OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Bupropion Hydrochloride (xl)

161 flagged reaction(s) · 3,433 total co-reports · max PRR 37.7
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Product Substitution Issue 282 37.7 41.9 signal
2 Cardiogenic Shock 36 19.4 19.6 signal
3 Status Epilepticus 22 14.9 15.0 signal
4 Generalised Tonic-clonic Seizure 30 14.1 14.2 signal
5 Coeliac Disease 17 13.3 13.4 signal
6 Product Odour Abnormal 15 11.1 11.1 signal
7 Insurance Issue 20 10.3 10.4 signal
8 Completed Suicide 111 10.1 10.5 signal
9 Intentional Overdose 81 9.7 10.0 signal
10 Crying 42 8.8 9.0 signal
11 Serotonin Syndrome 21 8.4 8.5 signal
12 Cardio-respiratory Arrest 45 8.2 8.3 signal
13 Ventricular Tachycardia 17 7.9 7.9 signal
14 Immunodeficiency 15 7.8 7.8 signal
15 Suicidal Ideation 92 7.7 7.9 signal
16 Euphoric Mood 10 7.4 7.5 signal
17 Middle Insomnia 18 7.4 7.5 signal
18 Myoclonus 11 7.1 7.1 signal
19 Inability To Afford Medication 9 7.0 7.0 signal
20 Tinnitus 42 7.0 7.1 signal
21 Suicide Attempt 52 6.6 6.7 signal
22 Sinus Tachycardia 12 6.5 6.5 signal
23 Brain Fog 12 6.3 6.3 signal
24 Depression 187 6.3 6.7 signal
25 Electrocardiogram Qt Prolonged 29 6.2 6.2 signal
26 Intentional Dose Omission 22 6.2 6.2 signal
27 Irritability 48 6.1 6.2 signal
28 Mental Status Changes 22 6.1 6.1 signal
29 Feeling Jittery 15 6.0 6.0 signal
30 Infusion Site Pain 10 6.0 6.0 signal
31 Seasonal Allergy 11 6.0 6.0 signal
32 Withdrawal Syndrome 32 5.8 5.9 signal
33 Panic Attack 27 5.7 5.7 signal
34 Economic Problem 11 5.5 5.5 signal
35 Impaired Gastric Emptying 9 5.4 5.4 signal
36 Impaired Quality Of Life 10 5.3 5.3 signal
37 Disease Recurrence 33 5.3 5.4 signal
38 Initial Insomnia 7 5.3 5.3 signal
39 Product Quality Issue 91 5.2 5.3 signal
40 Mania 11 5.1 5.1 signal
41 Disturbance In Attention 36 5.1 5.2 signal
42 Seizure 76 5.1 5.2 signal
43 Encephalopathy 16 5.0 5.0 signal
44 Anger 22 5.0 5.0 signal
45 Thinking Abnormal 12 4.9 4.9 signal
46 Mood Swings 20 4.8 4.8 signal
47 Mydriasis 8 4.8 4.8 signal
48 Surgery 36 4.8 4.8 signal
49 Prescribed Overdose 12 4.8 4.8 signal
50 Apathy 9 4.7 4.8 signal
51 Bursitis 7 4.4 4.5 signal
52 Spinal Operation 7 4.4 4.4 signal
53 Agitation 42 4.4 4.4 signal
54 Anxiety 160 4.3 4.5 signal
55 Product Physical Issue 11 4.2 4.2 signal
56 Hypokinesia 8 4.2 4.2 signal
57 Psychomotor Hyperactivity 9 4.1 4.1 signal
58 Anhedonia 14 4.1 4.1 signal
59 Impaired Driving Ability 6 4.0 4.0 signal
60 Hallucination, Visual 11 4.0 4.0 signal
61 Pharyngeal Swelling 5 4.0 4.0 signal
62 Hunger 7 4.0 4.0 signal
63 Therapy Change 5 4.0 4.0 signal
64 Knee Operation 5 3.9 4.0 signal
65 Impaired Work Ability 11 3.9 3.9 signal
66 Embedded Device 5 3.9 3.9 signal
67 Unresponsive To Stimuli 13 3.9 3.9 signal
68 Hypotonia 5 3.8 3.8 signal
69 Drug Effect Less Than Expected 7 3.8 3.8 signal
70 Nocturia 6 3.8 3.8 signal
71 Depressed Mood 26 3.8 3.8 signal
72 Poor Quality Product Administered 5 3.7 3.8 signal
73 Product Dose Omission In Error 13 3.7 3.7 signal
74 Mood Altered 13 3.7 3.7 signal
75 Intentional Product Use Issue 42 3.7 3.7 signal
76 Complication Of Device Removal 8 3.6 3.6 signal
77 Adverse Drug Reaction 42 3.6 3.6 signal
78 Poor Quality Sleep 10 3.6 3.6 signal
79 Rotator Cuff Syndrome 6 3.6 3.6 signal
80 Back Injury 5 3.5 3.5 signal
81 Laryngitis 5 3.5 3.5 signal
