Drug

Fruquintinib

86 flagged reaction(s) · 5,085 total co-reports · max PRR 141.7

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Colon Cancer	371	141.7	157.1	signal
2	Myelosuppression	217	35.7	37.8	signal
3	Proteinuria	101	29.9	30.7	signal
4	Palmar-plantar Erythrodysaesthesia Syndrome	124	29.6	30.6	signal
5	Metastases To Liver	67	21.3	21.7	signal
6	Metastases To Lung	44	21.3	21.5	signal
7	Dysphonia	209	20.0	21.1	signal
8	Posterior Reversible Encephalopathy Syndrome	27	15.8	15.9	signal
9	Aphonia	30	12.0	12.1	signal
10	Oral Pain	46	11.4	11.5	signal
11	Blood Pressure Increased	269	9.8	10.5	signal
12	Stomatitis	102	9.4	9.6	signal
13	Hypothyroidism	53	9.3	9.4	signal
14	Ascites	40	7.6	7.6	signal
15	Blood Bilirubin Increased	31	6.4	6.4	signal
16	Blood Pressure Abnormal	22	6.2	6.2	signal
17	Neuropathy Peripheral	98	5.8	5.9	signal
18	Decreased Appetite	239	5.7	6.1	signal
19	Metastases To Central Nervous System	13	5.6	5.7	signal
20	Death	850	5.5	6.8	signal
21	Metastases To Bone	16	5.4	5.5	signal
22	Ileus	12	5.4	5.4	signal
23	Mucosal Inflammation	24	5.1	5.2	signal
24	Hypertension	193	5.1	5.3	signal
25	Taste Disorder	18	5.0	5.0	signal
26	Brain Fog	13	5.0	5.0	signal
27	Blood Thyroid Stimulating Hormone Increased	8	4.8	4.8	signal
28	Hepatic Failure	25	4.6	4.6	signal
29	Neutrophil Count Decreased	32	4.4	4.4	signal
30	Hypophagia	20	4.4	4.4	signal
31	Blood Urine Present	15	4.4	4.4	signal
32	Brain Neoplasm	7	4.2	4.2	signal
33	Hepatic Function Abnormal	28	4.2	4.2	signal
34	Blister	42	4.2	4.2	signal
35	Hepatic Encephalopathy	7	4.2	4.2	signal
36	Oral Discomfort	10	4.0	4.0	signal
37	Intestinal Perforation	8	4.0	4.0	signal
38	Neoplasm	8	3.9	3.9	signal
39	Mouth Ulceration	14	3.7	3.7	signal
40	Renal Impairment	55	3.7	3.7	signal
41	Thyroid Disorder	10	3.6	3.6	signal
42	Platelet Count Decreased	68	3.6	3.6	signal
43	Asthenia	233	3.4	3.6	signal
44	Fatigue	470	3.4	3.7	signal
45	Therapy Partial Responder	9	3.3	3.3	signal
46	Jaundice	16	3.3	3.3	signal
47	Dehydration	75	3.1	3.2	signal
48	Intestinal Obstruction	21	3.1	3.1	signal
49	Hypersomnia	16	3.1	3.1	signal
50	Rectal Haemorrhage	24	3.1	3.1	signal
51	Feeding Disorder	11	3.1	3.1	signal
52	Colorectal Cancer	26	3.0	3.0	signal
53	Glossodynia	12	3.0	3.0	signal
54	Thrombotic Microangiopathy	5	2.9	2.9	signal
55	Gait Inability	17	2.9	2.9	signal
56	Gingival Bleeding	7	2.8	2.9	signal
57	Skin Ulcer	13	2.8	2.8	signal
58	Cerebral Haemorrhage	18	2.8	2.8	signal
59	Product Physical Issue	10	2.8	2.8	signal
60	Abscess	8	2.8	2.8	signal
61	White Blood Cell Count Decreased	54	2.8	2.8	signal
62	Hyperbilirubinaemia	5	2.7	2.7	no signal
63	Skin Fissures	9	2.7	2.7	signal
64	Illness	47	2.6	2.6	signal
65	Hernia	9	2.6	2.6	signal
66	Kidney Infection	9	2.6	2.6	signal
67	Nerve Injury	5	2.5	2.5	no signal
68	Quality Of Life Decreased	6	2.5	2.5	no signal
69	Product Dose Omission Issue	126	2.5	2.5	signal
70	Internal Haemorrhage	5	2.4	2.4	no signal
71	Diarrhoea Haemorrhagic	4	2.4	2.4	no signal
72	Skin Reaction	6	2.4	2.4	no signal
73	Disease Progression	50	2.4	2.4	signal
74	Oropharyngeal Pain	39	2.3	2.4	signal
75	Cytopenia	5	2.3	2.3	no signal
76	Dry Skin	52	2.2	2.2	signal
77	Fistula	4	2.0	2.0	no signal
78	Polyneuropathy	4	1.9	1.9	no signal
79	Pelvic Pain	6	1.8	1.8	no signal
80	Haematotoxicity	3	1.8	1.8	no signal
81	Skin Exfoliation	26	1.7	1.7	no signal
82	Neurotoxicity	5	1.6	1.6	no signal
83	Product Dose Omission In Error	7	1.4	1.5	no signal
84	Neoplasm Progression	8	1.3	1.3	no signal
85	Blood Glucose Decreased	10	1.2	1.2	no signal
86	Hepatic Cancer	4	0.9	0.9	no signal