OpenPV Signal Explorer
FAERS disproportionality dashboard
← All drugs
Drug

Entacapone

256 flagged reaction(s) · 10,862 total co-reports · max PRR 65.0
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Muscle Rigidity 152 65.0 67.5 signal
2 Dyskinesia 481 60.6 68.4 signal
3 Hallucination, Visual 192 46.6 48.8 signal
4 Delusion 110 36.1 37.1 signal
5 Hallucination 496 33.6 38.0 signal
6 Dystonia 123 32.1 33.0 signal
7 Orthostatic Hypotension 87 25.3 25.8 signal
8 Nocturia 58 24.3 24.6 signal
9 Device Occlusion 60 21.9 22.2 signal
10 Neuroleptic Malignant Syndrome 49 20.9 21.1 signal
11 Therapeutic Response Shortened 116 18.5 19.0 signal
12 Psychotic Disorder 97 16.6 17.0 signal
13 Paranoia 52 15.2 15.4 signal
14 Abnormal Dreams 71 12.9 13.1 signal
15 Dementia 71 12.9 13.1 signal
16 Initial Insomnia 26 12.9 13.0 signal
17 Motor Dysfunction 25 12.5 12.6 signal
18 Joint Dislocation 26 12.5 12.6 signal
19 Hypokinesia 35 12.2 12.3 signal
20 Parkinsonism 23 11.9 12.0 signal
21 Device Use Issue 40 11.7 11.8 signal
22 Cognitive Disorder 105 11.4 11.7 signal
23 Poor Quality Sleep 48 11.3 11.5 signal
24 Hospice Care 22 11.3 11.4 signal
25 Delirium 74 10.8 11.0 signal
26 Mania 35 10.8 10.9 signal
27 Psychomotor Hyperactivity 34 10.3 10.4 signal
28 Salivary Hypersecretion 20 10.1 10.2 signal
29 Device Dislocation 86 10.0 10.2 signal
30 Aggression 96 9.7 9.9 signal
31 Restlessness 68 9.4 9.5 signal
32 Abnormal Behaviour 73 9.3 9.4 signal
33 Balance Disorder 157 9.2 9.5 signal
34 Agitation 132 9.1 9.3 signal
35 Gait Inability 58 8.9 9.0 signal
36 Choking 34 8.9 8.9 signal
37 Mobility Decreased 124 8.8 9.0 signal
38 Speech Disorder 89 8.6 8.8 signal
39 Confusional State 270 8.4 8.9 signal
40 Hip Fracture 52 8.2 8.3 signal
41 Loss Of Personal Independence In Daily Activities 77 8.2 8.3 signal
42 Middle Insomnia 30 8.2 8.2 signal
43 Tremor 265 8.1 8.5 signal
44 Device Issue 139 8.1 8.3 signal
45 Sputum Discoloured 15 8.0 8.0 signal
46 Serotonin Syndrome 30 7.9 8.0 signal
47 Quality Of Life Decreased 21 7.9 7.9 signal
48 Urinary Retention 51 7.7 7.8 signal
49 Hypophagia 38 7.6 7.6 signal
50 Therapeutic Product Effect Incomplete 104 7.4 7.6 signal
51 Nightmare 51 7.4 7.5 signal
52 Fall 475 7.2 8.0 signal
53 Restless Legs Syndrome 26 7.2 7.3 signal
54 Gait Disturbance 268 7.1 7.5 signal
55 Pneumonia Aspiration 34 6.9 6.9 signal
56 Musculoskeletal Stiffness 119 6.9 7.0 signal
57 Movement Disorder 43 6.7 6.8 signal
58 Ileus 16 6.6 6.6 signal
59 Upper Limb Fracture 26 6.6 6.6 signal
60 Head Injury 40 6.4 6.5 signal
61 Hypersomnia 36 6.4 6.4 signal
62 Depressed Level Of Consciousness 49 6.3 6.3 signal
63 Incontinence 13 6.2 6.2 signal
