OpenPV Signal Explorer
FAERS disproportionality dashboard
← All drugs
Drug

Mannitol

317 flagged reaction(s) · 18,819 total co-reports · max PRR 68.8
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Fear 430 68.8 75.3 signal
2 Multi-organ Failure 276 68.2 72.2 signal
3 Appendicitis 132 61.5 63.2 signal
4 Ventricular Fibrillation 147 57.1 58.8 signal
5 Renal Injury 382 55.0 59.6 signal
6 Anhedonia 312 50.9 54.3 signal
7 Cardiogenic Shock 153 46.3 47.7 signal
8 Brain Oedema 111 37.9 38.7 signal
9 Injury 495 30.1 33.4 signal
10 Multiple Organ Dysfunction Syndrome 192 29.6 30.7 signal
11 Stress 463 27.7 30.4 signal
12 Incorrect Route Of Product Administration 106 27.1 27.7 signal
13 Bacterial Infection 117 27.1 27.7 signal
14 Unevaluable Event 470 26.7 29.4 signal
15 Ascites 150 21.9 22.5 signal
16 Hyperlipidaemia 61 21.8 22.1 signal
17 Neuralgia 118 20.9 21.4 signal
18 Renal Impairment 393 20.1 21.8 signal
19 Hypercholesterolaemia 44 19.7 19.9 signal
20 Renal Failure 592 19.0 21.4 signal
21 Blood Urea Increased 74 18.8 19.1 signal
22 End Stage Renal Disease 80 18.6 18.9 signal
23 Renal Failure Acute 184 18.3 19.0 signal
24 Hyponatraemia 233 17.8 18.6 signal
25 Blood Test Abnormal 54 16.5 16.7 signal
26 Aspiration 41 16.2 16.3 signal
27 Ulcer 60 16.1 16.3 signal
28 Neutrophil Count Increased 36 15.0 15.1 signal
29 Gout 59 14.1 14.2 signal
30 Lymphocyte Count Decreased 58 14.0 14.2 signal
31 Full Blood Count Abnormal 34 13.8 13.9 signal
32 Emotional Distress 386 13.6 14.7 signal
33 Micturition Urgency 36 13.6 13.7 signal
34 Blood Creatinine Increased 172 11.3 11.6 signal
35 Hyperkalaemia 88 10.8 11.0 signal
36 Blood Cholesterol Increased 110 10.1 10.3 signal
37 Posterior Reversible Encephalopathy Syndrome 22 9.9 9.9 signal
38 Transaminases Increased 51 9.8 9.9 signal
39 Sepsis 256 9.8 10.3 signal
40 Ataxia 27 9.7 9.7 signal
41 Nephropathy Toxic 25 9.6 9.6 signal
42 Cerebral Haemorrhage 79 9.4 9.6 signal
43 Chronic Obstructive Pulmonary Disease 114 9.4 9.6 signal
44 Subarachnoid Haemorrhage 22 9.2 9.2 signal
45 Circulatory Collapse 36 9.0 9.1 signal
46 Hypokalaemia 93 8.7 8.8 signal
47 Renal Tubular Necrosis 19 8.3 8.3 signal
48 Disseminated Intravascular Coagulation 26 7.9 7.9 signal
49 Electrolyte Imbalance 21 7.8 7.8 signal
50 Ventricular Tachycardia 30 7.7 7.8 signal
51 Anxiety 505 7.6 8.3 signal
52 Disability 35 7.6 7.6 signal
53 General Physical Health Deterioration 201 7.5 7.8 signal
54 Joint Injury 37 7.4 7.4 signal
55 Toxic Epidermal Necrolysis 26 7.4 7.4 signal
56 Cerebral Infarction 42 7.3 7.4 signal
57 Diabetes Mellitus 130 7.3 7.4 signal
58 Coronary Artery Disease 50 7.0 7.1 signal
59 Thrombosis 132 7.0 7.2 signal
60 Dry Mouth 132 7.0 7.1 signal
