Drug
Estrogen
Important: Reactions below are the flagged terms from this drug’s
FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate
disproportionality in spontaneous reporting, not causation.
Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
| Reaction | Co-reports (a) | PRR | ROR | Signal | |
|---|---|---|---|---|---|
| 1 | Madarosis | 21 | 12.9 | 13.0 | signal |
| 2 | Hair Texture Abnormal | 23 | 12.3 | 12.4 | signal |
| 3 | Breast Cancer Female | 37 | 9.9 | 10.0 | signal |
| 4 | Hair Colour Changes | 16 | 9.2 | 9.2 | signal |
| 5 | Osteopenia | 19 | 9.0 | 9.0 | signal |
| 6 | Intervertebral Disc Degeneration | 11 | 8.5 | 8.5 | signal |
| 7 | Bone Disorder | 21 | 8.2 | 8.3 | signal |
| 8 | Vitamin D Deficiency | 11 | 8.1 | 8.2 | signal |
| 9 | Vaginal Discharge | 10 | 7.2 | 7.2 | signal |
| 10 | Wrist Fracture | 11 | 6.6 | 6.6 | signal |
| 11 | Hot Flush | 69 | 6.6 | 6.7 | signal |
| 12 | Gastrointestinal Pain | 10 | 6.6 | 6.6 | signal |
| 13 | Multiple Fractures | 15 | 6.5 | 6.5 | signal |
| 14 | Eyelid Ptosis | 9 | 6.4 | 6.4 | signal |
| 15 | Osteoporosis | 35 | 6.1 | 6.2 | signal |
| 16 | Foot Fracture | 16 | 6.1 | 6.1 | signal |
| 17 | Drug Administered At Inappropriate Site | 9 | 6.1 | 6.1 | signal |
| 18 | Wrong Technique In Drug Usage Process | 31 | 6.1 | 6.1 | signal |
| 19 | Laceration | 8 | 6.0 | 6.1 | signal |
| 20 | Ankle Fracture | 13 | 6.0 | 6.1 | signal |
| 21 | Pharyngeal Oedema | 13 | 6.0 | 6.0 | signal |
| 22 | Body Height Decreased | 9 | 6.0 | 6.0 | signal |
| 23 | Vitreous Floaters | 8 | 5.9 | 5.9 | signal |
| 24 | Ovarian Cyst | 8 | 5.7 | 5.7 | signal |
| 25 | Feeling Jittery | 15 | 5.7 | 5.7 | signal |
| 26 | Fibromyalgia | 19 | 5.6 | 5.7 | signal |
| 27 | Tendonitis | 12 | 5.6 | 5.6 | signal |
| 28 | Restless Legs Syndrome | 14 | 5.5 | 5.6 | signal |
| 29 | Cystitis | 24 | 5.4 | 5.4 | signal |
| 30 | Pelvic Pain | 13 | 5.1 | 5.2 | signal |
| 31 | Cholecystectomy | 8 | 5.1 | 5.1 | signal |
| 32 | Rotator Cuff Syndrome | 9 | 5.0 | 5.0 | signal |
| 33 | Paralysis | 10 | 5.0 | 5.0 | signal |
| 34 | Hyperthyroidism | 10 | 5.0 | 5.0 | signal |
| 35 | Dry Throat | 7 | 5.0 | 5.0 | signal |
| 36 | Dry Eye | 32 | 4.8 | 4.8 | signal |
| 37 | Poor Quality Sleep | 14 | 4.7 | 4.7 | signal |
| 38 | Economic Problem | 10 | 4.7 | 4.7 | signal |
| 39 | Thyroid Disorder | 10 | 4.7 | 4.7 | signal |
| 40 | Scar | 11 | 4.6 | 4.6 | signal |
| 41 | Musculoskeletal Discomfort | 11 | 4.6 | 4.6 | signal |
| 42 | Muscle Atrophy | 8 | 4.6 | 4.6 | signal |
| 43 | Osteoarthritis | 27 | 4.6 | 4.6 | signal |
| 44 | Spinal Disorder | 6 | 4.6 | 4.6 | signal |
| 45 | Eructation | 12 | 4.5 | 4.6 | signal |
| 46 | Crying | 23 | 4.5 | 4.6 | signal |
| 47 | Nerve Injury | 7 | 4.5 | 4.5 | signal |
| 48 | Rash Papular | 14 | 4.5 | 4.5 | signal |
| 49 | Gallbladder Disorder | 11 | 4.4 | 4.4 | signal |
