OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Imiglucerase

177 flagged reaction(s) · 4,517 total co-reports · max PRR 26.1
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Poor Venous Access 60 26.1 26.4 signal
2 Splenomegaly 66 25.3 25.6 signal
3 Status Epilepticus 39 15.4 15.5 signal
4 Hepatomegaly 34 15.4 15.5 signal
5 Bone Disorder 48 11.7 11.8 signal
6 Exposure During Pregnancy 162 11.6 12.0 signal
7 Osteonecrosis 85 11.5 11.7 signal
8 Bone Pain 147 11.2 11.5 signal
9 Epilepsy 62 9.1 9.2 signal
10 Cyanosis 32 9.1 9.1 signal
11 Hip Arthroplasty 28 8.2 8.3 signal
12 Convulsion 103 7.9 8.1 signal
13 Abortion Spontaneous 70 7.8 7.9 signal
14 Aspiration 18 7.4 7.4 signal
15 Myoclonus 19 7.1 7.1 signal
16 Pulmonary Hypertension 32 6.8 6.9 signal
17 Malnutrition 17 6.8 6.9 signal
18 Device Related Infection 22 6.4 6.4 signal
19 Drug Exposure During Pregnancy 48 6.2 6.3 signal
20 Pregnancy 28 6.2 6.2 signal
21 Caesarean Section 16 6.1 6.1 signal
22 Respiratory Failure 95 5.8 5.9 signal
23 Femur Fracture 40 5.7 5.8 signal
24 Weight Fluctuation 13 5.6 5.6 signal
25 Pneumonia Aspiration 31 5.6 5.6 signal
26 Infusion Site Pain 15 5.2 5.3 signal
27 Osteomyelitis 21 5.2 5.2 signal
28 Respiratory Distress 32 5.2 5.2 signal
29 Lung Infection 18 5.1 5.1 signal
30 Hepatic Cirrhosis 21 5.0 5.0 signal
31 Sudden Death 12 5.0 5.0 signal
32 Disease Progression 128 4.8 5.0 signal
33 Respiratory Disorder 32 4.8 4.8 signal
34 Respiratory Arrest 28 4.5 4.5 signal
35 Nervous System Disorder 31 4.4 4.4 signal
36 Sars-cov-2 Test Positive 13 4.3 4.4 signal
37 Tachypnoea 13 4.3 4.3 signal
38 Upper Limb Fracture 19 4.2 4.2 signal
39 Choking 18 4.1 4.1 signal
40 Parkinsonism 9 4.1 4.1 signal
41 Wrist Fracture 11 4.1 4.1 signal
42 Hip Fracture 29 4.0 4.0 signal
43 Respiratory Tract Infection 23 4.0 4.0 signal
44 Maternal Exposure During Pregnancy 76 3.8 3.9 signal
45 Lower Respiratory Tract Infection 39 3.8 3.9 signal
46 Arthropathy 48 3.8 3.9 signal
47 Pharyngitis Streptococcal 9 3.7 3.7 signal
48 Haematemesis 21 3.7 3.7 signal
49 Hepatitis C 10 3.7 3.7 signal
50 Infusion Related Reaction 54 3.6 3.7 signal
51 Pallor 22 3.6 3.6 signal
52 Intentional Dose Omission 22 3.6 3.6 signal
53 Joint Injury 17 3.5 3.6 signal
54 Osteopenia 12 3.5 3.5 signal
55 Staphylococcal Infection 26 3.5 3.5 signal
56 Bronchospasm 11 3.4 3.4 signal
57 Anorexia 10 3.4 3.4 signal
58 Hypokinesia 11 3.4 3.4 signal
59 Accident 9 3.4 3.4 signal
60 Appendicitis 7 3.4 3.4 signal
61 Grand Mal Convulsion 7 3.3 3.3 signal
62 Platelet Count Decreased 79 3.3 3.3 signal
63 Multi-organ Failure 13 3.3 3.3 signal
64 Generalised Tonic-clonic Seizure 12 3.3 3.3 signal
65 Cholelithiasis 24 3.3 3.3 signal
66 Post Procedural Complication 14 3.2 3.3 signal
67 No Therapeutic Response 9 3.2 3.2 signal
68 Product Preparation Error 15 3.2 3.2 signal
69 Viral Infection 24 3.2 3.2 signal
70 Upper Respiratory Tract Infection 33 3.2 3.2 signal
71 Weight Increased 159 3.2 3.3 signal
72 Cardio-respiratory Arrest 30 3.2 3.2 signal
73 Disseminated Intravascular Coagulation 10 3.2 3.2 signal
74 Dialysis 10 3.1 3.1 signal
75 Road Traffic Accident 29 3.1 3.1 signal
76 Platelet Count Increased 9 3.1 3.1 signal
77 Fracture 13 3.1 3.1 signal
78 Body Temperature Increased 14 3.1 3.1 signal
79 Foot Fracture 13 3.0 3.1 signal
80 Eyelid Oedema 8 3.0 3.1 signal
81 Retinal Detachment 6 2.9 2.9 signal
82 Lymphoma 10 2.9 2.9 signal
83 Hepatic Encephalopathy 6 2.9 2.9 signal
84 Ear Infection 17 2.9 2.9 signal
85 Intervertebral Disc Protrusion 14 2.8 2.9 signal
86 Seizure 73 2.8 2.9 signal
87 Rib Fracture 13 2.8 2.8 signal
88 Treatment Noncompliance 34 2.8 2.8 signal
89 Septic Shock 27 2.8 2.8 signal