61 Ischaemic Stroke 29 6.9 7.0 signal
62 Abdominal Distension 168 6.9 7.1 signal
63 Pulmonary Embolism 154 6.9 7.1 signal
64 Hypomagnesaemia 22 6.8 6.8 signal
65 Metastases To Central Nervous System 20 6.7 6.7 signal
66 Tachypnoea 21 6.6 6.6 signal
67 Sleep Disorder 108 6.6 6.7 signal
68 White Blood Cell Count Increased 59 6.5 6.6 signal
69 Subdural Haematoma 22 6.5 6.6 signal
70 Coma 73 6.5 6.6 signal
71 Altered State Of Consciousness 33 6.5 6.6 signal
72 Bone Marrow Failure 31 6.5 6.5 signal
73 Clostridium Difficile Colitis 16 6.4 6.5 signal
74 Hemiparesis 25 6.3 6.3 signal
75 Haemorrhage Intracranial 22 6.3 6.3 signal
76 C-reactive Protein Increased 53 6.2 6.3 signal
77 Hepatic Function Abnormal 53 6.1 6.2 signal
78 Iron Deficiency Anaemia 13 6.0 6.1 signal
79 Status Epilepticus 16 6.0 6.1 signal
80 Lower Respiratory Tract Infection 63 5.9 6.0 signal
81 Encephalopathy 34 5.9 6.0 signal
82 Anaemia 264 5.9 6.2 signal
83 Cytomegalovirus Infection 23 5.9 5.9 signal
84 Intentional Product Misuse 119 5.9 6.0 signal
85 Swelling 126 5.8 5.9 signal
86 Pleural Effusion 82 5.8 5.8 signal
87 Cardiovascular Disorder 34 5.7 5.7 signal
88 Respiratory Failure 97 5.7 5.8 signal
89 Metabolic Acidosis 42 5.7 5.7 signal
90 Grand Mal Convulsion 12 5.5 5.5 signal
91 Drug Intolerance 123 5.5 5.6 signal
92 Sputum Discoloured 12 5.4 5.4 signal
93 Cyanosis 20 5.4 5.4 signal
94 Aspartate Aminotransferase Increased 67 5.4 5.5 signal
95 Atelectasis 12 5.3 5.3 signal
96 Anaphylactic Shock 31 5.2 5.2 signal
97 Brain Injury 12 5.1 5.1 signal
98 Blood Lactate Dehydrogenase Increased 19 5.1 5.1 signal
99 Bacteraemia 14 5.1 5.1 signal
100 Haemoptysis 33 5.0 5.1 signal
101 Drug-induced Liver Injury 35 4.8 4.9 signal
102 Cardiac Arrest 93 4.8 4.9 signal
103 Transient Ischaemic Attack 37 4.7 4.7 signal
104 Coagulopathy 18 4.6 4.6 signal
105 Liver Function Test Increased 23 4.6 4.6 signal
106 Obstructive Airways Disorder 12 4.6 4.6 signal
107 Alanine Aminotransferase Increased 66 4.6 4.6 signal
108 Blood Potassium Decreased 32 4.5 4.6 signal
109 Upper Respiratory Tract Infection 49 4.5 4.6 signal
110 Ventricular Extrasystoles 11 4.5 4.5 signal
111 Paralysis 15 4.5 4.5 signal
112 Leukopenia 52 4.5 4.5 signal
113 Sinus Bradycardia 10 4.4 4.4 signal
114 Somnolence 207 4.4 4.5 signal
115 Blood Triglycerides Increased 18 4.3 4.3 signal
116 Thrombocytopenia 112 4.3 4.4 signal
117 Pain 616 4.3 4.7 signal
118 Mucosal Inflammation 26 4.3 4.3 signal
119 Febrile Neutropenia 66 4.3 4.3 signal
120 Hyperglycaemia 36 4.2 4.3 signal
121 Constipation 212 4.2 4.3 signal
122 Temperature Intolerance 10 4.2 4.2 signal
123 Agranulocytosis 18 4.2 4.2 signal
124 Neutrophil Count Decreased 39 4.1 4.1 signal
