OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Dacarbazine

271 flagged reaction(s) · 12,134 total co-reports · max PRR 34.6
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Acute Myeloid Leukaemia 188 34.6 35.4 signal
2 Febrile Neutropenia 643 27.7 30.3 signal
3 Pneumocystis Jirovecii Pneumonia 86 24.5 24.8 signal
4 Haematotoxicity 55 16.9 17.0 signal
5 Myelodysplastic Syndrome 85 16.7 16.9 signal
6 Cytopenia 61 14.5 14.6 signal
7 Therapy Partial Responder 71 13.4 13.5 signal
8 Mucosal Inflammation 105 11.4 11.6 signal
9 Candida Infection 65 11.1 11.2 signal
10 Posterior Reversible Encephalopathy Syndrome 36 10.7 10.8 signal
11 Pneumonitis 102 10.7 10.8 signal
12 Neutropenia 504 10.6 11.3 signal
13 Polyneuropathy 43 10.3 10.3 signal
14 Ileus 44 10.1 10.2 signal
15 Neutrophil Count Decreased 132 9.2 9.4 signal
16 Neuropathy Peripheral 300 9.0 9.3 signal
17 Red Blood Cell Sedimentation Rate Increased 35 9.0 9.0 signal
18 Splenomegaly 36 8.7 8.8 signal
19 Spinal Pain 36 8.7 8.8 signal
20 Ejection Fraction Decreased 47 8.6 8.6 signal
21 Myelosuppression 99 8.3 8.4 signal
22 Pulmonary Congestion 38 8.1 8.2 signal
23 Clostridium Difficile Colitis 30 8.0 8.0 signal
24 Tenderness 29 7.9 7.9 signal
25 Pulmonary Fibrosis 53 7.9 7.9 signal
26 Lymphopenia 39 7.9 7.9 signal
27 Muscle Spasticity 34 7.8 7.8 signal
28 Interstitial Lung Disease 130 7.6 7.7 signal
29 Leukopenia 134 7.6 7.7 signal
30 Disease Progression 313 7.5 7.8 signal
31 Hypothyroidism 82 7.3 7.4 signal
32 Hypokinesia 35 6.8 6.9 signal
33 Bacteraemia 28 6.7 6.8 signal
34 Pancytopenia 132 6.7 6.8 signal
35 Cardiomyopathy 35 6.7 6.7 signal
36 Neoplasm Progression 83 6.7 6.8 signal
37 Metastases To Lung 27 6.6 6.7 signal
38 Premature Baby 68 6.4 6.4 signal
39 Intestinal Perforation 25 6.3 6.3 signal
40 Colitis 83 6.2 6.3 signal
41 Obesity 35 6.2 6.2 signal
42 Hepatotoxicity 48 6.1 6.2 signal
43 Hepatic Steatosis 40 6.1 6.1 signal
44 Acute Respiratory Distress Syndrome 38 6.1 6.1 signal
45 Pneumothorax 34 6.1 6.1 signal
46 Malignant Neoplasm Progression 211 5.9 6.0 signal
47 Lymphadenopathy 73 5.8 5.9 signal
48 Respiratory Failure 146 5.7 5.8 signal
49 Thrombocytopenia 223 5.7 5.8 signal
50 Septic Shock 85 5.6 5.6 signal
51 Neurotoxicity 34 5.5 5.6 signal
52 Sepsis 212 5.4 5.5 signal
53 Malignant Melanoma 25 5.3 5.3 signal
54 Brain Oedema 23 5.2 5.2 signal
55 Drug Toxicity 25 5.1 5.1 signal
56 Bone Marrow Failure 37 5.1 5.1 signal
57 Sleep Apnoea Syndrome 34 5.0 5.1 signal
58 Lung Disorder 87 5.0 5.1 signal
59 Inappropriate Antidiuretic Hormone Secretion 17 4.7 4.7 signal
60 Blood Lactate Dehydrogenase Increased 26 4.6 4.6 signal
61 Metastases To Central Nervous System 20 4.4 4.4 signal
62 Neutrophil Count Increased 16 4.4 4.4 signal
63 Transaminases Increased 33 4.2 4.2 signal
64 Sinus Tachycardia 21 4.2 4.2 signal
65 Clostridium Difficile Infection 32 4.2 4.2 signal
66 Blood Bilirubin Increased 38 4.0 4.0 signal