90 Acute Respiratory Distress Syndrome 11 2.8 2.8 signal
91 Pyrexia 213 2.7 2.8 signal
92 Ascites 18 2.7 2.7 signal
93 Thrombocytopenia 67 2.7 2.7 signal
94 Device Failure 9 2.6 2.6 signal
95 Osteoporosis 24 2.6 2.6 signal
96 Petechiae 6 2.6 2.6 signal
97 Lower Limb Fracture 11 2.6 2.6 signal
98 Metastases To Liver 10 2.5 2.5 signal
99 Joint Dislocation 6 2.5 2.5 signal
100 Hepatic Failure 17 2.5 2.5 signal
101 Pharyngitis 7 2.5 2.5 signal
102 Gout 10 2.5 2.5 signal
103 Throat Tightness 15 2.5 2.5 signal
104 Myelodysplastic Syndrome 8 2.5 2.5 signal
105 Gastroenteritis Viral 10 2.5 2.5 signal
106 Increased Tendency To Bruise 5 2.4 2.4 no signal
107 Bronchitis 40 2.4 2.4 signal
108 Oxygen Saturation Decreased 30 2.4 2.4 signal
109 Colon Cancer 8 2.4 2.4 signal
110 Immune System Disorder 7 2.4 2.4 signal
111 Circulatory Collapse 9 2.3 2.3 signal
112 Metastases To Lung 6 2.3 2.3 no signal
113 Fall 170 2.3 2.3 signal
114 Lymphadenopathy 18 2.3 2.3 signal
115 Respiratory Tract Congestion 8 2.2 2.2 signal
116 Muscle Rigidity 6 2.2 2.2 no signal
117 Blood Lactate Dehydrogenase Increased 8 2.2 2.2 signal
118 Spinal Fracture 10 2.2 2.2 signal
119 Hypotonia 5 2.2 2.2 no signal
120 Cardiac Arrest 40 2.2 2.2 signal
121 Multiple Fractures 8 2.2 2.2 no signal
122 Limb Injury 13 2.1 2.1 signal
123 Incorrect Route Of Product Administration 8 2.1 2.1 no signal
124 Bone Density Decreased 15 2.1 2.1 signal
125 Dementia 13 2.1 2.1 signal
126 Tuberculosis 6 2.1 2.1 no signal
127 Kidney Infection 9 2.0 2.0 no signal
128 Bedridden 6 2.0 2.0 no signal
129 Epistaxis 34 2.0 2.0 signal
130 Pancytopenia 25 2.0 2.0 signal
131 Obstructive Airways Disorder 5 2.0 2.0 no signal
132 Gallbladder Disorder 8 2.0 2.0 no signal
133 Cholecystectomy 5 2.0 2.0 no signal
134 Abasia 11 2.0 2.0 no signal
135 Gingival Bleeding 6 2.0 2.0 no signal
136 Illness 44 2.0 2.0 no signal
137 Cardiac Failure 35 1.9 1.9 no signal
138 Nerve Compression 4 1.9 1.9 no signal
139 Ovarian Cancer 4 1.9 1.9 no signal
140 Blindness Unilateral 6 1.9 1.9 no signal
141 Product Dose Omission 28 1.9 1.9 no signal
142 Ataxia 5 1.9 1.9 no signal
143 Nasopharyngitis 77 1.9 1.9 no signal
144 Influenza 46 1.8 1.8 no signal
145 Haemorrhage Intracranial 6 1.8 1.8 no signal
146 Subarachnoid Haemorrhage 4 1.7 1.7 no signal
147 Eye Discharge 4 1.7 1.7 no signal
148 Knee Arthroplasty 8 1.7 1.7 no signal
149 Breast Cancer Metastatic 4 1.7 1.7 no signal
150 Hospitalisation 56 1.6 1.6 no signal
151 Fistula 4 1.6 1.6 no signal
152 Inappropriate Schedule Of Product Administration 57 1.4 1.4 no signal
153 Cardiac Disorder 30 1.4 1.4 no signal
154 Metastases To Central Nervous System 4 1.4 1.4 no signal
155 Hernia 6 1.4 1.4 no signal
156 Ovarian Cyst 3 1.3 1.3 no signal
157 Breast Cancer Female 8 1.3 1.3 no signal
158 Haemorrhage 31 1.3 1.3 no signal
159 Coronary Artery Occlusion 4 1.3 1.3 no signal
160 Pulmonary Arterial Hypertension 4 1.2 1.2 no signal
161 Internal Haemorrhage 3 1.2 1.2 no signal
162 Neoplasm Malignant 17 1.1 1.1 no signal
163 Activities Of Daily Living Impaired 5 1.1 1.1 no signal
164 Thyroid Cancer 3 1.1 1.1 no signal
165 Muscle Spasticity 3 1.1 1.1 no signal
166 Cytomegalovirus Infection 4 1.1 1.1 no signal
167 Drug Dose Omission 39 1.0 1.0 no signal
168 Incorrect Product Storage 3 1.0 1.0 no signal
169 Diabetic Ketoacidosis 5 0.9 0.9 no signal
170 Product Storage Error 18 0.9 0.9 no signal
171 Pancreatic Carcinoma 5 0.8 0.8 no signal
172 Breast Cancer 13 0.6 0.6 no signal
173 Extrapyramidal Disorder 3 0.5 0.5 no signal
174 Gastric Cancer 3 0.5 0.5 no signal
175 Oesophageal Carcinoma 3 0.4 0.4 no signal
176 Device Dislocation 4 0.4 0.4 no signal
177 Renal Cancer 3 0.3 0.3 no signal