125 Aphasia 29 4.1 4.1 signal
126 Hypoxia 33 4.0 4.0 signal
127 Condition Aggravated 284 4.0 4.2 signal
128 Pulmonary Oedema 42 4.0 4.0 signal
129 Mydriasis 12 4.0 4.0 signal
130 Post Procedural Complication 18 4.0 4.0 signal
131 Intraocular Pressure Increased 12 4.0 4.0 signal
132 Pancytopenia 52 4.0 4.0 signal
133 Platelet Count Decreased 98 3.9 4.0 signal
134 Oesophagitis 10 3.9 3.9 signal
135 Cardio-respiratory Arrest 38 3.9 3.9 signal
136 Hypocalcaemia 17 3.8 3.9 signal
137 Malnutrition 10 3.8 3.9 signal
138 Mental Status Changes 25 3.8 3.9 signal
139 Cardiac Failure 72 3.8 3.9 signal
140 Unresponsive To Stimuli 23 3.8 3.8 signal
141 Blood Bilirubin Increased 24 3.8 3.8 signal
142 Epilepsy 27 3.8 3.8 signal
143 Liver Disorder 39 3.8 3.8 signal
144 Drug Ineffective For Unapproved Indication 49 3.8 3.8 signal
145 Shock 20 3.7 3.8 signal
146 Pulmonary Mass 13 3.7 3.7 signal
147 Abdominal Pain 201 3.7 3.8 signal
148 Lung Disorder 42 3.7 3.7 signal
149 Disorientation 34 3.7 3.7 signal
150 Deformity 8 3.6 3.6 signal
151 Haematocrit Decreased 17 3.6 3.6 signal
152 Depression 194 3.6 3.7 signal
153 Dialysis 12 3.6 3.6 signal
154 Blood Creatine Phosphokinase Increased 24 3.5 3.5 signal
155 Gamma-glutamyltransferase Increased 18 3.5 3.5 signal
156 Hepatomegaly 8 3.5 3.5 signal
157 Septic Shock 35 3.5 3.5 signal
158 Pneumonia Aspiration 20 3.4 3.4 signal
159 Drug Hypersensitivity 155 3.4 3.5 signal
160 Generalised Tonic-clonic Seizure 13 3.4 3.4 signal
161 Hepatic Failure 24 3.4 3.4 signal
162 Acute Respiratory Distress Syndrome 14 3.4 3.4 signal
163 Rash Erythematous 37 3.4 3.4 signal
164 Haemoglobin Decreased 81 3.4 3.4 signal
165 Oedema Peripheral 96 3.4 3.4 signal
166 Blood Pressure Decreased 51 3.3 3.3 signal
167 Hypotension 154 3.3 3.4 signal
168 Oral Candidiasis 10 3.3 3.3 signal
169 Therapy Non-responder 34 3.3 3.3 signal
170 Acute Kidney Injury 116 3.3 3.3 signal
171 Lung Infection 12 3.3 3.3 signal
172 Hyperthyroidism 11 3.2 3.3 signal
173 Depressed Level Of Consciousness 30 3.2 3.3 signal
174 Cerebrovascular Accident 129 3.2 3.3 signal
175 Drug Resistance 19 3.2 3.2 signal
176 Myelosuppression 25 3.1 3.1 signal
177 Bradycardia 39 3.1 3.2 signal
178 Respiratory Distress 20 3.1 3.1 signal
179 Nervousness 38 3.1 3.1 signal
180 Leukocytosis 13 3.1 3.1 signal
181 Lymphopenia 10 3.0 3.0 signal
182 Musculoskeletal Stiffness 62 3.0 3.0 signal
183 Sinus Tachycardia 10 3.0 3.0 signal
184 Pneumonitis 19 3.0 3.0 signal
185 Pallor 19 3.0 3.0 signal
186 Anaphylactic Reaction 38 3.0 3.0 signal
187 Inappropriate Antidiuretic Hormone Secretion 7 2.9 2.9 signal
188 Post Procedural Haemorrhage 8 2.9 2.9 signal
189 Vomiting 321 2.9 3.1 signal
