Drug

Pertuzumab, Trastuzumab, And Hyaluronidase-zzxf

71 flagged reaction(s) · 3,820 total co-reports · max PRR 23.4

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	No Adverse Event	907	23.4	28.9	signal
2	Metastases To Central Nervous System	48	17.1	17.3	signal
3	Ejection Fraction Decreased	40	11.7	11.8	signal
4	Injection Site Reaction	161	10.7	11.1	signal
5	Incorrect Route Of Product Administration	23	6.2	6.3	signal
6	Metastases To Bone	20	5.6	5.6	signal
7	Full Blood Count Abnormal	12	5.2	5.2	signal
8	Disease Progression	134	5.2	5.3	signal
9	Surgery	64	5.0	5.1	signal
10	Off Label Use	888	4.7	5.5	signal
11	Neoplasm	11	4.4	4.4	signal
12	Breast Cancer Metastatic	10	4.3	4.3	signal
13	Polyneuropathy	11	4.2	4.2	signal
14	Metastases To Liver	16	4.2	4.2	signal
15	Ageusia	22	4.0	4.0	signal
16	Mouth Ulceration	17	3.7	3.7	signal
17	Product Prescribing Error	19	3.7	3.7	signal
18	Product Administration Error	16	3.7	3.7	signal
19	Metastases To Lung	9	3.6	3.6	signal
20	Immunodeficiency	11	3.4	3.4	signal
21	Myelosuppression	25	3.4	3.4	signal
22	Mucosal Inflammation	19	3.3	3.3	signal
23	Central Nervous System Lesion	10	3.3	3.3	signal
24	Thrombotic Microangiopathy	7	3.3	3.3	signal
25	Skin Reaction	10	3.2	3.2	signal
26	Neuropathy Peripheral	67	3.2	3.3	signal
27	Injection Site Pain	210	3.2	3.3	signal
28	Diarrhoea	403	2.9	3.0	signal
29	Lymphadenopathy	22	2.8	2.8	signal
30	Brain Fog	9	2.8	2.8	signal
31	Cardiomyopathy	9	2.8	2.8	signal
32	Interstitial Lung Disease	29	2.7	2.7	signal
33	Taste Disorder	12	2.7	2.7	signal
34	Ill-defined Disorder	35	2.6	2.6	signal
35	Infusion Related Reaction	38	2.6	2.6	signal
36	Gait Inability	19	2.6	2.6	signal
37	Pneumothorax	9	2.6	2.6	signal
38	Breast Pain	6	2.6	2.6	signal
39	Pneumonitis	14	2.4	2.4	signal
40	Feeding Disorder	10	2.3	2.3	signal
41	Product Administered At Inappropriate Site	9	2.3	2.3	signal
42	Injection Site Discomfort	5	2.2	2.2	no signal
43	Folliculitis	5	2.2	2.2	no signal
44	Product Storage Error	41	2.2	2.2	signal
45	Renal Pain	5	2.2	2.2	no signal
46	Product Dispensing Error	10	2.1	2.1	signal
47	Erythema	87	1.9	2.0	no signal
48	Hepatic Cytolysis	5	1.9	1.9	no signal
49	Injection Site Discolouration	5	1.8	1.8	no signal
50	Pneumocystis Jirovecii Pneumonia	4	1.8	1.8	no signal
51	Neoplasm Malignant	26	1.8	1.8	no signal
52	Neoplasm Progression	12	1.6	1.6	no signal
53	Procedural Pain	9	1.5	1.5	no signal
54	Cytokine Release Syndrome	6	1.4	1.4	no signal
55	Pain Of Skin	8	1.4	1.4	no signal
56	Cardiac Disorder	27	1.3	1.3	no signal
57	Malignant Neoplasm Progression	29	1.3	1.3	no signal
58	Breast Cancer	25	1.2	1.2	no signal
59	Diabetic Ketoacidosis	6	1.1	1.1	no signal
60	Osteonecrosis Of Jaw	6	1.1	1.1	no signal
61	Injection Site Extravasation	3	1.1	1.1	no signal
62	Injection Site Erythema	27	1.0	1.0	no signal
63	Injection Site Swelling	16	1.0	1.0	no signal
64	Hepatic Cancer	5	0.9	0.9	no signal
65	Product Preparation Error	4	0.9	0.9	no signal
66	Acne	14	0.8	0.8	no signal
67	Application Site Erythema	4	0.7	0.7	no signal
68	Circumstance Or Information Capable Of Leading To Medication Error	5	0.7	0.7	no signal
69	Injection Site Warmth	3	0.7	0.7	no signal
70	Injection Site Rash	4	0.6	0.6	no signal
71	Injection Site Urticaria	3	0.6	0.6	no signal