Drug

Clofarabine

97 flagged reaction(s) · 3,183 total co-reports · max PRR 71.2

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Haematotoxicity	71	71.2	73.5	signal
2	Mucosal Inflammation	125	44.5	47.0	signal
3	Febrile Neutropenia	270	37.8	42.8	signal
4	Hyperbilirubinaemia	42	37.8	38.5	signal
5	Bone Marrow Failure	82	37.2	38.5	signal
6	Multi-organ Failure	68	35.9	37.0	signal
7	Acute Myeloid Leukaemia	60	35.7	36.7	signal
8	Blood Bilirubin Increased	97	33.2	34.6	signal
9	Multiple Organ Dysfunction Syndrome	89	29.5	30.7	signal
10	Nephropathy Toxic	33	27.4	27.8	signal
11	Palmar-plantar Erythrodysaesthesia Syndrome	68	26.9	27.7	signal
12	Hepatotoxicity	60	25.1	25.7	signal
13	Transaminases Increased	52	21.7	22.1	signal
14	Posterior Reversible Encephalopathy Syndrome	20	19.4	19.6	signal
15	Pancytopenia	100	16.6	17.3	signal
16	Septic Shock	73	15.6	16.1	signal
17	Cytomegalovirus Infection	27	15.0	15.2	signal
18	Staphylococcal Infection	51	14.2	14.5	signal
19	Aspartate Aminotransferase Increased	81	14.1	14.6	signal
20	Bacterial Infection	28	13.9	14.1	signal
21	Encephalopathy	36	13.6	13.8	signal
22	Oedema	79	13.5	13.9	signal
23	Bacteraemia	17	13.4	13.4	signal
24	Sepsis	159	13.2	14.1	signal
25	Alanine Aminotransferase Increased	86	12.9	13.4	signal
26	Cytokine Release Syndrome	26	12.6	12.7	signal
27	Toxic Epidermal Necrolysis	20	12.3	12.4	signal
28	Renal Failure Acute	54	11.6	11.9	signal
29	Neurotoxicity	19	10.1	10.2	signal
30	Coagulopathy	18	10.0	10.1	signal
31	Lung Infection	17	10.0	10.0	signal
32	Respiratory Failure	76	9.6	9.9	signal
33	Thrombotic Microangiopathy	10	9.5	9.6	signal
34	Acute Respiratory Distress Syndrome	18	9.4	9.5	signal
35	Fluid Overload	15	9.4	9.4	signal
36	Disseminated Intravascular Coagulation	14	9.2	9.2	signal
37	Generalised Oedema	12	9.0	9.0	signal
38	Atelectasis	9	8.6	8.6	signal
39	Pneumocystis Jirovecii Pneumonia	9	8.3	8.3	signal
40	Myelodysplastic Syndrome	13	8.3	8.3	signal
41	Neutropenia	121	8.3	8.7	signal
42	Drug Resistance	22	7.9	8.0	signal
43	Dialysis	12	7.8	7.8	signal
44	Fungal Infection	28	7.8	7.9	signal
45	Malnutrition	9	7.5	7.5	signal
46	Hypoxia	28	7.4	7.5	signal
47	Respiratory Distress	21	7.0	7.1	signal
48	Clostridium Difficile Colitis	8	7.0	7.0	signal
49	Thrombocytopenia	81	6.7	6.9	signal
50	Ascites	21	6.6	6.6	signal
51	Device Related Infection	11	6.6	6.6	signal
52	Pleural Effusion	43	6.5	6.6	signal
53	Pericardial Effusion	16	6.4	6.5	signal
54	Hepatic Failure	21	6.4	6.5	signal
55	Rash Maculo-papular	15	6.3	6.3	signal
56	Cerebral Haemorrhage	24	6.2	6.3	signal
57	No Therapeutic Response	8	6.0	6.0	signal
58	Leukaemia	6	5.9	5.9	signal
59	Therapy Non-responder	28	5.8	5.9	signal
60	Subdural Haematoma	9	5.8	5.8	signal
61	Renal Tubular Necrosis	6	5.6	5.6	signal
62	Eyelid Oedema	7	5.5	5.5	signal
63	Splenomegaly	7	5.5	5.5	signal
64	Tachypnoea	8	5.5	5.5	signal
65	Polyneuropathy	7	5.4	5.4	signal
66	Circulatory Collapse	10	5.4	5.4	signal
67	Mental Status Changes	16	5.3	5.3	signal
68	Ileus	7	5.3	5.3	signal
69	Colitis	21	5.1	5.2	signal
70	Disease Progression	65	5.1	5.2	signal
71	Candida Infection	9	5.0	5.0	signal
72	Acute Hepatic Failure	7	4.8	4.8	signal
73	Pulmonary Oedema	23	4.7	4.8	signal
74	Stomatitis	31	4.7	4.8	signal
75	Drug Eruption	9	4.7	4.7	signal
76	Haemorrhage Intracranial	7	4.3	4.3	signal
77	Clostridium Difficile Infection	10	4.3	4.3	signal
78	Metabolic Acidosis	14	4.1	4.1	signal
79	Drug Ineffective For Unapproved Indication	24	4.0	4.0	signal
80	Hepatocellular Injury	6	3.9	3.9	signal
81	Myelosuppression	14	3.8	3.8	signal
82	Hepatic Function Abnormal	15	3.7	3.8	signal
83	Treatment Failure	33	3.7	3.8	signal
84	Neoplasm Progression	14	3.7	3.7	signal
85	Subarachnoid Haemorrhage	4	3.6	3.6	signal
86	Neutrophil Count Decreased	15	3.4	3.4	signal
87	Pneumonitis	10	3.4	3.4	signal
88	Pericarditis	6	3.3	3.3	signal
89	Grand Mal Convulsion	3	3.0	3.0	no signal
90	Eye Haemorrhage	4	2.8	2.8	no signal
91	Toxic Skin Eruption	3	2.7	2.7	no signal
92	Drug Toxicity	4	2.7	2.7	no signal
93	Pulmonary Arterial Hypertension	4	2.5	2.5	no signal
94	Convulsion	15	2.4	2.4	signal
95	Cytopenia	3	2.3	2.3	no signal
96	Hepatitis C	3	2.3	2.3	no signal
97	Tuberculosis	3	2.2	2.2	no signal