67 Acute Hepatic Failure 19 4.0 4.0 signal
68 Acute Myocardial Infarction 41 3.9 3.9 signal
69 Cytomegalovirus Infection 23 3.9 3.9 signal
70 Bone Pain 80 3.9 3.9 signal
71 Anaemia 254 3.8 3.9 signal
72 Hypoxia 46 3.7 3.7 signal
73 Agranulocytosis 24 3.7 3.7 signal
74 Oesophagitis 14 3.6 3.6 signal
75 Acute Respiratory Failure 24 3.5 3.6 signal
76 Premature Delivery 20 3.5 3.5 signal
77 Thrombotic Microangiopathy 12 3.5 3.5 signal
78 Hepatic Cytolysis 15 3.5 3.5 signal
79 Platelet Count Increased 16 3.5 3.5 signal
80 Metastases To Bone 20 3.5 3.5 signal
81 Disease Recurrence 58 3.4 3.5 signal
82 Drug-induced Liver Injury 37 3.4 3.4 signal
83 Hypotonia 12 3.4 3.4 signal
84 Staphylococcal Infection 39 3.3 3.3 signal
85 Tachycardia 104 3.3 3.3 signal
86 Leukaemia 11 3.3 3.3 signal
87 Haematoma 30 3.3 3.3 signal
88 Exposure During Pregnancy 71 3.2 3.3 signal
89 White Blood Cell Count Decreased 123 3.2 3.2 signal
90 Pericardial Effusion 26 3.2 3.2 signal
91 Neoplasm 13 3.2 3.2 signal
92 Pyrexia 387 3.2 3.3 signal
93 Device Related Infection 17 3.1 3.1 signal
94 Viral Infection 36 3.1 3.1 signal
95 Alanine Aminotransferase Increased 66 3.0 3.1 signal
96 Hyperbilirubinaemia 11 3.0 3.0 signal
97 Aspartate Aminotransferase Increased 56 3.0 3.0 signal
98 Bacterial Infection 19 2.9 2.9 signal
99 Encephalopathy 25 2.9 2.9 signal
100 Tuberculosis 13 2.9 2.9 signal
101 Oral Candidiasis 13 2.8 2.8 signal
102 Cholestasis 19 2.8 2.8 signal
103 Disseminated Intravascular Coagulation 14 2.8 2.8 signal
104 Cardiogenic Shock 14 2.8 2.8 signal
105 Product Use In Unapproved Indication 239 2.8 2.8 signal
106 Mitral Valve Incompetence 11 2.8 2.8 signal
107 Pleural Effusion 59 2.7 2.8 signal
108 Hyponatraemia 54 2.7 2.7 signal
109 Hepatic Failure 29 2.7 2.7 signal
110 Hepatic Function Abnormal 35 2.7 2.7 signal
111 Infusion Site Pain 12 2.7 2.7 signal
112 Respiratory Disorder 28 2.6 2.6 signal
113 Foetal Exposure During Pregnancy 75 2.6 2.6 signal
114 Inflammation 47 2.6 2.6 signal
115 C-reactive Protein Increased 33 2.6 2.6 signal
116 Lymphocyte Count Decreased 16 2.6 2.6 signal
117 Deep Vein Thrombosis 59 2.6 2.6 signal
118 Haematocrit Decreased 18 2.6 2.6 signal
119 Gamma-glutamyltransferase Increased 20 2.6 2.6 signal
120 Hypercalcaemia 11 2.5 2.5 signal
121 Hypothermia 9 2.5 2.5 signal
122 Myocarditis 10 2.5 2.5 signal
123 Stomatitis 53 2.5 2.5 signal
124 Electrolyte Imbalance 10 2.5 2.5 signal
125 White Blood Cell Count Increased 33 2.4 2.4 signal
126 Anaphylactic Reaction 47 2.4 2.4 signal
127 Metastases To Liver 15 2.4 2.4 signal
128 Hypocalcaemia 16 2.4 2.4 signal
129 Infection 121 2.4 2.4 signal
130 Adrenal Insufficiency 10 2.4 2.4 signal
131 Hyperglycaemia 30 2.3 2.3 signal
132 Lung Infection 13 2.3 2.3 signal
133 Multiple Organ Dysfunction Syndrome 23 2.3 2.3 signal
134 General Physical Health Deterioration 94 2.3 2.3 signal
135 Hepatomegaly 8 2.3 2.3 signal
136 Cardiac Failure 65 2.3 2.3 signal
