OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Memantine Hydrochloride Oral

139 flagged reaction(s) · 3,181 total co-reports · max PRR 25.6
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Sopor 45 25.6 26.0 signal
2 Hyperlipidaemia 34 21.6 21.8 signal
3 Pneumonia Aspiration 58 17.7 18.1 signal
4 Orthostatic Hypotension 40 17.4 17.7 signal
5 Impaired Quality Of Life 31 16.4 16.6 signal
6 Sinus Bradycardia 20 15.7 15.8 signal
7 Dementia 56 15.3 15.6 signal
8 Metastases To Central Nervous System 24 14.2 14.4 signal
9 Myoclonus 22 14.0 14.1 signal
10 Poor Quality Sleep 38 13.5 13.7 signal
11 Neuroleptic Malignant Syndrome 21 13.4 13.5 signal
12 Oral Herpes 33 12.9 13.0 signal
13 Salivary Hypersecretion 16 12.2 12.2 signal
14 Inappropriate Antidiuretic Hormone Secretion 16 11.9 12.0 signal
15 Delusion 24 11.8 11.9 signal
16 Psychomotor Hyperactivity 24 10.9 11.0 signal
17 Brain Oedema 18 10.8 10.9 signal
18 Delirium 47 10.3 10.5 signal
19 Bradycardia 72 10.3 10.5 signal
20 Impaired Work Ability 28 9.9 10.0 signal
21 Hypothermia 13 9.7 9.8 signal
22 Hypophagia 32 9.6 9.7 signal
23 Mental Status Changes 35 9.6 9.7 signal
24 Aspiration 13 9.1 9.2 signal
25 Ataxia 14 8.9 9.0 signal
26 Cerebral Haemorrhage 39 8.3 8.4 signal
27 Skin Disorder 36 8.2 8.3 signal
28 Malnutrition 12 8.2 8.2 signal
29 Hallucination, Auditory 17 8.1 8.2 signal
30 Squamous Cell Carcinoma 10 8.1 8.1 signal
31 Agitation 78 8.0 8.2 signal
32 Bone Density Decreased 33 7.9 8.0 signal
33 Presyncope 24 7.5 7.6 signal
34 Hypertensive Crisis 11 7.5 7.5 signal
35 Subarachnoid Haemorrhage 10 7.4 7.5 signal
36 Dyskinesia 39 7.3 7.4 signal
37 Hallucination, Visual 20 7.2 7.3 signal
38 Decreased Activity 10 7.1 7.1 signal
39 Abnormal Behaviour 35 6.7 6.7 signal
40 Gastric Haemorrhage 10 6.6 6.6 signal
41 Pancreatitis Acute 19 6.5 6.5 signal
42 Hallucination 63 6.4 6.5 signal
43 Hyponatraemia 47 6.3 6.4 signal
44 Altered State Of Consciousness 18 6.3 6.4 signal
45 Rhabdomyolysis 34 6.2 6.3 signal
46 Pallor 22 6.1 6.2 signal
47 Metastases To Lung 9 5.9 5.9 signal
48 Electrocardiogram Qt Prolonged 28 5.9 6.0 signal
49 Confusional State 125 5.9 6.1 signal
50 Syncope 77 5.8 6.0 signal
51 Aggression 38 5.8 5.8 signal
52 Hypokinesia 11 5.7 5.8 signal
53 Incontinence 8 5.7 5.7 signal
54 Cellulitis 38 5.7 5.8 signal
55 Blood Creatine Phosphokinase Increased 22 5.7 5.7 signal
56 Metastases To Liver 13 5.6 5.6 signal
57 Depressed Level Of Consciousness 29 5.6 5.6 signal
58 Metastases To Bone 12 5.6 5.6 signal
59 Leukocytosis 13 5.5 5.5 signal
60 Parkinsonism 7 5.4 5.5 signal
61 Hospice Care 7 5.4 5.4 signal
62 Restlessness 26 5.4 5.4 signal
63 Disorientation 27 5.2 5.2 signal
64 Abasia 17 5.1 5.2 signal
65 Cataract 40 5.1 5.2 signal
66 Petechiae 7 5.1 5.1 signal
67 Aphasia 20 5.0 5.0 signal
68 Epilepsy 20 5.0 5.0 signal
