Drug

Nirogacestat

28 flagged reaction(s) · 386 total co-reports · max PRR 39.2

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Product Dose Omission In Error	42	39.2	41.2	signal
2	Amenorrhoea	17	25.5	26.0	signal
3	Dry Throat	10	24.7	25.0	signal
4	Stomatitis	59	24.4	26.1	signal
5	Folliculitis	8	19.4	19.6	signal
6	Intentional Dose Omission	19	17.4	17.8	signal
7	Brain Fog	10	17.2	17.4	signal
8	Insurance Issue	9	15.2	15.3	signal
9	Thirst	10	14.0	14.2	signal
10	Epistaxis	37	12.4	12.9	signal
11	Neoplasm Progression	17	12.1	12.4	signal
12	Cyst	6	12.1	12.2	signal
13	Hot Flush	35	11.6	12.1	signal
14	Ocular Discomfort	5	11.5	11.6	signal
15	Rash Maculo-papular	10	11.3	11.4	signal
16	Intestinal Perforation	5	11.1	11.2	signal
17	Impaired Driving Ability	5	11.0	11.1	signal
18	Skin Cancer	9	10.5	10.6	signal
19	Vitreous Floaters	4	10.3	10.3	signal
20	Menstruation Delayed	4	9.6	9.7	signal
21	Pharyngitis Streptococcal	4	9.2	9.3	signal
22	Therapy Cessation	16	7.8	8.0	signal
23	Underdose	20	6.9	7.0	signal
24	Cytokine Release Syndrome	5	6.6	6.6	signal
25	Peritonitis	5	6.0	6.1	signal
26	Hair Texture Abnormal	3	5.6	5.6	signal
27	Skin Irritation	8	4.4	4.4	signal
28	Menstruation Irregular	4	3.8	3.8	signal