Drug

Metreleptin

60 flagged reaction(s) · 1,201 total co-reports · max PRR 50.5

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Blood Triglycerides Increased	53	50.5	52.7	signal
2	Therapy Cessation	92	30.4	32.8	signal
3	Glycosylated Haemoglobin Increased	41	27.5	28.4	signal
4	Hepatic Steatosis	25	22.7	23.1	signal
5	Diabetes Mellitus Inadequate Control	21	20.0	20.3	signal
6	Hepatomegaly	10	17.1	17.2	signal
7	Treatment Noncompliance	52	16.1	16.8	signal
8	Therapy Interrupted	66	16.1	17.0	signal
9	Pancreatitis Acute	21	15.9	16.1	signal
10	Blood Glucose Abnormal	17	15.5	15.7	signal
11	Hypoglycaemia	40	13.9	14.3	signal
12	Iron Deficiency Anaemia	7	12.9	12.9	signal
13	Hunger	10	12.5	12.6	signal
14	Hyperglycaemia	27	12.5	12.8	signal
15	Increased Appetite	13	11.7	11.8	signal
16	Blood Glucose Decreased	33	11.5	11.8	signal
17	Hepatic Encephalopathy	6	10.8	10.9	signal
18	Pancreatitis	33	10.5	10.8	signal
19	Diabetic Ketoacidosis	14	9.9	10.0	signal
20	Weight Fluctuation	6	9.7	9.8	signal
21	Needle Issue	16	9.4	9.5	signal
22	Blood Glucose Fluctuation	6	9.2	9.2	signal
23	Maternal Exposure During Pregnancy	48	9.2	9.5	signal
24	Urosepsis	5	9.1	9.2	signal
25	Diabetes Mellitus	37	8.1	8.4	signal
26	Ill-defined Disorder	27	7.5	7.6	signal
27	Osteomyelitis	8	7.5	7.5	signal
28	Blood Glucose Increased	82	7.3	7.8	signal
29	Appendicitis	4	7.3	7.3	signal
30	Insurance Issue	6	6.8	6.8	signal
31	Injection Site Discolouration	5	6.8	6.8	signal
32	Injection Site Extravasation	5	6.8	6.8	signal
33	Product Use Complaint	6	6.5	6.6	signal
34	Injection Site Induration	5	6.5	6.5	signal
35	Intentional Dose Omission	10	6.2	6.2	signal
36	Injection Site Mass	13	5.9	6.0	signal
37	Product Dose Omission Issue	98	5.8	6.2	signal
38	Post Procedural Haemorrhage	4	5.8	5.8	signal
39	Product Dose Omission	21	5.3	5.4	signal
40	Amenorrhoea	5	5.0	5.1	signal
41	Ovarian Cyst	3	5.0	5.0	signal
42	Injection Site Pruritus	19	4.8	4.9	signal
43	Syringe Issue	5	4.8	4.8	signal
44	Injection Site Urticaria	6	4.2	4.2	signal
45	Injection Site Irritation	3	4.0	4.0	signal
46	Abortion Spontaneous	9	3.8	3.8	signal
47	Injection Site Haemorrhage	16	3.4	3.4	signal
48	Pregnancy	4	3.3	3.3	signal
49	Injection Site Warmth	4	3.3	3.3	signal
50	Premature Delivery	3	3.2	3.2	no signal
51	Injection Site Bruising	14	3.0	3.0	signal
52	Injection Site Reaction	12	2.9	3.0	signal
53	Injection Site Swelling	13	2.9	2.9	signal
54	Injection Site Rash	5	2.8	2.8	signal
55	Product Complaint	4	2.7	2.7	no signal
56	Injection Site Pain	48	2.7	2.7	signal
57	Injection Site Erythema	19	2.6	2.6	signal
58	Menstruation Irregular	4	2.5	2.5	no signal
59	Product Storage Error	9	1.8	1.8	no signal
60	Device Difficult To Use	3	0.8	0.8	no signal