OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Hyaluronidase

185 flagged reaction(s) · 25,705 total co-reports · max PRR 482.9
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Autoimmune Disorder 254 482.9 614.5 signal
2 Helicobacter Infection 262 467.2 599.7 signal
3 Folliculitis 241 423.1 531.0 signal
4 Bursitis 237 354.9 443.4 signal
5 Hand Deformity 243 335.2 421.5 signal
6 Pemphigus 218 316.1 387.2 signal
7 Joint Range Of Motion Decreased 204 274.5 331.4 signal
8 Wound Infection 160 264.6 305.8 signal
9 Sciatica 216 244.5 298.9 signal
10 Hypercholesterolaemia 127 238.2 266.7 signal
11 Pericarditis 214 230.4 281.0 signal
12 Obesity 192 215.7 257.3 signal
13 Synovitis 211 209.5 254.7 signal
14 Lower Limb Fracture 221 207.4 254.7 signal
15 Laryngitis 124 204.6 228.4 signal
16 Foot Deformity 123 198.5 221.4 signal
17 Glossodynia 233 186.5 232.0 signal
18 Fibromyalgia 236 173.8 216.8 signal
19 Irritable Bowel Syndrome 203 169.9 204.8 signal
20 Liver Injury 200 147.7 177.5 signal
21 Pulmonary Fibrosis 150 140.1 160.3 signal
22 Wound 217 139.3 170.3 signal
23 Red Blood Cell Sedimentation Rate Increased 85 136.8 147.3 signal
24 Hepatic Cirrhosis 141 134.6 152.7 signal
25 Sleep Disorder Due To A General Medical Condition 121 133.5 148.6 signal
26 Hip Arthroplasty 112 131.6 145.2 signal
27 Type 2 Diabetes Mellitus 249 131.5 166.3 signal
28 Joint Dislocation 75 127.0 135.6 signal
29 Impaired Healing 227 123.3 152.3 signal
30 Systemic Lupus Erythematosus 238 120.0 149.9 signal
31 Prescribed Overdose 119 109.6 121.7 signal
32 Night Sweats 191 105.7 125.8 signal
33 Blood Cholesterol Increased 265 101.2 130.1 signal
34 Weight Fluctuation 59 100.8 106.1 signal
35 Pregnancy 114 100.4 111.0 signal
36 Road Traffic Accident 233 99.1 123.2 signal
37 Knee Arthroplasty 116 99.1 109.7 signal
38 Lower Respiratory Tract Infection 243 95.5 119.9 signal
39 Psoriatic Arthropathy 211 93.4 113.4 signal
40 Osteoarthritis 221 92.6 113.7 signal
41 Liver Disorder 218 87.6 107.1 signal
42 Ear Infection 129 86.5 96.9 signal
43 Frequent Bowel Movements 129 85.3 95.6 signal
44 Delirium 161 82.8 95.7 signal
45 Arthropathy 250 79.7 100.8 signal
46 Blister 247 78.4 98.8 signal
47 Discomfort 264 77.5 99.4 signal
48 Lung Disorder 212 77.0 93.6 signal
49 Stomatitis 251 73.6 93.1 signal
50 Respiratory Disorder 123 72.9 81.2 signal
51 Hepatic Enzyme Increased 272 71.2 92.1 signal
52 Musculoskeletal Pain 211 71.0 86.2 signal
53 Rectal Haemorrhage 166 68.4 79.4 signal
54 Inflammation 191 66.1 78.7 signal
55 Gait Inability 123 66.1 73.6 signal
56 White Blood Cell Count Increased 139 64.2 72.6 signal
57 Infusion Related Reaction 232 62.4 77.4 signal
58 Colitis Ulcerative 156 62.2 71.4 signal
59 Oedema 186 61.1 72.3 signal
60 Ill-defined Disorder 205 59.9 72.3 signal
61 Laboratory Test Abnormal 99 59.7 65.0 signal
62 Contraindicated Product Administered 100 58.9 64.2 signal
63 Wheezing 193 58.0 69.1 signal
64 Mobility Decreased 230 57.1 70.6 signal
65 Joint Stiffness 84 56.9 61.1 signal
66 Incorrect Route Of Product Administration 53 56.0 58.6 signal
67 C-reactive Protein Increased 109 53.2 58.5 signal
68 Osteoporosis 118 50.9 56.4 signal
69 Injury 200 50.3 60.3 signal
70 Dry Mouth 225 49.3 60.7 signal
71 Contusion 260 48.0 61.3 signal
72 Swelling 249 47.3 59.7 signal
73 Maternal Exposure During Pregnancy 232 46.7 57.8 signal
74 Prescribed Underdose 52 46.3 48.4 signal
75 Gastrointestinal Disorder 229 46.0 56.8 signal
76 Musculoskeletal Stiffness 221 44.8 54.8 signal
77 Pancreatitis 133 44.6 50.1 signal
78 Sinusitis 252 43.5 55.0 signal
79 Amnesia 154 41.8 48.0 signal
80 Asthma 262 41.5 53.0 signal
81 Feeling Hot 129 37.3 41.7 signal
82 General Physical Health Deterioration 232 35.8 44.3 signal
83 Rheumatoid Arthritis 227 35.6 43.8 signal
84 Therapy Non-responder 87 34.6 37.3 signal
85 Ear Pain 37 33.8 34.8 signal
86 Therapeutic Product Effect Decreased 84 33.6 36.1 signal
87 Arthritis 145 32.7 37.1 signal
88 Joint Swelling 220 32.4 39.6 signal