82 Cardiac Arrest 38 3.5 3.6 signal
83 Bedridden 6 3.5 3.5 signal
84 Dental Caries 5 3.5 3.5 signal
85 Adverse Reaction 6 3.5 3.5 signal
86 Hyperhidrosis 58 3.4 3.5 signal
87 Sinus Congestion 6 3.4 3.4 signal
88 Restless Legs Syndrome 8 3.4 3.4 signal
89 Illness 44 3.4 3.4 signal
90 Covid-19 77 3.3 3.4 signal
91 Migraine 41 3.3 3.3 signal
92 Abnormal Dreams 12 3.3 3.3 signal
93 Knee Arthroplasty 9 3.3 3.3 signal
94 Nightmare 15 3.3 3.3 signal
95 Contraindicated Product Administered 13 3.3 3.3 signal
96 Affect Lability 4 3.2 3.2 no signal
97 Decreased Immune Responsiveness 4 3.1 3.1 no signal
98 Libido Decreased 5 3.1 3.1 signal
99 Salivary Hypersecretion 4 3.1 3.1 no signal
100 Feeling Abnormal 96 3.1 3.1 signal
101 Poisoning 5 3.0 3.0 signal
102 Hypothermia 4 3.0 3.0 no signal
103 Dry Throat 4 3.0 3.0 no signal
104 Psychotic Disorder 11 2.9 2.9 signal
105 Product Taste Abnormal 5 2.8 2.9 signal
106 Intentional Product Misuse 32 2.8 2.8 signal
107 Device Occlusion 5 2.8 2.8 no signal
108 Toxicity To Various Agents 60 2.7 2.8 signal
109 Disability 7 2.7 2.7 signal
110 Abnormal Behaviour 14 2.7 2.7 signal
111 Bone Density Decreased 11 2.7 2.7 signal
112 Paranoia 6 2.7 2.7 signal
113 Overdose 71 2.5 2.6 signal
114 Nerve Compression 3 2.5 2.5 no signal
115 Blood Thyroid Stimulating Hormone Increased 3 2.5 2.5 no signal
116 Nervousness 17 2.5 2.5 signal
117 Emotional Disorder 10 2.5 2.5 signal
118 Dermatitis Atopic 16 2.5 2.5 signal
119 Unevaluable Event 24 2.4 2.4 signal
120 Laceration 3 2.4 2.4 no signal
121 Product Availability Issue 7 2.4 2.4 signal
122 Therapeutic Response Unexpected 14 2.4 2.4 signal
123 Sleep Disorder Due To A General Medical Condition 5 2.4 2.4 no signal
124 Hair Texture Abnormal 4 2.3 2.3 no signal
125 Hereditary Angioedema 3 2.2 2.2 no signal
126 Pelvic Pain 5 2.1 2.1 no signal
127 Bipolar Disorder 3 2.1 2.1 no signal
128 Sedation 7 2.1 2.1 no signal
129 Exposure Via Skin Contact 6 2.0 2.0 no signal
130 Exposure During Pregnancy 16 2.0 2.0 no signal
131 Hallucination, Auditory 4 1.9 1.9 no signal
132 Psoriasis 32 1.9 1.9 no signal
133 Needle Issue 7 1.9 1.9 no signal
134 Multiple Fractures 4 1.8 1.9 no signal
135 Tooth Loss 5 1.8 1.8 no signal
136 Hair Colour Changes 3 1.8 1.8 no signal
137 Dysmenorrhoea 3 1.8 1.8 no signal
138 Device Breakage 9 1.8 1.8 no signal
139 Menstruation Irregular 6 1.7 1.7 no signal
140 Psoriatic Arthropathy 9 1.7 1.7 no signal
141 Therapeutic Response Shortened 7 1.7 1.7 no signal
142 Product Dose Omission 14 1.6 1.6 no signal
143 Intentional Self-injury 4 1.5 1.5 no signal
144 Emotional Distress 24 1.5 1.5 no signal
145 Product Dispensing Error 4 1.4 1.4 no signal
146 Drug Withdrawal Syndrome 16 1.4 1.4 no signal
147 Extra Dose Administered 7 1.3 1.3 no signal
148 Drug Effect Decreased 9 1.3 1.3 no signal
149 Device Dislocation 7 1.2 1.2 no signal
150 Product Complaint 4 1.2 1.2 no signal
151 Drug Abuse 13 1.2 1.2 no signal
152 Dystonia 3 1.2 1.2 no signal
153 Application Site Erythema 4 1.2 1.2 no signal
154 Multiple Sclerosis 7 1.1 1.1 no signal
155 Injection Site Rash 4 1.0 1.0 no signal
156 Accidental Exposure To Product 13 1.0 1.0 no signal
157 Device Leakage 5 0.9 0.9 no signal
158 Tardive Dyskinesia 3 0.8 0.8 no signal
159 Device Malfunction 7 0.8 0.8 no signal
160 Product Adhesion Issue 3 0.6 0.6 no signal
161 Drug Dependence 8 0.4 0.4 no signal