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Drug

Lidocaine Hydrochloride,epinephrine Bitartrate

380 flagged reaction(s) · 7,971 total co-reports · max PRR 42.4
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Anaphylactic Shock 227 42.4 44.7 signal
2 Shock 94 19.6 20.1 signal
3 Bronchospasm 57 19.0 19.2 signal
4 Ventricular Fibrillation 31 13.3 13.3 signal
5 Post Procedural Complication 50 12.4 12.5 signal
6 Toxic Epidermal Necrolysis 37 11.7 11.8 signal
7 Accident 29 11.6 11.7 signal
8 Haemorrhoids 47 11.4 11.6 signal
9 Ventricular Tachycardia 33 9.5 9.5 signal
10 Febrile Neutropenia 127 9.1 9.4 signal
11 Disseminated Intravascular Coagulation 27 9.1 9.1 signal
12 Anaphylactic Reaction 101 8.7 8.9 signal
13 Body Temperature Increased 34 7.9 8.0 signal
14 Mydriasis 21 7.8 7.8 signal
15 Mouth Ulceration 34 7.7 7.7 signal
16 Cyanosis 25 7.5 7.6 signal
17 Toxic Skin Eruption 16 7.5 7.6 signal
18 Blood Pressure Decreased 104 7.5 7.6 signal
19 Atelectasis 15 7.4 7.4 signal
20 Eosinophilia 27 7.4 7.4 signal
21 Ileus 19 7.3 7.4 signal
22 Altered State Of Consciousness 33 7.3 7.3 signal
23 Cardio-respiratory Arrest 62 7.0 7.1 signal
24 Oesophagitis 16 7.0 7.0 signal
25 Obesity 23 6.9 6.9 signal
26 Leukocytosis 26 6.8 6.9 signal
27 Conjunctivitis 26 6.7 6.8 signal
28 Circulatory Collapse 24 6.7 6.7 signal
29 Pallor 38 6.6 6.7 signal
30 Drug Toxicity 19 6.5 6.6 signal
31 Agranulocytosis 25 6.4 6.5 signal
32 Hypokalaemia 62 6.4 6.5 signal
33 Blood Lactate Dehydrogenase Increased 21 6.3 6.3 signal
34 Caesarean Section 15 6.1 6.1 signal
35 Cardiogenic Shock 18 6.0 6.0 signal
36 Respiratory Arrest 35 6.0 6.0 signal
37 Hyperlipidaemia 15 6.0 6.0 signal
38 End Stage Renal Disease 23 5.9 6.0 signal
39 Blood Urea Increased 21 5.9 6.0 signal
40 Hepatic Function Abnormal 46 5.9 6.0 signal
41 Staphylococcal Infection 41 5.9 5.9 signal
42 Hiatus Hernia 16 5.9 5.9 signal
43 Osteoarthritis 52 5.8 5.9 signal
44 Skin Laceration 13 5.7 5.7 signal
45 Post Procedural Haemorrhage 14 5.7 5.7 signal
46 Bone Disorder 22 5.7 5.7 signal
47 Tachycardia 105 5.6 5.7 signal
48 Dental Caries 13 5.6 5.6 signal
49 Ventricular Extrasystoles 12 5.5 5.5 signal
50 Supraventricular Tachycardia 11 5.5 5.5 signal
51 Mitral Valve Incompetence 13 5.5 5.5 signal
52 Bradycardia 60 5.4 5.4 signal
53 Renal Tubular Necrosis 11 5.3 5.3 signal
54 Diplopia 29 5.3 5.3 signal
55 Depressed Level Of Consciousness 44 5.3 5.3 signal
56 Convulsion 64 5.2 5.3 signal
57 Cardiac Arrest 91 5.2 5.3 signal
58 Iron Deficiency Anaemia 10 5.2 5.2 signal
59 Motor Dysfunction 11 5.2 5.2 signal
60 Drug Eruption 19 5.1 5.1 signal