64 Eating Disorder 26 6.1 6.2 signal
65 Prescribed Underdose 24 6.1 6.1 signal
66 Micturition Urgency 13 5.8 5.8 signal
67 Depressed Mood 59 5.7 5.7 signal
68 Sleep Disorder 76 5.5 5.6 signal
69 Pancreatitis Acute 24 5.4 5.5 signal
70 Bedridden 14 5.4 5.4 signal
71 Dysstasia 31 5.3 5.4 signal
72 Sensory Disturbance 17 5.3 5.3 signal
73 Unevaluable Event 78 5.2 5.3 signal
74 Aphasia 31 5.2 5.2 signal
75 Polyneuropathy 12 5.1 5.1 signal
76 Somnolence 201 5.1 5.3 signal
77 Dysphagia 93 5.0 5.1 signal
78 Inappropriate Antidiuretic Hormone Secretion 10 5.0 5.0 signal
79 Euphoric Mood 10 4.9 4.9 signal
80 Disturbance In Attention 52 4.9 4.9 signal
81 Disorientation 38 4.8 4.9 signal
82 Hallucination, Auditory 15 4.8 4.8 signal
83 Memory Impairment 129 4.7 4.9 signal
84 Mydriasis 12 4.7 4.7 signal
85 Skin Laceration 10 4.7 4.7 signal
86 Embedded Device 9 4.6 4.6 signal
87 Foot Deformity 10 4.6 4.6 signal
88 Constipation 193 4.5 4.7 signal
89 Fear 24 4.5 4.5 signal
90 Mood Altered 24 4.5 4.5 signal
91 Rib Fracture 18 4.4 4.4 signal
92 Cystitis 28 4.4 4.4 signal
93 Personality Change 8 4.3 4.3 signal
94 Blood Creatine Phosphokinase Increased 25 4.3 4.3 signal
95 Irritability 51 4.3 4.3 signal
96 Urinary Tract Infection 143 4.2 4.4 signal
97 Posterior Reversible Encephalopathy Syndrome 8 4.2 4.3 signal
98 Limb Discomfort 26 4.2 4.3 signal
99 Dizziness Postural 8 4.2 4.2 signal
100 Shock 19 4.2 4.2 signal
101 Apathy 12 4.2 4.2 signal
102 Dysarthria 31 4.2 4.2 signal
103 Device Difficult To Use 54 4.1 4.2 signal
104 Encephalopathy 20 4.1 4.1 signal
105 Device Breakage 32 4.1 4.1 signal
106 Malnutrition 9 4.1 4.1 signal
107 Mitral Valve Incompetence 9 4.0 4.0 signal
108 Oral Discomfort 11 4.0 4.0 signal
109 Mental Disorder 34 3.9 4.0 signal
110 General Physical Health Deterioration 89 3.9 4.0 signal
111 Emotional Disorder 24 3.9 3.9 signal
112 Incorrect Route Of Product Administration 13 3.9 3.9 signal
113 Therapeutic Product Effect Decreased 34 3.9 3.9 signal
114 Urosepsis 7 3.8 3.8 signal
115 Chromaturia 17 3.8 3.8 signal
116 Product Administration Error 15 3.8 3.8 signal
117 Sudden Death 8 3.8 3.8 signal
118 Unresponsive To Stimuli 19 3.7 3.7 signal
119 Transient Ischaemic Attack 25 3.7 3.7 signal
120 Product Prescribing Issue 15 3.7 3.7 signal
121 Generalised Tonic-clonic Seizure 12 3.7 3.7 signal
122 Musculoskeletal Disorder 14 3.7 3.7 signal
123 Mental Status Changes 20 3.6 3.6 signal
124 Hyponatraemia 40 3.6 3.6 signal
125 Urinary Incontinence 21 3.6 3.6 signal
126 Brain Injury 7 3.5 3.5 signal
127 Skin Haemorrhage 10 3.5 3.5 signal
128 Device Leakage 29 3.5 3.5 signal
129 Dysphonia 40 3.5 3.5 signal
130 Stress 49 3.4 3.5 signal