| 50 | Intentional Drug Misuse | 13 | 4.4 | 4.4 | signal |
| 51 | Coeliac Disease | 6 | 4.4 | 4.4 | signal |
| 52 | Arthritis | 48 | 4.4 | 4.4 | signal |
| 53 | Tinnitus | 28 | 4.4 | 4.4 | signal |
| 54 | Toothache | 11 | 4.4 | 4.4 | signal |
| 55 | Therapeutic Response Unexpected | 27 | 4.3 | 4.3 | signal |
| 56 | Eyelid Oedema | 7 | 4.3 | 4.3 | signal |
| 57 | Hypothyroidism | 19 | 4.3 | 4.3 | signal |
| 58 | Application Site Pain | 13 | 4.3 | 4.3 | signal |
| 59 | Inappropriate Antidiuretic Hormone Secretion | 6 | 4.2 | 4.3 | signal |
| 60 | Vaginal Haemorrhage | 25 | 4.2 | 4.3 | signal |
| 61 | Hypomagnesaemia | 8 | 4.2 | 4.2 | signal |
| 62 | Breast Cancer | 54 | 4.1 | 4.2 | signal |
| 63 | Tendon Rupture | 7 | 4.1 | 4.1 | signal |
| 64 | Joint Injury | 12 | 4.0 | 4.1 | signal |
| 65 | Night Sweats | 18 | 4.0 | 4.0 | signal |
| 66 | Paraesthesia Oral | 8 | 4.0 | 4.0 | signal |
| 67 | Impaired Quality Of Life | 8 | 4.0 | 4.0 | signal |
| 68 | Skin Laceration | 6 | 4.0 | 4.0 | signal |
| 69 | Laryngitis | 6 | 4.0 | 4.0 | signal |
| 70 | Injection Site Nodule | 6 | 3.9 | 3.9 | signal |
| 71 | Alopecia | 106 | 3.9 | 4.0 | signal |
| 72 | Feeling Cold | 15 | 3.9 | 3.9 | signal |
| 73 | Migraine | 51 | 3.9 | 3.9 | signal |
| 74 | Middle Insomnia | 10 | 3.9 | 3.9 | signal |
| 75 | Ankylosing Spondylitis | 7 | 3.9 | 3.9 | signal |
| 76 | Neck Pain | 30 | 3.9 | 3.9 | signal |
| 77 | Eye Infection | 6 | 3.9 | 3.9 | signal |
| 78 | Nervousness | 28 | 3.8 | 3.9 | signal |
| 79 | Squamous Cell Carcinoma | 5 | 3.8 | 3.8 | signal |
| 80 | Hyperhidrosis | 68 | 3.8 | 3.9 | signal |
| 81 | Blood Cholesterol Increased | 24 | 3.7 | 3.7 | signal |
| 82 | Impaired Work Ability | 11 | 3.7 | 3.7 | signal |
| 83 | Splenomegaly | 6 | 3.7 | 3.7 | signal |
| 84 | Lymphadenopathy | 18 | 3.7 | 3.7 | signal |
| 85 | Peripheral Coldness | 7 | 3.7 | 3.7 | signal |
| 86 | Blood Triglycerides Increased | 9 | 3.7 | 3.7 | signal |
| 87 | Application Site Rash | 7 | 3.7 | 3.7 | signal |
| 88 | Abnormal Dreams | 14 | 3.6 | 3.6 | signal |
| 89 | Aphonia | 7 | 3.6 | 3.6 | signal |
| 90 | Upper Limb Fracture | 10 | 3.6 | 3.6 | signal |
| 91 | Coordination Abnormal | 7 | 3.6 | 3.6 | signal |
| 92 | Bursitis | 6 | 3.6 | 3.6 | signal |
| 93 | Application Site Erythema | 13 | 3.6 | 3.6 | signal |
| 94 | Pain In Jaw | 14 | 3.6 | 3.6 | signal |
| 95 | Musculoskeletal Pain | 26 | 3.5 | 3.6 | signal |
| 96 | Incorrect Drug Administration Duration | 14 | 3.5 | 3.5 | signal |
| 97 | Eye Discharge | 5 | 3.5 | 3.5 | signal |
| 98 | Feeling Hot | 30 | 3.5 | 3.5 | signal |
| 99 | Ear Discomfort | 5 | 3.5 | 3.5 | signal |
| 100 | Feeling Abnormal | 117 | 3.5 | 3.6 | signal |
| 101 | Secretion Discharge | 6 | 3.5 | 3.5 | signal |
| 102 | Euphoric Mood | 5 | 3.5 | 3.5 | signal |
| 103 | Emotional Disorder | 15 | 3.5 | 3.5 | signal |
