OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Pazopanib

161 flagged reaction(s) · 6,219 total co-reports · max PRR 41.5
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Metastases To Lung 100 41.5 42.4 signal
2 Thyroid Cancer 85 33.5 34.2 signal
3 Malignant Neoplasm Progression 513 24.0 27.0 signal
4 Hair Colour Changes 59 22.4 22.7 signal
5 Pneumothorax 63 18.9 19.2 signal
6 Posterior Reversible Encephalopathy Syndrome 36 18.0 18.2 signal
7 Hepatotoxicity 75 16.1 16.4 signal
8 Metastases To Liver 57 15.5 15.7 signal
9 Palmar-plantar Erythrodysaesthesia Syndrome 75 15.3 15.5 signal
10 Proteinuria 56 14.1 14.3 signal
11 Metastases To Central Nervous System 37 13.7 13.9 signal
12 Metastases To Bone 47 13.7 13.8 signal
13 Blood Bilirubin Increased 70 12.3 12.5 signal
14 Neoplasm Progression 82 11.1 11.3 signal
15 Alanine Aminotransferase Increased 136 10.5 10.8 signal
16 Hepatic Function Abnormal 82 10.5 10.7 signal
17 Ascites 65 10.5 10.7 signal
18 Disease Progression 257 10.4 10.9 signal
19 Hypothyroidism 68 10.2 10.3 signal
20 Transaminases Increased 46 9.8 9.9 signal
21 Therapy Partial Responder 31 9.8 9.8 signal
22 Haematotoxicity 19 9.7 9.8 signal
23 Hyperbilirubinaemia 21 9.7 9.7 signal
24 Mucosal Inflammation 52 9.5 9.6 signal
25 Hypertensive Crisis 21 8.9 9.0 signal
26 Blood Thyroid Stimulating Hormone Increased 17 8.8 8.8 signal
27 Aspartate Aminotransferase Increased 86 7.7 7.8 signal
28 Ejection Fraction Decreased 25 7.6 7.7 signal
29 Intestinal Perforation 18 7.6 7.6 signal
30 Blood Alkaline Phosphatase Increased 39 7.5 7.5 signal
31 Gamma-glutamyltransferase Increased 34 7.3 7.3 signal
32 Jaundice 40 7.0 7.1 signal
33 Ileus 18 7.0 7.0 signal
34 Cardiomyopathy 21 6.7 6.8 signal
35 Pulmonary Mass 21 6.7 6.7 signal
36 Product Use In Unapproved Indication 343 6.7 7.1 signal
37 Hyperthyroidism 20 6.6 6.6 signal
38 Hypercalcaemia 17 6.5 6.6 signal
39 Pleural Effusion 78 6.1 6.2 signal
40 Drug-induced Liver Injury 39 6.0 6.1 signal
41 Thrombocytopenia 139 5.9 6.1 signal
42 Osteonecrosis Of Jaw 30 5.7 5.8 signal
43 Pneumonitis 32 5.6 5.7 signal
44 Flank Pain 11 5.6 5.6 signal
45 Febrile Neutropenia 72 5.2 5.2 signal
46 Liver Function Test Increased 23 5.1 5.1 signal
47 Liver Function Test Abnormal 31 5.0 5.1 signal
48 Pericardial Effusion 24 5.0 5.0 signal
49 Rebound Effect 11 4.6 4.6 signal
50 Haemoptysis 26 4.4 4.4 signal
51 Hepatic Failure 28 4.4 4.4 signal
52 Disseminated Intravascular Coagulation 13 4.4 4.4 signal
53 Malignant Melanoma 12 4.2 4.3 signal
54 Myocarditis 10 4.2 4.2 signal
55 Hyperglycaemia 32 4.2 4.2 signal
56 Blood Lactate Dehydrogenase Increased 14 4.2 4.2 signal
57 Hypertension 185 4.1 4.3 signal
58 Retinal Detachment 8 4.1 4.1 signal
59 Haematuria 29 4.0 4.0 signal
60 Cholecystitis 10 4.0 4.0 signal
61 Neutropenia 113 4.0 4.0 signal
62 Bone Marrow Failure 17 3.9 4.0 signal
63 Thrombotic Microangiopathy 8 3.9 3.9 signal
64 Cardiomegaly 10 3.8 3.8 signal
65 Haemorrhage Intracranial 12 3.8 3.8 signal
66 Blood Creatinine Increased 52 3.8 3.8 signal
67 Pulmonary Embolism 74 3.7 3.7 signal
68 Hepatocellular Injury 11 3.7 3.7 signal
69 General Physical Health Deterioration 88 3.6 3.7 signal
70 Brain Neoplasm 7 3.6 3.6 signal
71 Multiple Organ Dysfunction Syndrome 21 3.6 3.6 signal
72 Dehydration 99 3.5 3.6 signal
73 Hypocalcaemia 14 3.5 3.5 signal
74 Anaemia 141 3.5 3.6 signal
75 Acute Respiratory Distress Syndrome 13 3.5 3.5 signal
76 Decreased Appetite 169 3.5 3.6 signal
77 Renal Impairment 61 3.5 3.5 signal
