Drug

Isoflurane

115 flagged reaction(s) · 3,710 total co-reports · max PRR 79.1

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Status Epilepticus	82	79.1	82.5	signal
2	Multi-organ Failure	87	54.0	56.5	signal
3	Fear	111	44.6	47.2	signal
4	Anhedonia	94	38.6	40.5	signal
5	Renal Injury	100	36.2	38.1	signal
6	Metabolic Acidosis	87	29.9	31.2	signal
7	Cardiomegaly	34	29.8	30.3	signal
8	Ventricular Fibrillation	29	28.3	28.7	signal
9	Sinus Tachycardia	36	27.6	28.1	signal
10	Intestinal Perforation	26	25.1	25.5	signal
11	Drug Exposure During Pregnancy	75	23.6	24.5	signal
12	Caesarean Section	25	23.1	23.4	signal
13	Blood Creatine Phosphokinase Increased	62	23.0	23.7	signal
14	Shock	48	22.8	23.4	signal
15	Bronchospasm	29	22.0	22.3	signal
16	Injury	137	21.0	22.6	signal
17	Post Procedural Complication	37	20.9	21.3	signal
18	Hyperkalaemia	66	20.5	21.2	signal
19	Ventricular Tachycardia	31	20.3	20.6	signal
20	Muscle Rigidity	21	19.1	19.3	signal
21	Ventricular Extrasystoles	18	18.8	19.0	signal
22	Acute Hepatic Failure	23	18.4	18.6	signal
23	Sinus Bradycardia	16	17.9	18.1	signal
24	Unevaluable Event	124	17.8	18.9	signal
25	Abscess	25	17.0	17.2	signal
26	Bradycardia	80	16.3	17.0	signal
27	Brain Oedema	19	16.3	16.5	signal
28	Electrocardiogram Qt Prolonged	53	16.0	16.4	signal
29	Ileus	18	15.9	16.0	signal
30	Dystonia	28	15.6	15.8	signal
31	Myoclonus	15	13.6	13.7	signal
32	Tachypnoea	17	13.6	13.7	signal
33	Supraventricular Tachycardia	12	13.6	13.7	signal
34	Renal Failure Acute	53	13.4	13.7	signal
35	Renal Failure	159	12.9	14.0	signal
36	Hypotension	236	12.8	14.4	signal
37	Coagulopathy	19	12.4	12.5	signal
38	Renal Impairment	95	12.3	12.9	signal
39	Premature Baby	33	11.9	12.0	signal
40	Stress	77	11.6	12.1	signal
41	Cardiac Arrest	85	11.1	11.6	signal
42	Renal Tubular Necrosis	10	11.0	11.1	signal
43	Leukocytosis	18	10.8	10.9	signal
44	Disseminated Intravascular Coagulation	14	10.8	10.8	signal
45	Hypothermia	10	10.7	10.7	signal
46	Inappropriate Antidiuretic Hormone Secretion	10	10.7	10.7	signal
47	Arrhythmia	46	10.5	10.7	signal
48	Rebound Effect	10	9.6	9.6	signal
49	Emotional Distress	104	9.3	9.8	signal
50	Rhabdomyolysis	35	9.1	9.3	signal
51	Serotonin Syndrome	15	8.5	8.6	signal
52	Pulmonary Oedema	35	8.5	8.6	signal
53	Mydriasis	10	8.5	8.5	signal
54	Unresponsive To Stimuli	20	8.4	8.5	signal
55	Cardiogenic Shock	11	8.4	8.4	signal
56	Drug Interaction	122	8.3	8.8	signal
57	Pulmonary Hypertension	16	8.3	8.4	signal
58	Circulatory Collapse	13	8.2	8.3	signal
59	Drug Ineffective For Unapproved Indication	42	8.2	8.3	signal
60	No Therapeutic Response	9	7.9	7.9	signal
61	Tachycardia	64	7.8	8.0	signal
62	Anaphylactic Shock	18	7.6	7.7	signal
63	Hypotonia	7	7.6	7.6	signal
64	Lactic Acidosis	22	7.4	7.5	signal
65	Respiratory Arrest	19	7.4	7.5	signal
66	Acute Respiratory Distress Syndrome	12	7.4	7.4	signal
67	Neuroleptic Malignant Syndrome	8	7.3	7.3	signal
68	Adrenal Insufficiency	8	7.2	7.3	signal
69	Blood Pressure Decreased	44	7.2	7.3	signal
70	Aphasia	19	6.8	6.9	signal
71	Oxygen Saturation Decreased	35	6.8	6.9	signal
72	Blood Lactate Dehydrogenase Increased	10	6.8	6.8	signal
73	Hepatomegaly	6	6.6	6.6	signal
74	Disability	12	6.6	6.6	signal
75	Brain Injury	6	6.5	6.5	signal
76	Ejection Fraction Decreased	9	6.3	6.3	signal
77	Ischaemic Stroke	10	6.1	6.1	signal
78	Clostridium Difficile Infection	12	6.0	6.0	signal
79	Hypocalcaemia	10	5.7	5.8	signal
80	Posterior Reversible Encephalopathy Syndrome	5	5.7	5.7	signal
81	Myocardial Ischaemia	6	5.7	5.7	signal
82	Jaundice	14	5.6	5.7	signal
83	Exposure During Pregnancy	32	5.6	5.7	signal
84	Cyanosis	8	5.5	5.5	signal
85	Drug Toxicity	7	5.5	5.5	signal
86	Depressed Level Of Consciousness	20	5.5	5.5	signal
87	Body Temperature Decreased	5	5.5	5.5	signal
88	Hepatic Failure	15	5.4	5.4	signal
89	Hepatotoxicity	11	5.4	5.4	signal
90	Respiratory Depression	6	5.3	5.3	signal
91	Hypokinesia	7	5.2	5.2	signal
92	Hypertensive Crisis	5	4.9	4.9	signal
93	Hyperthyroidism	6	4.5	4.5	signal
94	Fluid Overload	6	4.4	4.4	signal
95	Muscle Spasticity	5	4.4	4.4	signal
96	Anaphylactic Reaction	22	4.3	4.4	signal
97	Coma	18	4.1	4.1	signal
98	Agitation	27	4.0	4.0	signal
99	Cholestasis	7	4.0	4.0	signal
100	Product Substitution Issue	21	4.0	4.0	signal
101	Maternal Exposure During Pregnancy	32	3.9	4.0	signal
102	Drug Resistance	9	3.8	3.8	signal
103	Dyskinesia	14	3.7	3.8	signal
104	Post Procedural Haemorrhage	4	3.7	3.7	signal
105	Foetal Exposure During Pregnancy	26	3.5	3.5	signal
106	Poisoning	4	3.4	3.4	signal
107	Convulsion	18	3.4	3.4	signal
108	Akathisia	4	3.2	3.2	no signal
109	Nephropathy Toxic	3	2.9	2.9	no signal
110	Premature Delivery	4	2.7	2.7	no signal
111	Drug Withdrawal Syndrome Neonatal	3	2.2	2.2	no signal
112	Incorrect Route Of Drug Administration	7	2.1	2.1	no signal
113	Drug Effect Decreased	9	1.8	1.8	no signal
114	Drug Withdrawal Syndrome	14	1.7	1.7	no signal
115	Extrapyramidal Disorder	3	1.3	1.3	no signal