61 Bone Marrow Failure 22 5.1 5.1 signal
62 Lymphocyte Count Decreased 19 5.1 5.1 signal
63 Aspartate Aminotransferase Increased 57 5.1 5.2 signal
64 Grand Mal Convulsion 10 5.1 5.1 signal
65 Face Oedema 18 5.1 5.1 signal
66 Osteomyelitis 19 5.0 5.0 signal
67 Joint Range Of Motion Decreased 14 5.0 5.0 signal
68 Acute Respiratory Failure 20 5.0 5.0 signal
69 Gamma-glutamyltransferase Increased 23 4.9 5.0 signal
70 Tendonitis 16 4.9 4.9 signal
71 Cerebral Infarction 25 4.9 4.9 signal
72 Intraocular Pressure Increased 13 4.8 4.8 signal
73 Pneumothorax 16 4.8 4.8 signal
74 Oral Candidiasis 13 4.8 4.8 signal
75 Mucosal Inflammation 26 4.7 4.8 signal
76 Hypoaesthesia Oral 15 4.7 4.7 signal
77 Generalised Oedema 12 4.6 4.6 signal
78 Paralysis 14 4.6 4.6 signal
79 Heart Rate Decreased 34 4.6 4.6 signal
80 Aphasia 29 4.6 4.6 signal
81 Coronary Artery Disease 29 4.5 4.5 signal
82 C-reactive Protein Increased 34 4.4 4.5 signal
83 Musculoskeletal Discomfort 16 4.4 4.4 signal
84 Sinus Bradycardia 9 4.4 4.4 signal
85 Musculoskeletal Pain 49 4.4 4.4 signal
86 Stomatitis 56 4.4 4.4 signal
87 Myoclonus 11 4.4 4.4 signal
88 Sinus Tachycardia 13 4.4 4.4 signal
89 Hypocalcaemia 17 4.3 4.3 signal
90 Malnutrition 10 4.3 4.3 signal
91 Pharyngeal Oedema 14 4.3 4.3 signal
92 Joint Injury 19 4.2 4.2 signal
93 Cardiomegaly 11 4.2 4.2 signal
94 Blood Alkaline Phosphatase Increased 22 4.2 4.2 signal
95 Angioedema 39 4.2 4.2 signal
96 Hypotension 173 4.1 4.2 signal
97 Intervertebral Disc Degeneration 8 4.1 4.1 signal
98 Erythema Multiforme 8 4.1 4.1 signal
99 Inflammation 44 4.1 4.1 signal
100 Generalised Tonic-clonic Seizure 14 4.1 4.1 signal
101 Rotator Cuff Syndrome 11 4.1 4.1 signal
102 Incontinence 9 4.0 4.0 signal
103 Bacteraemia 10 4.0 4.0 signal
104 Eye Inflammation 8 4.0 4.0 signal
105 Sudden Death 9 4.0 4.0 signal
106 Wound Infection 9 3.9 3.9 signal
107 Sciatica 13 3.9 3.9 signal
108 Uveitis 11 3.9 3.9 signal
109 Pneumonitis 22 3.9 3.9 signal
110 Hepatic Steatosis 15 3.8 3.8 signal
111 Bladder Disorder 8 3.8 3.8 signal
112 Tooth Extraction 10 3.8 3.8 signal
113 Gastritis 21 3.8 3.8 signal
114 Hypotonia 8 3.8 3.8 signal
115 Cellulitis 40 3.8 3.8 signal
116 Neutrophil Count Decreased 32 3.8 3.8 signal
117 Thirst 14 3.7 3.7 signal
118 Chronic Kidney Disease 60 3.7 3.8 signal
119 Alanine Aminotransferase Increased 48 3.7 3.7 signal
120 Loss Of Consciousness 100 3.7 3.8 signal
121 Oedema 42 3.7 3.7 signal
122 Synovitis 14 3.7 3.7 signal
123 Oxygen Saturation Decreased 43 3.7 3.7 signal
124 Hypoxia 27 3.7 3.7 signal
125 Erythema 158 3.7 3.8 signal
126 Rash Maculo-papular 17 3.6 3.7 signal