131 Wrong Technique In Device Usage Process 31 3.4 3.4 signal
132 Drug Effect Decreased 37 3.4 3.4 signal
133 Ventricular Extrasystoles 7 3.4 3.4 signal
134 Weight Fluctuation 7 3.4 3.4 signal
135 Prescribed Overdose 13 3.4 3.4 signal
136 Drug Effect Less Than Expected 9 3.2 3.2 signal
137 Extrapyramidal Disorder 16 3.2 3.2 signal
138 Infusion Site Pain 8 3.2 3.2 signal
139 Paralysis 9 3.2 3.2 signal
140 Rotator Cuff Syndrome 8 3.1 3.1 signal
141 Dry Throat 6 3.0 3.0 signal
142 Insomnia 157 3.0 3.0 signal
143 Myoclonus 7 3.0 3.0 signal
144 Drug Interaction 92 2.9 3.0 signal
145 Mental Impairment 14 2.9 2.9 signal
146 Muscular Weakness 65 2.9 2.9 signal
147 Treatment Noncompliance 31 2.9 2.9 signal
148 Contraindicated Product Administered 17 2.8 2.9 signal
149 Subdural Haematoma 8 2.8 2.8 signal
150 Muscle Tightness 9 2.8 2.8 signal
151 Impaired Quality Of Life 8 2.8 2.8 signal
152 Blood Pressure Abnormal 11 2.8 2.8 signal
153 Body Height Decreased 6 2.8 2.8 signal
154 Product Physical Issue 11 2.8 2.8 signal
155 Incorrect Dose Administered By Device 14 2.8 2.8 signal
156 Product Prescribing Error 13 2.8 2.8 signal
157 Impaired Gastric Emptying 7 2.8 2.8 signal
158 Panic Attack 20 2.8 2.8 signal
159 Adverse Drug Reaction 49 2.8 2.8 signal
160 Gastrointestinal Pain 6 2.8 2.8 signal
161 Diplopia 14 2.7 2.7 signal
162 Anxiety 153 2.7 2.8 signal
163 Thinking Abnormal 10 2.7 2.7 signal
164 Underdose 39 2.7 2.7 signal
165 Dry Mouth 43 2.7 2.7 signal
166 Foot Fracture 10 2.7 2.7 signal
167 Gastric Ulcer 10 2.7 2.7 signal
168 Sars-cov-2 Test Positive 7 2.6 2.6 signal
169 Muscle Twitching 12 2.6 2.6 signal
170 Throat Irritation 23 2.6 2.6 signal
171 Product Dose Omission 34 2.6 2.6 signal
172 Unintentional Medical Device Removal 6 2.6 2.6 signal
173 Hyperhidrosis 66 2.6 2.6 signal
174 Head Discomfort 9 2.6 2.6 signal
175 Abscess 8 2.5 2.5 signal
176 Feeding Disorder 10 2.5 2.5 signal
177 Wrist Fracture 6 2.5 2.5 signal
178 Blood Pressure Fluctuation 12 2.5 2.5 signal
179 Carpal Tunnel Syndrome 7 2.5 2.5 signal
180 Spinal Operation 6 2.5 2.5 signal
181 Hypothermia 5 2.5 2.5 no signal
182 Sluggishness 5 2.5 2.5 no signal
183 Loss Of Consciousness 62 2.4 2.5 signal
184 Cough 134 2.4 2.5 signal
185 Altered State Of Consciousness 10 2.3 2.3 signal
186 Back Injury 5 2.3 2.3 no signal
187 Hip Arthroplasty 7 2.3 2.3 signal
188 Feeling Abnormal 109 2.3 2.3 signal
189 Therapeutic Response Unexpected 20 2.2 2.2 signal
190 Anger 15 2.2 2.2 signal
191 Gastric Haemorrhage 5 2.2 2.2 no signal
192 Coordination Abnormal 6 2.2 2.2 no signal
193 Increased Appetite 8 2.1 2.2 no signal
194 Fracture 8 2.1 2.1 no signal
195 Product Dose Omission Issue 117 2.1 2.1 signal
