OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Melphalan

1,118 flagged reaction(s) · 78,117 total co-reports · max PRR 806.5
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Meningomyelitis Herpes 15 806.5 807.0 signal
2 Protothecosis 37 603.9 604.9 signal
3 Mucoepidermoid Carcinoma Of Salivary Gland 15 326.4 326.7 signal
4 Choroidal Infarction 28 281.2 281.6 signal
5 Chorioretinal Atrophy 48 274.2 274.8 signal
6 Juvenile Melanoma Benign 14 250.9 251.1 signal
7 Pre-engraftment Immune Reaction 17 250.6 250.8 signal
8 Engraftment Syndrome 122 243.5 244.8 signal
9 Refractory Cytopenia With Multilineage Dysplasia 21 237.0 237.2 signal
10 Clonal Haematopoiesis 15 236.4 236.5 signal
11 Malignant Transformation 85 217.0 217.8 signal
12 Iris Atrophy 39 214.7 215.1 signal
13 Neuroblastoma Recurrent 34 188.3 188.6 signal
14 Blood Stem Cell Transplant Failure 35 179.7 180.0 signal
15 Myelodysplastic Syndrome With Excess Blasts 19 179.0 179.2 signal
16 Poems Syndrome 17 178.6 178.7 signal
17 Adenovirus Reactivation 21 165.5 165.6 signal
18 Idiopathic Pneumonia Syndrome 45 165.2 165.5 signal
19 Autologous Haematopoietic Stem Cell Transplant 13 160.6 160.7 signal
20 Adenoviral Hepatitis 34 159.4 159.6 signal
21 Delayed Engraftment 19 159.3 159.5 signal
22 Pneumonia Adenoviral 27 152.3 152.5 signal
23 Engraft Failure 40 151.1 151.3 signal
24 Chronic Graft Versus Host Disease In Intestine 26 150.4 150.6 signal
25 Mucoepidermoid Carcinoma 13 144.9 145.0 signal
26 Light Chain Disease 18 129.5 129.7 signal
27 Acute Graft Versus Host Disease In Intestine 165 123.6 124.5 signal
28 Human Herpesvirus 6 Encephalitis 33 121.6 121.8 signal
29 Gastroenteritis Adenovirus 18 120.1 120.2 signal
30 Adenovirus Infection 325 118.5 120.3 signal
31 Retinal Depigmentation 33 112.1 112.3 signal
32 Hepatic Infection Fungal 13 112.1 112.2 signal
33 Human Herpesvirus 6 Infection Reactivation 37 110.5 110.7 signal
34 Venoocclusive Liver Disease 515 108.5 111.0 signal
35 Acute Graft Versus Host Disease In Skin 289 108.5 109.9 signal
36 Adenoviral Haemorrhagic Cystitis 22 108.1 108.2 signal
37 Acute Graft Versus Host Disease 473 105.8 108.1 signal
38 Atrophy Of Globe 13 105.2 105.2 signal
39 Epstein-barr Virus Infection Reactivation 128 104.4 105.0 signal
40 Chronic Graft Versus Host Disease In Skin 91 102.9 103.4 signal
41 Cystitis Viral 37 99.8 99.9 signal
42 Aspiration Bone Marrow 13 99.0 99.1 signal
43 Chorioretinal Disorder 18 96.8 96.9 signal
44 Acute Graft Versus Host Disease In Liver 68 96.5 96.8 signal
45 Viral Haemorrhagic Cystitis 66 95.6 95.9 signal
46 Graft Versus Host Disease In Gastrointestinal Tract 194 93.0 93.8 signal
47 Venoocclusive Disease 217 87.9 88.7 signal
48 Mantle Cell Lymphoma Recurrent 37 87.6 87.8 signal
49 Autoimmune Neutropenia 25 86.9 87.0 signal
50 Graft Versus Host Disease In Skin 188 86.6 87.3 signal
51 Chronic Graft Versus Host Disease 304 84.5 85.6 signal
52 Plasmacytosis 16 84.0 84.1 signal
53 Chromosomal Deletion 13 83.7 83.7 signal
54 Plasma Cell Myeloma Refractory 104 80.9 81.3 signal
55 Epstein-barr Viraemia 83 76.6 76.9 signal
56 Human Herpesvirus 6 Infection 145 76.3 76.8 signal
57 B-cell Type Acute Leukaemia 54 75.4 75.5 signal
58 Central Hypothyroidism 23 74.5 74.6 signal
59 Refractory Anaemia With An Excess Of Blasts 23 72.5 72.6 signal
60 Chronic Graft Versus Host Disease Oral 17 70.6 70.7 signal
61 Nasal Abscess 16 70.0 70.0 signal
62 Viraemia 95 67.9 68.2 signal
63 B-cell Lymphoma Recurrent 36 65.9 66.0 signal
64 Bone Debridement 32 65.0 65.1 signal
65 Osteosarcoma 25 64.4 64.4 signal
66 Cytomegalovirus Infection Reactivation 277 64.3 65.1 signal
67 Polychromasia 19 62.2 62.3 signal
68 Plasma Cell Myeloma Recurrent 204 61.7 62.2 signal
69 Ureaplasma Infection 25 61.1 61.2 signal
70 Plasma Cell Leukaemia 37 61.0 61.1 signal
71 B Precursor Type Acute Leukaemia 24 60.9 61.0 signal
72 Graft Versus Host Disease 441 60.2 61.3 signal
73 Apoptosis 19 60.1 60.1 signal
74 Cerebral Toxoplasmosis 55 57.9 58.1 signal
75 Bone Marrow Transplant Rejection 13 57.4 57.4 signal
76 Jc Virus Infection 93 57.3 57.5 signal
77 Mucocutaneous Ulceration 13 57.1 57.2 signal
78 Morganella Infection 17 56.9 57.0 signal
79 Graft Versus Host Disease In Liver 40 55.1 55.2 signal
80 Gastrointestinal Fungal Infection 28 53.7 53.7 signal
81 Wound Debridement 23 53.5 53.5 signal
82 Monoclonal Immunoglobulin Increased 15 51.9 52.0 signal
83 Primary Sequestrum 47 50.0 50.1 signal
84 Chronic Graft Versus Host Disease In Liver 18 48.8 48.9 signal
85 Complications Of Bone Marrow Transplant 18 48.0 48.0 signal
86 Bk Virus Infection 157 45.6 45.9 signal
87 Stem Cell Transplant 115 45.2 45.4 signal
88 Iris Adhesions 23 44.2 44.2 signal
89 Myelodysplastic Syndrome 655 43.9 45.2 signal
90 Pneumonia Respiratory Syncytial Viral 37 43.5 43.5 signal
91 Osteolysis 90 42.5 42.7 signal
92 Thrombotic Microangiopathy 425 42.5 43.3 signal
93 Post Transplant Lymphoproliferative Disorder 218 42.1 42.5 signal
94 Transplantation Complication 18 41.9 41.9 signal
95 Neutropenic Colitis 89 41.8 42.0 signal
96 Device Related Bacteraemia 13 41.8 41.9 signal
97 Plasmacytoma 81 41.8 41.9 signal
98 Mucosal Inflammation 1,097 40.7 42.7 signal
99 Retinal Pigment Epitheliopathy 18 39.9 40.0 signal
100 Human Herpesvirus 8 Infection 25 39.7 39.8 signal
101 Human Polyomavirus Infection 21 39.0 39.0 signal
102 Growth Failure 14 39.0 39.0 signal
103 Gastrointestinal Mucosal Disorder 26 38.9 38.9 signal
104 Graft Versus Host Disease In Lung 19 38.6 38.6 signal
105 Sequestrectomy 26 37.2 37.3 signal
106 Transplant Failure 94 37.1 37.3 signal
107 Metapneumovirus Infection 29 36.8 36.9 signal
108 Diffuse Large B-cell Lymphoma Recurrent 82 36.8 36.9 signal
109 Metastatic Lymphoma 15 36.7 36.7 signal
110 Klebsiella Bacteraemia 35 36.2 36.3 signal
111 Parainfluenzae Virus Infection 58 36.1 36.2 signal
112 Aseptic Necrosis Bone 29 35.2 35.2 signal
113 Transformation To Acute Myeloid Leukaemia 24 35.1 35.1 signal
114 Cystitis Haemorrhagic 146 34.9 35.1 signal
115 Acute Lymphocytic Leukaemia 102 34.6 34.8 signal
116 Metastases To Bone Marrow 18 34.3 34.4 signal
