OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Chlorambucil

137 flagged reaction(s) · 4,393 total co-reports · max PRR 45.4
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Acute Myeloid Leukaemia 131 45.4 46.9 signal
2 Myelodysplastic Syndrome 100 37.2 38.2 signal
3 Lymphopenia 58 22.2 22.5 signal
4 Cytopenia 46 20.7 20.9 signal
5 Squamous Cell Carcinoma 31 17.7 17.8 signal
6 Device Related Infection 40 13.9 14.0 signal
7 Febrile Neutropenia 162 13.1 13.6 signal
8 Respiratory Tract Infection 61 12.6 12.8 signal
9 Blood Lactate Dehydrogenase Increased 33 11.1 11.2 signal
10 Splenomegaly 24 11.0 11.1 signal
11 Cytomegalovirus Infection 34 11.0 11.0 signal
12 Lung Infection 32 10.9 11.0 signal
13 Neutropenia 275 10.9 11.6 signal
14 Thrombocytopenia 192 9.2 9.7 signal
15 Lymphadenopathy 59 8.9 9.0 signal
16 Pneumocystis Jirovecii Pneumonia 16 8.6 8.6 signal
17 Bone Marrow Failure 32 8.4 8.4 signal
18 Infusion Related Reaction 101 8.2 8.4 signal
19 Skin Infection 16 7.7 7.7 signal
20 Pancytopenia 75 7.2 7.3 signal
21 Disease Progression 156 7.1 7.3 signal
22 Leukocytosis 21 6.2 6.3 signal
23 Basal Cell Carcinoma 18 6.2 6.2 signal
24 Agranulocytosis 21 6.1 6.1 signal
25 Septic Shock 49 6.1 6.1 signal
26 Covid-19 Pneumonia 13 5.9 5.9 signal
27 Haematotoxicity 10 5.8 5.8 signal
28 Haemorrhage Intracranial 16 5.7 5.7 signal
29 Tenderness 11 5.6 5.7 signal
30 Lymphoma 16 5.5 5.6 signal
31 Nephropathy Toxic 11 5.3 5.3 signal
32 Leukopenia 49 5.3 5.3 signal
33 Body Temperature Increased 20 5.2 5.3 signal
34 Incorrect Product Storage 13 5.2 5.2 signal
35 Pneumonitis 26 5.2 5.2 signal
36 Leukaemia 9 5.1 5.1 signal
37 Transaminases Increased 21 5.1 5.1 signal
38 Neoplasm Progression 31 4.7 4.8 signal
39 Cardiomyopathy 13 4.7 4.7 signal
40 Intentional Product Use Issue 77 4.7 4.8 signal
41 Infection 124 4.6 4.7 signal
42 Treatment Failure 70 4.6 4.6 signal
43 Sudden Death 9 4.5 4.5 signal
44 Posterior Reversible Encephalopathy Syndrome 8 4.5 4.5 signal
45 Cardiac Disorder 78 4.4 4.5 signal
46 Anaemia 157 4.4 4.5 signal
47 Hemiparesis 14 4.4 4.4 signal
48 Pneumonia 265 4.4 4.6 signal
49 Malignant Neoplasm Progression 83 4.4 4.4 signal
50 Bacterial Infection 15 4.3 4.3 signal
51 Sepsis 89 4.3 4.3 signal
52 Lymphocyte Count Decreased 14 4.2 4.3 signal
53 Drug Reaction With Eosinophilia And Systemic Symptoms 20 4.2 4.2 signal
54 White Blood Cell Count Increased 30 4.2 4.2 signal
55 Polyneuropathy 9 4.1 4.1 signal
56 Cardiac Failure Congestive 61 4.0 4.1 signal
57 Rash Maculo-papular 16 3.9 3.9 signal
58 Hospice Care 7 3.8 3.8 signal
59 Disseminated Intravascular Coagulation 10 3.8 3.8 signal
60 Tubulointerstitial Nephritis 13 3.7 3.7 signal
61 Pyrexia 237 3.7 3.8 signal
62 Night Sweats 22 3.7 3.7 signal
63 Bacteraemia 8 3.6 3.6 signal
64 Pleural Effusion 41 3.6 3.6 signal
65 Malignant Melanoma 9 3.6 3.6 signal
66 Therapy Partial Responder 10 3.6 3.6 signal
67 Herpes Zoster 38 3.5 3.6 signal