| 104 | Cyst | 6 | 3.5 | 3.5 | signal |
| 105 | Product Odour Abnormal | 5 | 3.5 | 3.5 | signal |
| 106 | Thinking Abnormal | 9 | 3.5 | 3.5 | signal |
| 107 | Fear | 13 | 3.5 | 3.5 | signal |
| 108 | Palpitations | 56 | 3.4 | 3.5 | signal |
| 109 | Hereditary Angioedema | 5 | 3.4 | 3.4 | signal |
| 110 | Inappropriate Schedule Of Drug Administration | 34 | 3.4 | 3.4 | signal |
| 111 | Mood Swings | 15 | 3.4 | 3.4 | signal |
| 112 | Breast Pain | 5 | 3.4 | 3.4 | signal |
| 113 | Irritable Bowel Syndrome | 10 | 3.4 | 3.4 | signal |
| 114 | Panic Attack | 17 | 3.4 | 3.4 | signal |
| 115 | Platelet Count Increased | 6 | 3.3 | 3.3 | signal |
| 116 | Intervertebral Disc Protrusion | 10 | 3.3 | 3.3 | signal |
| 117 | Pruritus Generalised | 10 | 3.3 | 3.3 | signal |
| 118 | Hypersomnia | 13 | 3.3 | 3.3 | signal |
| 119 | Intestinal Obstruction | 17 | 3.3 | 3.3 | signal |
| 120 | Limb Discomfort | 14 | 3.3 | 3.3 | signal |
| 121 | Local Swelling | 8 | 3.3 | 3.3 | signal |
| 122 | Menorrhagia | 9 | 3.3 | 3.3 | signal |
| 123 | Joint Range Of Motion Decreased | 6 | 3.2 | 3.2 | signal |
| 124 | Fistula | 5 | 3.2 | 3.2 | signal |
| 125 | Bone Pain | 26 | 3.2 | 3.2 | signal |
| 126 | Product Quality Issue | 59 | 3.2 | 3.2 | signal |
| 127 | Injection Site Warmth | 9 | 3.1 | 3.2 | signal |
| 128 | Weight Increased | 97 | 3.1 | 3.2 | signal |
| 129 | Coronary Artery Occlusion | 6 | 3.1 | 3.1 | signal |
| 130 | Retinal Detachment | 4 | 3.1 | 3.1 | no signal |
| 131 | Dermatitis | 9 | 3.1 | 3.1 | signal |
| 132 | Ovarian Cancer | 4 | 3.1 | 3.1 | no signal |
| 133 | Irritability | 26 | 3.1 | 3.1 | signal |
| 134 | Stress | 31 | 3.1 | 3.1 | signal |
| 135 | Mass | 6 | 3.1 | 3.1 | signal |
| 136 | Carpal Tunnel Syndrome | 6 | 3.1 | 3.1 | signal |
| 137 | Product Adhesion Issue | 15 | 3.0 | 3.1 | signal |
| 138 | Oropharyngeal Pain | 39 | 3.0 | 3.1 | signal |
| 139 | Lower Limb Fracture | 8 | 3.0 | 3.0 | signal |
| 140 | Anger | 14 | 3.0 | 3.0 | signal |
| 141 | Flushing | 42 | 3.0 | 3.0 | signal |
| 142 | Restlessness | 15 | 2.9 | 3.0 | signal |
| 143 | Frequent Bowel Movements | 11 | 2.9 | 3.0 | signal |
| 144 | Embedded Device | 4 | 2.9 | 2.9 | no signal |
| 145 | Eye Swelling | 15 | 2.9 | 2.9 | signal |
| 146 | Gastric Disorder | 14 | 2.9 | 2.9 | signal |
| 147 | Product Physical Issue | 8 | 2.9 | 2.9 | signal |
| 148 | Activities Of Daily Living Impaired | 8 | 2.9 | 2.9 | signal |
| 149 | Bone Loss | 6 | 2.8 | 2.8 | signal |
| 150 | Subarachnoid Haemorrhage | 4 | 2.8 | 2.8 | no signal |
| 151 | Disturbance In Attention | 21 | 2.8 | 2.8 | signal |
| 152 | Folliculitis | 4 | 2.8 | 2.8 | no signal |
| 153 | Product Preparation Error | 8 | 2.8 | 2.8 | signal |
| 154 | Basal Cell Carcinoma | 6 | 2.8 | 2.8 | signal |
| 155 | Swollen Tongue | 12 | 2.8 | 2.8 | signal |
| 156 | Injection Site Pruritus | 25 | 2.7 | 2.7 | signal |