117 Enterococcal Sepsis 29 34.1 34.2 signal
118 Pneumonia Cytomegaloviral 68 34.0 34.1 signal
119 Lenticular Opacities 15 33.4 33.5 signal
120 Pulmonary Veno-occlusive Disease 24 33.1 33.1 signal
121 Enterococcal Bacteraemia 36 32.7 32.8 signal
122 Infection Reactivation 39 32.7 32.7 signal
123 Varicella Zoster Virus Infection 69 32.0 32.1 signal
124 Sinus Polyp 19 31.6 31.6 signal
125 Epstein-barr Virus Infection 203 31.2 31.5 signal
126 Plasma Cell Myeloma 1,274 31.2 33.0 signal
127 Rotavirus Infection 18 30.3 30.3 signal
128 Aplasia 63 30.2 30.3 signal
129 Second Primary Malignancy 261 30.0 30.4 signal
130 Premature Menopause 29 30.0 30.0 signal
131 Actinomycosis 30 29.7 29.7 signal
132 Encephalitis Viral 37 29.2 29.3 signal
133 Monoclonal Gammopathy 19 28.9 28.9 signal
134 Acute Myeloid Leukaemia 470 28.8 29.4 signal
135 Encephalitis Cytomegalovirus 13 28.7 28.7 signal
136 Systemic Mycosis 35 28.6 28.7 signal
137 Minimal Residual Disease 14 28.5 28.5 signal
138 Bacterial Sepsis 96 28.1 28.2 signal
139 Epstein-barr Virus Associated Lymphoproliferative Disorder 52 28.0 28.1 signal
140 Pneumococcal Sepsis 19 27.8 27.9 signal
141 Cytomegalovirus Viraemia 127 27.7 27.8 signal
142 Vitreous Haemorrhage 80 27.5 27.6 signal
143 Cytomegalovirus Test Positive 51 27.5 27.5 signal
144 Systemic Candida 69 26.6 26.7 signal
145 Candida Sepsis 25 26.5 26.5 signal
146 Fusarium Infection 19 26.5 26.5 signal
147 Aortic Calcification 16 25.8 25.8 signal
148 Chronic Myelomonocytic Leukaemia 18 25.7 25.8 signal
149 Cytomegalovirus Infection 444 25.4 25.9 signal
150 Amyloidosis 46 25.3 25.4 signal
151 Cryptosporidiosis Infection 14 25.3 25.4 signal
152 Klebsiella Sepsis 30 25.3 25.3 signal
153 Hepatitis E 41 24.9 24.9 signal
154 Toxoplasmosis 28 24.6 24.6 signal
155 Follicular Lymphoma 22 24.5 24.5 signal
156 Abdominal Compartment Syndrome 16 24.4 24.4 signal
157 Retinal Toxicity 26 24.3 24.3 signal
158 Obliterative Bronchiolitis 33 23.6 23.7 signal
159 Monoclonal Immunoglobulin Present 19 23.6 23.6 signal
160 Scedosporium Infection 17 23.3 23.3 signal
161 Pulmonary Mycosis 19 22.8 22.8 signal
162 Staphylococcal Bacteraemia 104 22.8 22.9 signal
163 Herpes Zoster Disseminated 19 22.8 22.8 signal
164 Escherichia Bacteraemia 55 22.6 22.6 signal
165 Enterovirus Infection 20 22.2 22.2 signal
166 Cytomegalovirus Chorioretinitis 45 22.1 22.2 signal
167 Mantle Cell Lymphoma 35 21.9 21.9 signal
168 Fungaemia 36 21.8 21.9 signal
169 Vertebral Foraminal Stenosis 19 21.8 21.8 signal
170 Hypogammaglobulinaemia 147 21.7 21.9 signal
171 Bone Swelling 22 21.4 21.4 signal
172 Bone Lesion 81 21.3 21.3 signal
173 Streptococcal Bacteraemia 24 21.2 21.2 signal
174 Enterococcal Infection 107 20.9 21.0 signal
175 Stenotrophomonas Infection 29 20.5 20.5 signal
176 Cytopenia 258 20.4 20.7 signal
177 Osteosclerosis 34 20.4 20.4 signal
178 Progressive Multifocal Leukoencephalopathy 176 20.2 20.3 signal
179 Polyneuropathy 251 20.0 20.2 signal
180 Hepatitis B Reactivation 67 19.9 20.0 signal
181 Mucosal Erosion 19 19.8 19.8 signal
182 Pneumonia Fungal 79 19.3 19.3 signal
183 Endocarditis Bacterial 16 19.2 19.2 signal
184 Vith Nerve Paralysis 23 19.1 19.1 signal
185 Aspergillus Infection 129 18.8 18.9 signal
186 Intervertebral Disc Space Narrowing 16 18.8 18.8 signal
187 Bacteraemia 232 18.6 18.8 signal
188 Acute Myeloid Leukaemia Recurrent 42 18.6 18.7 signal
189 Cytomegalovirus Enterocolitis 15 18.6 18.6 signal
190 Visceral Leishmaniasis 14 18.5 18.5 signal
191 Bronchopulmonary Aspergillosis 151 18.5 18.6 signal
192 Haemophagocytic Lymphohistiocytosis 141 18.4 18.5 signal
193 Diarrhoea Infectious 15 18.2 18.2 signal
194 Fungal Oesophagitis 13 17.7 17.7 signal
195 Iiird Nerve Paralysis 15 17.5 17.5 signal
196 Febrile Neutropenia 1,217 17.3 18.3 signal
197 Staphylococcal Sepsis 91 17.3 17.4 signal
198 Parvovirus B19 Infection 16 17.1 17.1 signal
199 Ejection Fraction Abnormal 22 16.9 16.9 signal
200 Disturbance In Social Behaviour 42 16.7 16.8 signal
201 Haematotoxicity 164 16.7 16.8 signal
202 Cytogenetic Abnormality 20 16.6 16.6 signal
203 Adenocarcinoma Of Colon 33 16.6 16.6 signal
204 Retinal Degeneration 22 16.5 16.5 signal
205 Bone Marrow Toxicity 21 16.5 16.5 signal
206 Adenocarcinoma Gastric 16 16.4 16.4 signal
207 Therapy Partial Responder 261 16.3 16.5 signal
208 Haematological Infection 40 16.2 16.3 signal
209 Abscess Jaw 18 16.1 16.2 signal
210 Polyomavirus Viraemia 17 16.0 16.0 signal
211 Peripheral Sensorimotor Neuropathy 21 16.0 16.0 signal
212 Vascular Calcification 18 15.8 15.8 signal
213 Posterior Reversible Encephalopathy Syndrome 156 15.4 15.5 signal
214 Capillary Leak Syndrome 33 15.1 15.2 signal
215 Febrile Bone Marrow Aplasia 67 15.1 15.1 signal
216 Exposed Bone In Jaw 35 15.0 15.1 signal
217 Cytomegalovirus Colitis 36 15.0 15.0 signal
218 Pneumonia Influenzal 19 15.0 15.0 signal
219 Autonomic Neuropathy 16 14.8 14.9 signal
220 Escherichia Sepsis 43 14.0 14.0 signal
221 Gastrointestinal Wall Thickening 22 13.9 13.9 signal
222 Febrile Infection 17 13.9 13.9 signal
223 Renal Tubular Injury 17 13.8 13.8 signal
224 Acute Promyelocytic Leukaemia 15 13.8 13.8 signal
225 Pneumonia Streptococcal 16 13.7 13.7 signal
226 Gastrointestinal Inflammation 112 13.5 13.6 signal
227 Hypoperfusion 15 13.5 13.5 signal
228 Mucosal Disorder 14 13.2 13.3 signal
229 Rhinovirus Infection 53 13.1 13.1 signal
230 Mycobacterial Infection 24 13.1 13.1 signal
231 Clostridium Colitis 17 13.0 13.1 signal
232 Gastrointestinal Toxicity 65 13.0 13.0 signal
233 Cardiac Amyloidosis 15 13.0 13.0 signal
234 Lymphoproliferative Disorder 40 12.8 12.8 signal
235 Cutaneous T-cell Lymphoma 16 12.7 12.7 signal
236 Multiple Organ Dysfunction Syndrome 372 12.5 12.7 signal
237 Meningitis Bacterial 19 12.4 12.5 signal
238 Pharyngeal Inflammation 16 12.4 12.4 signal
239 Diffuse Large B-cell Lymphoma 101 12.4 12.5 signal
240 Pneumonia Pseudomonal 20 12.4 12.4 signal
241 Transitional Cell Carcinoma 17 12.3 12.3 signal
242 Pseudomonal Sepsis 23 12.3 12.3 signal
243 Mucous Membrane Disorder 18 12.1 12.2 signal
244 Peripheral Sensory Neuropathy 75 12.0 12.1 signal
245 Device Related Sepsis 26 12.0 12.0 signal