127 Stevens-johnson Syndrome 17 3.6 3.6 signal
128 Osteonecrosis Of Jaw 19 3.6 3.6 signal
129 Retinal Detachment 7 3.6 3.6 signal
130 Pleural Effusion 46 3.6 3.6 signal
131 Abscess 12 3.6 3.6 signal
132 Encephalopathy 18 3.5 3.5 signal
133 Acute Respiratory Distress Syndrome 13 3.5 3.5 signal
134 Laceration 7 3.5 3.5 signal
135 Osteonecrosis 24 3.4 3.5 signal
136 Delirium 25 3.4 3.5 signal
137 Pharyngitis 9 3.4 3.4 signal
138 Pneumonia Aspiration 18 3.4 3.4 signal
139 Arrhythmia 34 3.4 3.4 signal
140 Osteoporosis 29 3.3 3.4 signal
141 Haematocrit Decreased 14 3.3 3.3 signal
142 Unresponsive To Stimuli 18 3.3 3.3 signal
143 Myocardial Ischaemia 8 3.3 3.3 signal
144 Premature Baby 21 3.3 3.3 signal
145 Lung Disorder 34 3.3 3.3 signal
146 Tubulointerstitial Nephritis 13 3.3 3.3 signal
147 Emphysema 7 3.3 3.3 signal
148 Hyperglycaemia 25 3.3 3.3 signal
149 Neutrophil Count Increased 7 3.2 3.2 signal
150 Eye Disorder 22 3.2 3.2 signal
151 Tachypnoea 9 3.2 3.2 signal
152 Bursitis 8 3.2 3.2 signal
153 Cytomegalovirus Infection 11 3.1 3.1 signal
154 Pericarditis 11 3.1 3.1 signal
155 Pelvic Pain 12 3.1 3.1 signal
156 Gingival Bleeding 9 3.1 3.1 signal
157 Osteopenia 10 3.1 3.1 signal
158 Respiratory Depression 8 3.1 3.1 signal
159 Respiratory Distress 18 3.1 3.1 signal
160 White Blood Cell Count Increased 25 3.1 3.1 signal
161 Musculoskeletal Chest Pain 10 3.1 3.1 signal
162 Acute Myeloid Leukaemia 10 3.1 3.1 signal
163 Anhedonia 17 3.1 3.1 signal
164 Flank Pain 6 3.0 3.0 signal
165 Melaena 14 3.0 3.0 signal
166 Gastric Ulcer 12 3.0 3.0 signal
167 Hyperkalaemia 22 3.0 3.0 signal
168 Red Blood Cell Count Decreased 18 3.0 3.0 signal
169 Ulcer 10 3.0 3.0 signal
170 Multi-organ Failure 11 3.0 3.0 signal
171 Dizziness Postural 6 3.0 3.0 signal
172 Blister 35 3.0 3.0 signal
173 Fistula 7 3.0 3.0 signal
174 Blood Calcium Decreased 7 2.9 3.0 signal
175 Status Epilepticus 7 2.9 2.9 signal
176 Gastroenteritis 9 2.9 2.9 signal
177 Vitreous Floaters 6 2.9 2.9 signal
178 Ascites 18 2.9 2.9 signal
179 Feeling Cold 17 2.9 2.9 signal
180 Injury 43 2.9 2.9 signal
181 Pericardial Effusion 14 2.9 2.9 signal
182 Hepatomegaly 6 2.9 2.9 signal
183 Hyponatraemia 34 2.9 2.9 signal
184 Pulmonary Congestion 8 2.9 2.9 signal
185 Renal Failure Acute 26 2.9 2.9 signal
186 Vasculitis 7 2.9 2.9 signal
187 Eyelid Oedema 7 2.8 2.8 signal
188 Renal Failure 80 2.8 2.9 signal
189 Cardiac Failure 48 2.8 2.9 signal
190 Incorrect Route Of Product Administration 10 2.8 2.8 signal
191 Intervertebral Disc Protrusion 13 2.8 2.8 signal
192 Speech Disorder 31 2.8 2.8 signal
193 Hypothermia 6 2.8 2.8 signal