| 157 | Nightmare | 13 | 2.7 | 2.7 | signal |
| 158 | Throat Tightness | 10 | 2.7 | 2.7 | signal |
| 159 | Back Disorder | 6 | 2.6 | 2.6 | signal |
| 160 | Pulmonary Thrombosis | 4 | 2.6 | 2.6 | no signal |
| 161 | Gingival Bleeding | 5 | 2.6 | 2.6 | no signal |
| 162 | Product Substitution Issue | 21 | 2.6 | 2.6 | signal |
| 163 | Ocular Hyperaemia | 17 | 2.6 | 2.6 | signal |
| 164 | Oral Herpes | 7 | 2.6 | 2.6 | signal |
| 165 | Psychomotor Hyperactivity | 6 | 2.6 | 2.6 | signal |
| 166 | Tooth Disorder | 8 | 2.6 | 2.6 | signal |
| 167 | Rebound Effect | 4 | 2.5 | 2.5 | no signal |
| 168 | Impaired Driving Ability | 4 | 2.5 | 2.5 | no signal |
| 169 | Skin Haemorrhage | 5 | 2.5 | 2.5 | no signal |
| 170 | Paranoia | 6 | 2.5 | 2.5 | no signal |
| 171 | Incorrect Product Administration Duration | 7 | 2.5 | 2.5 | signal |
| 172 | Anosmia | 5 | 2.5 | 2.5 | no signal |
| 173 | Sexual Dysfunction | 4 | 2.5 | 2.5 | no signal |
| 174 | Arthropathy | 19 | 2.5 | 2.5 | signal |
| 175 | Haemorrhage Intracranial | 5 | 2.4 | 2.4 | no signal |
| 176 | Withdrawal Syndrome | 14 | 2.4 | 2.4 | signal |
| 177 | Mood Altered | 9 | 2.4 | 2.4 | signal |
| 178 | Injection Site Urticaria | 8 | 2.4 | 2.4 | signal |
| 179 | Drug Effect Decreased | 18 | 2.4 | 2.4 | signal |
| 180 | Injection Site Erythema | 40 | 2.3 | 2.4 | signal |
| 181 | Drug Dispensing Error | 5 | 2.3 | 2.3 | no signal |
| 182 | Tooth Extraction | 4 | 2.3 | 2.3 | no signal |
| 183 | Personality Change | 3 | 2.3 | 2.3 | no signal |
| 184 | Injection Site Bruising | 25 | 2.3 | 2.3 | signal |
| 185 | Intraocular Pressure Increased | 4 | 2.2 | 2.2 | no signal |
| 186 | Systemic Lupus Erythematosus | 11 | 2.2 | 2.2 | signal |
| 187 | Affect Lability | 3 | 2.2 | 2.2 | no signal |
| 188 | Genital Haemorrhage | 4 | 2.2 | 2.2 | no signal |
| 189 | Knee Operation | 3 | 2.2 | 2.2 | no signal |
| 190 | Dysmenorrhoea | 4 | 2.2 | 2.2 | no signal |
| 191 | Suicidal Ideation | 28 | 2.2 | 2.2 | signal |
| 192 | Eye Irritation | 17 | 2.2 | 2.2 | signal |
| 193 | Expired Product Administered | 10 | 2.2 | 2.2 | signal |
| 194 | Incorrect Product Storage | 4 | 2.2 | 2.2 | no signal |
| 195 | Eye Haemorrhage | 4 | 2.2 | 2.2 | no signal |
| 196 | Visual Acuity Reduced | 10 | 2.1 | 2.2 | signal |
| 197 | Hunger | 4 | 2.1 | 2.1 | no signal |
| 198 | Product Taste Abnormal | 4 | 2.1 | 2.1 | no signal |
| 199 | Pain Of Skin | 8 | 2.1 | 2.1 | no signal |
| 200 | Poor Quality Product Administered | 3 | 2.1 | 2.1 | no signal |
| 201 | Procedural Pain | 8 | 2.1 | 2.1 | no signal |
| 202 | Metrorrhagia | 5 | 2.1 | 2.1 | no signal |
| 203 | Tooth Loss | 6 | 2.1 | 2.1 | no signal |
| 204 | Drug Dose Omission | 48 | 2.1 | 2.1 | signal |
| 205 | Bone Density Decreased | 9 | 2.0 | 2.0 | no signal |
| 206 | Blindness Unilateral | 4 | 2.0 | 2.0 | no signal |