78 Platelet Count Decreased 75 3.3 3.4 signal
79 Liver Injury 17 3.3 3.3 signal
80 Electrolyte Imbalance 8 3.3 3.3 signal
81 Hyponatraemia 39 3.3 3.3 signal
82 Hepatic Enzyme Increased 47 3.3 3.3 signal
83 Cardiac Failure 55 3.3 3.3 signal
84 Drug Level Decreased 7 3.2 3.3 signal
85 Multi-organ Failure 12 3.2 3.3 signal
86 Bacteraemia 8 3.2 3.2 signal
87 Rhabdomyolysis 28 3.2 3.2 signal
88 Sudden Death 7 3.1 3.1 signal
89 Mental Status Changes 18 3.1 3.1 signal
90 Myelosuppression 22 3.1 3.1 signal
91 Musculoskeletal Chest Pain 10 3.1 3.1 signal
92 Erythema Multiforme 6 3.1 3.1 signal
93 Colitis 24 3.0 3.0 signal
94 Lung Infection 10 3.0 3.0 signal
95 Hepatitis 16 3.0 3.0 signal
96 Drug Resistance 16 3.0 3.0 signal
97 Chromaturia 14 2.9 2.9 signal
98 Skin Ulcer 16 2.9 2.9 signal
99 Respiratory Failure 45 2.9 2.9 signal
100 Drug Interaction 97 2.9 2.9 signal
101 Neoplasm 7 2.9 2.9 signal
102 Hemiparesis 10 2.8 2.8 signal
103 Adrenal Insufficiency 7 2.8 2.8 signal
104 Stomatitis 35 2.7 2.8 signal
105 Cholestasis 11 2.7 2.7 signal
106 Hyperkalaemia 20 2.7 2.7 signal
107 Small Intestinal Obstruction 7 2.7 2.7 signal
108 Brain Oedema 7 2.6 2.6 signal
109 Cardiovascular Disorder 14 2.6 2.6 signal
110 Melaena 12 2.6 2.6 signal
111 Pancreatitis Acute 12 2.6 2.6 signal
112 Aphasia 16 2.5 2.5 signal
113 Nervous System Disorder 16 2.4 2.4 signal
114 Pancreatitis 27 2.4 2.4 signal
115 Body Temperature Decreased 5 2.4 2.4 no signal
116 Lymphopenia 7 2.4 2.4 signal
117 Inappropriate Antidiuretic Hormone Secretion 5 2.3 2.3 no signal
118 Cerebral Infarction 12 2.3 2.3 signal
119 Subarachnoid Haemorrhage 5 2.3 2.3 no signal
120 Lymphadenopathy 17 2.3 2.3 signal
121 Pancytopenia 26 2.2 2.2 signal
122 Therapeutic Response Decreased 28 2.2 2.2 signal
123 Nodule 6 2.2 2.2 no signal
124 Transient Ischaemic Attack 15 2.1 2.1 signal
125 Disease Recurrence 21 2.1 2.1 signal
126 Central Nervous System Lesion 6 2.1 2.1 no signal
127 Ovarian Cancer 4 2.1 2.1 no signal
128 Gastrointestinal Haemorrhage 36 2.0 2.0 signal
129 Polyneuropathy 5 2.0 2.0 no signal
130 Cerebral Haemorrhage 15 2.0 2.0 no signal
131 Cytopenia 5 2.0 2.0 no signal
132 Renal Failure Acute 18 2.0 2.0 no signal
133 Electrocardiogram Qt Prolonged 15 2.0 2.0 no signal
134 Pneumocystis Jirovecii Pneumonia 4 1.9 1.9 no signal
135 Ischaemic Stroke 7 1.9 1.9 no signal
136 Thyroid Disorder 6 1.8 1.8 no signal
137 Dysgeusia 29 1.8 1.8 no signal
138 Acute Myeloid Leukaemia 6 1.8 1.8 no signal
139 Eye Haemorrhage 5 1.8 1.8 no signal
140 Neutrophil Count Decreased 15 1.8 1.8 no signal
141 Acute Hepatic Failure 5 1.7 1.7 no signal
142 Cytokine Release Syndrome 7 1.7 1.7 no signal
143 Renal Injury 11 1.7 1.7 no signal
144 Nephropathy Toxic 4 1.7 1.7 no signal
145 Fistula 4 1.7 1.7 no signal
146 Death 304 1.7 1.7 no signal
147 Drug Effect Incomplete 13 1.7 1.7 no signal
148 Interstitial Lung Disease 17 1.7 1.7 no signal
149 Myelodysplastic Syndrome 5 1.6 1.6 no signal
150 Neurotoxicity 6 1.6 1.6 no signal
151 Peritonitis 7 1.6 1.6 no signal
152 No Therapeutic Response 4 1.5 1.5 no signal
153 Grand Mal Convulsion 3 1.5 1.5 no signal
154 Toxicity To Various Agents 52 1.5 1.5 no signal
155 Injection Site Induration 4 1.5 1.5 no signal
156 Renal Cancer 13 1.3 1.3 no signal
157 Hepatic Cytolysis 3 1.2 1.2 no signal
158 Anorexia 3 1.1 1.1 no signal
159 Drug Effective For Unapproved Indication 6 1.0 1.0 no signal
160 Gastric Cancer 4 0.7 0.7 no signal
161 Needle Issue 4 0.7 0.7 no signal