246 Acute Lymphocytic Leukaemia Recurrent 33 12.0 12.0 signal
247 Neutropenic Sepsis 91 11.9 12.0 signal
248 Soft Tissue Infection 23 11.9 11.9 signal
249 Ototoxicity 23 11.6 11.6 signal
250 Aplastic Anaemia 65 11.6 11.7 signal
251 Haemolytic Uraemic Syndrome 29 11.6 11.6 signal
252 Klebsiella Infection 62 11.6 11.6 signal
253 Neurological Decompensation 28 11.6 11.6 signal
254 Autoimmune Haemolytic Anaemia 42 11.5 11.6 signal
255 Histiocytosis Haematophagic 37 11.5 11.5 signal
256 Hyperammonaemic Encephalopathy 21 11.5 11.5 signal
257 Blood Culture Positive 37 11.5 11.5 signal
258 Pneumonia Pneumococcal 18 11.4 11.4 signal
259 Keratopathy 19 11.3 11.3 signal
260 Leukaemia Recurrent 20 11.1 11.1 signal
261 Pulmonary Toxicity 81 10.8 10.8 signal
262 Neoplasm Recurrence 39 10.8 10.8 signal
263 Mastication Disorder 35 10.8 10.8 signal
264 Blood Immunoglobulin G Increased 14 10.7 10.8 signal
265 Aspergillosis 15 10.6 10.6 signal
266 Kyphosis 20 10.6 10.6 signal
267 Pneumatosis Intestinalis 32 10.6 10.6 signal
268 Gastroenteritis Norovirus 15 10.5 10.5 signal
269 Acute Leukaemia 18 10.4 10.4 signal
270 Hepatitis B 67 10.3 10.4 signal
271 Embolism Arterial 13 10.1 10.1 signal
272 Gene Mutation 21 9.9 9.9 signal
273 Enterocolitis 60 9.8 9.9 signal
274 Myelopathy 20 9.8 9.8 signal
275 Pancytopenia 583 9.8 10.0 signal
276 Clostridium Difficile Colitis 111 9.8 9.8 signal
277 Lung Infiltration 93 9.8 9.8 signal
278 Kidney Fibrosis 18 9.7 9.7 signal
279 Lymphopenia 146 9.7 9.8 signal
280 Bone Marrow Failure 212 9.7 9.8 signal
281 Ventricular Hypokinesia 33 9.6 9.6 signal
282 Enteritis 65 9.6 9.6 signal
283 Lichenoid Keratosis 23 9.5 9.5 signal
284 Multiple Myeloma 48 9.5 9.5 signal
285 Pneumocystis Jirovecii Pneumonia 100 9.4 9.4 signal
286 Pulmonary Haemorrhage 78 9.3 9.4 signal
287 Myelitis Transverse 14 9.3 9.3 signal
288 H1n1 Influenza 14 9.3 9.3 signal
289 Pseudomonas Infection 83 9.2 9.2 signal
290 Leukoencephalopathy 36 9.0 9.0 signal
291 Squamous Cell Carcinoma Of Skin 57 8.9 8.9 signal
292 Osteitis 24 8.8 8.8 signal
293 Acute Respiratory Distress Syndrome 166 8.8 8.8 signal
294 Septic Shock 405 8.8 8.9 signal
295 Nocardiosis 24 8.8 8.8 signal
296 Cardiotoxicity 83 8.8 8.8 signal
297 Thrombocytopenia 1,043 8.7 9.1 signal
298 Nephropathy Toxic 104 8.7 8.8 signal
299 Aortic Arteriosclerosis 24 8.7 8.7 signal
300 Acute Sinusitis 16 8.7 8.7 signal
301 Escherichia Infection 76 8.7 8.7 signal
302 Multi-organ Failure 161 8.6 8.6 signal
303 Tumour Lysis Syndrome 80 8.6 8.6 signal
304 Optic Atrophy 15 8.6 8.6 signal
305 Jugular Vein Thrombosis 16 8.5 8.5 signal
306 Neoplasm Skin 14 8.4 8.4 signal
307 Paresis 20 8.4 8.4 signal
308 Encephalitis 61 8.3 8.3 signal
309 Bacterial Infection 164 8.3 8.3 signal
310 Basal Cell Carcinoma 137 8.2 8.2 signal
311 Computerised Tomogram Abnormal 20 8.2 8.2 signal
312 Enterocolitis Haemorrhagic 13 8.2 8.2 signal
313 Lung Adenocarcinoma 26 8.0 8.1 signal
314 Spondylolisthesis 15 8.0 8.0 signal
315 Tooth Extraction 107 8.0 8.1 signal
316 Hepatic Cyst 29 8.0 8.0 signal
317 Renal Tubular Disorder 24 7.9 7.9 signal
318 Invasive Ductal Breast Carcinoma 23 7.9 7.9 signal
319 Granulocyte Count Decreased 15 7.9 7.9 signal
320 Immune Thrombocytopenic Purpura 24 7.8 7.8 signal
321 Atelectasis 81 7.8 7.8 signal
322 Neutropenia 1,114 7.7 8.0 signal
323 Hyperammonaemia 41 7.7 7.7 signal
324 Purulent Discharge 35 7.6 7.7 signal
325 Mucormycosis 21 7.6 7.6 signal
326 Ileus Paralytic 36 7.6 7.6 signal
327 Opportunistic Infection 15 7.6 7.6 signal
328 Respiratory Syncytial Virus Infection 70 7.6 7.6 signal
329 Pathological Fracture 41 7.5 7.5 signal
330 Herpes Simplex 52 7.5 7.5 signal
331 Pseudomembranous Colitis 18 7.5 7.5 signal
332 Small Intestinal Perforation 15 7.5 7.5 signal
333 Bone Disorder 146 7.4 7.5 signal
334 Brain Abscess 20 7.4 7.4 signal
335 Venous Thrombosis 31 7.3 7.4 signal
336 Lung Consolidation 22 7.3 7.3 signal
337 Hyperuricaemia 32 7.3 7.3 signal
338 Hyporeflexia 15 7.3 7.3 signal
339 Retinopathy 29 7.2 7.3 signal
340 Hypoalbuminaemia 59 7.2 7.2 signal
341 Oral Fungal Infection 21 7.1 7.1 signal
342 Deafness Neurosensory 25 7.1 7.1 signal
343 Osteonecrosis 252 7.1 7.2 signal
344 Myelosuppression 258 7.1 7.1 signal
345 Cytokine Release Syndrome 144 7.1 7.1 signal
346 Renal Cell Carcinoma 37 7.0 7.0 signal
347 Hepatosplenomegaly 19 6.9 6.9 signal
348 Systemic Inflammatory Response Syndrome 28 6.9 6.9 signal
349 Neuropathy Peripheral 694 6.9 7.0 signal
350 Clostridial Infection 25 6.8 6.8 signal
351 Bone Marrow Disorder 22 6.8 6.8 signal
352 Embolism Venous 22 6.8 6.8 signal
353 Hypophosphataemia 53 6.7 6.7 signal
354 Arterial Thrombosis 14 6.7 6.7 signal
355 Radiculopathy 19 6.7 6.7 signal
356 Candida Infection 120 6.7 6.7 signal
357 Duodenitis 22 6.7 6.7 signal
358 Retinal Haemorrhage 51 6.7 6.7 signal
359 Sepsis 800 6.7 6.9 signal
360 Pulmonary Alveolar Haemorrhage 40 6.7 6.7 signal
361 Ischaemia 33 6.7 6.7 signal
362 Hepatitis Fulminant 21 6.6 6.6 signal
363 Immune Reconstitution Inflammatory Syndrome 35 6.5 6.5 signal
364 Autonomic Nervous System Imbalance 20 6.5 6.5 signal
365 Hypercalcaemia 85 6.4 6.4 signal
366 Oesophagitis 75 6.4 6.4 signal
367 Hyperbilirubinaemia 69 6.2 6.3 signal
368 Myositis 60 6.2 6.3 signal
369 Osteomyelitis 120 6.2 6.2 signal
370 Cardiomyopathy 98 6.2 6.2 signal
371 Disease Progression 777 6.1 6.3 signal
372 Escherichia Urinary Tract Infection 28 6.1 6.1 signal
373 Spinal Osteoarthritis 58 6.1 6.1 signal
374 Ventricular Dysfunction 17 6.1 6.1 signal
375 Hepatomegaly 64 6.0 6.1 signal
376 Left Ventricular Dysfunction 42 5.9 5.9 signal
377 Pneumonia Viral 20 5.9 5.9 signal
378 Gastrointestinal Injury 17 5.8 5.8 signal
379 Necrosis 35 5.8 5.8 signal
380 Pericardial Effusion 144 5.8 5.9 signal
381 Pneumocystis Jiroveci Pneumonia 14 5.8 5.8 signal
382 Multiple-drug Resistance 19 5.7 5.7 signal
383 Cardiac Tamponade 29 5.7 5.7 signal
384 Blood Lactate Dehydrogenase Increased 97 5.7 5.7 signal
385 Growth Retardation 18 5.7 5.7 signal
386 Hypervolaemia 29 5.6 5.6 signal
387 Oral Disorder 44 5.6 5.6 signal
388 Leukaemia 56 5.5 5.5 signal
389 Haemorrhage Urinary Tract 15 5.5 5.5 signal