| 207 | Breast Cancer Metastatic | 3 | 2.0 | 2.0 | no signal |
| 208 | Influenza Like Illness | 23 | 2.0 | 2.0 | signal |
| 209 | Bipolar Disorder | 3 | 2.0 | 2.0 | no signal |
| 210 | Injection Site Mass | 10 | 2.0 | 2.0 | no signal |
| 211 | Application Site Pruritus | 6 | 1.9 | 1.9 | no signal |
| 212 | Blood Count Abnormal | 4 | 1.9 | 1.9 | no signal |
| 213 | Convulsion | 15 | 1.9 | 1.9 | no signal |
| 214 | Injection Site Pain | 77 | 1.8 | 1.8 | no signal |
| 215 | Incorrect Dose Administered | 57 | 1.8 | 1.8 | no signal |
| 216 | Psoriatic Arthropathy | 10 | 1.8 | 1.8 | no signal |
| 217 | Hepatitis C | 3 | 1.8 | 1.8 | no signal |
| 218 | Drug Effect Incomplete | 9 | 1.8 | 1.8 | no signal |
| 219 | Libido Decreased | 3 | 1.7 | 1.7 | no signal |
| 220 | Application Site Irritation | 3 | 1.7 | 1.7 | no signal |
| 221 | Injection Site Haemorrhage | 19 | 1.7 | 1.7 | no signal |
| 222 | Skin Burning Sensation | 17 | 1.7 | 1.7 | no signal |
| 223 | Injection Site Swelling | 18 | 1.7 | 1.7 | no signal |
| 224 | Acne | 18 | 1.7 | 1.7 | no signal |
| 225 | Drug Reaction With Eosinophilia And Systemic Symptoms | 6 | 1.7 | 1.7 | no signal |
| 226 | Injection Site Rash | 7 | 1.7 | 1.7 | no signal |
| 227 | Pharmaceutical Product Complaint | 6 | 1.6 | 1.6 | no signal |
| 228 | Product Dose Omission | 15 | 1.6 | 1.6 | no signal |
| 229 | Drug Withdrawal Syndrome | 20 | 1.6 | 1.6 | no signal |
| 230 | Product Administered At Inappropriate Site | 4 | 1.6 | 1.6 | no signal |
| 231 | Wrong Technique In Product Usage Process | 43 | 1.5 | 1.5 | no signal |
| 232 | Tardive Dyskinesia | 6 | 1.5 | 1.5 | no signal |
| 233 | Dystonia | 4 | 1.5 | 1.5 | no signal |
| 234 | Drug Prescribing Error | 4 | 1.5 | 1.5 | no signal |
| 235 | Injection Site Reaction | 14 | 1.5 | 1.5 | no signal |
| 236 | Drug Administration Error | 6 | 1.4 | 1.4 | no signal |
| 237 | Device Issue | 16 | 1.3 | 1.3 | no signal |
| 238 | Amenorrhoea | 3 | 1.3 | 1.3 | no signal |
| 239 | Syringe Issue | 3 | 1.2 | 1.2 | no signal |
| 240 | Synovitis | 3 | 1.2 | 1.2 | no signal |
| 241 | Device Dislocation | 7 | 1.2 | 1.2 | no signal |
| 242 | Psoriasis | 20 | 1.1 | 1.1 | no signal |
| 243 | Skin Irritation | 7 | 1.1 | 1.1 | no signal |
| 244 | Injury Associated With Device | 3 | 1.1 | 1.1 | no signal |
| 245 | Device Malfunction | 10 | 1.1 | 1.1 | no signal |
| 246 | Incorrect Route Of Drug Administration | 5 | 1.0 | 1.0 | no signal |
| 247 | Multiple Sclerosis Relapse | 9 | 0.9 | 0.9 | no signal |
| 248 | Multiple Sclerosis | 6 | 0.9 | 0.9 | no signal |
| 249 | Hepatic Cancer | 3 | 0.9 | 0.9 | no signal |
| 250 | Gynaecomastia | 3 | 0.7 | 0.7 | no signal |
| 251 | Completed Suicide | 8 | 0.7 | 0.7 | no signal |
| 252 | Accidental Exposure To Product | 9 | 0.6 | 0.6 | no signal |
| 253 | Device Leakage | 3 | 0.5 | 0.5 | no signal |