Drug

Pegloticase

61 flagged reaction(s) · 2,957 total co-reports · max PRR 183.7

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Gout	562	183.7	216.6	signal
2	Infusion Related Reaction	365	31.6	35.0	signal
3	Therapeutic Response Decreased	240	22.7	24.2	signal
4	Anaphylactic Reaction	102	10.6	10.9	signal
5	Throat Tightness	36	7.6	7.7	signal
6	Glomerular Filtration Rate Decreased	14	6.6	6.6	signal
7	Pharyngeal Swelling	11	6.5	6.6	signal
8	Unresponsive To Stimuli	27	6.0	6.0	signal
9	Circumstance Or Information Capable Of Leading To Medication Error	33	5.6	5.6	signal
10	Chest Discomfort	100	5.6	5.7	signal
11	Blood Pressure Decreased	65	5.6	5.7	signal
12	Urticaria	144	4.9	5.1	signal
13	Dialysis	12	4.8	4.8	signal
14	Flushing	83	4.6	4.7	signal
15	Poor Venous Access	8	4.4	4.4	signal
16	Renal Pain	8	4.3	4.3	signal
17	Hypoaesthesia Oral	11	4.2	4.2	signal
18	Therapy Partial Responder	11	4.2	4.2	signal
19	Gait Inability	24	4.1	4.1	signal
20	Cold Sweat	12	3.9	3.9	signal
21	Osteomyelitis	12	3.8	3.8	signal
22	Therapy Non-responder	28	3.6	3.6	signal
23	Loss Of Consciousness	80	3.6	3.6	signal
24	Chest Pain	115	3.5	3.6	signal
25	Blood Potassium Increased	10	3.5	3.5	signal
26	Feeling Hot	37	3.4	3.5	signal
27	Product Storage Error	52	3.4	3.5	signal
28	Blood Pressure Increased	91	3.4	3.4	signal
29	Chromaturia	13	3.3	3.3	signal
30	Paraesthesia Oral	8	3.2	3.2	signal
31	Hyperhidrosis	71	3.1	3.2	signal
32	Contraindicated Product Administered	16	3.0	3.0	signal
33	Dizziness Postural	5	3.0	3.0	signal
34	Swollen Tongue	16	2.9	2.9	signal
35	Presyncope	12	2.8	2.8	signal
36	Throat Irritation	22	2.8	2.8	signal
37	Lip Swelling	16	2.7	2.7	signal
38	Inappropriate Schedule Of Product Administration	85	2.7	2.8	signal
39	Peripheral Swelling	73	2.7	2.7	signal
40	Transfusion	5	2.7	2.7	no signal
41	Therapeutic Product Effect Decreased	21	2.7	2.7	signal
42	Sars-cov-2 Test Positive	6	2.6	2.6	signal
43	Cyanosis	7	2.5	2.5	signal
44	Cardiac Failure Congestive	36	2.5	2.5	signal
45	Intentional Dose Omission	12	2.5	2.5	signal
46	Brain Neoplasm	4	2.5	2.5	no signal
47	Localised Infection	10	2.4	2.4	signal
48	Therapy Interrupted	28	2.3	2.3	signal
49	Hip Arthroplasty	6	2.2	2.3	no signal
50	Adverse Reaction	5	2.1	2.1	no signal
51	Hypertensive Crisis	4	2.0	2.0	no signal
52	Anaphylactic Shock	9	2.0	2.0	no signal
53	Blood Glucose Increased	66	2.0	2.0	no signal
54	Muscle Rigidity	4	1.9	1.9	no signal
55	Cardiac Disorder	28	1.7	1.7	no signal
56	Myocardial Infarction	49	1.6	1.6	no signal
57	Blood Glucose Abnormal	5	1.5	1.5	no signal
58	Diabetic Ketoacidosis	6	1.4	1.4	no signal
59	Cytomegalovirus Infection	4	1.4	1.4	no signal
60	Abortion Spontaneous	7	1.0	1.0	no signal
61	Therapeutic Response Shortened	5	0.9	0.9	no signal