390 Neurotoxicity 102 5.5 5.5 signal
391 Aortic Valve Incompetence 25 5.5 5.5 signal
392 Lymphoma 90 5.4 5.4 signal
393 Osteonecrosis Of Jaw 144 5.4 5.4 signal
394 Vascular Device Infection 26 5.4 5.4 signal
395 Actinic Keratosis 15 5.4 5.4 signal
396 Organising Pneumonia 28 5.3 5.3 signal
397 Chronic Myeloid Leukaemia 26 5.2 5.2 signal
398 Haemodynamic Instability 42 5.2 5.2 signal
399 Skin Toxicity 31 5.2 5.2 signal
400 Covid-19 Pneumonia 66 5.2 5.2 signal
401 Gastrointestinal Necrosis 16 5.1 5.1 signal
402 Metastasis 39 5.1 5.1 signal
403 Encephalopathy 132 5.0 5.0 signal
404 Acute Respiratory Failure 103 5.0 5.0 signal
405 Failure To Thrive 28 5.0 5.0 signal
406 Bronchiolitis 19 5.0 5.0 signal
407 Leukopenia 266 5.0 5.0 signal
408 Colitis 200 4.9 5.0 signal
409 Drug Resistance 136 4.9 5.0 signal
410 Malignant Melanoma 71 4.9 4.9 signal
411 Respiratory Failure 384 4.9 5.0 signal
412 Pneumonitis 142 4.9 4.9 signal
413 Compression Fracture 27 4.8 4.8 signal
414 Recurrent Cancer 21 4.8 4.8 signal
415 Stomatitis 311 4.8 4.8 signal
416 Cardiac Failure Acute 34 4.8 4.8 signal
417 Clonus 14 4.8 4.8 signal
418 Pathogen Resistance 46 4.7 4.7 signal
419 Pneumonia Bacterial 46 4.7 4.7 signal
420 Pulmonary Hypertension 105 4.7 4.7 signal
421 Infection 708 4.6 4.7 signal
422 Retinal Detachment 45 4.6 4.6 signal
423 Papilloedema 22 4.5 4.5 signal
424 Nephrotic Syndrome 33 4.5 4.5 signal
425 Inappropriate Antidiuretic Hormone Secretion 49 4.5 4.5 signal
426 Disease Recurrence 228 4.4 4.5 signal
427 Cardiomegaly 59 4.4 4.4 signal
428 Transplant Rejection 38 4.4 4.4 signal
429 Respiratory Tract Infection 123 4.4 4.4 signal
430 Herpes Virus Infection 27 4.4 4.4 signal
431 Aplasia Pure Red Cell 16 4.3 4.3 signal
432 Hypoxia 162 4.3 4.3 signal
433 Brain Natriuretic Peptide Increased 14 4.2 4.2 signal
434 Chest X-ray Abnormal 14 4.2 4.2 signal
435 Atrial Flutter 36 4.2 4.2 signal
436 Herpes Zoster 258 4.2 4.2 signal
437 Haemolytic Anaemia 40 4.1 4.1 signal
438 Cerebral Ischaemia 23 4.1 4.1 signal
439 Hepatotoxicity 98 4.1 4.1 signal
440 Arthritis Bacterial 18 4.1 4.1 signal
441 Device Related Infection 68 4.1 4.1 signal
442 Tooth Abscess 45 4.1 4.1 signal
443 Hepatic Lesion 19 4.1 4.1 signal
444 Ileus 54 4.1 4.1 signal
445 Atypical Pneumonia 13 4.1 4.1 signal
446 Jaw Disorder 24 4.0 4.0 signal
447 Granuloma 15 4.0 4.0 signal
448 Metabolic Encephalopathy 13 4.0 4.0 signal
449 Loose Tooth 14 4.0 4.0 signal
450 Bronchopneumonia 15 4.0 4.0 signal
451 Ascites 127 4.0 4.0 signal
452 Endocarditis 22 4.0 4.0 signal
453 Pleural Effusion 260 4.0 4.0 signal
454 Immune-mediated Enterocolitis 15 4.0 4.0 signal
455 Cerebral Atrophy 17 4.0 4.0 signal
456 Respiratory Distress 116 3.9 3.9 signal
457 Squamous Cell Carcinoma 39 3.8 3.9 signal
458 Streptococcal Infection 23 3.8 3.8 signal
459 Pulmonary Arterial Hypertension 60 3.8 3.8 signal
460 Dermatitis Exfoliative Generalised 14 3.8 3.8 signal
461 Angiopathy 23 3.8 3.8 signal
462 Partial Seizures 21 3.8 3.8 signal
463 Embolism 34 3.8 3.8 signal
464 Mitral Valve Incompetence 46 3.8 3.8 signal
465 Toxic Skin Eruption 41 3.8 3.8 signal
466 Left Ventricular Hypertrophy 17 3.7 3.7 signal
467 Staphylococcal Infection 131 3.7 3.7 signal
468 Hypovolaemia 23 3.7 3.7 signal
469 Fungal Infection 130 3.6 3.6 signal
470 Oliguria 24 3.6 3.6 signal
471 Gingival Swelling 17 3.6 3.6 signal
472 Exercise Tolerance Decreased 22 3.6 3.6 signal
473 Renal Failure Chronic 30 3.6 3.6 signal
474 Adrenal Insufficiency 46 3.6 3.6 signal
475 Agranulocytosis 71 3.6 3.6 signal
476 Pulseless Electrical Activity 16 3.6 3.6 signal
477 Hypernatraemia 19 3.6 3.6 signal
478 Hypertransaminasaemia 26 3.5 3.6 signal
479 Tricuspid Valve Incompetence 30 3.5 3.5 signal
480 Fluid Overload 56 3.5 3.5 signal
481 Metabolic Disorder 22 3.5 3.5 signal
482 Product Use In Unapproved Indication 921 3.5 3.6 signal
483 Renal Cyst 30 3.5 3.5 signal
484 Spinal Column Stenosis 18 3.5 3.5 signal
485 Bronchiectasis 25 3.5 3.5 signal
486 Neutrophil Count Decreased 152 3.5 3.5 signal
487 Hepatic Failure 113 3.5 3.5 signal
488 Immune Effector Cell-associated Neurotoxicity Syndrome 21 3.5 3.5 signal
489 Blood Bilirubin Increased 101 3.5 3.5 signal
490 Odynophagia 22 3.5 3.5 signal
491 Acute Kidney Injury 566 3.5 3.5 signal
492 Deep Vein Thrombosis 242 3.4 3.5 signal
493 Gingivitis 20 3.4 3.4 signal
494 Spinal Compression Fracture 31 3.4 3.4 signal
495 Candidiasis 15 3.4 3.4 signal
496 Decubitus Ulcer 30 3.4 3.4 signal
497 Conjunctival Haemorrhage 14 3.4 3.4 signal
498 Periorbital Oedema 19 3.4 3.4 signal
499 Toxic Encephalopathy 18 3.4 3.4 signal
500 Clostridium Difficile Infection 79 3.4 3.4 signal
501 Anaemia 692 3.4 3.4 signal
502 Intentional Product Use Issue 317 3.4 3.4 signal
503 Gastrointestinal Infection 32 3.3 3.3 signal
504 Spinal Cord Compression 14 3.3 3.3 signal
505 Intervertebral Disc Degeneration 33 3.3 3.3 signal
506 Ejection Fraction Decreased 55 3.3 3.3 signal
507 Guillain-barre Syndrome 17 3.3 3.3 signal
508 Intestinal Ischaemia 19 3.2 3.2 signal
509 Diverticulum Intestinal 15 3.2 3.2 signal
510 Cardiac Failure 276 3.2 3.2 signal
511 Lung Infection 54 3.2 3.2 signal
512 Haemodialysis 29 3.2 3.2 signal
513 Disseminated Intravascular Coagulation 48 3.2 3.2 signal
514 Neoplasm Progression 119 3.2 3.2 signal
515 Physical Disability 15 3.1 3.1 signal
516 Pulmonary Oedema 149 3.1 3.1 signal
517 Tachypnoea 45 3.1 3.1 signal
518 No Therapeutic Response 41 3.1 3.1 signal
519 Hypocalcaemia 62 3.1 3.1 signal
520 Bundle Branch Block Left 14 3.0 3.0 signal
521 Pneumonia 1,055 3.0 3.1 signal
522 Tubulointerstitial Nephritis 61 3.0 3.0 signal
523 Myopathy 28 3.0 3.0 signal
524 Pneumothorax 51 3.0 3.0 signal
525 Toxicity To Various Agents 539 3.0 3.0 signal
526 Hypomagnesaemia 44 2.9 3.0 signal
527 Dermatitis Exfoliative 16 2.9 2.9 signal
528 Renal Failure 423 2.9 3.0 signal
529 Blood Albumin Decreased 25 2.9 2.9 signal
530 Lymphadenopathy 112 2.9 2.9 signal
531 Meningitis 21 2.9 2.9 signal
532 Immunosuppression 27 2.9 2.9 signal
533 Pulmonary Congestion 41 2.9 2.9 signal
534 Hypokalaemia 142 2.9 2.9 signal
535 Generalised Oedema 38 2.9 2.9 signal
