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Drug

Leuprolide

52 flagged reaction(s) · 704 total co-reports · max PRR 26.6
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Prostatic Specific Antigen Increased 26 26.6 27.1 signal
2 Pneumocystis Jirovecii Pneumonia 16 22.7 22.9 signal
3 Metastases To Bone 26 22.5 22.9 signal
4 Respiratory Depression 17 19.6 19.9 signal
5 Breast Cancer Metastatic 13 17.2 17.3 signal
6 Hypomagnesaemia 12 12.2 12.3 signal
7 Tenderness 8 10.8 10.9 signal
8 Transfusion 8 10.8 10.8 signal
9 Obesity 12 10.6 10.7 signal
10 Metastases To Liver 13 10.5 10.6 signal
11 Febrile Neutropenia 48 10.3 10.6 signal
12 Product Prescribing Error 16 9.6 9.7 signal
13 Malignant Neoplasm Progression 56 7.8 8.0 signal
14 Therapy Partial Responder 8 7.5 7.6 signal
15 Product Storage Error 45 7.4 7.6 signal
16 Metastases To Lung 6 7.4 7.4 signal
17 Hot Flush 37 6.9 7.1 signal
18 Brain Fog 7 6.8 6.8 signal
19 Disease Progression 56 6.7 6.9 signal
20 Nephropathy Toxic 5 6.4 6.4 signal
21 Myocardial Ischaemia 5 6.2 6.2 signal
22 Treatment Failure 34 5.9 6.0 signal
23 Rhabdomyolysis 17 5.8 5.8 signal
24 Osteonecrosis Of Jaw 10 5.7 5.7 signal
25 Metastases To Central Nervous System 5 5.5 5.5 signal
26 Erectile Dysfunction 10 5.5 5.5 signal
27 Cytokine Release Syndrome 7 5.2 5.2 signal
28 Abortion Spontaneous 14 4.9 5.0 signal
29 Madarosis 4 4.8 4.8 signal
30 Acute Myeloid Leukaemia 5 4.5 4.6 signal
31 Drug Resistance 8 4.4 4.4 signal
32 Decreased Immune Responsiveness 3 4.3 4.4 signal
33 Injection Site Urticaria 7 4.1 4.1 signal
34 Pelvic Pain 5 3.9 3.9 signal
35 Injection Site Mass 10 3.8 3.9 signal
36 Premature Delivery 4 3.5 3.5 signal
37 Hepatic Cytolysis 3 3.5 3.5 no signal
38 Needle Issue 7 3.5 3.5 signal
39 Hair Colour Changes 3 3.4 3.4 no signal
40 Injection Site Irritation 3 3.4 3.4 no signal
41 Complication Associated With Device 3 3.2 3.2 no signal
42 Hair Texture Abnormal 3 3.1 3.2 no signal
43 Diabetic Ketoacidosis 5 3.0 3.0 signal
44 Neoplasm Progression 7 2.8 2.8 signal
45 Prostate Cancer 16 2.8 2.8 signal
46 Drug Abuse 14 2.4 2.4 signal
47 Injection Site Rash 5 2.3 2.3 no signal
48 Injection Site Pruritus 9 1.9 1.9 no signal
49 Gynaecomastia 4 1.8 1.8 no signal
50 Injection Site Erythema 14 1.6 1.6 no signal
51 Drug Dependence 18 1.6 1.6 no signal
52 Injection Site Haemorrhage 7 1.2 1.2 no signal