190 Cytokine Release Syndrome 13 2.9 2.9 signal
191 Drug Eruption 12 2.9 2.9 signal
192 Fluid Overload 10 2.9 2.9 signal
193 Hypoaesthesia Oral 10 2.8 2.8 signal
194 Pelvic Pain 12 2.8 2.8 signal
195 White Blood Cell Count Decreased 71 2.8 2.8 signal
196 Brain Neoplasm 6 2.8 2.8 signal
197 Respiratory Depression 8 2.8 2.8 signal
198 Upper Gastrointestinal Haemorrhage 11 2.8 2.8 signal
199 Device Related Infection 10 2.8 2.8 signal
200 Haematuria 22 2.7 2.7 signal
201 Colitis 24 2.7 2.7 signal
202 Gastrointestinal Disorder 56 2.7 2.7 signal
203 Hepatocellular Injury 9 2.7 2.7 signal
204 Pulmonary Fibrosis 12 2.7 2.7 signal
205 Deep Vein Thrombosis 41 2.7 2.7 signal
206 Supraventricular Tachycardia 6 2.7 2.7 signal
207 Paraesthesia Oral 9 2.7 2.7 signal
208 Intestinal Perforation 7 2.7 2.7 signal
209 Blood Calcium Decreased 7 2.6 2.7 signal
210 Procedural Pain 17 2.6 2.6 signal
211 Cardiomyopathy 9 2.6 2.6 signal
212 Atrial Fibrillation 59 2.6 2.6 signal
213 Rhabdomyolysis 25 2.6 2.6 signal
214 Hypotonia 6 2.6 2.6 signal
215 Neutropenia 81 2.6 2.6 signal
216 Heart Rate Decreased 21 2.5 2.5 signal
217 Jaundice 16 2.5 2.5 signal
218 Arrhythmia 28 2.5 2.5 signal
219 Acute Hepatic Failure 8 2.5 2.5 signal
220 Cytopenia 7 2.5 2.5 signal
221 Agitation 43 2.5 2.5 signal
222 Blood Urine Present 11 2.5 2.5 signal
223 Neurotoxicity 10 2.5 2.5 signal
224 Ileus 7 2.4 2.4 signal
225 Cold Sweat 10 2.4 2.4 signal
226 Premature Delivery 9 2.4 2.4 signal
227 Chills 66 2.4 2.4 signal
228 Pharyngitis 7 2.4 2.4 signal
229 Lactic Acidosis 18 2.4 2.4 signal
230 Dysarthria 21 2.4 2.4 signal
231 Meningioma 8 2.3 2.3 signal
232 Dysphagia 51 2.3 2.3 signal
233 Liver Injury 13 2.3 2.3 signal
234 Dehydration 71 2.3 2.3 signal
235 Premature Baby 16 2.3 2.3 signal
236 Product Use In Unapproved Indication 128 2.2 2.3 signal
237 Thrombotic Microangiopathy 5 2.2 2.2 no signal
238 Emotional Disorder 16 2.2 2.2 signal
239 Splenomegaly 6 2.2 2.2 no signal
240 Drug Toxicity 7 2.2 2.2 no signal
241 Myoclonus 6 2.1 2.2 no signal
242 Electrocardiogram Qt Prolonged 18 2.1 2.1 signal
243 Convulsion 29 2.1 2.1 signal
244 Deafness 13 2.1 2.1 signal
245 Death 423 2.1 2.2 signal
246 Chest Discomfort 50 2.1 2.1 signal
247 Conjunctivitis 9 2.1 2.1 signal
248 Disease Progression 57 2.1 2.1 signal
249 Chronic Kidney Disease 37 2.1 2.1 signal
250 Mental Disorder 21 2.1 2.1 signal
251 Dermatitis Allergic 6 2.1 2.1 no signal
252 Petechiae 5 2.1 2.1 no signal
253 Tubulointerstitial Nephritis 9 2.1 2.1 no signal
254 Nervous System Disorder 15 2.0 2.0 signal
255 Seizure 54 2.0 2.0 signal
256 Serotonin Syndrome 9 2.0 2.0 no signal
257 Glaucoma 9 2.0 2.0 no signal
258 Discomfort 28 2.0 2.0 no signal