69 Cerebral Infarction 16 5.0 5.0 signal
70 Herpes Zoster 37 4.9 4.9 signal
71 Subdural Haematoma 9 4.8 4.8 signal
72 Dizziness Postural 6 4.7 4.7 signal
73 Unresponsive To Stimuli 16 4.7 4.7 signal
74 Sedation 16 4.7 4.7 signal
75 Encephalopathy 15 4.6 4.7 signal
76 Dysphagia 57 4.6 4.6 signal
77 Motor Dysfunction 6 4.5 4.5 signal
78 Muscle Rigidity 7 4.4 4.5 signal
79 Cognitive Disorder 27 4.4 4.4 signal
80 Dysstasia 17 4.4 4.4 signal
81 Rectal Haemorrhage 25 4.4 4.4 signal
82 Urinary Incontinence 17 4.4 4.4 signal
83 Fall 190 4.3 4.6 signal
84 Therapy Non-responder 25 4.3 4.3 signal
85 Somnolence 112 4.2 4.4 signal
86 Dehydration 74 4.2 4.3 signal
87 Faeces Discoloured 12 4.2 4.2 signal
88 Femur Fracture 17 4.2 4.2 signal
89 Liver Function Test Abnormal 16 4.1 4.2 signal
90 Hemiparesis 9 4.0 4.0 signal
91 Speech Disorder 27 3.9 3.9 signal
92 Cyanosis 8 3.9 3.9 signal
93 Head Injury 16 3.8 3.9 signal
94 Transient Ischaemic Attack 17 3.8 3.8 signal
95 Sluggishness 5 3.7 3.7 signal
96 Mania 8 3.7 3.7 signal
97 Drug Level Increased 8 3.7 3.7 signal
98 Apathy 7 3.7 3.7 signal
99 Neurotoxicity 8 3.5 3.5 signal
100 Hepatic Function Abnormal 17 3.5 3.5 signal
101 Bedridden 6 3.5 3.5 signal
102 Mobility Decreased 32 3.4 3.4 signal
103 Jaundice 12 3.4 3.4 signal
104 Chromaturia 10 3.4 3.4 signal
105 Loss Of Consciousness 56 3.3 3.4 signal
106 Hip Fracture 14 3.3 3.3 signal
107 Personality Change 4 3.2 3.2 signal
108 Cholestasis 8 3.2 3.2 signal
109 Hypotonia 4 3.0 3.0 no signal
110 Product Use Complaint 6 2.9 2.9 signal
111 International Normalised Ratio Increased 11 2.9 2.9 signal
112 Generalised Tonic-clonic Seizure 6 2.8 2.8 signal
113 Choking 7 2.7 2.7 signal
114 Coma 17 2.7 2.7 signal
115 Prescribed Underdose 7 2.7 2.7 signal
116 Drug Abuse 29 2.6 2.6 signal
117 Paranoia 6 2.6 2.6 signal
118 Medication Error 19 2.6 2.6 signal
119 Psychotic Disorder 10 2.6 2.6 signal
120 Schizophrenia 4 2.5 2.5 no signal
121 Dystonia 6 2.3 2.3 no signal
122 Activities Of Daily Living Impaired 6 2.3 2.3 no signal
123 Central Nervous System Lesion 4 2.2 2.2 no signal
124 Prostatic Specific Antigen Increased 4 2.2 2.2 no signal
125 Anger 9 2.0 2.0 no signal
126 Application Site Pruritus 6 2.0 2.0 no signal
127 Glycosylated Haemoglobin Increased 6 1.8 1.8 no signal
128 Application Site Erythema 6 1.7 1.7 no signal
129 Akathisia 3 1.7 1.7 no signal
130 Tardive Dyskinesia 6 1.6 1.6 no signal
131 Serotonin Syndrome 4 1.6 1.6 no signal
132 Extrapyramidal Disorder 5 1.5 1.5 no signal
133 Suicide Attempt 12 1.5 1.5 no signal
134 Lung Neoplasm Malignant 8 1.5 1.5 no signal
135 Product Adhesion Issue 6 1.3 1.3 no signal
136 Withdrawal Syndrome 7 1.3 1.3 no signal
137 Drug Prescribing Error 3 1.2 1.2 no signal
138 Myelosuppression 5 1.1 1.1 no signal
139 Wrong Technique In Drug Usage Process 5 1.0 1.0 no signal