 1.4 1.4 no signal
219 Therapeutic Response Shortened 15 1.4 1.4 no signal
220 Haematoma 12 1.4 1.4 no signal
221 Feeling Hot 28 1.3 1.3 no signal
222 Multi-organ Failure 8 1.3 1.3 no signal
223 Drug Dispensing Error 7 1.3 1.3 no signal
224 Urticaria 75 1.3 1.3 no signal
225 Abasia 11 1.3 1.3 no signal
226 Product Use Issue 82 1.3 1.3 no signal
227 Accidental Overdose 16 1.3 1.3 no signal
228 Renal Injury 13 1.3 1.3 no signal
229 Knee Arthroplasty 9 1.3 1.3 no signal
230 Aphonia 6 1.3 1.3 no signal
231 Burning Sensation 30 1.3 1.3 no signal
232 Splenomegaly 5 1.3 1.3 no signal
233 Deformity 4 1.3 1.3 no signal
234 Skin Reaction 6 1.3 1.3 no signal
235 Agitation 31 1.2 1.2 no signal
236 Posterior Reversible Encephalopathy Syndrome 4 1.2 1.2 no signal
237 Psychomotor Hyperactivity 7 1.2 1.2 no signal
238 Speech Disorder 22 1.2 1.2 no signal
239 Lower Respiratory Tract Infection 19 1.2 1.2 no signal
240 Drug Administration Error 13 1.2 1.2 no signal
241 Unevaluable Event 31 1.2 1.2 no signal
242 Wrong Technique In Drug Usage Process 15 1.2 1.2 no signal
243 Psychotic Disorder 12 1.2 1.2 no signal
244 Hepatotoxicity 9 1.2 1.2 no signal
245 Paranoia 7 1.2 1.2 no signal
246 Tendon Rupture 5 1.2 1.2 no signal
247 Ovarian Cyst 4 1.2 1.2 no signal
248 Ill-defined Disorder 24 1.2 1.2 no signal
249 Subarachnoid Haemorrhage 4 1.1 1.1 no signal
250 Ear Discomfort 4 1.1 1.1 no signal
251 Joint Swelling 47 1.1 1.1 no signal
252 Intraocular Pressure Increased 5 1.1 1.1 no signal
253 Toothache 7 1.1 1.1 no signal
254 Arthralgia 160 1.1 1.1 no signal
255 Tendonitis 6 1.1 1.1 no signal
256 Ejection Fraction Decreased 6 1.1 1.1 no signal
257 Transient Ischaemic Attack 13 1.1 1.1 no signal
258 Nodule 5 1.1 1.1 no signal
259 Alopecia 75 1.1 1.1 no signal
260 Complication Associated With Device 5 1.1 1.1 no signal
261 Hepatic Function Abnormal 14 1.1 1.1 no signal
262 Anhedonia 10 1.1 1.1 no signal
263 Hallucination, Auditory 6 1.1 1.1 no signal
264 Mental Impairment 9 1.1 1.1 no signal
265 Jaundice 10 1.1 1.1 no signal
266 Serotonin Syndrome 7 1.1 1.1 no signal
267 Therapeutic Response Decreased 22 1.1 1.1 no signal
268 Stevens-johnson Syndrome 8 1.1 1.1 no signal
269 Cholecystectomy 4 1.0 1.0 no signal
270 Pregnancy 7 1.0 1.0 no signal
271 Toxicity To Various Agents 57 1.0 1.0 no signal
272 Fear 9 1.0 1.0 no signal
273 Expired Product Administered 11 1.0 1.0 no signal
274 Emotional Distress 40 1.0 1.0 no signal
275 Impaired Work Ability 7 1.0 1.0 no signal
276 Tooth Extraction 4 0.9 0.9 no signal
277 Device Issue 27 0.9 0.9 no signal
278 Dystonia 6 0.9 0.9 no signal
279 Metastases To Bone 5 0.9 0.9 no signal
280 Inflammatory Bowel Disease 3 0.9 0.9 no signal
281 Adverse Reaction 4 0.9 0.9 no signal
282 Eye Haemorrhage 4 0.9 0.9 no signal
283 Overdose 64 0.9 0.9 no signal
284 Foetal Exposure During Pregnancy 24 0.9 0.9 no signal
285 Poor Quality Product Administered 3 0.9 0.9 no signal
286 Tooth Loss 6 0.8 0.8 no signal
287 Skeletal Injury 3 0.8 0.8 no signal
288 Eosinophilia 5 0.8 0.8 no signal
289 Hepatocellular Injury 4 0.8 0.8 no signal
290 Osteonecrosis Of Jaw 7 0.8 0.8 no signal
291 Device Dislocation 12 0.8 0.8 no signal
292 Pelvic Pain 5 0.8 0.8 no signal
293 Osteonecrosis 9 0.8 0.8 no signal
294 Circumstance Or Information Capable Of Leading To Medication Error 9 0.8 0.8 no signal
295 Fistula 3 0.8 0.8 no signal
296 Device Deployment Issue 3 0.7 0.7 no signal
297 Lung Neoplasm Malignant 10 0.7 0.7 no signal
298 Extrapyramidal Disorder 6 0.7 0.7 no signal
299 Anger 8 0.7 0.7 no signal
300 No Adverse Event 41 0.7 0.7 no signal
301 Injection Site Swelling 17 0.7 0.7 no signal
302 Device Malfunction 15 0.7 0.7 no signal
303 Device Occlusion 3 0.6 0.6 no signal
304 Rheumatoid Arthritis 24 0.6 0.6 no signal
305 Cytokine Release Syndrome 4 0.6 0.6 no signal
306 Neoplasm Progression 7 0.6 0.6 no signal
307 Incorrect Dose Administered By Device 5 0.6 0.6 no signal
308 Product Preparation Error 4 0.6 0.6 no signal
309 Bone Density Decreased 5 0.5 0.5 no signal
310 Extra Dose Administered 6 0.4 0.4 no signal
311 Injection Site Warmth 3 0.4 0.4 no signal
312 Device Leakage 6 0.4 0.4 no signal
313 Intentional Overdose 8 0.4 0.4 no signal
314 Tardive Dyskinesia 3 0.3 0.3 no signal
315 Drug Dependence 17 0.3 0.3 no signal
316 Pancreatic Carcinoma 3 0.3 0.3 no signal
317 Device Breakage 4 0.3 0.3 no signal
318 Accidental Exposure To Product 9 0.3 0.3 no signal