194 Blood Bilirubin Increased 16 2.8 2.8 signal
195 Eyelid Ptosis 6 2.8 2.8 signal
196 Eye Discharge 6 2.8 2.8 signal
197 Liver Disorder 26 2.8 2.8 signal
198 Adrenal Insufficiency 7 2.8 2.8 signal
199 Economic Problem 9 2.8 2.8 signal
200 Device Related Infection 9 2.8 2.8 signal
201 Hyperbilirubinaemia 6 2.8 2.8 signal
202 Pulmonary Oedema 26 2.8 2.8 signal
203 Central Nervous System Lesion 8 2.7 2.8 signal
204 Glomerular Filtration Rate Decreased 7 2.7 2.7 signal
205 Cytokine Release Syndrome 11 2.7 2.7 signal
206 Respiratory Failure 42 2.7 2.8 signal
207 Tenderness 6 2.7 2.7 signal
208 Multiple Organ Dysfunction Syndrome 16 2.7 2.7 signal
209 Haemoptysis 16 2.7 2.7 signal
210 Renal Pain 6 2.7 2.7 signal
211 Cystitis 18 2.7 2.7 signal
212 Dysarthria 21 2.7 2.7 signal
213 Epilepsy 17 2.6 2.7 signal
214 Eczema 28 2.6 2.7 signal
215 Septic Shock 24 2.6 2.6 signal
216 Brain Oedema 7 2.6 2.6 signal
217 Myelodysplastic Syndrome 8 2.6 2.6 signal
218 Hypophagia 14 2.6 2.6 signal
219 Metastases To Bone 9 2.6 2.6 signal
220 Tooth Fracture 6 2.6 2.6 signal
221 Nervous System Disorder 17 2.6 2.6 signal
222 Skin Ulcer 14 2.6 2.6 signal
223 Cardiomyopathy 8 2.6 2.6 signal
224 Nerve Injury 6 2.6 2.6 signal
225 Bedridden 7 2.5 2.5 signal
226 Renal Injury 16 2.5 2.5 signal
227 Pulmonary Hypertension 11 2.5 2.5 signal
228 Cataract 31 2.5 2.5 signal
229 Neurotoxicity 9 2.5 2.5 signal
230 Prescribed Overdose 10 2.5 2.5 signal
231 Thrombotic Microangiopathy 5 2.5 2.5 no signal
232 Atrial Fibrillation 50 2.4 2.5 signal
233 Spinal Pain 6 2.4 2.4 no signal
234 Cold Sweat 9 2.4 2.4 signal
235 Lymphadenopathy 18 2.4 2.4 signal
236 Peripheral Coldness 7 2.4 2.4 signal
237 Visual Acuity Reduced 17 2.4 2.4 signal
238 Urinary Incontinence 15 2.4 2.4 signal
239 Coma 24 2.4 2.4 signal
240 Hypothyroidism 16 2.4 2.4 signal
241 Respiratory Disorder 15 2.4 2.4 signal
242 Ovarian Cyst 5 2.4 2.4 no signal
243 Blindness Unilateral 7 2.4 2.4 signal
244 Incorrect Route Of Drug Administration 18 2.4 2.4 signal
245 Deafness 13 2.4 2.4 signal
246 Back Pain 115 2.4 2.4 signal
247 Muscle Tightness 8 2.3 2.4 signal
248 Hypersensitivity 91 2.3 2.4 signal
249 Oral Pain 11 2.3 2.3 signal
250 Subarachnoid Haemorrhage 5 2.3 2.3 no signal
251 Small Intestinal Obstruction 6 2.3 2.3 no signal
252 Drug Level Decreased 5 2.3 2.3 no signal
253 Ear Discomfort 5 2.3 2.3 no signal
254 Paraesthesia Oral 7 2.3 2.3 no signal
255 Medication Error 27 2.3 2.3 signal
256 Impaired Quality Of Life 7 2.3 2.3 no signal
257 Haemoglobin Decreased 50 2.3 2.3 signal
258 Discomfort 29 2.3 2.3 signal
259 Tinnitus 22 2.3 2.3 signal