137 Nephropathy Toxic 9 2.3 2.3 signal
138 Pancreatitis Acute 18 2.3 2.3 signal
139 Intestinal Obstruction 30 2.3 2.3 signal
140 Mass 11 2.2 2.2 signal
141 Myocardial Ischaemia 9 2.2 2.2 signal
142 Abdominal Pain 181 2.2 2.2 signal
143 Drug Ineffective For Unapproved Indication 43 2.2 2.2 signal
144 Caesarean Section 9 2.2 2.2 signal
145 Appendicitis 7 2.1 2.1 no signal
146 Orthostatic Hypotension 13 2.1 2.1 signal
147 Treatment Failure 61 2.1 2.1 signal
148 Drug Resistance 19 2.1 2.1 signal
149 Ischaemic Stroke 13 2.1 2.1 signal
150 Coagulopathy 12 2.0 2.0 signal
151 Malnutrition 8 2.0 2.0 no signal
152 Hypokalaemia 33 2.0 2.0 signal
153 Drug Intolerance 68 2.0 2.0 no signal
154 Off Label Use 613 2.0 2.1 no signal
155 Hepatocellular Injury 10 2.0 2.0 no signal
156 Dehydration 93 2.0 2.0 no signal
157 Pulmonary Oedema 31 2.0 2.0 no signal
158 Toxicity To Various Agents 116 2.0 2.0 no signal
159 Multi-organ Failure 12 1.9 1.9 no signal
160 Night Sweats 22 1.9 1.9 no signal
161 Rash Maculo-papular 15 1.9 1.9 no signal
162 Haemorrhage Intracranial 10 1.9 1.9 no signal
163 Tachypnoea 9 1.9 1.9 no signal
164 Liver Injury 16 1.9 1.9 no signal
165 Platelet Count Decreased 70 1.9 1.9 no signal
166 Small Intestinal Obstruction 8 1.8 1.8 no signal
167 Blood Alkaline Phosphatase Increased 16 1.8 1.8 no signal
168 Hepatic Encephalopathy 6 1.8 1.8 no signal
169 Pneumonia 207 1.8 1.8 no signal
170 Abortion Induced 6 1.8 1.8 no signal
171 Osteonecrosis 21 1.8 1.8 no signal
172 Skin Infection 7 1.8 1.8 no signal
173 Hyperthyroidism 9 1.8 1.8 no signal
174 Abortion Spontaneous 25 1.8 1.8 no signal
175 Respiratory Distress 17 1.7 1.7 no signal
176 Liver Function Test Abnormal 18 1.7 1.7 no signal
177 Anorexia 8 1.7 1.7 no signal
178 Generalised Tonic-clonic Seizure 10 1.7 1.7 no signal
179 Immunodeficiency 9 1.7 1.7 no signal
180 Pulmonary Embolism 58 1.7 1.7 no signal
181 Chills 70 1.7 1.7 no signal
182 Toxic Skin Eruption 6 1.7 1.7 no signal
183 Dysphagia 56 1.7 1.7 no signal
184 Speech Disorder 31 1.7 1.7 no signal
185 Tubulointerstitial Nephritis 11 1.7 1.7 no signal
186 Stevens-johnson Syndrome 13 1.7 1.7 no signal
187 Proteinuria 11 1.7 1.7 no signal
188 Blood Creatinine Increased 38 1.6 1.6 no signal
189 Diverticulitis 16 1.6 1.6 no signal
190 Hypomagnesaemia 8 1.6 1.6 no signal
191 Fear 15 1.6 1.6 no signal
192 Hypophagia 14 1.6 1.6 no signal
193 Haematemesis 14 1.6 1.6 no signal
194 Pelvic Pain 10 1.6 1.6 no signal
195 Neoplasm Malignant 36 1.5 1.5 no signal
196 Hypertensive Crisis 6 1.5 1.5 no signal
197 Colon Cancer 8 1.5 1.5 no signal
198 Cellulitis 27 1.5 1.5 no signal
199 Nephropathy 5 1.5 1.5 no signal
200 Cerebral Haemorrhage 19 1.5 1.5 no signal
201 Status Epilepticus 6 1.5 1.5 no signal
202 Sinus Bradycardia 5 1.5 1.5 no signal
203 Nervous System Disorder 16 1.4 1.4 no signal
204 Cardiovascular Disorder 13 1.4 1.4 no signal
205 Cholecystitis 6 1.4 1.4 no signal