536 Bronchospasm 44 2.9 2.9 signal
537 Pyrexia 1,060 2.8 2.9 signal
538 Transaminases Increased 68 2.8 2.8 signal
539 Diverticulum 22 2.8 2.8 signal
540 Renal Failure Acute 131 2.8 2.8 signal
541 Pain In Jaw 86 2.8 2.8 signal
542 Intestinal Perforation 34 2.8 2.8 signal
543 Intervertebral Disc Disorder 13 2.8 2.8 signal
544 Acute Hepatic Failure 41 2.8 2.8 signal
545 Drug Ineffective For Unapproved Indication 167 2.8 2.8 signal
546 Neurological Symptom 17 2.8 2.8 signal
547 Renal Impairment 248 2.8 2.8 signal
548 Gastroenteritis 43 2.7 2.7 signal
549 Hypovolaemic Shock 14 2.7 2.7 signal
550 Cachexia 15 2.7 2.7 signal
551 Viral Infection 97 2.7 2.7 signal
552 Ecchymosis 20 2.7 2.7 signal
553 Immune Thrombocytopenia 13 2.7 2.7 signal
554 Glomerular Filtration Rate Decreased 35 2.7 2.7 signal
555 Arteriosclerosis Coronary Artery 19 2.7 2.7 signal
556 Blood Disorder 23 2.7 2.7 signal
557 Atrial Fibrillation 279 2.7 2.7 signal
558 Coagulopathy 47 2.6 2.6 signal
559 Status Epilepticus 32 2.6 2.6 signal
560 Off Label Use 2,448 2.6 2.8 signal
561 Eyelid Oedema 33 2.6 2.6 signal
562 Dental Caries 31 2.6 2.6 signal
563 Eyelid Ptosis 28 2.6 2.6 signal
564 Drug Toxicity 38 2.6 2.6 signal
565 Impaired Healing 90 2.5 2.6 signal
566 Exostosis 25 2.5 2.5 signal
567 Immune System Disorder 36 2.5 2.5 signal
568 Platelet Count Decreased 291 2.5 2.6 signal
569 Haemolysis 21 2.5 2.5 signal
570 Paranoia 47 2.5 2.5 signal
571 Malnutrition 30 2.5 2.5 signal
572 Malignant Neoplasm Progression 274 2.5 2.5 signal
573 Osteopenia 41 2.5 2.5 signal
574 Humerus Fracture 13 2.5 2.5 signal
575 Rib Fracture 55 2.5 2.5 signal
576 Pulmonary Fibrosis 51 2.5 2.5 signal
577 Emphysema 27 2.5 2.5 signal
578 Deformity 25 2.5 2.5 signal
579 Acute Coronary Syndrome 22 2.4 2.5 signal
580 Orthostatic Hypotension 46 2.4 2.5 signal
581 Hepatitis Acute 17 2.4 2.4 signal
582 Pulmonary Mass 39 2.4 2.4 signal
583 Ataxia 31 2.4 2.4 signal
584 Cardiogenic Shock 37 2.4 2.4 signal
585 Large Intestine Perforation 18 2.4 2.4 signal
586 Hyperglycaemia 94 2.4 2.4 signal
587 Rash Maculo-papular 57 2.4 2.4 signal
588 Mass 36 2.4 2.4 signal
589 Right Ventricular Failure 18 2.4 2.4 signal
590 Proteinuria 48 2.4 2.4 signal
591 Anuria 22 2.4 2.4 signal
592 Electrolyte Imbalance 29 2.3 2.3 signal
593 Lung Disorder 123 2.3 2.3 signal
594 Acute Pulmonary Oedema 14 2.3 2.3 signal
595 Prothrombin Time Prolonged 15 2.3 2.3 signal
596 Sinus Tachycardia 35 2.3 2.3 signal
597 Joint Effusion 17 2.3 2.3 signal
598 Nephropathy 23 2.3 2.3 signal
599 Abscess 39 2.3 2.3 signal
600 Cerebral Disorder 18 2.3 2.3 signal
601 Pyelonephritis 21 2.3 2.3 signal
602 Granulocytopenia 14 2.3 2.3 signal
603 Hypertriglyceridaemia 14 2.2 2.2 signal
604 Toxic Epidermal Necrolysis 36 2.2 2.2 signal
605 Gingival Pain 19 2.2 2.2 signal
606 Mental Status Changes 66 2.2 2.2 signal
607 Decreased Interest 14 2.2 2.2 signal
608 Cholecystitis 28 2.2 2.2 signal
609 Metastases To Lung 27 2.2 2.2 signal
610 Interstitial Lung Disease 113 2.2 2.2 signal
611 Splenomegaly 27 2.1 2.1 signal
612 Cholestasis 44 2.1 2.1 signal
613 Hepatitis C 28 2.1 2.1 signal
614 Therapy Non-responder 102 2.1 2.1 signal
615 Small Intestinal Obstruction 28 2.1 2.1 signal
616 Hyponatraemia 128 2.1 2.1 signal
617 Upper Respiratory Tract Infection 105 2.1 2.1 signal
618 Drug Eruption 40 2.1 2.1 signal
619 Nervous System Disorder 71 2.1 2.1 signal
620 Hepatitis 58 2.1 2.1 signal
621 Scoliosis 14 2.1 2.1 signal
622 General Physical Condition Abnormal 15 2.1 2.1 signal
623 Mouth Haemorrhage 16 2.0 2.0 signal
624 Pulmonary Embolism 203 2.0 2.0 no signal
625 End Stage Renal Disease 39 2.0 2.0 no signal
626 Skin Mass 14 2.0 2.0 no signal
627 Hiccups 17 1.9 1.9 no signal
628 Metastases To Bone 34 1.9 1.9 no signal
629 Oral Candidiasis 27 1.9 1.9 no signal
630 Haemorrhage Intracranial 31 1.9 1.9 no signal
631 Sinus Bradycardia 20 1.9 1.9 no signal
632 Appendicitis 19 1.9 1.9 no signal
633 Renal Tubular Necrosis 20 1.9 1.9 no signal
634 Lymphoedema 14 1.9 1.9 no signal
635 Ventricular Extrasystoles 21 1.9 1.9 no signal
636 Pharyngitis 25 1.9 1.9 no signal
637 Hiatus Hernia 26 1.9 1.9 no signal
638 Hyperlipidaemia 24 1.9 1.9 no signal
639 Mouth Ulceration 42 1.9 1.9 no signal
640 Supraventricular Tachycardia 19 1.8 1.8 no signal
641 Angina Unstable 13 1.8 1.8 no signal
642 Sudden Death 21 1.8 1.8 no signal
643 Incorrect Route Of Product Administration 33 1.8 1.8 no signal
644 Blood Urea Increased 33 1.8 1.8 no signal
645 Aspartate Aminotransferase Increased 104 1.8 1.8 no signal
646 Deafness 51 1.8 1.8 no signal
647 Neuralgia 47 1.8 1.8 no signal
648 Tenderness 20 1.8 1.8 no signal
649 Anorexia 25 1.8 1.8 no signal
650 Altered State Of Consciousness 41 1.8 1.8 no signal
651 Haemorrhoids 37 1.8 1.8 no signal
652 Hydronephrosis 14 1.7 1.7 no signal
653 Gastritis 49 1.7 1.7 no signal
654 Therapeutic Product Effect Incomplete 130 1.7 1.7 no signal
655 Haematuria 63 1.7 1.7 no signal
656 Petechiae 19 1.7 1.7 no signal
657 Neoplasm 21 1.7 1.7 no signal
658 Subdural Haematoma 26 1.7 1.7 no signal
659 Transfusion 19 1.7 1.7 no signal
660 Blood Creatinine Increased 118 1.7 1.7 no signal
661 Haematocrit Decreased 36 1.7 1.7 no signal
662 Arteriosclerosis 17 1.7 1.7 no signal
663 Spinal Disorder 17 1.7 1.7 no signal
664 Intervertebral Disc Protrusion 39 1.7 1.7 no signal
665 Fistula 20 1.6 1.6 no signal
666 Leukocytosis 32 1.6 1.6 no signal
667 Oedema 95 1.6 1.6 no signal
668 Hepatic Function Abnormal 65 1.6 1.6 no signal
669 Gastrointestinal Haemorrhage 147 1.6 1.6 no signal
670 Tooth Infection 23 1.6 1.6 no signal
671 Jaundice 47 1.6 1.6 no signal
672 Pneumonia Aspiration 43 1.6 1.6 no signal
673 Cellulitis 87 1.6 1.6 no signal
674 Hyperthermia 13 1.6 1.6 no signal
675 Disorientation 68 1.6 1.6 no signal
676 Diarrhoea Haemorrhagic 16 1.6 1.6 no signal
677 Acidosis 13 1.6 1.6 no signal
678 Purpura 15 1.6 1.6 no signal
679 Aphthous Ulcer 13 1.6 1.6 no signal
680 Dialysis 24 1.6 1.6 no signal
681 Brain Oedema 21 1.5 1.5 no signal
682 Bone Pain 97 1.5 1.5 no signal
683 Unevaluable Event 124 1.5 1.5 no signal
684 Hepatic Encephalopathy 15 1.5 1.5 no signal
685 Liver Disorder 71 1.5 1.5 no signal