260 Muscle Atrophy 6 2.3 2.3 no signal
261 Musculoskeletal Disorder 9 2.2 2.2 signal
262 Procedural Pain 13 2.2 2.2 signal
263 Drug Reaction With Eosinophilia And Systemic Symptoms 12 2.2 2.2 signal
264 Platelet Count Decreased 50 2.2 2.2 signal
265 Irritable Bowel Syndrome 10 2.2 2.2 signal
266 Drug Prescribing Error 9 2.2 2.2 signal
267 Haematoma 12 2.2 2.2 signal
268 Syncope 46 2.2 2.2 signal
269 Blood Pressure Systolic Increased 9 2.2 2.2 signal
270 Dysmenorrhoea 6 2.2 2.2 no signal
271 Tooth Infection 6 2.2 2.2 no signal
272 Complication Associated With Device 6 2.2 2.2 no signal
273 Drug Hypersensitivity 88 2.2 2.2 signal
274 Product Use Complaint 7 2.1 2.1 no signal
275 Foot Deformity 5 2.1 2.1 no signal
276 Drug Administration Error 14 2.1 2.1 signal
277 Pancytopenia 25 2.1 2.1 signal
278 Arthropathy 25 2.1 2.1 signal
279 Hypertensive Crisis 5 2.1 2.1 no signal
280 Intestinal Perforation 5 2.1 2.1 no signal
281 Jaundice 12 2.1 2.1 signal
282 Blood Creatine Phosphokinase Increased 13 2.1 2.1 signal
283 Metabolic Acidosis 14 2.1 2.1 signal
284 Toothache 8 2.1 2.1 no signal
285 Urticaria 73 2.1 2.1 signal
286 Premature Delivery 7 2.1 2.1 no signal
287 Neutropenia 59 2.1 2.1 signal
288 Interstitial Lung Disease 21 2.1 2.1 signal
289 Sensory Disturbance 7 2.1 2.1 no signal
290 Blood Thyroid Stimulating Hormone Increased 4 2.1 2.1 no signal
291 Metastases To Lung 5 2.1 2.1 no signal
292 Hypoglycaemia 21 2.1 2.1 signal
293 Appendicitis 4 2.0 2.0 no signal
294 Palmar-plantar Erythrodysaesthesia Syndrome 10 2.0 2.0 signal
295 Intestinal Obstruction 16 2.0 2.0 signal
296 Ataxia 5 2.0 2.0 no signal
297 Macular Degeneration 5 2.0 2.0 no signal
298 Dyskinesia 17 2.0 2.0 no signal
299 Hyperthyroidism 6 2.0 2.0 no signal
300 Restlessness 15 1.9 1.9 no signal
301 Hepatic Cytolysis 5 1.9 1.9 no signal
302 Rhabdomyolysis 17 1.9 1.9 no signal
303 Fear 11 1.9 1.9 no signal
304 Lacrimation Increased 12 1.9 1.9 no signal
305 Flushing 41 1.9 1.9 no signal
306 Asthma 45 1.9 1.9 no signal
307 Salivary Hypersecretion 4 1.9 1.9 no signal
308 Vaginal Discharge 4 1.9 1.9 no signal
309 Hypoacusis 17 1.9 1.9 no signal
310 Ischaemic Stroke 7 1.9 1.9 no signal
311 Disturbance In Attention 21 1.8 1.8 no signal
312 Angina Pectoris 11 1.8 1.8 no signal
313 Rash Generalised 10 1.8 1.8 no signal
314 Agitation 28 1.8 1.8 no signal
315 Wrong Technique In Drug Usage Process 14 1.8 1.8 no signal
316 Serotonin Syndrome 7 1.7 1.7 no signal
317 Emotional Distress 44 1.7 1.7 no signal
318 Red Blood Cell Sedimentation Rate Increased 4 1.7 1.7 no signal
319 Device Occlusion 5 1.7 1.7 no signal
