Drug

Methylphenidate Hcl

72 flagged reaction(s) · 1,135 total co-reports · max PRR 22.1

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Mania	22	22.1	22.5	signal
2	Apathy	19	21.6	21.9	signal
3	Affect Lability	12	20.5	20.7	signal
4	Aggression	62	20.4	21.4	signal
5	Sudden Death	13	20.1	20.3	signal
6	Gastrointestinal Pain	13	19.6	19.8	signal
7	Abnormal Behaviour	44	18.2	18.9	signal
8	Hypotonia	11	18.1	18.3	signal
9	Grand Mal Convulsion	10	17.6	17.8	signal
10	Pharmaceutical Product Complaint	27	16.9	17.3	signal
11	Intentional Drug Misuse	21	16.4	16.6	signal
12	Dystonia	19	16.1	16.4	signal
13	Peripheral Coldness	13	15.6	15.7	signal
14	Drug Toxicity	13	15.6	15.7	signal
15	Serotonin Syndrome	18	15.5	15.8	signal
16	Psychomotor Hyperactivity	14	13.9	14.0	signal
17	Coordination Abnormal	11	12.9	13.0	signal
18	Mydriasis	10	12.9	13.0	signal
19	Anorexia	10	12.6	12.7	signal
20	Delusion	11	11.7	11.8	signal
21	Sinus Tachycardia	10	11.7	11.7	signal
22	Joint Dislocation	7	11.0	11.0	signal
23	No Therapeutic Response	8	10.7	10.7	signal
24	Hallucination, Auditory	10	10.4	10.5	signal
25	Convulsion	36	10.3	10.5	signal
26	Respiratory Arrest	17	10.1	10.2	signal
27	Agitation	45	10.1	10.4	signal
28	Psychotic Disorder	18	10.1	10.2	signal
29	Crying	21	9.5	9.7	signal
30	Hallucination, Visual	12	9.4	9.5	signal
31	Irritability	34	9.3	9.6	signal
32	Bipolar Disorder	6	9.1	9.1	signal
33	Suicide Attempt	33	9.0	9.2	signal
34	Ventricular Tachycardia	9	9.0	9.0	signal
35	Completed Suicide	45	8.8	9.1	signal
36	Intentional Overdose	34	8.8	9.0	signal
37	Dysarthria	20	8.8	8.9	signal
38	Impaired Driving Ability	6	8.7	8.7	signal
39	Paranoia	9	8.6	8.6	signal
40	Pallor	14	8.5	8.6	signal
41	Drug Effect Decreased	28	8.5	8.6	signal
42	Disorientation	19	7.9	8.0	signal
43	Poisoning	6	7.9	7.9	signal
44	Disturbance In Attention	25	7.6	7.8	signal
45	Intentional Self-injury	9	7.4	7.4	signal
46	Cardiac Arrest	36	7.2	7.4	signal
47	Personality Change	4	7.1	7.1	signal
48	Emotional Disorder	13	6.9	7.0	signal
49	Restlessness	15	6.8	6.8	signal
50	Dyskinesia	16	6.5	6.6	signal
51	Initial Insomnia	4	6.5	6.5	signal
52	Anger	13	6.3	6.4	signal
53	Nightmare	13	6.2	6.2	signal
54	Increased Appetite	7	6.2	6.2	signal
55	Akathisia	5	6.0	6.1	signal
56	Product Substitution Issue	21	6.0	6.1	signal
57	Suicidal Ideation	33	5.9	6.1	signal
58	Status Epilepticus	4	5.8	5.9	signal
59	Muscle Rigidity	4	5.5	5.5	signal
60	Respiratory Depression	4	5.4	5.4	signal
61	Drug Dispensing Error	5	5.3	5.3	signal
62	Extrapyramidal Disorder	8	5.3	5.3	signal
63	Drug Exposure During Pregnancy	11	5.3	5.3	signal
64	Activities Of Daily Living Impaired	6	4.9	5.0	signal
65	Euphoric Mood	3	4.8	4.8	signal
66	Mood Swings	9	4.7	4.7	signal
67	Neuroleptic Malignant Syndrome	3	4.2	4.2	signal
68	Abasia	6	4.0	4.0	signal
69	Drug Abuse	17	3.4	3.4	signal
70	Pregnancy	4	3.3	3.3	signal
71	Drug Withdrawal Syndrome	14	2.6	2.6	signal
72	Dependence	3	0.9	0.9	no signal