Drug

Imipenem And Cilastatin

70 flagged reaction(s) · 1,110 total co-reports · max PRR 27.0

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Toxic Skin Eruption	22	27.0	27.3	signal
2	Electrocardiogram Qt Prolonged	64	22.0	22.9	signal
3	Drug Resistance	41	19.8	20.3	signal
4	Neutrophil Count Increased	15	18.1	18.2	signal
5	Epilepsy	42	17.1	17.5	signal
6	Rash Maculo-papular	30	16.8	17.1	signal
7	Nephropathy Toxic	15	16.7	16.8	signal
8	Septic Shock	53	15.2	15.7	signal
9	Multiple Organ Dysfunction Syndrome	34	15.1	15.4	signal
10	Drug Reaction With Eosinophilia And Systemic Symptoms	29	14.1	14.3	signal
11	Hepatotoxicity	25	14.0	14.2	signal
12	Tuberculosis	14	13.5	13.6	signal
13	Eosinophilia	19	13.5	13.6	signal
14	Lymphocyte Count Decreased	19	13.3	13.4	signal
15	Toxic Epidermal Necrolysis	16	13.1	13.3	signal
16	Clostridium Difficile Colitis	11	12.8	12.9	signal
17	Blood Urea Increased	17	12.5	12.6	signal
18	Acute Respiratory Distress Syndrome	16	11.2	11.3	signal
19	Clostridium Difficile Infection	19	10.9	11.0	signal
20	Cytomegalovirus Infection	14	10.4	10.5	signal
21	Myoclonus	10	10.4	10.4	signal
22	Drug-induced Liver Injury	25	10.0	10.2	signal
23	Agranulocytosis	14	9.4	9.4	signal
24	Generalised Tonic-clonic Seizure	12	9.1	9.1	signal
25	Bone Marrow Failure	15	9.1	9.2	signal
26	Device Related Infection	11	8.8	8.9	signal
27	Neurotoxicity	12	8.6	8.6	signal
28	Respiratory Failure	50	8.5	8.7	signal
29	Bacteraemia	8	8.4	8.5	signal
30	Encephalopathy	16	8.1	8.2	signal
31	Cardiogenic Shock	9	7.8	7.8	signal
32	Posterior Reversible Encephalopathy Syndrome	6	7.8	7.8	signal
33	Thrombocytopenia	70	7.8	8.1	signal
34	White Blood Cell Count Increased	24	7.7	7.8	signal
35	Platelet Count Increased	8	7.6	7.6	signal
36	Altered State Of Consciousness	13	7.5	7.5	signal
37	Candida Infection	10	7.4	7.5	signal
38	Hypocalcaemia	11	7.2	7.3	signal
39	Incorrect Product Administration Duration	11	6.7	6.7	signal
40	Hepatic Function Abnormal	20	6.7	6.7	signal
41	Cholestasis	10	6.5	6.5	signal
42	Drug Eruption	9	6.3	6.4	signal
43	Leukopenia	25	6.2	6.3	signal
44	Lymphopenia	7	6.2	6.2	signal
45	Disseminated Intravascular Coagulation	7	6.1	6.2	signal
46	Treatment Failure	38	5.7	5.8	signal
47	Multi-organ Failure	8	5.6	5.7	signal
48	Pancreatitis Acute	10	5.5	5.6	signal
49	Status Epilepticus	5	5.5	5.5	signal
50	Hepatitis	11	5.3	5.3	signal
51	Hepatic Encephalopathy	4	5.3	5.3	signal
52	Hepatocellular Injury	6	5.2	5.2	signal
53	Stevens-johnson Syndrome	9	5.0	5.0	signal
54	Pneumocystis Jirovecii Pneumonia	4	5.0	5.0	signal
55	Blood Triglycerides Increased	7	4.9	4.9	signal
56	Hypothermia	4	4.9	4.9	signal
57	Premature Delivery	6	4.6	4.7	signal
58	Drug Level Increased	6	4.5	4.5	signal
59	Mucosal Inflammation	9	4.3	4.3	signal
60	Cytopenia	4	4.1	4.2	signal
61	Hepatitis C	4	4.1	4.1	signal
62	Grand Mal Convulsion	3	4.0	4.0	signal
63	Serotonin Syndrome	6	3.9	3.9	signal
64	Hypoacusis	13	3.7	3.8	signal
65	Peritonitis Bacterial	3	3.7	3.7	no signal
66	Procedural Pain	7	3.1	3.1	signal
67	Hepatic Cytolysis	3	3.0	3.0	no signal
68	Bone Loss	3	2.4	2.4	no signal
69	Myelosuppression	6	2.2	2.2	no signal
70	Incorrect Route Of Drug Administration	3	1.0	1.0	no signal