259 Platelet Count Increased 6 2.0 2.0 no signal
260 Dental Caries 5 1.9 1.9 no signal
261 Feeding Disorder 9 1.9 1.9 no signal
262 Rash Maculo-papular 10 1.9 1.9 no signal
263 Stevens-johnson Syndrome 10 1.9 1.9 no signal
264 Pancreatitis Acute 10 1.9 1.9 no signal
265 Hypertensive Crisis 5 1.9 1.9 no signal
266 Liver Function Test Abnormal 13 1.9 1.9 no signal
267 Gastric Haemorrhage 5 1.8 1.8 no signal
268 Respiratory Arrest 12 1.8 1.8 no signal
269 Hepatitis 11 1.8 1.8 no signal
270 Erythema Multiforme 4 1.8 1.8 no signal
271 Palmar-plantar Erythrodysaesthesia Syndrome 10 1.8 1.8 no signal
272 Tremor 71 1.8 1.8 no signal
273 Coordination Abnormal 6 1.8 1.8 no signal
274 Abortion Induced 4 1.8 1.8 no signal
275 Loss Of Consciousness 54 1.8 1.8 no signal
276 Neuroleptic Malignant Syndrome 5 1.8 1.8 no signal
277 Speech Disorder 22 1.8 1.8 no signal
278 Dyskinesia 17 1.8 1.8 no signal
279 Muscle Rigidity 5 1.8 1.8 no signal
280 Dystonia 8 1.8 1.8 no signal
281 Therapy Partial Responder 6 1.7 1.7 no signal
282 Hypothermia 4 1.7 1.7 no signal
283 Malignant Neoplasm Progression 40 1.7 1.7 no signal
284 Exposure During Pregnancy 23 1.6 1.6 no signal
285 Metastases To Bone 6 1.6 1.6 no signal
286 Asthma 41 1.6 1.6 no signal
287 Rebound Effect 4 1.5 1.5 no signal
288 Eosinophilia 6 1.5 1.5 no signal
289 Myocardial Infarction 60 1.5 1.5 no signal
290 Peritonitis 7 1.4 1.4 no signal
291 Polyneuropathy 4 1.4 1.4 no signal
292 Haematotoxicity 3 1.4 1.4 no signal
293 No Therapeutic Response 4 1.4 1.4 no signal
294 Toxicity To Various Agents 53 1.3 1.4 no signal
295 Musculoskeletal Disorder 6 1.3 1.3 no signal
296 Neoplasm Progression 11 1.3 1.3 no signal
297 Interstitial Lung Disease 15 1.3 1.3 no signal
298 Pneumocystis Jirovecii Pneumonia 3 1.3 1.3 no signal
299 Visual Acuity Reduced 10 1.3 1.3 no signal
300 Toxic Skin Eruption 3 1.3 1.3 no signal
301 Central Nervous System Lesion 4 1.2 1.2 no signal
302 Fistula 3 1.1 1.1 no signal
303 Acute Myeloid Leukaemia 4 1.1 1.1 no signal
304 Madarosis 3 1.1 1.1 no signal
305 Activities Of Daily Living Impaired 5 1.1 1.1 no signal
306 Hepatic Cytolysis 3 1.0 1.0 no signal
307 Wrong Technique In Drug Usage Process 9 1.0 1.0 no signal
308 Hair Colour Changes 3 1.0 1.0 no signal
309 Drug Reaction With Eosinophilia And Systemic Symptoms 6 1.0 1.0 no signal
310 Foetal Exposure During Pregnancy 19 1.0 1.0 no signal
311 Plasma Cell Myeloma 9 1.0 1.0 no signal
312 Anorexia 3 1.0 1.0 no signal
313 Hair Texture Abnormal 3 0.9 0.9 no signal
314 Blood Glucose Increased 41 0.9 0.9 no signal
315 Drug Administration Error 6 0.8 0.8 no signal
316 Gastric Cancer 4 0.7 0.7 no signal
317 Incorrect Route Of Drug Administration 4 0.5 0.5 no signal