196 Neurotoxicity 7 2.0 2.0 no signal
197 Bladder Disorder 4 2.0 2.0 no signal
198 Death 345 2.0 2.1 signal
199 Expired Product Administered 13 2.0 2.0 no signal
200 Economic Problem 6 2.0 2.0 no signal
201 Product Use Complaint 6 2.0 2.0 no signal
202 Haematoma 10 1.9 1.9 no signal
203 Rhabdomyolysis 16 1.9 1.9 no signal
204 Coma 18 1.9 1.9 no signal
205 Product Packaging Quantity Issue 4 1.9 1.9 no signal
206 Injection Site Nodule 4 1.8 1.8 no signal
207 Ageusia 9 1.8 1.8 no signal
208 Stevens-johnson Syndrome 8 1.8 1.8 no signal
209 Cardiovascular Disorder 9 1.8 1.8 no signal
210 Impaired Driving Ability 4 1.8 1.8 no signal
211 Activities Of Daily Living Impaired 7 1.8 1.8 no signal
212 Sedation 9 1.7 1.7 no signal
213 Anosmia 5 1.7 1.7 no signal
214 Device Delivery System Issue 9 1.7 1.7 no signal
215 Accident 4 1.7 1.7 no signal
216 Therapy Cessation 17 1.7 1.7 no signal
217 Intentional Dose Omission 9 1.7 1.7 no signal
218 Femur Fracture 10 1.6 1.6 no signal
219 Hospitalisation 48 1.6 1.6 no signal
220 Laceration 3 1.6 1.6 no signal
221 Hernia 6 1.6 1.6 no signal
222 Knee Operation 3 1.6 1.6 no signal
223 Withdrawal Syndrome 13 1.6 1.6 no signal
224 Inability To Afford Medication 3 1.5 1.5 no signal
225 Malignant Melanoma 4 1.5 1.5 no signal
226 Product Dose Omission In Error 8 1.5 1.5 no signal
227 Breast Pain 3 1.4 1.4 no signal
228 Nephropathy Toxic 3 1.4 1.4 no signal
229 Drug Abuse 22 1.3 1.3 no signal
230 Suicidal Ideation 24 1.3 1.3 no signal
231 Incorrect Dose Administered 58 1.3 1.3 no signal
232 Tardive Dyskinesia 7 1.2 1.2 no signal
233 Suicide Attempt 14 1.2 1.2 no signal
234 Product Dispensing Error 5 1.2 1.2 no signal
235 Anorexia 3 1.2 1.2 no signal
236 Extra Dose Administered 9 1.1 1.1 no signal
237 Drug Administration Error 7 1.1 1.1 no signal
238 Drug Effect Incomplete 8 1.1 1.1 no signal
239 Drug Withdrawal Syndrome 19 1.1 1.1 no signal
240 Device Defective 3 0.9 0.9 no signal
241 Wrong Technique In Product Usage Process 36 0.9 0.9 no signal
242 Device Use Error 6 0.9 0.9 no signal
243 Drug Dose Omission 29 0.9 0.9 no signal
244 Intentional Self-injury 3 0.8 0.8 no signal
245 Drug Effective For Unapproved Indication 4 0.7 0.7 no signal
246 Device Malfunction 9 0.7 0.7 no signal
247 Intentional Overdose 8 0.6 0.6 no signal
248 Hepatic Cancer 3 0.6 0.6 no signal
249 Device Expulsion 8 0.6 0.6 no signal
250 Product Adhesion Issue 4 0.6 0.6 no signal
251 Injection Site Mass 4 0.5 0.5 no signal
252 Injection Site Pruritus 7 0.5 0.5 no signal
253 Pancreatic Carcinoma 3 0.5 0.5 no signal
254 Incorrect Route Of Drug Administration 3 0.4 0.4 no signal
255 Prostate Cancer 6 0.4 0.4 no signal
256 Dependence 4 0.4 0.4 no signal