686 Tachycardia 142 1.5 1.5 no signal
687 C-reactive Protein Increased 58 1.5 1.5 no signal
688 General Physical Health Deterioration 183 1.5 1.5 no signal
689 Delirium 55 1.5 1.5 no signal
690 Melaena 35 1.5 1.5 no signal
691 Arrhythmia 75 1.5 1.5 no signal
692 Product Use Issue 294 1.5 1.5 no signal
693 Pancreatitis Acute 35 1.5 1.5 no signal
694 Cerebral Haemorrhage 56 1.5 1.5 no signal
695 Gastrointestinal Disorder 138 1.4 1.5 no signal
696 Oral Pain 35 1.4 1.4 no signal
697 Dermatitis 32 1.4 1.4 no signal
698 Tooth Fracture 17 1.4 1.4 no signal
699 Optic Neuritis 14 1.4 1.4 no signal
700 Hypotension 307 1.4 1.4 no signal
701 Diarrhoea 979 1.4 1.4 no signal
702 Hyperkalaemia 53 1.4 1.4 no signal
703 Scar 26 1.4 1.4 no signal
704 Alanine Aminotransferase Increased 93 1.4 1.4 no signal
705 White Blood Cell Count Decreased 164 1.4 1.4 no signal
706 Hypophagia 38 1.4 1.4 no signal
707 Cardiac Murmur 13 1.4 1.4 no signal
708 Bursitis 18 1.4 1.4 no signal
709 Blood Alkaline Phosphatase Increased 37 1.4 1.4 no signal
710 Upper Gastrointestinal Haemorrhage 25 1.4 1.4 no signal
711 Tuberculosis 19 1.4 1.4 no signal
712 Lymphocyte Count Decreased 26 1.4 1.4 no signal
713 Subarachnoid Haemorrhage 15 1.4 1.4 no signal
714 Generalised Tonic-clonic Seizure 24 1.4 1.4 no signal
715 Hypercholesterolaemia 14 1.4 1.4 no signal
716 Haematemesis 37 1.3 1.4 no signal
717 Liver Function Test Increased 31 1.3 1.3 no signal
718 Acute Myocardial Infarction 43 1.3 1.3 no signal
719 Oedema Peripheral 177 1.3 1.3 no signal
720 Haemoglobin Decreased 148 1.3 1.3 no signal
721 Toothache 26 1.3 1.3 no signal
722 Metastases To Liver 25 1.3 1.3 no signal
723 Musculoskeletal Chest Pain 22 1.3 1.3 no signal
724 Myocarditis 16 1.3 1.3 no signal
725 Lower Respiratory Tract Infection 64 1.3 1.3 no signal
726 Shock 32 1.3 1.3 no signal
727 Treatment Failure 115 1.3 1.3 no signal
728 Gamma-glutamyltransferase Increased 31 1.3 1.3 no signal
729 Hypotonia 14 1.3 1.3 no signal
730 Depressed Level Of Consciousness 55 1.3 1.3 no signal
731 Stevens-johnson Syndrome 31 1.3 1.3 no signal
732 Tooth Loss 29 1.3 1.3 no signal
733 Hypertension 292 1.3 1.3 no signal
734 Renal Disorder 64 1.3 1.3 no signal
735 Dysuria 50 1.3 1.3 no signal
736 Ventricular Tachycardia 22 1.2 1.2 no signal
737 Skin Disorder 44 1.2 1.2 no signal
738 Thyroid Cancer 16 1.2 1.2 no signal
739 Myocardial Ischaemia 15 1.2 1.2 no signal
740 Abnormal Behaviour 52 1.2 1.2 no signal
741 Face Oedema 22 1.2 1.2 no signal
742 Tooth Disorder 29 1.2 1.2 no signal
743 Osteoarthritis 55 1.2 1.2 no signal
744 Aspiration 14 1.2 1.2 no signal
745 Osteoporosis 53 1.2 1.2 no signal
746 Epilepsy 39 1.2 1.2 no signal
747 Pericarditis 21 1.2 1.2 no signal
748 Red Blood Cell Count Decreased 36 1.2 1.2 no signal
749 Skin Infection 14 1.2 1.2 no signal
750 Autoimmune Disorder 12 1.2 1.2 no signal
751 Dyspnoea Exertional 47 1.2 1.2 no signal
752 Skin Lesion 34 1.2 1.2 no signal
753 Infusion Related Reaction 82 1.2 1.2 no signal
754 Joint Dislocation 13 1.1 1.1 no signal
755 Cardiac Failure Congestive 100 1.1 1.1 no signal
756 Ischaemic Stroke 22 1.1 1.1 no signal
757 Therapeutic Response Decreased 74 1.1 1.1 no signal
758 Hypothyroidism 39 1.1 1.1 no signal
759 Bradycardia 65 1.1 1.1 no signal
760 Cardiac Arrest 100 1.1 1.1 no signal
761 Urinary Retention 40 1.1 1.1 no signal
762 Respiratory Disorder 36 1.1 1.1 no signal
763 Thrombosis 96 1.1 1.1 no signal
764 Cerebral Infarction 29 1.1 1.1 no signal
765 Myoclonus 14 1.1 1.1 no signal
766 Circulatory Collapse 20 1.1 1.1 no signal
767 Peritonitis 24 1.1 1.1 no signal
768 Colon Cancer 17 1.1 1.1 no signal
769 Gastric Cancer 29 1.0 1.0 no signal
770 Hepatic Steatosis 21 1.0 1.0 no signal
771 Body Temperature Increased 23 1.0 1.0 no signal
772 Intestinal Obstruction 42 1.0 1.0 no signal
773 Covid-19 198 1.0 1.0 no signal
774 Liver Injury 27 1.0 1.0 no signal
775 Post Procedural Haemorrhage 13 1.0 1.0 no signal
776 Spinal Pain 13 1.0 1.0 no signal
777 Bronchitis 82 1.0 1.0 no signal
778 Cataract 65 1.0 1.0 no signal
779 Drug Reaction With Eosinophilia And Systemic Symptoms 28 1.0 1.0 no signal
780 Cystitis 35 1.0 1.0 no signal
781 Cardiovascular Disorder 28 1.0 1.0 no signal
782 Metastases To Central Nervous System 14 1.0 1.0 no signal
783 Diverticulitis 30 1.0 1.0 no signal
784 Urosepsis 10 1.0 1.0 no signal
785 Confusional State 175 1.0 1.0 no signal
786 Dehydration 144 1.0 1.0 no signal
787 Obstructive Airways Disorder 12 1.0 1.0 no signal
788 Hypertensive Crisis 12 1.0 1.0 no signal
789 Inflammation 55 1.0 1.0 no signal
790 Epistaxis 80 1.0 1.0 no signal
791 Cholelithiasis 35 1.0 1.0 no signal
792 Ulcer 17 1.0 1.0 no signal
793 Skin Reaction 15 1.0 1.0 no signal
794 Folliculitis 11 1.0 1.0 no signal
795 Blood Calcium Decreased 12 1.0 1.0 no signal
796 Muscular Weakness 119 1.0 1.0 no signal
797 Drug Ineffective 1,378 1.0 1.0 no signal
798 Paralysis 15 1.0 1.0 no signal
799 Urinary Tract Infection 176 1.0 1.0 no signal
800 Conjunctivitis 19 1.0 1.0 no signal
801 Muscle Atrophy 13 1.0 1.0 no signal
802 Oral Herpes 20 1.0 1.0 no signal
803 Amenorrhoea 17 0.9 0.9 no signal
804 Drug Intolerance 97 0.9 0.9 no signal
805 Fracture 19 0.9 0.9 no signal
806 Haemoptysis 28 0.9 0.9 no signal
807 Hemiparesis 17 0.9 0.9 no signal
808 Presyncope 24 0.9 0.9 no signal
809 Ventricular Fibrillation 11 0.9 0.9 no signal
810 Glaucoma 19 0.9 0.9 no signal
811 Metabolic Acidosis 31 0.9 0.9 no signal
812 Drug Effect Incomplete 36 0.9 0.9 no signal
813 Neutrophil Count Increased 10 0.9 0.9 no signal
814 Haematoma 25 0.9 0.9 no signal
815 Syncope 96 0.9 0.9 no signal
816 Coronary Artery Disease 29 0.9 0.9 no signal
817 Convulsion 55 0.9 0.9 no signal
818 Vasculitis 11 0.9 0.9 no signal
819 Full Blood Count Decreased 19 0.9 0.9 no signal
820 Impaired Gastric Emptying 12 0.9 0.9 no signal
821 Drug-induced Liver Injury 29 0.9 0.9 no signal
822 Vomiting 438 0.9 0.9 no signal
823 Hallucination 70 0.9 0.9 no signal
824 Dysphagia 87 0.9 0.9 no signal
825 Haemorrhage 96 0.9 0.9 no signal
826 Urinary Incontinence 27 0.8 0.8 no signal
827 Decreased Appetite 211 0.8 0.8 no signal