89 Abdominal Discomfort 297 31.5 41.7 signal
90 Hypoaesthesia 250 29.6 37.2 signal
91 Sleep Disorder 112 28.4 31.3 signal
92 Confusional State 255 27.9 35.3 signal
93 Infection 221 27.2 33.2 signal
94 Muscular Weakness 169 26.4 30.6 signal
95 Hypersensitivity 275 26.3 34.0 signal
96 Back Injury 16 26.2 26.6 signal
97 Alopecia 286 25.8 33.7 signal
98 Drug Intolerance 138 25.4 28.7 signal
99 Migraine 135 25.2 28.4 signal
100 Neutrophil Count Increased 14 24.2 24.4 signal
101 Peripheral Swelling 205 23.7 28.4 signal
102 Intraocular Pressure Increased 17 23.5 23.8 signal
103 Dyspepsia 129 23.3 26.0 signal
104 Urticaria 218 23.2 28.2 signal
105 Treatment Failure 106 22.9 25.1 signal
106 Loss Of Personal Independence In Daily Activities 61 22.7 23.9 signal
107 Hypertension 271 22.7 29.1 signal
108 Chest Pain 236 22.5 27.9 signal
109 Drug Hypersensitivity 241 22.0 27.4 signal
110 Nasopharyngitis 227 21.8 26.7 signal
111 Paraesthesia 193 21.7 25.7 signal
112 Abdominal Pain Upper 240 20.7 25.7 signal
113 Muscle Spasms 211 20.4 24.6 signal
114 Memory Impairment 156 20.1 23.0 signal
115 Oedema Peripheral 138 20.0 22.5 signal
116 Intentional Product Use Issue 99 20.0 21.7 signal
117 Decreased Appetite 258 19.7 25.0 signal
118 Immunodeficiency 16 19.3 19.5 signal
119 Weight Increased 234 18.6 23.0 signal
120 Eyelid Oedema 12 18.2 18.3 signal
121 Adrenal Insufficiency 12 17.8 17.9 signal
122 Lymphopenia 14 17.6 17.8 signal
123 Sensory Disturbance 16 17.6 17.8 signal
124 Visual Impairment 122 17.6 19.5 signal
125 Medication Error 54 17.2 18.0 signal
126 Ejection Fraction Decreased 15 17.1 17.3 signal
127 Exposure During Pregnancy 58 16.5 17.3 signal
128 Coeliac Disease 9 16.2 16.4 signal
129 Taste Disorder 18 15.9 16.2 signal
130 Liver Function Test Increased 19 15.8 16.0 signal
131 Adverse Event 82 15.8 16.9 signal
132 Eyelid Ptosis 9 15.7 15.8 signal
133 Product Administered At Inappropriate Site 16 15.6 15.8 signal
134 Anxiety 249 15.5 19.3 signal
135 Retinal Detachment 8 15.4 15.5 signal
136 Blood Urea Increased 14 14.7 14.9 signal
137 Condition Aggravated 248 14.6 18.1 signal
138 Disability 16 14.3 14.5 signal
139 Post Procedural Complication 15 13.8 14.0 signal
140 Deformity 7 13.2 13.3 signal
141 Visual Acuity Reduced 25 13.2 13.5 signal
142 Insomnia 198 13.2 15.6 signal
143 Asthenia 274 12.9 16.5 signal
144 Depression 166 12.9 14.8 signal
145 Pyrexia 245 12.5 15.6 signal
146 Mydriasis 9 12.4 12.5 signal
147 Adverse Drug Reaction 62 12.3 12.9 signal
148 Muscle Twitching 16 12.3 12.4 signal
149 Gait Disturbance 130 12.0 13.4 signal
150 Product Use Issue 125 11.8 13.1 signal
151 Arthralgia 276 11.8 15.1 signal
152 Blood Bilirubin Increased 18 11.8 11.9 signal
153 Epilepsy 20 11.6 11.8 signal
154 Drug-induced Liver Injury 20 11.5 11.7 signal
155 Ascites 19 11.4 11.6 signal
156 Blood Alkaline Phosphatase Increased 16 11.4 11.5 signal
157 Weight Decreased 174 11.1 12.8 signal
158 Pruritus 233 10.9 13.4 signal
159 Generalised Tonic-clonic Seizure 10 10.8 10.9 signal
160 Osteopenia 9 10.5 10.5 signal
161 Neck Pain 33 10.4 10.7 signal
162 Drug Administered At Inappropriate Site 6 9.9 10.0 signal
163 Malaise 241 9.7 11.9 signal
164 Vomiting 252 9.5 11.8 signal
165 Underdose 39 9.5 9.7 signal
166 Device Related Infection 8 9.2 9.2 signal
167 Dizziness 256 9.1 11.3 signal
168 Rash 222 9.1 10.9 signal
169 Cerebral Haemorrhage 18 8.9 9.0 signal
170 Back Disorder 8 8.7 8.7 signal
171 Muscle Spasticity 6 8.6 8.6 signal
172 Crying 17 8.3 8.4 signal
173 Agitation 28 6.7 6.9 signal
174 Depressed Mood 20 6.7 6.8 signal
175 Rebound Effect 4 6.2 6.3 signal
176 Eye Swelling 13 6.2 6.3 signal
177 Eye Inflammation 3 5.6 5.6 signal
178 Inflammatory Bowel Disease 3 5.4 5.4 signal
179 Osteonecrosis Of Jaw 7 5.0 5.0 signal
180 Respiratory Depression 3 4.3 4.3 signal
181 Neoplasm Progression 8 4.0 4.1 signal
182 Psoriasis 22 3.0 3.0 signal
183 Foetal Exposure During Pregnancy 13 2.8 2.9 signal
184 Pharmaceutical Product Complaint 3 2.0 2.0 no signal
185 Device Breakage 3 1.4 1.4 no signal