206 Covid-19 Pneumonia 6 1.4 1.4 no signal
207 Herpes Zoster 29 1.4 1.4 no signal
208 Ataxia 6 1.4 1.4 no signal
209 Electrocardiogram Qt Prolonged 18 1.4 1.4 no signal
210 Blood Test Abnormal 7 1.4 1.4 no signal
211 Skin Reaction 7 1.4 1.4 no signal
212 Sensory Disturbance 8 1.4 1.4 no signal
213 Haemoglobin Decreased 51 1.4 1.4 no signal
214 Ventricular Tachycardia 8 1.4 1.4 no signal
215 Gastrointestinal Disorder 42 1.3 1.3 no signal
216 Device Malfunction 31 1.3 1.3 no signal
217 Thyroid Disorder 7 1.3 1.3 no signal
218 Lymphoma 7 1.3 1.3 no signal
219 Blood Triglycerides Increased 8 1.3 1.3 no signal
220 Basal Cell Carcinoma 7 1.3 1.3 no signal
221 Myalgia 76 1.3 1.3 no signal
222 Lactic Acidosis 14 1.2 1.2 no signal
223 Dermatitis 9 1.2 1.2 no signal
224 Abdominal Pain Lower 11 1.2 1.2 no signal
225 Maternal Exposure During Pregnancy 38 1.2 1.2 no signal
226 Palmar-plantar Erythrodysaesthesia Syndrome 10 1.2 1.2 no signal
227 Blindness Unilateral 6 1.2 1.2 no signal
228 Pain In Jaw 12 1.2 1.2 no signal
229 Dialysis 6 1.2 1.2 no signal
230 Loss Of Consciousness 54 1.2 1.2 no signal
231 Blindness 17 1.2 1.2 no signal
232 Fluid Overload 6 1.2 1.2 no signal
233 No Therapeutic Response 5 1.1 1.1 no signal
234 Dermatitis Allergic 5 1.1 1.1 no signal
235 Drug Abuse 33 1.1 1.1 no signal
236 Anaphylactic Shock 10 1.1 1.1 no signal
237 Visual Acuity Reduced 13 1.1 1.1 no signal
238 Angina Pectoris 11 1.1 1.1 no signal
239 Immune System Disorder 5 1.1 1.1 no signal
240 Abscess 6 1.1 1.1 no signal
241 Jaundice 10 1.0 1.0 no signal
242 Pregnancy 7 1.0 1.0 no signal
243 Cardiac Failure Congestive 28 1.0 1.0 no signal
244 Pulmonary Arterial Hypertension 5 1.0 1.0 no signal
245 Myoclonus 4 0.9 0.9 no signal
246 Diabetic Ketoacidosis 8 0.9 0.9 no signal
247 Hepatitis C 4 0.9 0.9 no signal
248 Erythema Multiforme 3 0.9 0.9 no signal
249 Drug Exposure During Pregnancy 11 0.9 0.9 no signal
250 Hair Colour Changes 4 0.9 0.9 no signal
251 Erectile Dysfunction 8 0.9 0.9 no signal
252 Sars-cov-2 Test Positive 4 0.8 0.8 no signal
253 Uveitis 4 0.8 0.8 no signal
254 Coronary Artery Occlusion 4 0.8 0.8 no signal
255 Osteonecrosis Of Jaw 7 0.8 0.8 no signal
256 Convulsion 16 0.8 0.8 no signal
257 Anosmia 4 0.8 0.8 no signal
258 Drug Reaction With Eosinophilia And Systemic Symptoms 7 0.8 0.8 no signal
259 Madarosis 3 0.7 0.7 no signal
260 Activities Of Daily Living Impaired 5 0.7 0.7 no signal
261 Thyroid Cancer 3 0.7 0.7 no signal
262 Lung Neoplasm Malignant 10 0.7 0.7 no signal
263 Hair Texture Abnormal 3 0.6 0.6 no signal
264 Sickle Cell Anaemia With Crisis 3 0.5 0.5 no signal
265 Amenorrhoea 3 0.5 0.5 no signal
266 Drug Effective For Unapproved Indication 5 0.5 0.5 no signal
267 Gastric Cancer 4 0.4 0.4 no signal
268 Breast Cancer Female 4 0.4 0.4 no signal
269 Device Delivery System Issue 3 0.3 0.3 no signal
270 Device Use Error 3 0.2 0.2 no signal
271 Renal Cancer 3 0.2 0.2 no signal