828 Agitation 67 0.8 0.8 no signal
829 Anhedonia 24 0.8 0.8 no signal
830 Ear Infection 24 0.8 0.8 no signal
831 Wound 25 0.8 0.8 no signal
832 Joint Range Of Motion Decreased 12 0.8 0.8 no signal
833 Ovarian Cyst 9 0.8 0.8 no signal
834 Motor Dysfunction 9 0.8 0.8 no signal
835 Post Procedural Complication 17 0.8 0.8 no signal
836 Gingival Bleeding 12 0.8 0.8 no signal
837 Abdominal Pain 203 0.8 0.8 no signal
838 Night Sweats 28 0.8 0.8 no signal
839 Pollakiuria 36 0.8 0.8 no signal
840 Oral Discomfort 12 0.8 0.8 no signal
841 Anaphylactic Shock 22 0.8 0.8 no signal
842 Rectal Haemorrhage 37 0.8 0.8 no signal
843 Flank Pain 8 0.8 0.8 no signal
844 Rash Erythematous 40 0.8 0.8 no signal
845 Rotator Cuff Syndrome 11 0.8 0.8 no signal
846 Constipation 184 0.8 0.8 no signal
847 Incontinence 9 0.8 0.8 no signal
848 Influenza 95 0.8 0.8 no signal
849 Productive Cough 40 0.8 0.8 no signal
850 Chronic Obstructive Pulmonary Disease 44 0.8 0.8 no signal
851 Femur Fracture 26 0.8 0.8 no signal
852 Sinusitis 86 0.8 0.8 no signal
853 Visual Acuity Reduced 28 0.8 0.8 no signal
854 Chronic Kidney Disease 64 0.8 0.8 no signal
855 Cardio-respiratory Arrest 35 0.8 0.8 no signal
856 Gastroenteritis Viral 15 0.8 0.8 no signal
857 Transient Ischaemic Attack 28 0.8 0.8 no signal
858 Chills 97 0.8 0.8 no signal
859 Rash 353 0.8 0.8 no signal
860 Sinus Disorder 16 0.7 0.7 no signal
861 Fluid Retention 41 0.7 0.7 no signal
862 Cyst 10 0.7 0.7 no signal
863 Cardiac Disorder 75 0.7 0.7 no signal
864 Brain Injury 8 0.7 0.7 no signal
865 Diabetes Mellitus 61 0.7 0.7 no signal
866 Musculoskeletal Pain 42 0.7 0.7 no signal
867 Cough 222 0.7 0.7 no signal
868 Local Swelling 14 0.7 0.7 no signal
869 Hypoaesthesia 118 0.7 0.7 no signal
870 Drug Effective For Unapproved Indication 23 0.7 0.7 no signal
871 Drug Level Decreased 8 0.7 0.7 no signal
872 Ear Discomfort 8 0.7 0.7 no signal
873 Coma 37 0.7 0.7 no signal
874 Hepatocellular Injury 11 0.7 0.7 no signal
875 Paraesthesia Oral 11 0.7 0.7 no signal
876 Angina Pectoris 22 0.7 0.7 no signal
877 Aphasia 23 0.7 0.7 no signal
878 Pancreatitis 40 0.7 0.7 no signal
879 Obesity 12 0.7 0.7 no signal
880 Erythema Multiforme 7 0.7 0.7 no signal
881 Lactic Acidosis 24 0.7 0.7 no signal
882 Immunodeficiency 11 0.7 0.7 no signal
883 Nocturia 9 0.7 0.7 no signal
884 Disturbance In Attention 40 0.7 0.7 no signal
885 Unresponsive To Stimuli 19 0.7 0.7 no signal
886 Blindness 30 0.7 0.7 no signal
887 Hepatic Cytolysis 9 0.7 0.7 no signal
888 Laceration 7 0.7 0.7 no signal
889 Blood Triglycerides Increased 13 0.7 0.7 no signal
890 Diplopia 19 0.7 0.7 no signal
891 Death 627 0.7 0.7 no signal
892 Palmar-plantar Erythrodysaesthesia Syndrome 17 0.7 0.7 no signal
893 Gout 13 0.7 0.7 no signal
894 Central Nervous System Lesion 10 0.7 0.7 no signal
895 Injury 51 0.7 0.7 no signal
896 Ear Pain 14 0.7 0.7 no signal
897 Vitreous Floaters 7 0.7 0.7 no signal
898 Nausea 553 0.6 0.6 no signal
899 Salivary Hypersecretion 7 0.6 0.6 no signal
900 Erectile Dysfunction 18 0.6 0.6 no signal
901 Skin Ulcer 18 0.6 0.6 no signal
902 Seizure 80 0.6 0.6 no signal
903 Dyspnoea 394 0.6 0.6 no signal
904 Erythema 140 0.6 0.6 no signal
905 Asthenia 256 0.6 0.6 no signal
906 Sars-cov-2 Test Positive 9 0.6 0.6 no signal
907 Macular Degeneration 8 0.6 0.6 no signal
908 Photosensitivity Reaction 11 0.6 0.6 no signal
909 Renal Injury 20 0.6 0.6 no signal
910 Sinus Congestion 9 0.6 0.6 no signal
911 Blood Potassium Decreased 20 0.6 0.6 no signal
912 Swelling 62 0.6 0.6 no signal
913 Adverse Event 61 0.6 0.6 no signal
914 Lethargy 38 0.6 0.6 no signal
915 Condition Aggravated 198 0.6 0.6 no signal
916 Liver Function Test Abnormal 19 0.6 0.6 no signal
917 Abdominal Distension 67 0.6 0.6 no signal
918 Dermatitis Allergic 8 0.6 0.6 no signal
919 Ill-defined Disorder 39 0.6 0.6 no signal
920 Incorrect Product Administration Duration 13 0.6 0.6 no signal
921 Grand Mal Convulsion 6 0.6 0.6 no signal
922 Electrocardiogram Qt Prolonged 23 0.6 0.6 no signal
923 Haematochezia 35 0.6 0.6 no signal
924 Foot Fracture 12 0.6 0.6 no signal
925 Medication Error 35 0.6 0.6 no signal
926 Gastric Ulcer 12 0.6 0.6 no signal
927 Eosinophilia 11 0.6 0.6 no signal
928 Prostate Cancer 51 0.6 0.6 no signal
929 Intentional Product Misuse 54 0.6 0.6 no signal
930 Back Pain 144 0.6 0.6 no signal
931 Micturition Urgency 7 0.6 0.6 no signal
932 Rebound Effect 7 0.6 0.6 no signal
933 Dermatitis Contact 7 0.6 0.6 no signal
934 Neoplasm Malignant 41 0.6 0.6 no signal
935 Nodule 8 0.6 0.6 no signal
936 Bedridden 8 0.6 0.6 no signal
937 Oxygen Saturation Decreased 34 0.6 0.6 no signal
938 Hospice Care 6 0.6 0.6 no signal
939 Madarosis 7 0.6 0.6 no signal
940 Hypoglycaemia 29 0.6 0.6 no signal
941 Emotional Distress 71 0.5 0.5 no signal
942 Thyroid Disorder 9 0.5 0.5 no signal
943 Paraesthesia 92 0.5 0.5 no signal
944 Musculoskeletal Discomfort 10 0.5 0.5 no signal
945 Weight Decreased 162 0.5 0.5 no signal
946 Respiratory Tract Congestion 9 0.5 0.5 no signal
947 Hip Fracture 18 0.5 0.5 no signal
948 Sensory Disturbance 9 0.5 0.5 no signal
949 Hair Colour Changes 7 0.5 0.5 no signal
950 Disability 11 0.5 0.5 no signal
951 Blood Creatine Phosphokinase Increased 16 0.5 0.5 no signal
952 Drug Level Increased 9 0.5 0.5 no signal
953 Tinnitus 25 0.5 0.5 no signal
954 Red Blood Cell Sedimentation Rate Increased 6 0.5 0.5 no signal
955 Foot Deformity 6 0.5 0.5 no signal
956 Respiratory Arrest 15 0.5 0.5 no signal
957 Dementia 15 0.5 0.5 no signal
958 Arthropathy 30 0.5 0.5 no signal
959 Localised Infection 13 0.5 0.5 no signal
960 Hypoacusis 23 0.5 0.5 no signal
961 Eye Infection 6 0.5 0.5 no signal
962 Personality Change 5 0.5 0.5 no signal
963 Rash Papular 12 0.5 0.5 no signal
964 Oropharyngeal Pain 49 0.5 0.5 no signal
965 Bone Loss 8 0.5 0.5 no signal
966 Wheezing 31 0.5 0.5 no signal
967 Drug Interaction 83 0.5 0.5 no signal
968 Hepatic Enzyme Increased 35 0.5 0.5 no signal
969 Tendonitis 8 0.5 0.5 no signal
970 Fatigue 398 0.5 0.5 no signal
971 Gastrooesophageal Reflux Disease 41 0.5 0.5 no signal
972 Skin Cancer 11 0.5 0.5 no signal
973 Prostatic Specific Antigen Increased 7 0.5 0.5 no signal