68 Urosepsis 6 3.5 3.5 signal
69 Chills 76 3.5 3.5 signal
70 Neurotoxicity 11 3.4 3.4 signal
71 Hepatotoxicity 14 3.4 3.4 signal
72 Bronchospasm 9 3.4 3.4 signal
73 Immunodeficiency 9 3.3 3.3 signal
74 Colon Cancer 9 3.2 3.2 signal
75 Candida Infection 10 3.2 3.2 signal
76 Blood Pressure Decreased 39 3.1 3.2 signal
77 Neutrophil Count Increased 6 3.1 3.1 signal
78 Hyperglycaemia 21 3.1 3.1 signal
79 Cytokine Release Syndrome 11 3.1 3.1 signal
80 Gastroenteritis 8 2.9 2.9 signal
81 Oesophagitis 6 2.9 2.9 signal
82 Acute Myocardial Infarction 16 2.9 2.9 signal
83 Musculoskeletal Chest Pain 8 2.8 2.8 signal
84 Multi-organ Failure 9 2.7 2.8 signal
85 Atrial Fibrillation 50 2.7 2.8 signal
86 Skin Cancer 11 2.7 2.7 signal
87 Cholecystitis 6 2.7 2.7 signal
88 Myoclonus 6 2.7 2.7 signal
89 White Blood Cell Count Decreased 54 2.7 2.7 signal
90 Hypercalcaemia 6 2.6 2.6 signal
91 Folliculitis 5 2.6 2.6 no signal
92 Drug Administration Error 15 2.6 2.6 signal
93 Petechiae 5 2.6 2.6 no signal
94 Fungal Infection 16 2.6 2.6 signal
95 Proteinuria 9 2.6 2.6 signal
96 Platelet Count Decreased 50 2.5 2.5 signal
97 Drug Resistance 12 2.5 2.5 signal
98 Mucosal Inflammation 12 2.5 2.5 signal
99 Platelet Count Increased 6 2.5 2.5 no signal
100 Anorexia 6 2.5 2.5 no signal
101 Hypertensive Crisis 5 2.4 2.4 no signal
102 Cerebral Haemorrhage 16 2.4 2.4 signal
103 Neoplasm 5 2.3 2.3 no signal
104 Skin Reaction 6 2.3 2.3 no signal
105 Lower Respiratory Tract Infection 19 2.2 2.3 signal
106 Hypokinesia 6 2.2 2.2 no signal
107 Inappropriate Antidiuretic Hormone Secretion 4 2.1 2.1 no signal
108 Blood Count Abnormal 6 2.1 2.1 no signal
109 Transfusion 4 2.0 2.0 no signal
110 Cholestasis 7 2.0 2.0 no signal
111 Dementia 10 1.9 1.9 no signal
112 Disease Recurrence 17 1.9 1.9 no signal
113 Hepatocellular Injury 5 1.9 1.9 no signal
114 Subdural Haematoma 5 1.9 1.9 no signal
115 Eosinophilia 6 1.8 1.8 no signal
116 Local Swelling 6 1.8 1.8 no signal
117 Increased Tendency To Bruise 3 1.7 1.7 no signal
118 No Therapeutic Response 4 1.7 1.7 no signal
119 Erythema Multiforme 3 1.7 1.7 no signal
120 Grand Mal Convulsion 3 1.7 1.7 no signal
121 Myelosuppression 10 1.6 1.6 no signal
122 Drug Toxicity 4 1.6 1.6 no signal
123 Toxicity To Various Agents 45 1.4 1.4 no signal
124 Rebound Effect 3 1.4 1.4 no signal
125 Hepatitis C 3 1.3 1.3 no signal
126 Hepatic Cytolysis 3 1.3 1.3 no signal
127 Neoplasm Malignant 16 1.3 1.3 no signal
128 Synovitis 4 1.2 1.2 no signal
129 Palmar-plantar Erythrodysaesthesia Syndrome 5 1.1 1.1 no signal
130 Drug Dispensing Error 3 1.0 1.0 no signal
131 Drug Exposure During Pregnancy 6 0.9 0.9 no signal
132 Drug Effect Incomplete 6 0.9 0.9 no signal
133 Pharmaceutical Product Complaint 4 0.8 0.8 no signal
134 Product Storage Error 12 0.7 0.7 no signal
135 Prostate Cancer 10 0.7 0.7 no signal
136 Renal Cancer 3 0.3 0.3 no signal
137 Bladder Cancer 3 0.3 0.3 no signal