Drug

Levoleucovorin

110 flagged reaction(s) · 3,298 total co-reports · max PRR 21.4

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Myelosuppression	128	21.4	22.1	signal
2	Neutrophil Count Decreased	136	19.1	19.8	signal
3	Hypomagnesaemia	40	16.4	16.5	signal
4	Diarrhoea Haemorrhagic	23	13.9	14.0	signal
5	Interstitial Lung Disease	117	13.7	14.2	signal
6	Colon Cancer	35	13.3	13.4	signal
7	Hyperbilirubinaemia	23	12.7	12.7	signal
8	Thrombotic Microangiopathy	19	11.1	11.2	signal
9	Metastases To Liver	33	10.7	10.8	signal
10	Disseminated Intravascular Coagulation	26	10.4	10.5	signal
11	Neutropenia	249	10.4	11.1	signal
12	Anaphylactic Shock	46	10.2	10.3	signal
13	Mucosal Inflammation	44	9.6	9.7	signal
14	Hepatic Cytolysis	20	9.3	9.3	signal
15	Neuropathy Peripheral	153	9.2	9.5	signal
16	Febrile Neutropenia	107	9.2	9.4	signal
17	Malignant Neoplasm Progression	163	9.1	9.4	signal
18	Rash Maculo-papular	33	8.4	8.5	signal
19	Posterior Reversible Encephalopathy Syndrome	13	7.7	7.8	signal
20	Altered State Of Consciousness	28	7.4	7.4	signal
21	Hepatic Encephalopathy	12	7.3	7.3	signal
22	Melaena	28	7.2	7.2	signal
23	Folliculitis	13	7.1	7.2	signal
24	Leukopenia	61	6.9	7.0	signal
25	Thrombocytopenia	129	6.6	6.8	signal
26	Ascites	34	6.5	6.6	signal
27	Ileus	14	6.4	6.5	signal
28	Stomatitis	69	6.4	6.5	signal
29	Drug Eruption	20	6.4	6.5	signal
30	Hypocalcaemia	21	6.3	6.3	signal
31	Cerebral Infarction	27	6.3	6.3	signal
32	Metastases To Lung	12	5.9	5.9	signal
33	Peritonitis	21	5.7	5.8	signal
34	Polyneuropathy	12	5.7	5.7	signal
35	Proteinuria	19	5.7	5.7	signal
36	Oesophagitis	11	5.7	5.7	signal
37	Hypokalaemia	45	5.6	5.6	signal
38	Device Related Infection	15	5.5	5.5	signal
39	Skin Disorder	32	5.4	5.5	signal
40	Intestinal Obstruction	36	5.4	5.5	signal
41	Palmar-plantar Erythrodysaesthesia Syndrome	22	5.3	5.4	signal
42	Splenomegaly	11	5.3	5.3	signal
43	Pneumonia Aspiration	23	5.2	5.3	signal
44	Blood Alkaline Phosphatase Increased	21	4.8	4.8	signal
45	White Blood Cell Count Decreased	89	4.6	4.7	signal
46	Decreased Appetite	187	4.6	4.8	signal
47	Hypertensive Crisis	9	4.6	4.6	signal
48	Body Temperature Decreased	8	4.6	4.6	signal
49	Hyperkalaemia	28	4.5	4.6	signal
50	Myocarditis	9	4.5	4.5	signal
51	Infusion Related Reaction	50	4.3	4.3	signal
52	Cytopenia	9	4.3	4.3	signal
53	Salivary Hypersecretion	7	4.0	4.0	signal
54	Pneumocystis Jirovecii Pneumonia	7	4.0	4.0	signal
55	Accident	8	3.8	3.8	signal
56	Face Oedema	11	3.7	3.7	signal
57	Hepatic Function Abnormal	24	3.7	3.7	signal
58	Transaminases Increased	14	3.6	3.6	signal
59	Hepatitis	16	3.5	3.6	signal
60	Metastases To Central Nervous System	8	3.5	3.5	signal
61	Anaemia	119	3.5	3.6	signal
62	Pulmonary Arterial Hypertension	9	3.5	3.5	signal
63	Respiratory Distress	17	3.5	3.5	signal
64	Colorectal Cancer	29	3.4	3.4	signal
65	Adrenal Insufficiency	7	3.3	3.3	signal
66	Platelet Count Decreased	62	3.3	3.3	signal
67	Ejection Fraction Decreased	9	3.3	3.3	signal
68	Gastric Ulcer	11	3.3	3.3	signal
69	Weight Fluctuation	6	3.3	3.3	signal
70	Lymphopenia	8	3.2	3.2	signal
71	Pneumothorax	9	3.2	3.2	signal
72	Leukocytosis	10	3.1	3.1	signal
73	Blood Thyroid Stimulating Hormone Increased	5	3.1	3.1	signal
74	Haematotoxicity	5	3.1	3.1	signal
75	Scab	6	3.0	3.0	signal
76	Vasculitis	6	2.9	2.9	signal
77	Haematemesis	13	2.9	2.9	signal
78	Disease Progression	60	2.9	2.9	signal
79	Skin Ulcer	13	2.9	2.9	signal
80	Drug-induced Liver Injury	15	2.8	2.8	signal
81	Secretion Discharge	6	2.7	2.8	signal
82	Petechiae	5	2.7	2.7	no signal
83	Cholestasis	9	2.7	2.7	signal
84	Hepatic Failure	14	2.6	2.6	signal
85	Neurotoxicity	8	2.6	2.6	signal
86	Neoplasm Progression	16	2.6	2.6	signal
87	Tooth Fracture	5	2.6	2.6	no signal
88	Intestinal Perforation	5	2.5	2.5	no signal
89	Deep Vein Thrombosis	29	2.5	2.5	signal
90	Diverticulitis	12	2.5	2.5	signal
91	Device Occlusion	6	2.4	2.4	no signal
92	Erythema Multiforme	4	2.4	2.4	no signal
93	Swollen Tongue	13	2.4	2.4	signal
94	Full Blood Count Decreased	8	2.2	2.2	signal
95	Ischaemic Stroke	7	2.2	2.2	no signal
96	Tuberculosis	5	2.2	2.2	no signal
97	Dermatitis	8	2.2	2.2	signal
98	Respiratory Tract Congestion	6	2.1	2.1	no signal
99	Sudden Death	4	2.1	2.1	no signal
100	Skin Fissures	7	2.1	2.1	no signal
101	Fracture	7	2.1	2.1	no signal
102	Cytokine Release Syndrome	7	2.1	2.1	no signal
103	Gingival Bleeding	5	2.1	2.1	no signal
104	Incorrect Product Administration Duration	7	2.0	2.0	no signal
105	Multi-organ Failure	6	1.9	1.9	no signal
106	Disease Recurrence	15	1.8	1.8	no signal
107	Lactic Acidosis	10	1.8	1.8	no signal
108	Bone Marrow Failure	6	1.7	1.7	no signal
109	Osteonecrosis Of Jaw	6	1.4	1.4	no signal
110	Pancreatic Carcinoma	5	1.0	1.0	no signal