974 Carpal Tunnel Syndrome 7 0.5 0.5 no signal
975 Arthritis 39 0.5 0.5 no signal
976 Hypothermia 5 0.5 0.5 no signal
977 Temperature Intolerance 5 0.5 0.5 no signal
978 Respiratory Depression 6 0.5 0.5 no signal
979 Lung Neoplasm Malignant 20 0.4 0.4 no signal
980 Dysgeusia 36 0.4 0.4 no signal
981 Hepatic Cirrhosis 9 0.4 0.4 no signal
982 Dysarthria 18 0.4 0.4 no signal
983 Discomfort 29 0.4 0.4 no signal
984 Anaphylactic Reaction 26 0.4 0.4 no signal
985 Lower Limb Fracture 9 0.4 0.4 no signal
986 White Blood Cell Count Increased 18 0.4 0.4 no signal
987 Hypoaesthesia Oral 7 0.4 0.4 no signal
988 Premature Baby 14 0.4 0.4 no signal
989 Device Failure 7 0.4 0.4 no signal
990 Nephrolithiasis 21 0.4 0.4 no signal
991 Joint Stiffness 12 0.4 0.4 no signal
992 Blood Count Abnormal 7 0.4 0.4 no signal
993 International Normalised Ratio Increased 13 0.4 0.4 no signal
994 Spinal Fracture 9 0.4 0.4 no signal
995 Dyspepsia 44 0.4 0.4 no signal
996 Nerve Injury 5 0.4 0.4 no signal
997 Gait Disturbance 85 0.4 0.4 no signal
998 Ageusia 11 0.4 0.4 no signal
999 Abdominal Pain Lower 11 0.4 0.4 no signal
1000 Eye Inflammation 4 0.4 0.4 no signal
1001 Treatment Noncompliance 23 0.4 0.4 no signal
1002 Multiple Fractures 7 0.4 0.4 no signal
1003 Musculoskeletal Disorder 8 0.4 0.4 no signal
1004 Drug Administration Error 13 0.4 0.4 no signal
1005 Hyperthyroidism 6 0.4 0.4 no signal
1006 Affect Lability 4 0.4 0.4 no signal
1007 Pancreatic Carcinoma 12 0.4 0.4 no signal
1008 Schizophrenia 5 0.4 0.4 no signal
1009 Drug Abuse 34 0.4 0.4 no signal
1010 Chest Pain 75 0.4 0.4 no signal
1011 Tremor 67 0.4 0.4 no signal
1012 Rash Macular 14 0.4 0.4 no signal
1013 Pain 246 0.4 0.4 no signal
1014 Activities Of Daily Living Impaired 8 0.4 0.4 no signal
1015 Amnesia 26 0.4 0.4 no signal
1016 Gallbladder Disorder 7 0.4 0.4 no signal
1017 Cognitive Disorder 18 0.4 0.4 no signal
1018 Genital Haemorrhage 5 0.4 0.4 no signal
1019 Pharyngeal Oedema 6 0.4 0.4 no signal
1020 Rhabdomyolysis 16 0.4 0.4 no signal
1021 Unintended Pregnancy 4 0.4 0.4 no signal
1022 Myocardial Infarction 67 0.4 0.4 no signal
1023 Rash Generalised 10 0.4 0.4 no signal
1024 Adverse Drug Reaction 34 0.4 0.4 no signal
1025 Complication Associated With Device 5 0.4 0.4 no signal
1026 Weight Increased 84 0.3 0.3 no signal
1027 Blood Pressure Decreased 25 0.3 0.3 no signal
1028 Fall 125 0.3 0.3 no signal
1029 Nasal Congestion 22 0.3 0.3 no signal
1030 Pain In Extremity 109 0.3 0.3 no signal
1031 Anxiety 105 0.3 0.3 no signal
1032 Hernia 7 0.3 0.3 no signal
1033 Breast Cancer 34 0.3 0.3 no signal
1034 Neck Pain 20 0.3 0.3 no signal
1035 Blister 20 0.3 0.3 no signal
1036 Multiple Sclerosis 17 0.3 0.3 no signal
1037 Chest Discomfort 36 0.3 0.3 no signal
1038 Cerebrovascular Accident 60 0.3 0.3 no signal
1039 Upper Limb Fracture 7 0.3 0.3 no signal
1040 Skin Exfoliation 29 0.3 0.3 no signal
1041 Dry Mouth 28 0.3 0.3 no signal
1042 Hypersensitivity 64 0.3 0.3 no signal
1043 Gastric Haemorrhage 4 0.3 0.3 no signal
1044 Mental Disorder 15 0.3 0.3 no signal
1045 Product Prescribing Issue 7 0.3 0.3 no signal
1046 Insomnia 91 0.3 0.3 no signal
1047 Contusion 32 0.3 0.3 no signal
1048 Blood Thyroid Stimulating Hormone Increased 3 0.3 0.3 no signal
1049 Ovarian Cancer 3 0.3 0.3 no signal
1050 Heart Rate Increased 32 0.3 0.3 no signal
1051 Muscle Spasticity 4 0.3 0.3 no signal
1052 Ocular Hyperaemia 15 0.3 0.3 no signal
1053 Bladder Cancer 19 0.3 0.3 no signal
1054 Depression 72 0.3 0.3 no signal
1055 Intraocular Pressure Increased 4 0.3 0.3 no signal
1056 Rhinorrhoea 20 0.3 0.3 no signal
1057 Loss Of Consciousness 39 0.3 0.3 no signal
1058 Dizziness 151 0.3 0.3 no signal
1059 Adverse Reaction 4 0.3 0.3 no signal
1060 Vision Blurred 41 0.3 0.3 no signal
1061 Somnolence 59 0.3 0.3 no signal
1062 Swelling Face 19 0.3 0.3 no signal
1063 Abasia 7 0.3 0.3 no signal
1064 Mobility Decreased 20 0.3 0.3 no signal
1065 Vertigo 17 0.3 0.3 no signal
1066 Pelvic Pain 5 0.3 0.3 no signal
1067 Psoriatic Arthropathy 11 0.3 0.3 no signal
1068 Eye Pruritus 9 0.3 0.3 no signal
1069 Muscle Spasms 50 0.3 0.3 no signal
1070 Myalgia 46 0.3 0.2 no signal
1071 Sedation 7 0.2 0.2 no signal
1072 Dry Eye 13 0.2 0.2 no signal
1073 Oesophageal Carcinoma 8 0.2 0.2 no signal
1074 Arthralgia 109 0.2 0.2 no signal
1075 Suicidal Ideation 24 0.2 0.2 no signal
1076 Visual Impairment 32 0.2 0.2 no signal
1077 Dystonia 5 0.2 0.2 no signal
1078 Dysphonia 15 0.2 0.2 no signal
1079 Abdominal Pain Upper 52 0.2 0.2 no signal
1080 Premature Delivery 4 0.2 0.2 no signal
1081 Injection Site Reaction 17 0.2 0.2 no signal
1082 Sleep Disorder 17 0.2 0.2 no signal
1083 Alopecia 47 0.2 0.2 no signal
1084 Burning Sensation 16 0.2 0.2 no signal
1085 Dry Skin 30 0.2 0.2 no signal
1086 Sopor 3 0.2 0.2 no signal
1087 Bone Density Decreased 7 0.2 0.2 no signal
1088 Drug Effect Decreased 12 0.2 0.2 no signal
1089 Flushing 22 0.2 0.2 no signal
1090 Pruritus 80 0.2 0.2 no signal
1091 Influenza Like Illness 17 0.2 0.2 no signal
1092 Headache 128 0.2 0.2 no signal
1093 Meningioma 3 0.2 0.2 no signal
1094 No Adverse Event 35 0.2 0.2 no signal
1095 Blood Pressure Increased 29 0.2 0.2 no signal
1096 Joint Swelling 22 0.2 0.2 no signal
1097 Asthma 20 0.2 0.2 no signal
1098 Palpitations 20 0.2 0.2 no signal
1099 Hospitalisation 26 0.2 0.2 no signal
1100 Hyperhidrosis 22 0.2 0.2 no signal
1101 Abdominal Discomfort 28 0.2 0.2 no signal
1102 Drug Hypersensitivity 29 0.1 0.1 no signal
1103 Device Malfunction 10 0.1 0.1 no signal
1104 Peripheral Swelling 22 0.1 0.1 no signal
1105 Device Dislocation 6 0.1 0.1 no signal
1106 Memory Impairment 19 0.1 0.1 no signal
1107 Urticaria 22 0.1 0.1 no signal
1108 Malaise 58 0.1 0.1 no signal
1109 Blood Glucose Increased 24 0.1 0.1 no signal
1110 Psoriasis 16 0.1 0.1 no signal
1111 Nasopharyngitis 22 0.1 0.1 no signal
1112 Pharmaceutical Product Complaint 3 0.1 0.1 no signal
1113 Inappropriate Schedule Of Product Administration 18 0.1 0.1 no signal
1114 Gynaecomastia 3 0.1 0.1 no signal
1115 Renal Cancer 4 0.1 0.1 no signal
1116 Colorectal Cancer 4 0.1 0.1 no signal
1117 Device Breakage 3 0.1 0.1 no signal
1118 Overdose 14 0.1 0.1 no signal