320 Aphonia 5 1.7 1.7 no signal
321 Glossodynia 8 1.7 1.7 no signal
322 Myocarditis 4 1.7 1.7 no signal
323 Spinal Fracture 7 1.7 1.7 no signal
324 Drug Exposure During Pregnancy 12 1.7 1.7 no signal
325 Paranoia 6 1.6 1.6 no signal
326 Toxicity To Various Agents 57 1.6 1.6 no signal
327 Tooth Loss 7 1.6 1.6 no signal
328 Muscle Rigidity 4 1.6 1.6 no signal
329 Gastrointestinal Haemorrhage 28 1.6 1.6 no signal
330 Malignant Neoplasm Progression 33 1.5 1.5 no signal
331 Tendon Rupture 4 1.5 1.5 no signal
332 Emotional Disorder 10 1.5 1.5 no signal
333 Femur Fracture 10 1.5 1.5 no signal
334 Abortion Induced 3 1.5 1.5 no signal
335 Hair Colour Changes 4 1.5 1.5 no signal
336 Abdominal Pain Lower 8 1.5 1.5 no signal
337 Cardiovascular Disorder 8 1.5 1.5 no signal
338 Drug Effect Decreased 17 1.5 1.5 no signal
339 Knee Operation 3 1.5 1.5 no signal
340 Injection Site Induration 4 1.5 1.5 no signal
341 Sedation 8 1.5 1.5 no signal
342 Haemorrhage 32 1.5 1.5 no signal
343 Pharmaceutical Product Complaint 8 1.4 1.4 no signal
344 Adverse Reaction 4 1.4 1.4 no signal
345 Accidental Overdose 11 1.4 1.4 no signal
346 Activities Of Daily Living Impaired 6 1.4 1.4 no signal
347 Blindness 12 1.4 1.4 no signal
348 Myelosuppression 10 1.4 1.4 no signal
349 Exposure During Pregnancy 18 1.4 1.4 no signal
350 Breast Cancer Metastatic 3 1.3 1.3 no signal
351 Anosmia 4 1.3 1.3 no signal
352 Gastric Cancer 7 1.3 1.3 no signal
353 Madarosis 3 1.2 1.2 no signal
354 Menorrhagia 5 1.2 1.2 no signal
355 Pemphigus 3 1.1 1.1 no signal
356 Pancreatic Carcinoma 7 1.1 1.1 no signal
357 Abasia 6 1.1 1.1 no signal
358 Ankylosing Spondylitis 3 1.1 1.1 no signal
359 Hair Texture Abnormal 3 1.1 1.1 no signal
360 Overdose 48 1.1 1.1 no signal
361 Akathisia 3 1.0 1.0 no signal
362 Foetal Exposure During Pregnancy 17 1.0 1.0 no signal
363 Dystonia 4 1.0 1.0 no signal
364 Glycosylated Haemoglobin Increased 5 0.9 0.9 no signal
365 Injection Site Warmth 4 0.9 0.9 no signal
366 Therapeutic Response Shortened 6 0.9 0.9 no signal
367 Device Dislocation 8 0.9 0.9 no signal
368 Psoriatic Arthropathy 7 0.8 0.8 no signal
369 Lung Neoplasm Malignant 7 0.8 0.8 no signal
370 Device Breakage 6 0.7 0.7 no signal
371 Injection Site Erythema 18 0.7 0.7 no signal
372 Multiple Sclerosis 7 0.7 0.7 no signal
373 Tardive Dyskinesia 4 0.7 0.7 no signal
374 Prostate Cancer 9 0.5 0.5 no signal
375 Breast Cancer 10 0.5 0.5 no signal
376 Completed Suicide 8 0.5 0.5 no signal
377 Drug Abuse 7 0.4 0.4 no signal
378 Drug Dependence 11 0.3 0.3 no signal
379 Bladder Cancer 3 0.2 0.2 no signal
380 Device Difficult To Use 3 0.2 0.2 no signal