Drug

Emtricitabine, Rilpivirine Hydrochloride, And Tenofovir Disoproxil Fumarate

89 flagged reaction(s) · 32,532 total co-reports · max PRR 1,130.6

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Skeletal Injury	2,775	1,130.6	1,925.1	signal
2	Bone Density Decreased	3,553	394.7	836.1	signal
3	Bone Loss	1,565	359.0	467.6	signal
4	Renal Injury	2,962	341.9	610.5	signal
5	Tooth Loss	2,002	331.2	471.3	signal
6	Multiple Fractures	1,518	314.9	406.4	signal
7	Osteopenia	896	194.7	224.5	signal
8	Anhedonia	1,219	150.5	183.7	signal
9	Osteonecrosis	1,517	149.7	193.0	signal
10	Vitamin D Deficiency	380	126.6	134.1	signal
11	Osteoporosis	1,384	108.5	136.4	signal
12	Nephropathy	297	102.0	106.6	signal
13	Economic Problem	406	84.4	89.8	signal
14	Chronic Kidney Disease	1,993	83.3	118.0	signal
15	Tooth Fracture	149	42.7	43.7	signal
16	Renal Failure	1,621	38.3	50.1	signal
17	Emotional Distress	1,370	35.6	44.4	signal
18	Fracture	209	34.8	35.9	signal
19	Foot Fracture	192	31.8	32.7	signal
20	Bone Disorder	178	30.5	31.3	signal
21	Ankle Fracture	141	28.6	29.2	signal
22	Wrist Fracture	90	23.6	23.9	signal
23	Intervertebral Disc Degeneration	69	23.3	23.5	signal
24	End Stage Renal Disease	132	22.5	22.9	signal
25	Dental Caries	75	21.3	21.5	signal
26	Blood Creatinine Increased	413	19.8	21.0	signal
27	Rib Fracture	111	17.0	17.2	signal
28	Proteinuria	89	14.8	15.0	signal
29	Hip Arthroplasty	70	14.4	14.6	signal
30	Anxiety	1,263	13.9	16.8	signal
31	Renal Impairment	330	12.3	12.9	signal
32	Decreased Activity	41	12.0	12.0	signal
33	Osteoarthritis	158	11.6	11.9	signal
34	Glomerular Filtration Rate Decreased	44	11.4	11.4	signal
35	Upper Limb Fracture	69	10.8	10.9	signal
36	Quality Of Life Decreased	45	10.5	10.5	signal
37	Lower Limb Fracture	59	9.7	9.7	signal
38	Acute Kidney Injury	440	9.0	9.6	signal
39	Hip Fracture	86	8.4	8.5	signal
40	Tooth Extraction	32	8.0	8.1	signal
41	Pain	1,390	7.1	8.6	signal
42	Spinal Fracture	40	6.3	6.3	signal
43	Dysstasia	53	5.7	5.7	signal
44	Nephrolithiasis	75	5.1	5.2	signal
45	Loss Of Personal Independence In Daily Activities	67	4.4	4.4	signal
46	Renal Tubular Necrosis	13	4.1	4.1	signal
47	Bone Pain	76	4.0	4.1	signal
48	Pregnancy	26	4.0	4.0	signal
49	Impaired Work Ability	27	3.9	3.9	signal
50	Renal Pain	13	3.8	3.8	signal
51	Femur Fracture	32	3.2	3.2	signal
52	Renal Disorder	47	3.1	3.2	signal
53	Depression	198	2.7	2.8	signal
54	Abnormal Dreams	23	2.6	2.6	signal
55	Joint Injury	17	2.5	2.5	signal
56	Kidney Infection	15	2.4	2.4	signal
57	Knee Arthroplasty	15	2.2	2.2	signal
58	Tooth Disorder	16	2.2	2.2	signal
59	Eating Disorder	15	2.2	2.2	signal
60	Nightmare	24	2.2	2.2	signal
61	Joint Dislocation	7	2.1	2.1	no signal
62	Mobility Decreased	46	2.0	2.0	signal
63	Intervertebral Disc Protrusion	14	2.0	2.0	no signal
64	Osteomyelitis	11	1.9	1.9	no signal
65	Tooth Abscess	6	1.8	1.8	no signal
66	Haematuria	20	1.8	1.8	no signal
67	Pollakiuria	24	1.8	1.8	no signal
68	Back Injury	6	1.7	1.7	no signal
69	Nerve Injury	6	1.7	1.7	no signal
70	Spinal Pain	6	1.6	1.6	no signal
71	Arthritis	39	1.5	1.5	no signal
72	Gait Disturbance	92	1.5	1.5	no signal
73	Toothache	8	1.4	1.4	no signal
74	Drug Resistance	11	1.3	1.3	no signal
75	Abortion Induced	4	1.3	1.3	no signal
76	Fear	11	1.3	1.3	no signal
77	Bipolar Disorder	4	1.1	1.1	no signal
78	Nephropathy Toxic	4	1.1	1.1	no signal
79	Tendon Rupture	4	1.0	1.0	no signal
80	Musculoskeletal Disorder	6	1.0	1.0	no signal
81	Renal Cancer	14	0.9	0.9	no signal
82	Abortion Spontaneous	11	0.9	0.9	no signal
83	Foetal Exposure During Pregnancy	21	0.8	0.8	no signal
84	Sexual Dysfunction	3	0.8	0.8	no signal
85	Hepatitis C	3	0.8	0.8	no signal
86	Exposure During Pregnancy	15	0.8	0.8	no signal
87	Product Dispensing Error	5	0.7	0.7	no signal
88	Product Taste Abnormal	3	0.7	0.7	no signal
89	Extrapyramidal Disorder	3	0.4	0.4	no signal