Drug

Estradiol/norethindrone Acetate

73 flagged reaction(s) · 1,237 total co-reports · max PRR 78.1

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Breast Cancer Female	191	78.1	86.6	signal
2	Breast Cancer Metastatic	44	45.0	46.0	signal
3	Breast Cancer	281	32.7	38.2	signal
4	Bursitis	20	18.1	18.3	signal
5	Body Temperature Decreased	16	17.6	17.8	signal
6	Brain Fog	20	15.0	15.1	signal
7	Hypokinesia	17	12.8	12.9	signal
8	Bone Density Decreased	32	11.0	11.2	signal
9	Menorrhagia	20	11.0	11.1	signal
10	Blood Pressure Systolic Increased	19	10.6	10.7	signal
11	Middle Insomnia	18	10.6	10.7	signal
12	Deformity	9	10.5	10.5	signal
13	Breast Pain	10	10.3	10.3	signal
14	Product Administration Error	18	9.9	9.9	signal
15	Vaginal Haemorrhage	35	9.0	9.1	signal
16	Abnormal Dreams	21	8.3	8.3	signal
17	Abdominal Pain Lower	18	7.8	7.8	signal
18	Micturition Urgency	8	7.7	7.7	signal
19	Hot Flush	51	7.4	7.6	signal
20	Heart Rate Decreased	23	7.1	7.2	signal
21	Dental Caries	7	6.9	6.9	signal
22	Blood Potassium Decreased	19	6.9	7.0	signal
23	Obesity	9	6.2	6.2	signal
24	Tooth Fracture	6	5.9	6.0	signal
25	Nerve Compression	5	5.9	5.9	signal
26	Joint Injury	11	5.6	5.6	signal
27	Poor Quality Sleep	11	5.6	5.6	signal
28	Vitreous Floaters	5	5.6	5.6	signal
29	Gingival Bleeding	7	5.6	5.6	signal
30	Pneumocystis Jirovecii Pneumonia	5	5.5	5.5	signal
31	Pelvic Pain	9	5.4	5.4	signal
32	Secretion Discharge	6	5.3	5.3	signal
33	Thyroid Disorder	7	5.0	5.0	signal
34	Drug Dispensing Error	7	4.9	4.9	signal
35	Hypertensive Crisis	5	4.9	4.9	signal
36	Tooth Disorder	10	4.9	4.9	signal
37	Blood Thyroid Stimulating Hormone Increased	4	4.7	4.7	signal
38	Ovarian Cancer	4	4.7	4.7	signal
39	Skin Reaction	6	4.7	4.7	signal
40	Blood Pressure Fluctuation	10	4.5	4.6	signal
41	Metrorrhagia	7	4.4	4.4	signal
42	Application Site Irritation	5	4.4	4.4	signal
43	Vaginal Discharge	4	4.3	4.4	signal
44	Bone Loss	6	4.3	4.3	signal
45	Dry Throat	4	4.3	4.3	signal
46	Needle Issue	11	4.2	4.2	signal
47	Dysmenorrhoea	5	4.2	4.2	signal
48	Drug Administered At Inappropriate Site	4	4.1	4.1	signal
49	Back Disorder	6	4.0	4.0	signal
50	Lip Swelling	12	3.9	4.0	signal
51	Intestinal Perforation	4	3.9	3.9	signal
52	Local Swelling	6	3.7	3.7	signal
53	Abnormal Weight Gain	4	3.5	3.5	signal
54	Breast Cancer Stage I	3	3.5	3.5	no signal
55	Abortion Induced	3	3.5	3.5	no signal
56	Application Site Erythema	8	3.3	3.3	signal
57	Angioedema	13	3.2	3.2	signal
58	Akathisia	4	3.2	3.2	signal
59	Emotional Disorder	9	3.2	3.2	signal
60	Application Site Rash	4	3.2	3.2	no signal
61	Bipolar Disorder	3	3.0	3.0	no signal
62	Pharmaceutical Product Complaint	7	2.9	2.9	signal
63	Madarosis	3	2.8	2.8	no signal
64	Product Adhesion Issue	9	2.8	2.8	signal
65	Acne	18	2.6	2.6	signal
66	Product Dispensing Error	5	2.5	2.5	no signal
67	Product Substitution Issue	13	2.5	2.5	signal
68	Osteonecrosis Of Jaw	5	2.2	2.2	no signal
69	Incorrect Drug Administration Duration	4	1.5	1.5	no signal
70	Application Site Pruritus	3	1.4	1.4	no signal
71	Multiple Sclerosis Relapse	9	1.4	1.4	no signal
72	Injection Site Mass	4	1.2	1.2	no signal
73	Drug Withdrawal Syndrome	8	1.0	1.0	no signal